Negative / Null Result ReportMedicine
Jesus, Alves, Resende · 2026 · CoDAS
To validate and standardize the online application of the Scale of Self-Perception of Central Auditory Processing Skills (EAPAC) - expanded for Brazilian adults. The EAPAC was expanded and answered by 1,274 Brazilian individuals aged 18 to…
View details →Negative / Null Result ReportMedicine
Inoue, Ono, Okazaki et al. · 2026 · Cureus
Objectives Early prediction of neurological outcomes in patients with out-of-hospital cardiac arrest (OHCA) is critical for guiding treatment decisions. Machine learning (ML) model and grey-white matter ratio (GWR), both derived from brain…
View details →Negative / Null Result ReportMedicine
Kataruka, Sannyashi, Bhattacharjee et al. · 2026 · Cureus
Neuropathic ulcers occur mainly at the plantar aspect and correspond to areas with peak plantar pressure, usually seen in a sensory-deficient foot. Trophic ulcers are seen in diabetic neuropathy, post-leprosy, and any other neurological…
View details →Negative / Null Result ReportMedicine
Harvey, Morita, Huynh et al. · 2026 · JMIR medical informatics
Health care providers spend an excessive amount of time within electronic medical record (EMR) systems documenting patient encounters, often amounting to hours of work outside of regular office hours. This affects physician productivity…
View details →Negative / Null Result ReportMedicine
Bala, Akyazi, Eraslan et al. · 2026 · BMC veterinary research
Environmental noise is a non-specific stressor that can activate stress-response pathways and increase the production of reactive oxygen species, contributing to oxidative stress in the brain. Limbic regions such as the amygdala and…
View details →Negative / Null Result ReportMedicine
Chen, Wen, Zheng · 2026 · Shock (Augusta, Ga.)
Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly occurs in…
View details →Negative / Null Result ReportMedicine
Mod, Keskin, Can et al. · 2026 · International journal of impotence research
This study aimed to compare the effects of absorbable and non-absorbable sutures on postoperative erectile function, ejaculatory function and sexual satisfaction in patients undergoing penile fracture repair. In this single-center…
View details →Negative / Null Result ReportMedicine
Fazal, Loya, Muayad et al. · 2026 · American journal of ophthalmology
Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. Emerging evidence suggests that targeting dopaminergic pathways may influence AMD progression. This study evaluates whether levodopa ±…
View details →Negative / Null Result ReportMedicine
Eroğlu, Taş, Ekici · 2026 · Zeitschrift fur Orthopadie und Unfallchirurgie
In hemiplegic patients, joint cartilage alterations may arise from impaired balance reactions, decreased selective motor control, abnormal muscle tone, or reduced weight shifting toward the affected limb. This study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Seehra, Ellis, Doleman et al. · 2026 · Journal of surgical education
Compare the demographics of UK surgical trainees and Annual Review of Competence Progression (ARCP) panel members to assess proportional representation. Retrospective cross-sectional analysis of national trainee and assessor records, with…
View details →Negative / Null Result ReportMedicine
Levine, Lyons, Chatha et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques
Paraesophageal hernias are a prevalent medical condition often treated with surgical intervention, and decisions regarding hernia sac management are involved. Sac excision during PEH repair has emerged as a viable and safe management…
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yuka Nadai, Yuka Nadai, Kathrin Held et al. · 2019 · Frontiers in Immunology
Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o
View details →Negative / Null Result ReportOpen accessBotany
R. mawar, S. Lodha · 2002 · Phytopathologia Mediterranea
The combined effect of Brassica amendments (mustard oil–cake or mustard residue at 2.5 tons ha-1) and summer irrigation was tested for survival of Macrophomina phaseolina and Fusarium oxysporum f. sp. cumini and on the severity of dry root rot on clusterbean in the rainy season and on wilt of cumin in the subsequent winter season in the same field. Seed coating with a Bacillus sp., an antagonist bacterium against M. phaseolina, was also integrated with pod residues to improve control of dry root rot. The soil temperature of amended soil after one summer irrigation in June ranged from 38–44°C a
View details →Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Christopher J. Kirwan, Barbara J. Philips, Iain A. M. MacPhee · 2013 · Critical Care Research and Practice
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI. Aim. This study t
View details →Negative / Null Result ReportOpen accessPsychology
Phietica R. R. Silva, Phietica R. R. Silva, Regina H. Silva et al. · 2020 · Frontiers in Psychology
Empathy is the ability to (a) be affected by and share the emotional state of another; (b) assess the reasons for the other’s state; and (c) identify with the other, adopting their perspective. This phenomenon has been shown to exist in several species and is proposed as a motivator for prosocial behavior. The experimental study of this feature in laboratory rodents is a more viable alternative in comparison to wild animals. A recent report showed that rats opened a door to free their cage mate from a restraint box. Although this behavior has been suggested to be motivated by empathy, this fac
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal
Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michał Sobstyl, Nina Kożuch, Magdalena Iwaniuk-Gugała et al. · 2023 · Epilepsy & Behavior Reports
