Negative / Null Result ReportOpen accessImmunology and Microbiology
Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink et al. · 2013 · Proceedings of the National Academy of Sciences
Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We…
View details →Negative / Null Result ReportImmunology and Microbiology
Edwin Hoe, Fiona C. McKay, Stephen D. Schibeci et al. · 2010 · The Journal of Immunology
Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. Transcription of the gene…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Mieke Metzemaekers, Seppe Cambier, Marfa Blanter et al. · 2021 · Clinical & Translational Immunology
OBJECTIVES: Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID-19). We isolated neutrophils from the blood of COVID-19 patients receiving…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Koichi Araki, Shivaprakash Gangappa, Dirck L. Dillehay et al. · 2010 · The Journal of Experimental Medicine
Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506. These findings were surprising because LCMV is a…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal et al. · 2024 · Nature Communications
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ryosuke Omori, Yukihiko Nakata, Heidi L. Tessmer et al. · 2015 · Scientific Reports
Until the early 1990 s, incidences of Mycoplasma pneumoniae (MP) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the MP epidemic cycle has not been understood. Here, we investigate the determinant of periodicity in MP incidence by employing a mathematical model describing MP transmission dynamics. Three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiological interference between MP serotypes. We find that minor variation in the duration of immunity at
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Melony J. Sellars, M Rao, SJ Arnold et al. · 2011 · Diseases of Aquatic Organisms
Gill-associated virus (GAV) is a nidovirus that commonly infects Penaeus monodon (black tiger shrimp) in eastern Australia, causing morbidity and mortalities in the acute stage of disease. Here we explored the possibility of inhibiting GAV…
View details →Negative / Null Result ReportImmunology and Microbiology
Jennifer Kyle, Cameron Casey, Kelly G. Stratton et al. · 2016 · Rapid Communications in Mass Spectrometry
RATIONALE: The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as the smaller blood volume required, storage at room temperature, and ability to sample in remote locations. However,…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Roberta Amoriello, Maria Chernigovskaya, Victor Greiff et al. · 2021 · EBioMedicine
BACKGROUND: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Rania Magadmi, Judit Mészáros, Zoheir A. Damanhouri et al. · 2019 · Frontiers in Cellular Neuroscience
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external environment; both are specialized to sense potential damage by injury or pathogens and signal to the immune system and nervous system respectively, to elicit protective responses. Cell adhesion molecule 1 (CADM1), also known as SynCAM1, has previously been identified as an adhesion molecule which may couple mast cells t
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Duc Tin Tran, Sri Nagarjun Batchu, Andrew Advani · 2024 · Frontiers in Cardiovascular Medicine
Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during the pathogenesis of non-infectious diseases, where they may contribute to organ injury, or function in a compensatory manner. In this review, we explore the roles of IFNs and IFN-related pathways in heart disease. We consider the cardiac effects of type I IFNs and IFN-stimulated genes (ISGs); the emerging role of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; the seemingly paradoxical effects of the type
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yitong Li, Erika S. Wittchen, Elizabeth Monaghan-Benson et al. · 2019 · PLoS ONE
As a key homeostasis regulator in mammals, the MERTK receptor tyrosine kinase is crucial for efferocytosis, a process that requires remodeling of the cell membrane and adjacent actin cytoskeleton. Membrane and cytoskeletal reorganization also occur in endothelial cells during inflammation, particularly during neutrophil transendothelial migration (TEM) and during changes in permeability. However, MERTK's function in endothelial cells remains unclear. This study evaluated the contribution of endothelial MERTK to neutrophil TEM and endothelial barrier function. In vitro experiments using primary
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Tzu‐Hsing Kuo, Julie A. Williams · 2014 · SLEEP
STUDY OBJECTIVES: Sleep is known to increase as an acute response to infection. However, the function of this behavioral response in host defense is not well understood. To address this problem, we evaluated the effect of acute sleep…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Michael Talledo, Giovanni López, Jeroen R. Huyghe et al. · 2010 · Journal of Medical Virology
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Alexis Dunkle, Ivan Dzhagalov, Y-W He · 2011 · Cell Death and Disease
Myeloid cell leukemia sequence-1 (Mcl-1) is a critical anti-apoptotic factor in T lymphocytes. However, in spite of the many pro-apoptotic proteins with proposed binding to Mcl-1, the specific interactions by which Mcl-1 regulates primary T-cell survival under different conditions have not been fully explored. Further, how different trophic cytokines modulate the specific role(s) of Mcl-1 is unknown. Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes. Using the inducible Mcl-1-floxed estrogen receptor-Cre fusion protein (Mcl-1(f/f)ERCre) deletion system in
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
D. Beaujean, Fedor Gassner, A Wong et al. · 2016 · BMC Public Health
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren. METHODS: A total of 887 children, aged 9-13 years and attending the two final years of primary
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Makoto Miyara, Driss Chader, Aude Burlion et al. · 2016 · Oncotarget
// Makoto Miyara 1,2 , Driss Chader 1,2 , Aude Burlion 2 , Jérémie Goldstein 2 , Delphine Sterlin 1,2 , Françoise Norol 3 , Hélène Trebeden-Nègre 3 , Laetitia Claër 1,2 , Shimon Sakaguchi 4,* , Gilles Marodon 2,* , Zahir Amoura 1,2,5,6,* and Guy Gorochov 1,2,6 1 Department of immunology, AP-HP Pitié Salpêtrière, Paris, France 2 Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France 3 Cell Therapy, AP-HP Pitié Salpêtriè
