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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 112 of 674

Negative / Null Result Report

Climate Change Can Drive a Significant Loss of Suitable Habitat for Polylepis quadrijuga, a Treeline Species in the Sky Islands of the Northern Andes

Lina Caballero-Villalobos, Francisco Fajardo-Gutiérrez, Mariasole Calbi et al. · 2021 · Frontiers in Ecology and Evolution

It is predicted that climate change will strongly affect plant distributions in high elevation “sky islands” of tropical Andes. Polylepis forests are a dominant element of the treeline throughout the Andes Cordillera in South America.…

View details →DOI: 10.3389/fevo.2021.661550Cited by 18
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Refining Pheromone Lures for the Invasive Halyomorpha halys (Hemiptera: Pentatomidae) Through Collaborative Trials in the United States and Europe

Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology

Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…

View details →DOI: 10.1093/jee/toab088Cited by 18
Negative / Null Result ReportOpen accessMedicine

Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density

Paul Sondo, Biébo Bihoun, Marc Christian Tahita et al. · 2021 · Malaria Journal

BACKGROUND: Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explored host and parasite-related risk factors for gametocyte carriage, and the extent to which some specific P. falciparum genetic variants are associated with gametocyte carriage. METHODS: Gametocytes and asexual forms were detected by light microscopy

View details →DOI: 10.1186/s12936-020-03559-0Cited by 18
Negative / Null Result Report

Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016

Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety

Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…

View details →DOI: 10.1002/pds.4881Cited by 18
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Significant Association of Caveolin-1 Genotypes with Bladder Cancer Susceptibility in Taiwan

Da‐Tian Bau · 2011 · The Chinese Journal of Physiology

Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…

View details →DOI: 10.4077/cjp.2011.amm009Cited by 18
Negative / Null Result Report

Decreasing but still significant facilitation effect of cold-season macrophytes on wetlands purification function during cold winter

Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports

Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…

View details →DOI: 10.1038/srep27011Cited by 18
Negative / Null Result Report

Single and repeated intra‐articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow‐derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin‐1β model of synovitis

Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal

Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…

View details →DOI: 10.1111/evj.13222Cited by 18
Negative / Null Result Report

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture

RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…

View details →DOI: 10.3390/biom12040541Cited by 18
Negative / Null Result Report

Using Bibliometrics to Demonstrate the Value of Library Journal Collections

Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries

Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…

View details →DOI: 10.5860/crl.77.4.410Cited by 18
Negative / Null Result ReportOpen accessDentistry

Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?

Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal

This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…

View details →DOI: 10.4012/dmj.2021-208Cited by 18
Negative / Null Result ReportOpen accessEngineering

On the co-rotational method for geometrically nonlinear topology optimization

Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization

Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem

View details →DOI: 10.1007/s00158-020-02605-4Cited by 18
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

Andrea J. Savio, Mathieu Lemire, Miralem Mrkonjic et al. · 2012 · PLoS ONE

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between different tissues and matched normal versus tumor cells of patients. To date, most epigenetic studie

View details →DOI: 10.1371/journal.pone.0051531Cited by 18
Negative / Null Result ReportOpen accessPsychology

Adolescent perfectionism: Structural features of the Frost Multidimensional Perfectionism Scale and correlates with attachment and psychopathology

Emily P. Taylor, Rachel Couper, Carolyn Maeve Butler · 2017 · Psychology and Psychotherapy Theory Research and Practice

OBJECTIVES: Perfectionism is recognized as a significant risk factor for psychopathology. Emerging research links attachment to perfectionism in adult and college-age samples. The Frost Multidimensional Perfectionism Scale (FMPS) has been…

View details →DOI: 10.1111/papt.12133Cited by 18
Negative / Null Result ReportOpen accessPsychology

Psychometric Validation Study of the Liebowitz Social Anxiety Scale - Self-Reported Version for Brazilian Portuguese

Larissa Forni dos Santos, Sônia Regina Loureiro, José Alexandre S. Crippa et al. · 2013 · PLoS ONE

Social Anxiety Disorder (SAD) is prevalent and rarely diagnosed due to the difficulty in recognizing its symptoms as belonging to a disorder. Therefore, the evaluation/screening scales are of great importance for its detection, with the most used being the Liebowitz Social Anxiety Scale (LSAS). Thus, this study proposed to evaluate the psychometric properties of internal consistency and convergent validity, as well as the confirmatory factorial analysis and reliability of the self-reported version of the LSAS (LSAS-SR), translated into Brazilian Portuguese, in a sample of the general populatio

