Spironolactone for Heart Failure with Preserved Ejection Fraction
Bertram Pitt; Marc A. Pfeffer; Susan F. Assmann; Robin Boineau; Inder S. Anand; Brian Claggett; Nadine Clausell; Akshay S. Desai · 2014 · New England Journal of Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a…
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Metadata source: OpenAlex · DOI 10.1056/nejmoa1313731