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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21165 results · page 10 of 706

Negative / Null Result ReportOpen accessDentistry

Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study

Mario Imburgia, Silvia Logozzo, Uli Hauschild et al. · 2017 · BMC Oral Health

BACKGROUND: Until now, only a few studies have compared the ability of different intraoral scanners (IOS) to capture high-quality impressions in patients with dental implants. Hence, the aim of this study was to compare the trueness and precision of four IOS in a partially edentulous model (PEM) with three implants and in a fully edentulous model (FEM) with six implants. METHODS: Two gypsum models were prepared with respectively three and six implant analogues, and polyether-ether-ketone cylinders screwed on. These models were scanned with a reference scanner (ScanRider®), and with four IOS (C

View details →DOI: 10.1186/s12903-017-0383-4Cited by 389
Negative / Null Result ReportMedicine

Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction

Jay H. Traverse, Timothy D. Henry, Carl J. Pepine et al. · 2012 · JAMA

CONTEXT: While the delivery of cell therapy after ST-segment elevation myocardial infarction (STEMI) has been evaluated in previous clinical trials, the influence of the timing of cell delivery on the effect on left ventricular function…

View details →DOI: 10.1001/jama.2012.28726Cited by 388
Negative / Null Result ReportSocial Sciences

Relationships between place attachment, place satisfaction and pro-environmental behaviour in an Australian national park

Haywantee Ramkissoon, Liam Smith, Betty Weiler · 2012 · Journal of Sustainable Tourism

Place attachment is a multidimensional construct comprising place dependence, place affect, place identity, and place social bonding. Yet, studies investigating the relationships between place attachment, place satisfaction, and…

View details →DOI: 10.1080/09669582.2012.708042Cited by 388
Negative / Null Result ReportOpen accessPsychology

The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts

Paola Ferri, Matteo Guadi, Luigi Marcheselli et al. · 2016 · Risk Management and Healthcare Policy

BACKGROUND: Shift work is considered necessary to ensure continuity of care in hospitals and residential facilities. In particular, the night shift is one of the most frequent reasons for the disruption of circadian rhythms, causing…

View details →DOI: 10.2147/rmhp.s115326Cited by 388
Negative / Null Result ReportOpen accessMedicine

Neuraminidase inhibitors for preventing and treating influenza in adults and children

Tom Jefferson, Mark Jones, Peter Doshi et al. · 2014 · Cochrane Database of Systematic Reviews

BACKGROUND: Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide. OBJECTIVES: To describe the potential…

View details →DOI: 10.1002/14651858.cd008965.pub4Cited by 388
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Identification of loci governing eight agronomic traits using a GBS‐GWAS approach and validation by QTL mapping in soya bean

Humira Sonah, Louise S. O’Donoughue, Elroy R. Cober et al. · 2014 · Plant Biotechnology Journal

Soya bean is a major source of edible oil and protein for human consumption as well as animal feed. Understanding the genetic basis of different traits in soya bean will provide important insights for improving breeding strategies for this…

View details →DOI: 10.1111/pbi.12249Cited by 387
Negative / Null Result ReportEconomics, Econometrics and Finance

Racial Bias in Bail Decisions*

David Arnold, Will Dobbie, Crystal Yang · 2018 · The Quarterly Journal of Economics

Abstract This article develops a new test for identifying racial bias in the context of bail decisions—a high-stakes setting with large disparities between white and black defendants. We motivate our analysis using Becker’s model of racial…

View details →DOI: 10.1093/qje/qjy012Cited by 387
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

Peiming Zheng, Qin Luo, Weiwei Wang et al. · 2018 · Cell Death and Disease

Abstract Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment and have been shown to contribute to tumor aggressiveness. However, the detailed mechanisms underlying the pro-metastatic effect of TAMs on gastric cancer are not clearly defined. Here, we show that TAMs are enriched in gastric cancer. TAMs are characterized by M2-polarized phenotype and promote migration of gastric cancer cells in vitro and in vivo. Furthermore, we find that M2-derived exosomes determine the TAMs-mediated pro-migratory activity. Using mass spectrometry, we identify that apolipopro

View details →DOI: 10.1038/s41419-018-0465-5Cited by 387
Negative / Null Result ReportOpen accessPsychology

The Effect of Problem-Based Learning on the Creative Thinking and Critical Thinking Disposition of Students in Visual Arts Education

Kani Ülger · 2018 · Interdisciplinary Journal of Problem-based Learning

The problem-based learning (PBL) approach was implemented as a treatment for higher education visual arts students over one semester to examine its effect on the creative thinking and critical thinking disposition of these students. PBL…

View details →DOI: 10.7771/1541-5015.1649Cited by 387
Negative / Null Result ReportOpen accessImmunology and Microbiology

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

Dermot McGovern, Michelle R. Jones, Kent D. Taylor et al. · 2010 · Human Molecular Genetics