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Madeleine P. J. White, Chris Johnston, John R. Grainger et al. · 2020 · Frontiers in Immunology
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimise excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune disease characterised by inflammatory lesions within the central nervous system; there are very limited therapeutic options for the progressive forms of the disease and none are curative. Here, we used the experimental autoimmune encephalomyelitis (EAE) model to examine if the intestinal helminth He
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
In-Woo Park, Yan Fan, Xiaoyu Luo et al. · 2014 · PLoS ONE
HIV-1 infection enhances HCV replication and as a consequence accelerates HCV-mediated hepatocellular carcinoma (HCC). However, the precise molecular mechanism by which this takes place is currently unknown. Our data showed that infectious HIV-1 failed to replicate in human hepatocytic cell lines. No discernible virus replication was observed, even when the cell lines transfected with HIV-1 proviral DNA were co-cultured with Jurkat T cells, indicating that the problem of liver deterioration in the co-infected patient is not due to the replication of HIV-1 in the hepatocytes of the HCV infected
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Jayson L. Parker, Jillian Clare Köhler · 2010 · Journal of Pharmacy & Pharmaceutical Sciences
PURPOSE: To determine the risk of drug failure during clinical trial testing in Crohn's disease and determine what steps can be taken to improve outcomes. This is the first study to quantify such risk for a single disease. METHODS: Moderate to severe Crohn's disease was investigated by reviewing press releases from 1998 to June 2008. Clinical trial failure causes were classified as commercial or clinical and compared with industry expectations. The risk of failure was also reviewed based on whether the compound was a small molecule drug or a biologic. Lastly, the role of the sponsor was examin
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
C. M. Chang, Victoria M. Chia, Marc J. Gunter et al. · 2013 · Carcinogenesis
Inherited variation in genes that regulate innate immunity and inflammation may contribute to colorectal neoplasia risk. To evaluate this association, we conducted a nested case-control study of 451 colorectal cancer cases, 694 colorectal…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
John F. Krisko, Nurjahan Begum, Caroline E. Baker et al. · 2016 · Journal of Virology
UNLABELLED: The multifunctional HIV-1 accessory protein Vif counters the antiviral activities of APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of APOBEC3H (A3H). Studies in humanized mice have shown that HIV-1…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Daniel Doyle, Gerald McDonald, Claire Pratt et al. · 2021 · PLoS ONE
OBJECTIVES: Inappropriate antibiotic use contributes to antimicrobial resistance. The SpectrumTM app provides antibiotic decision support, based on local antimicrobial resistance rates. We determined the impact of regional implementation of the app on inpatient antimicrobial appropriateness, inpatient antimicrobial usage (AMU), population-based Clostridioides difficile infection (CDI) rates and cost, using a retrospective, before and after quasi-experimental design, including a one-year study period. METHODS: The SpectrumTM app was released to prescribers in February, 2019. We performed two on
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Sergio Cleto, Camila Eleutério Rodrigues, Ceila María Sant’Ana Malaque et al. · 2016 · PLoS ONE
BACKGROUND: Leptospirosis is a health problem worldwide. Its most severe form is a classic model of sepsis, provoking acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI), with associated mortality that remains unacceptably high. We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. However, the mode of clearance can also affect dialysis patient outcomes. Therefore, the objective of this study was to compare the effects of SLED with traditional (diffusive) clearance, via hemodia
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Clara Young, Mandeep Singh, Katherine Jackson et al. · 2025 · Immunity
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immu
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Soumik Barman, Francesco Borriello, Byron Brook et al. · 2022 · ACS Chemical Biology
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Amy Robinson, Matthew Burgess, Sheila Webb et al. · 2022 · Cancers
There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here, we show that there is an increase in the number of bone marrow, circulating and splenic monocytes by using mouse models of breast cancer caused by the mammary epithelial expression of the polyoma middle T antigen. Cancer does not affect ratios of classical to non-classical populations of monocytes in the circulation nor does it affect their half-lives. Single cell RNA sequencing also indicates that cancer doe
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Jose Ruiz, Saravana Kanagavelu, Claudia Flores et al. · 2016 · Frontiers in Cellular and Infection Microbiology
Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how systemic TRIF activation enhances intestinal immune defense against Gram-negative bacteria. First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. This prote
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Galina Stoyancheva, Nikolina Mihaylova, Maria Gerginova et al. · 2025 · International Journal of Molecular Sciences
The human endometrium, previously considered a sterile environment, is now recognized as a low-biomass but biologically active microbial niche critical to reproductive health. Advances in sequencing technologies, particularly shotgun metagenomics, have provided unprecedented insights into the taxonomic and functional complexity of the endometrial microbiome. While 16S rRNA sequencing has delineated the distinction between Lactobacillus-dominant and non-dominant microbial communities, shotgun metagenomics has revealed additional diversity at the species and strain level, uncovering microbial si
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