Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes
Alexis Dunkle; Ivan Dzhagalov; Y-W He · 2011 · Cell Death and Disease
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Abstract
Myeloid cell leukemia sequence-1 (Mcl-1) is a critical anti-apoptotic factor in T lymphocytes. However, in spite of the many pro-apoptotic proteins with proposed binding to Mcl-1, the specific interactions by which Mcl-1 regulates primary T-cell survival under different conditions have not been fully explored. Further, how different trophic cytokines modulate the specific role(s) of Mcl-1 is unknown. Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes. Using the inducible Mcl-1-floxed estrogen receptor-Cre fusion protein (Mcl-1(f/f)ERCre) deletion system in
Abstract by Alexis Dunkle; Ivan Dzhagalov; Y-W He, Cell Death and Disease (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/cddis.2011.95