Reproducible brain-wide association studies require thousands of individuals
Scott Marek; Brenden Tervo‐Clemmens; Finnegan J. Calabro; David F. Montez; Benjamin P. Kay; Alexander S. Hatoum; Meghan Rose Donohue; William Foran · 2022 · Nature
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Abstract Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes approp
Abstract by Scott Marek; Brenden Tervo‐Clemmens; Finnegan J. Calabro; David F. Montez; Benjamin P. Kay; Alexander S. Hatoum; Meghan Rose Donohue; William Foran, Nature (2022) — licensed CC BY 4.0.
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WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1038/s41586-022-04492-9