A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19808 results in Negative / Null Result Report · page 112 of 661
Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care
OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…
Lucy Brazil, Angela Swampillai, Ka Man Mak et al. · 2020 · Neuro-Oncology Advances
BACKGROUND: Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. METHODS: We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0-1 were included. Radiotherapy
Jose Ruiz, Saravana Kanagavelu, Claudia Flores et al. · 2016 · Frontiers in Cellular and Infection Microbiology
Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how systemic TRIF activation enhances intestinal immune defense against Gram-negative bacteria. First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. This prote
Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace
AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…
Etsuro Ogata, Masafumi Fukagawa, Hideki Hirakata et al. · 2016 · Clinical and Experimental Nephrology
BACKGROUND: Calcium (Ca)-based phosphate (P) binders, compared to non-Ca-based P binders, contribute to vascular calcification, which is associated with cardiovascular events. METHODS: The LANDMARK study is a multicenter, randomized, open-label, parallel comparative study of lanthanum carbonate (LC) and calcium carbonate (CC) in hemodialysis patients. Stable hemodialysis patients with intact parathyroid hormone ≤240 pg/mL meeting ≥1 of the following criteria (age >65 years, postmenopause, diabetes mellitus) were randomized into the LC and CC groups. LC group patients initially received LC 750
Annelise Mennicke, Heather M. Bush, Candace J. Brancato et al. · 2021 · Journal of Family Violence
Abstract Youth who witness parental intimate partner violence (IPV) are at increased risk of teen dating violence (DV). This analysis of secondary data investigated whether a bystander intervention program, Green Dot, was effective at…
Lijun Lu, Youqing Deng, Renshi Xu · 2024 · Frontiers in Neurology
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which there is still no cure. The disease seriously jeopardizes the health and lifespan of adult populations. The authors extensively retrieved the current literature about clinical and experimental ALS treatments. Based on them, this review primarily focused on summarizing the current potential clinical usage and trialing therapeutics of ALS. Currently, the clinical ALS treatments have focused primarily on relieving symptoms to improve the quality of life yet. There are a number of therapeutic approaches suc
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
Robert S. Wallis · 2014 · Open Forum Infectious Diseases
OBJECTIVES: There is increasing interest in the potential role of adjunctive anti-inflammatory therapy to accelerate tuberculosis (TB) treatment. Sputum culture conversion is an important biomarker predictor of durable TB cure. METHODS:…
Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics
In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…
Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer
BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…
Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion
Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…
Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism
OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti
Marta Arroyo‐Izaga, Concepción Martínez de la Pera, Laura Ansotegui et al. · 2026 · Archivos Latinoamericanos de Nutrición
The objective of this study was to determine whether a short training program, using real foods, would decreased their portion-size estimation errors after training. 90 student volunteers (20.18+/-0.44 y old) of the University of the…
Xiaoxiao Ma · 2023 · Green and Low-Carbon Economy
Facing severe air pollution, the Chinese government has introduced bottom-up public participation in environmental policy. The increase in public environmental attention can promote the participation of all people in environmental…
Enrique Rozengurt, G. Eibl · 2026 · Signal Transduction and Targeted Therapy
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which there is no effective treatment. A deep understanding of the mechanisms underlying the molecular pathogenesis, signaling pathways and risk factors leading to PDAC is of paramount importance for identifying novel targets, prognostic markers, preventive strategies, and signature markers for use in specific and personalized therapeutic procedures. Activating somatic mutations in the KRAS oncogene play a critical role in PDAC initiation and maintenance. Here, we highlight the complex interplay between KRAS signaling, the tr
Michael Rabbia, Maitea Guridi Ormazabal, Hannah Staunton et al. · 2024 · Journal of Neuromuscular Diseases
Background: Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne muscular dystrophy (DMD) aged ≥4 years. Objective: To compare SV95C-in its first-ever clinical trial application as a secondary endpoint-with established motor function COAs used in the trial (Four-Stair Climb [4SC] velocity, North Star Ambulatory Assessment [NSAA], and Six-Minute Walk Distance [6MWD]). Methods: SV95C was a secondary endpoint in a subset (n = 47)
Attila Salamon, Stefania Uccheddu, Melitta Csepregi et al. · 2023 · Scientific Reports
Abstract The dog is a so far unique species to study interspecific communication and a promising evolutionary model for preverbal human communication. Recently cats were reported to show some similar skills to dogs. Here we directly…
Nicholas S. OSCROFT, Ian E. SMITH · 2010 · Respirology
ABSTRACT Background and objective: Volume‐assured non‐invasive positive pressure ventilation (va‐NIPPV) is a novel mode designed to adapt pressure support (PS) to achieve a target minute ventilation (TgV). This may optimize ventilation;…
Nikola Hrabovska, Erik Kajati, Iveta Zolotova · 2023 · Electronics
This research article presents an analysis of health data collected from wearable devices, aiming to uncover the practical applications and implications of such analyses in personalized healthcare. The study explores insights derived from…
K. C. Yates, B. S. Bauer, S. Fuelling et al. · 2019 · Physics of Plasmas
We report the first observation of a significant change in plasma formation and evolution caused by a small change in the material composition (metal alloy). Thick copper rod alloys were varied in the initial diameter from 0.5 mm to 1.59…
David R. Chalcraft · 2019 · Ecology Letters
Abstract Recent simulations suggest that ecologists can enhance the predictive ability of models by designing experiments that maximise the number of levels of an experimental factor by sacrificing replication. Here, I describe how these…
Maureen van Eijnatten, Leonardo Rundo, Batenburg, Joost et al. · 2021 · Data Archiving and Networked Services (DANS)
Background and Objectives: Deep learning is being increasingly used for deformable image registration and unsupervised approaches, in particular, have shown great potential. However, the registration of abdominopelvic Computed Tomography…
Michael K. Urban, Kristy M. Labib, Shane C. Reid et al. · 2018 · HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Background The treatment of postoperative pain is a challenge after posterior spinal fusions. Pain management using predominantly opioids is often associated with multiple adverse effects, while multimodal postoperative analgesia may…
Martin Grosse Holtforth, David Altenstein, Emily Ansell et al. · 2011 · Journal of Clinical Psychology
Abstract Whereas previous interpersonal research in depression has frequently used self‐reports, patients' impact on others is rarely analyzed. We analyzed impacts of 180 depressed psychotherapy outpatients out of 832 diagnostically…
Jekaterina Kazantseva, Roman Ivanov, Michael Gasik et al. · 2016 · Scientific Reports
Abstract Three-dimensional (3D) customized scaffolds capable to mimic a native extracellular matrix open new frontiers in cells manipulation and advanced therapy. The major challenge is in a proper substrate for in vitro models on…
Yun Gi Kim, Jong‐Il Choi, Ki Yung Boo et al. · 2019 · Clinical Cardiology
Abstract Background Age is a well‐established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. Methods The prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large‐scale single‐center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. Results NHIS sample cohort dat
Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability
Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat
Endre Willassen, Jon-Ivar Westgaard, Jon Anders Kongsrud et al. · 2022 · PeerJ
To protect and restore ecosystems and biodiversity is one of the 10 challenges identified by the United Nations’s Decade of the Ocean Science. In this study we used eDNA from sediments collected in two fjords of the Svalbard archipelago…
Kohei Ohnishi, Yuma Ono, Tatsuya Nomura et al. · 2014 · Scientific Reports
Abstract The combination between the spin-dependent and super-conducting (SC) transports is expected to provide intriguing properties such as crossed Andreev reflection and spin-triplet superconductivity. This may be able to open a new…