e-ISSN: Pending

Browse the failure-mode index

19,840 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comparison of Prognostic Performance Between a Machine Learning Model and Manually Measured Grey-White-Matter Ratio on Early Brain Computed Tomography After Out-of-Hospital Cardiac Arrest.

Inoue, Ono, Okazaki et al. · 2026 · Cureus

Objectives Early prediction of neurological outcomes in patients with out-of-hospital cardiac arrest (OHCA) is critical for guiding treatment decisions. Machine learning (ML) model and grey-white matter ratio (GWR), both derived from brain…

View details →
Negative / Null Result ReportMedicine

Ultrasound Assessment of Talar, Femoral and Metacarpal Cartilage Thicknesses in Hemiplegic Patients and their Relationship with Functional Parameters.

Eroğlu, Taş, Ekici · 2026 · Zeitschrift fur Orthopadie und Unfallchirurgie

In hemiplegic patients, joint cartilage alterations may arise from impaired balance reactions, decreased selective motor control, abnormal muscle tone, or reduced weight shifting toward the affected limb. This study aimed to investigate…

View details →
Negative / Null Result ReportOpen accessImmunologic diseases. Allergy

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Yuka Nadai, Yuka Nadai, Kathrin Held et al. · 2019 · Frontiers in Immunology

Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o

View details →
Negative / Null Result ReportOpen accessBotany

Brassica amendments and summer irrigation for the control of Macrophomina phaseolina and Fusarium oxysporum f. sp. cumini in hot arid region

R. mawar, S. Lodha · 2002 · Phytopathologia Mediterranea

The combined effect of Brassica amendments (mustard oil–cake or mustard residue at 2.5 tons ha-1) and summer irrigation was tested for survival of Macrophomina phaseolina and Fusarium oxysporum f. sp. cumini and on the severity of dry root rot on clusterbean in the rainy season and on wilt of cumin in the subsequent winter season in the same field. Seed coating with a Bacillus sp., an antagonist bacterium against M. phaseolina, was also integrated with pod residues to improve control of dry root rot. The soil temperature of amended soil after one summer irrigation in June ranged from 38–44°C a

View details →
Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid

Estimated Glomerular Filtration Rate Correlates Poorly with Four-Hour Creatinine Clearance in Critically Ill Patients with Acute Kidney Injury

Christopher J. Kirwan, Barbara J. Philips, Iain A. M. MacPhee · 2013 · Critical Care Research and Practice

Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI. Aim. This study t

View details →
Negative / Null Result ReportOpen accessPsychology

Are There Multiple Motivators for Helping Behavior in Rats?

Phietica R. R. Silva, Phietica R. R. Silva, Regina H. Silva et al. · 2020 · Frontiers in Psychology

Empathy is the ability to (a) be affected by and share the emotional state of another; (b) assess the reasons for the other’s state; and (c) identify with the other, adopting their perspective. This phenomenon has been shown to exist in several species and is proposed as a motivator for prosocial behavior. The experimental study of this feature in laboratory rodents is a more viable alternative in comparison to wild animals. A recent report showed that rats opened a door to free their cage mate from a restraint box. Although this behavior has been suggested to be motivated by empathy, this fac

View details →
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure

Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants

Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system

View details →
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Partial revascularization plus medical treatment versus medical treatment alone in patients with multivessel coronary artery disease not eligible for CABG

M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal

Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group

View details →
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

Muscle wasting and function after muscle activation and early protocol‐based physiotherapy: an explorative trial

Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle

Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p

View details →
Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Deep brain stimulation in a patient with progressive myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). A case report and review of the literature

Michał Sobstyl, Nina Kożuch, Magdalena Iwaniuk-Gugała et al. · 2023 · Epilepsy & Behavior Reports

Progressive myoclonic epilepsy (PME) is characterized by prominent myoclonus, generalized tonic-clonic seizures, and less often focal, tonic, or absence seizures. The KCNC1 mutation is responsible for specific clinical phenotype of PME which has been defined as myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). We present a case of a 44 years-old male patient with genetically proven MEAK who underwent subthalamic nucleus/substantia nigra (STN/SNr) deep brain stimulation (DBS) for his pharmacological-refractory myoclonus and drug-resistant epilepsy (DRE). Since the age of 4

View details →
Negative / Null Result ReportOpen accessPsychiatry

Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double- Blind, Randomized, Placebo-Controlled Trial

Jiaojiao Zhou, Xu Chen, Le Xiao et al. · 2021 · Frontiers in Psychiatry

Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence. Cordyceps militaris (C. militaris) is thought to have the potential to treat insomnia. This study aimed to examine the efficacy and safety of duloxetine with C. militaris in improving sleep symptoms in patients with depression.Methods: This study was a single-center, randomized, double-blind, placebo-controlled study that recruited outpatients admitted to Beijing Anding hospital from January 2018 to January 2019. Majo

View details →
Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Phosphatidylserine enriched with polyunsaturated n‐3 fatty acid supplementation for attention‐deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo‐controlled trial

Sylvain Rheims, Vania Herbillon, Ségolène Gaillard et al. · 2024 · Epilepsia Open

Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi

View details →
Negative / Null Result ReportOpen accessMedicine (General)

Permissible Outcomes of Lobe-Specific Lymph Node Dissection for Elevated Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Hiroaki Kuroda, Junji Ichinose, Katsuhiro Masago et al. · 2021 · Medicina

Background and Objectives : Lobe-specific nodal dissection (L-SND) is currently acceptable for the dissection of early-stage non-small cell lung cancer (NSCLC) but not for cancers of more advanced clinical stages. We aimed to assess the efficacy of L-SND, compared to systemic nodal dissection (SND). Materials and Methods : We retrospectively collected the clinical data of patients with carcinoembryonic antigen (CEA) abnormality who underwent complete resection of NSCLC via lobectomy or more in addition to either SND or L-SND at two cancer-specific institutions from January 2006 to December 201

View details →
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Clinical analysis of four serum tumor markers in 458 patients with ovarian tumors: diagnostic value of the combined use of HE4, CA125, CA19-9, and CEA in ovarian tumors

Chen F, Shen J, Wang J et al. · 2018 · Cancer Management and Research

Fawen Chen,1,2 Jing Shen,3 Jianwei Wang,1 Pengwei Cai,1 Yi Huang3 1Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, 2Department of Blood Transfusion, 3Department of Clinical Laboratory, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, People’s Republic of China Purpose: To investigate the diagnostic values of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) for ovarian tumors. Methods: The participants were divided into three gr

View details →
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Understanding the Sensory Influences of Oak in the Production of Smoke-Affected Wines: A Case Study with Cabernet Sauvignon

Jenna A. Fryer, Elizabeth Tomasino · 2025 · Beverages

Wines produced from grapes exposed to wildfire smoke exhibit smoke-related flavors, such as smoky, burnt, and an ashy finish. While grapes are impacted on the vine, winemaking strategies can influence the perception of smoke-related properties in the resulting wine. This case study evaluated eight smoke-affected wines across three vintages from commercial production to assess how oak influences smoke-related flavors. Each vintage explored a different usage of oak, including oak origin, oak chips with carbon fining, and potential carryover of flavors through reused barrels. Wines were assessed

View details →
Negative / Null Result ReportOpen accessBusiness

Determinants of Technical Efficiency in Wheat Production in Ethiopia

Daniel Hailu · 2020 · International Journal of Agricultural Economics

Ethiopia is the second largest wheat producing countries in Sub-Saharan Africa and most people rely on rain fed agriculture for their livelihoods. Wheat production has increased from 2,176,603 tons in 2005 to 4,219,257 tons in 2016 with…

View details →
Negative / Null Result ReportOpen accessVeterinary medicine

Effect of Shearing for Improving the Thermoregulatory Responses of Crossbred Sheep During Heat Stress

Lina Fernanda Pulido-Rodríguez, Alfredo Manuel Franco Pereira, Fábio Luís Henrique et al. · 2025 · Veterinary Sciences

Shearing to improve heat dissipation is common in sheep farming. This study evaluated the influence of shearing on thermoregulatory responses of crossbred sheep from adapted breeds exposed to heat stress. Ten ewes were kept in a climate chamber exposed to heat stress (10–13 h), reaching 37 ± 1.0 °C for nine days, during two consecutive periods, without shearing, and then at 14 days after shearing, evaluating all variables. Rectal temperature, respiration rate, sweating rate, ocular surface temperature, and skin temperature were analyzed at 7, 10, 13, 17, and 20 h, and blood cortisol was analyz

View details →
Negative / Null Result ReportOpen accessOphthalmology

Comparison of intravitreal injection of ranibizumab, steroids, and pars plana vitrectomy for chronic persistent nonimproving diabetic macular edema with nontractional epiretinal membrane

Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology

Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography

View details →
Negative / Null Result ReportOpen accessMedicine

Treating social cognition impairment with the online therapy 'SoCoBo': A randomized controlled trial including traumatic brain injury patients.

Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE

Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des

View details →
Negative / Null Result ReportOpen accessVeterinary medicine

Effect of Combining a Prebiotic (Autolyzed Yeast from Saccharomyces cerevisiae ) and Probiotic ( Bacillus subtilis ) Added in a High-Energy Diet on Growth Performance, Dietary Energetics, and Carcass Traits of Fattening Hairy Lambs

Jesús A. Quezada-Rubio, Alfredo Estrada-Angulo, Beatriz I. Castro-Pérez et al. · 2026 · Animals

Due to their specific properties, the autolyzed yeast Saccharomyces cerevisiae (SC) and bacterial Bacillus subtilis (BS) theoretically can have a synergistic effect when combined and offered in ruminant diets. Thus, the aim of this experiment was to evaluate the effect of their combination as feed additives on growth performance, dietary energy, carcass traits, and visceral organ mass in finishing lambs. For this reason, 48 Pelibuey × Katahdin lambs (98 ± 17 d age; initial weight = 20.25 ± 3.37 kg) were used in a feeding trial lasting 83 d. Lambs were blocked by weight and assigned to 24 pens.

View details →
Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid

The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats

Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke et al. · 2021 · Intensive Care Medicine Experimental

Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w

View details →