Genetic variation in both innate and adaptive immune systems is associated with Crohn's disease (CD) susceptibility, but much of the heritability to CD remains unknown. We performed a genome-wide association study (GWAS) in 896 CD cases…

View details →DOI: 10.1093/hmg/ddq248Cited by 387
Negative / Null Result ReportOpen accessSocial Sciences

The President and the Distribution of Federal Spending

Christopher R. Berry, Barry C. Burden, William G. Howell · 2010 · American Political Science Review

Scholarship on distributive politics focuses almost exclusively on the internal operations of Congress, paying particular attention to committees and majority parties. This article highlights the president, who has extensive opportunities,…

View details →DOI: 10.1017/s0003055410000377Cited by 387
Negative / Null Result ReportPsychology

New tricks for an old measure: The development of the Barratt Impulsiveness Scale–Brief (BIS-Brief).

Lynne Steinberg, Carla Sharp, Matthew S. Stanford et al. · 2012 · Psychological Assessment

The Barratt Impulsivity Scale (BIS), a 30-item self-report measure, is one of the most commonly used scales for the assessment of the personality construct of impulsiveness. It has recently marked 50 years of use in research and clinical…

View details →DOI: 10.1037/a0030550Cited by 386
Negative / Null Result ReportOpen accessPhysics and Astronomy

The NANOGrav 11 Year Data Set: Pulsar-timing constraints on the Stochastic Gravitational-wave Background

Zaven Arzoumanian, P. T. Baker, Adam Brazier et al. · 2024 · Figshare

We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a GWB, we place constraints on a population of inspiraling supermassive black hole (SMBH) binaries, a network of decaying cosmic strings, and a primordial GWB. For the first time, we find that the GWB constraints are sensitive to the solar system ephemeris (SSE) model used and that SSE errors can mimic a GWB signal. We developed an approach that bridges systematic SSE diff

View details →DOI: 10.25916/sut.26295832.v1Cited by 385
Negative / Null Result ReportSocial Sciences

Emotional labour, burnout and job satisfaction in UK teachers: the role of workplace social support

Gail Kinman, Siobhan Wray, Calista Strange · 2011 · Educational Psychology

Although teaching has been described as a profoundly emotional activity, little is known about the emotional demands faced by teachers or how this impacts on their well-being. This study examined relationships between ‘emotional labour’,…

View details →DOI: 10.1080/01443410.2011.608650Cited by 385
Negative / Null Result ReportMaterials Science

Phase behaviour and complex coacervation of aqueous polypeptide solutions

Dimitrios Priftis, Matthew Tirrell · 2012 · Soft Matter

Mixing of oppositely charged polyelectrolytes in aqueous solutions may result in the formation of polyelectrolyte complexes (PEC). Phase separation and complex coacervation of polypeptides are investigated in this study. Polypeptides have…

View details →DOI: 10.1039/c2sm25604eCited by 385
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Formation and dissociation of M 1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

Jonathan A. Hern, Asma Baig, Gregory I. Mashanov et al. · 2010 · Proceedings of the National Academy of Sciences

G-protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in the human genome. Events in the GPCR signaling cascade have been well characterized, but the receptor composition and its membrane…

View details →DOI: 10.1073/pnas.0907915107Cited by 383
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The making of a pest: the evolution of a fruit-penetrating ovipositor inDrosophila suzukiiand related species

Joel Atallah, Lisa Teixeira, Raul Salazar et al. · 2014 · Proceedings of the Royal Society B Biological Sciences

Evolutionary innovation can allow a species access to a new ecological niche, potentially reducing competition with closely related species. While the vast majority of Drosophila flies feed on rotting fruit and other decaying matter, and…

View details →DOI: 10.1098/rspb.2013.2840Cited by 382
Negative / Null Result ReportOpen accessSocial Sciences

Online Reputation Management: Estimating the Impact of Management Responses on Consumer Reviews

Davide Proserpio, Georgios Zervas · 2017 · Marketing Science

We investigate the relationship between a firm’s use of management responses and its online reputation. We focus on the hotel industry and present several findings. First, hotels are likely to start responding following a negative shock to…

View details →DOI: 10.1287/mksc.2017.1043Cited by 380
Negative / Null Result ReportOpen accessSocial Sciences

Happy Marriage, Happy Life? Marital Quality and Subjective Well‐being in Later Life

Deborah Carr, Vicki A. Freedman, Jennifer C. Cornman et al. · 2014 · Journal of Marriage and the Family

The authors examined associations between marital quality and both general life satisfaction and experienced (momentary) well‐being among older husbands and wives, the relative importance of own versus spouse's marital appraisals for…

View details →DOI: 10.1111/jomf.12133Cited by 380
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Lasse Folkersen, Eric B. Fauman, Maria Sabater‐Lleal et al. · 2017 · PLoS Genetics

Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We id

View details →DOI: 10.1371/journal.pgen.1006706Cited by 380
Negative / Null Result ReportPsychology

The benefits of self-compassion and optimism exercises for individuals vulnerable to depression