View details →DOI: 10.1371/journal.pone.0070235Cited by 18
Negative / Null Result ReportOpen accessNeuroscience

Wearing a bike helmet leads to less cognitive control, revealed by lower frontal midline theta power and risk indifference

Barbara Schmidt, Luisa Keßler, Clay B. Holroyd et al. · 2019 · Psychophysiology

A recent study claims that participants wearing a bike helmet behave riskier in a computer-based risk task compared to control participants without a bike helmet. We hypothesized that wearing a bike helmet reduces cognitive control over risky behavior. To test our hypothesis, we recorded participants' EEG brain responses while they played a risk game developed in our laboratory. Previously, we found that, in this risk game, anxious participants showed greater levels of cognitive control as revealed by greater frontal midline theta power, which was associated with less risky decisions. Here, we

View details →DOI: 10.1111/psyp.13458Cited by 18
Negative / Null Result ReportOpen accessMedicine

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202

Valentine Wanga, Charles S. Venuto, Gene D. Morse et al. · 2015 · Pharmacogenetics and Genomics

BACKGROUND: Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We carried out genomewide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first…

View details →DOI: 10.1097/fpc.0000000000000156Cited by 18
Negative / Null Result ReportOpen accessPsychology

Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder

Hubertus Himmerich, Jörg-Egbert Wolf, Peter Zimmermann et al. · 2016 · Chinese Medical Journal

To the Editor: With great interest we read the original article of Chen et al.[1] published in the Chinese Medical Journal comparing serum concentrations of cytokines in patients of Han and Li ethnicity with posttraumatic stress disorder…

View details →DOI: 10.4103/0366-6999.178039Cited by 18
Negative / Null Result ReportPsychology

Effects of the Reread-Adapt and Answer-Comprehend and goal setting intervention on decoding and reading comprehension skills of young adults with intellectual disabilities

Youjia Hua, Chengan Yuan, Kristin V. Monroe et al. · 2016 · Developmental Neurorehabilitation

OBJECTIVE: Reread-Adapt and Answer-Comprehend (RAAC) + Goal Setting intervention is a reading intervention that addresses both oral reading fluency (ORF) and reading comprehension while supporting persistence and motivation for learners…

View details →DOI: 10.3109/17518423.2016.1139011Cited by 18
Negative / Null Result ReportOpen accessImmunology and Microbiology

Systemic Influences of Mammary Cancer on Monocytes in Mice

Amy Robinson, Matthew Burgess, Sheila Webb et al. · 2022 · Cancers

There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here, we show that there is an increase in the number of bone marrow, circulating and splenic monocytes by using mouse models of breast cancer caused by the mammary epithelial expression of the polyoma middle T antigen. Cancer does not affect ratios of classical to non-classical populations of monocytes in the circulation nor does it affect their half-lives. Single cell RNA sequencing also indicates that cancer doe

View details →DOI: 10.3390/cancers14030833Cited by 18
Negative / Null Result ReportComputer Science

Mining statistically significant connected subgraphs in vertex labeled graphs

Akhil Arora, Mayank Sachan, Arnab Bhattacharya · 2014

The steady growth of graph data in various applications has resulted in wide-spread research in finding significant sub-structures in a graph. In this paper, we address the problem of finding statistically significant connected subgraphs…

View details →DOI: 10.1145/2588555.2588574Cited by 18
Negative / Null Result ReportOpen accessMathematics

Testing the interhemispheric deficit theory of dyslexia using the visual half-field technique

Abigail Bradshaw, Dorothy Bishop, Zoe Woodhead · 2019 · Quarterly Journal of Experimental Psychology

A deficit in interhemispheric transfer has been proposed as a neuropsychological theory of dyslexia. Interactions between the hemispheres during word recognition can be studied using the visual half-field paradigm. The well-established…

View details →DOI: 10.1177/1747021819895472Cited by 18
Negative / Null Result ReportNeuroscience

No evidence that self-rated negative emotion boosts visual working memory precision.