Progressive myoclonic epilepsy (PME) is characterized by prominent myoclonus, generalized tonic-clonic seizures, and less often focal, tonic, or absence seizures. The KCNC1 mutation is responsible for specific clinical phenotype of PME which has been defined as myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). We present a case of a 44 years-old male patient with genetically proven MEAK who underwent subthalamic nucleus/substantia nigra (STN/SNr) deep brain stimulation (DBS) for his pharmacological-refractory myoclonus and drug-resistant epilepsy (DRE). Since the age of 4
View details →Negative / Null Result ReportOpen accessPsychiatry
Jiaojiao Zhou, Xu Chen, Le Xiao et al. · 2021 · Frontiers in Psychiatry
Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence. Cordyceps militaris (C. militaris) is thought to have the potential to treat insomnia. This study aimed to examine the efficacy and safety of duloxetine with C. militaris in improving sleep symptoms in patients with depression.Methods: This study was a single-center, randomized, double-blind, placebo-controlled study that recruited outpatients admitted to Beijing Anding hospital from January 2018 to January 2019. Majo
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Sylvain Rheims, Vania Herbillon, Ségolène Gaillard et al. · 2024 · Epilepsia Open
Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Hiroaki Kuroda, Junji Ichinose, Katsuhiro Masago et al. · 2021 · Medicina
Background and Objectives : Lobe-specific nodal dissection (L-SND) is currently acceptable for the dissection of early-stage non-small cell lung cancer (NSCLC) but not for cancers of more advanced clinical stages. We aimed to assess the efficacy of L-SND, compared to systemic nodal dissection (SND). Materials and Methods : We retrospectively collected the clinical data of patients with carcinoembryonic antigen (CEA) abnormality who underwent complete resection of NSCLC via lobectomy or more in addition to either SND or L-SND at two cancer-specific institutions from January 2006 to December 201
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Chen F, Shen J, Wang J et al. · 2018 · Cancer Management and Research
Fawen Chen,1,2 Jing Shen,3 Jianwei Wang,1 Pengwei Cai,1 Yi Huang3 1Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, 2Department of Blood Transfusion, 3Department of Clinical Laboratory, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, People’s Republic of China Purpose: To investigate the diagnostic values of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) for ovarian tumors. Methods: The participants were divided into three gr
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Jenna A. Fryer, Elizabeth Tomasino · 2025 · Beverages
Wines produced from grapes exposed to wildfire smoke exhibit smoke-related flavors, such as smoky, burnt, and an ashy finish. While grapes are impacted on the vine, winemaking strategies can influence the perception of smoke-related properties in the resulting wine. This case study evaluated eight smoke-affected wines across three vintages from commercial production to assess how oak influences smoke-related flavors. Each vintage explored a different usage of oak, including oak origin, oak chips with carbon fining, and potential carryover of flavors through reused barrels. Wines were assessed
View details →Negative / Null Result ReportOpen accessBusiness
Daniel Hailu · 2020 · International Journal of Agricultural Economics
Ethiopia is the second largest wheat producing countries in Sub-Saharan Africa and most people rely on rain fed agriculture for their livelihoods. Wheat production has increased from 2,176,603 tons in 2005 to 4,219,257 tons in 2016 with…
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Lina Fernanda Pulido-Rodríguez, Alfredo Manuel Franco Pereira, Fábio Luís Henrique et al. · 2025 · Veterinary Sciences
Shearing to improve heat dissipation is common in sheep farming. This study evaluated the influence of shearing on thermoregulatory responses of crossbred sheep from adapted breeds exposed to heat stress. Ten ewes were kept in a climate chamber exposed to heat stress (10–13 h), reaching 37 ± 1.0 °C for nine days, during two consecutive periods, without shearing, and then at 14 days after shearing, evaluating all variables. Rectal temperature, respiration rate, sweating rate, ocular surface temperature, and skin temperature were analyzed at 7, 10, 13, 17, and 20 h, and blood cortisol was analyz
View details →Negative / Null Result ReportOpen accessOphthalmology
Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology
Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography
View details →Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Jesús A. Quezada-Rubio, Alfredo Estrada-Angulo, Beatriz I. Castro-Pérez et al. · 2026 · Animals
Due to their specific properties, the autolyzed yeast Saccharomyces cerevisiae (SC) and bacterial Bacillus subtilis (BS) theoretically can have a synergistic effect when combined and offered in ruminant diets. Thus, the aim of this experiment was to evaluate the effect of their combination as feed additives on growth performance, dietary energy, carcass traits, and visceral organ mass in finishing lambs. For this reason, 48 Pelibuey × Katahdin lambs (98 ± 17 d age; initial weight = 20.25 ± 3.37 kg) were used in a feeding trial lasting 83 d. Lambs were blocked by weight and assigned to 24 pens.
View details →Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke et al. · 2021 · Intensive Care Medicine Experimental
Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w
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