Leah B. Shapira, Myriam Mongrain · 2010 · The Journal of Positive Psychology

The effectiveness of two online exercises intended to help individuals experience (1) self-compassion (n = 63) and (2) optimism (n = 55) were compared to a control intervention where participants wrote about an early memory (n = 70). A…

View details →DOI: 10.1080/17439760.2010.516763Cited by 380
Negative / Null Result Report

ESG did not immunize stocks during the COVID‐19 crisis, but investments in intangible assets did

Elizabeth Demers, Jurian Hendrikse, Philip Joos et al. · 2021 · Journal of Business Finance & Accounting

Abstract Environmental, social and governance (“ESG”) scores have been widely touted as indicators of share price resilience during the COVID‐19 crisis. Contrary to this conventional wisdom, we present robust evidence that once industry…

View details →DOI: 10.1111/jbfa.12523Cited by 380
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Why do people buy organic food? The moderating role of environmental concerns and trust

Anushree Tandon, Amandeep Dhir, Puneet Kaur et al. · 2020 · Journal of Retailing and Consumer Services

Although consumer interest in organic food has risen over time, resulting in a generally positive attitude toward these organic food products, scholarly research suggests a comparatively low volume of its consumption in the market. This has resulted in an urgent need to study the motivations which enhance consumers’ proclivity to purchase food items produced organically. The current research attempts to understand potential associations between motivations (intrinsic and extrinsic), attitude, and buying behaviour towards organic food. Self-determination theory (SDT) was applied to develop a th

View details →DOI: 10.1016/j.jretconser.2020.102247Cited by 380
Negative / Null Result ReportEconomics, Econometrics and Finance

Recourse and Residential Mortgage Default: Evidence from US States

Andra C. Ghent, Marianna Kudlyak · 2011 · Review of Financial Studies

We quantify the effect of recourse on default and find that recourse affects default by lowering the borrower's sensitivity to negative equity. At the mean value of the default option for defaulted loans, borrowers are 30% more likely to…

View details →DOI: 10.1093/rfs/hhr055Cited by 379
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Effects of Green Manufacturing and Eco-innovation on Sustainability Performance

Bülent Sezen, Sibel Yıldız Çankaya · 2013 · Procedia - Social and Behavioral Sciences

Firms are facing growing pressure to become “greener” or more environmentally friendly. Consequently, firms have had to review their production processes as a result of pressures from the community and governments. This pilot study…

View details →DOI: 10.1016/j.sbspro.2013.10.481Cited by 379
Negative / Null Result ReportEconomics, Econometrics and Finance

The Effects of Fiscal Stimulus: Evidence from the 2009 Cash for Clunkers Program*

Atif Mian, Amir Sufi · 2012 · The Quarterly Journal of Economics

Abstract We evaluate the impact of the 2009 Cash for Clunkers program on short- and medium-run auto purchases. Our empirical strategy exploits variation across U.S. cities in ex ante exposure to the program as measured by the number of…

View details →DOI: 10.1093/qje/qjs024Cited by 379
Negative / Null Result ReportOpen accessNeuroscience

Age-related changes in the default mode network are more advanced in Alzheimer disease

David T. Jones, Mary M. Machulda, Prashanthi Vemuri et al. · 2011 · Neurology

OBJECTIVE: To investigate age-related default mode network (DMN) connectivity in a large cognitively normal elderly cohort and in patients with Alzheimer disease (AD) compared with age-, gender-, and education-matched controls. METHODS: We…

View details →DOI: 10.1212/wnl.0b013e318233b33dCited by 378
Negative / Null Result ReportOpen accessNeuroscience

Individual common variants exert weak effects on the risk for autism spectrum disorders

Richard Anney, Lambertus Klei, Dalila Pinto et al. · 2012 · Human Molecular Genetics

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more…

View details →DOI: 10.1093/hmg/dds301Cited by 378
Negative / Null Result ReportOpen accessDecision Sciences

Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time

Robert M. Kaplan, Veronica L. Irvin · 2015 · PLoS ONE

BACKGROUND: We explore whether the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased over time. METHODS: We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or dietary supplements for the treatment or prevention of cardiovascular disease. Trials were included if direct costs >$500,000/year, participants were adult humans, and the primary outcome was cardiovascular risk, disease or death. The 55 trials meeting these criteria were coded for whether they were published prior to or after the year 2000, wheth

View details →DOI: 10.1371/journal.pone.0132382Cited by 378
Negative / Null Result ReportSocial Sciences

The Ties That Double Bind: Social Roles and Women's Underrepresentation in Politics

Dawn Langan Teele, Joshua Kalla, Frances Rosenbluth · 2018 · American Political Science Review

This paper theorizes three forms of bias that might limit women's representation: outright hostility, double standards, and a double bind whereby desired traits present bigger burdens for women than men. We examine these forms of bias…

View details →DOI: 10.1017/s0003055418000217Cited by 376