Alessandra S. Souza, Theresa Thaler, Heinrich R. Liesefeld et al. · 2020 · Journal of Experimental Psychology Human Perception & Performance

Emotion is assumed to change how people process information by modulating attentional focus. Two recent studies (Spachtholz et al., 2014; Xie & Zhang, 2016) reported that self-reported negative emotion boosted the precision with which…

View details →DOI: 10.1037/xhp0000891Cited by 18
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Amino Acid Residues 489–503 of Dihydropyridine Receptor (DHPR) β1a Subunit Are Critical for Structural Communication between the Skeletal Muscle DHPR Complex and Type 1 Ryanodine Receptor

José M. Eltit, Clara Franzini‐Armstrong, Claudio F. Pérez · 2014 · Journal of Biological Chemistry

The β1a subunit is a cytoplasmic component of the dihydropyridine receptor (DHPR) complex that plays an essential role in skeletal muscle excitation-contraction (EC) coupling. Here we investigate the role of the C-terminal end of this auxiliary subunit in the functional and structural communication between the DHPR and the Ca2+ release channel (RyR1). Progressive truncation of the β1a C terminus showed that deletion of amino acid residues Gln489 to Trp503 resulted in a loss of depolarization-induced Ca2+ release, a severe reduction of L-type Ca2+ currents, and a lack of tetrad formation as eva

View details →DOI: 10.1074/jbc.m114.615526Cited by 18
Negative / Null Result ReportOpen accessNeuroscience

Handedness, Earnings, Ability and Personality. Evidence from the Lab

Marcello Sartarelli · 2016 · PLoS ONE

Evidence showing that on average left-handed (L), who are 10% in a population, tend to earn less than others is solely based on survey data. This paper is the first to test the relationship between handedness and earnings experimentally and also to assess whether the mechanism underlying it is predominantly cognitive or psychological. Data on 432 undergraduate students show that L do not obtain significantly different payoffs, a proxy for earnings, in a stylised labour market with multiple principals and agents. Similarly, scores in the Cognitive Reflection Test are not significantly different

View details →DOI: 10.1371/journal.pone.0164412Cited by 18
Negative / Null Result ReportOpen accessMedicine

Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4

Mark B. Stoddard, Hui Li, Shuyi Wang et al. · 2015 · mBio

UNLABELLED: Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a "quasispecies." Transmission is generally associated with a stringent population bottleneck characterized by infection by limited numbers of "transmitted/founder" (T/F) viruses. Characterization of T/F genomes of human immunodeficiency virus type 1 (HIV-1) has been integral to studies of transmission, immunopathogenesis, and vaccine development. Here, we describe the identification of complete T/F genomes of HCV by single-genome sequencing of plasma viral RNA from a

View details →DOI: 10.1128/mbio.02518-14Cited by 18
Negative / Null Result ReportMedicine

Adaptation and Transmission of a Wild Duck Avian Influenza Isolate in Chickens

Jinling Li, Carol J. Cardona · 2010 · Avian Diseases

Mutations in a wild duck isolate of avian influenza virus were detected in isolates shed by chickens within 1 day after inoculation. The newly adapted virus was transmitted to naïve chickens in direct contact and sharing food and water.…

View details →DOI: 10.1637/8806-040109-resnote.1Cited by 18
Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics

Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the dissolution profile in conventional mini-USP II and a biorelevant colon model

Michael Schütt, Konstantinos Stamatopoulos, Hannah Batchelor et al. · 2022 · European Journal of Pharmaceutical Sciences

The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised replica, the mini-USP II. However, these fail to replicate the hydrodynamics and shear stresses in the colonic environment, which is crucial for the tablet's drug release process. In this work, computer simulations are used to create a digital twin of a dissolution apparatus and to develop a method to create a digital twin of a tablet that behaves realistically. These models are used to investigate the drug release profiles and s

View details →DOI: 10.1016/j.ejps.2022.106310Cited by 18
Negative / Null Result ReportOpen accessPsychology

Confirmatory Factor Analysis of the Male Body Attitudes Scale (MBAS) among Spanish Adolescent Males

Ana R. Sepúlveda, Dimitra Anastasiadou, Yolanda de Pellegrin et al. · 2016 · Men and Masculinities

The aim of this study was to examine the factor structure of the Male Body Attitudes Scale (MBAS) among a sample of 212 adolescent males by conducting a confirmatory factor analysis. The data revealed that while muscularity and low body fat factors were appropriate for the male sample, the height factor was not supported. The composite MBAS-Spanish version (MBAS-S) and its two factors had high internal consistency and were not significantly related to the traditionally used measure of body image (Eating Disorder Inventory–Body Dissatisfaction [BD]), confirming that this subscale only appears t

View details →DOI: 10.1177/1097184x16634798Cited by 18