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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 94 of 674

Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Intensifying cropping systems through doubled-up legumes in Eastern Zambia

Mulundu Mwila, Blessing Mhlanga, Christian Thierfelder · 2021 · Scientific Reports

Abstract Declining soil fertility and negative impacts of climate effects threaten the food security of millions in Africa. Conservation Agriculture (CA) is a promising strategy to address these challenges. However, lack of viable economic entry points and short-term benefits for smallholders limit its adoption. Legume intensification can possibly increase the output per unit area, thus making the system more attractive. Rotations of maize with intensified legume systems were tested for three consecutive years under ridge and furrow (RF) tillage and CA to investigate: (a) increases in producti

View details →DOI: 10.1038/s41598-021-87594-0Cited by 27
Negative / Null Result ReportPsychology

Towards a dialect-neutral assessment instrument for the language skills of Afrikaans-speaking children: the role of socioeconomic status

Frenette Southwood · 2012 · Journal of Child Language

The aims of the study were to establish whether there is a correlation between the socioeconomic background of Afrikaans-speaking children and their performance on a dialect-neutral language test, and to ascertain whether the allowance the…

View details →DOI: 10.1017/s0305000912000037Cited by 27
Negative / Null Result ReportOpen accessPsychology

Community-based randomized controlled trial of psychological first aid with crime victims.

Michael R. McCart, Jason E. Chapman, Kristyn Zajac et al. · 2020 · Journal of Consulting and Clinical Psychology

OBJECTIVE: The first randomized controlled trial of psychological first aid (PFA) was conducted, using crime victims as participants. For study Aim 1, investigators tested whether paraprofessional victim advocates could be trained to…

View details →DOI: 10.1037/ccp0000588Cited by 27
Negative / Null Result ReportOpen accessEnvironmental Science

Variability in Fitness Trade-Offs Amongst Coral Juveniles With Mixed Genetic Backgrounds Held in the Wild

Kate M. Quigley, Magena R. Marzonie, Blake D. Ramsby et al. · 2021 · Frontiers in Marine Science

Novel restoration methods are currently under consideration worldwide to help coral reefs recover or become more resilient to higher temperature stress. Critical field-based information concerning the paradigm of “local is best” is lacking for many methods; information which is essential to determine the risk and feasibility associated with restoration. One method involves breeding corals from different reef regions with expected variation in heat tolerance and moving those offspring to new locations to enhance offspring survival; thereby augmenting local stock to enhance survival for anticipa

View details →DOI: 10.3389/fmars.2021.636177Cited by 27
Negative / Null Result ReportOpen accessPsychology

Test-retest reliability of a smartphone-based approach-avoidance task: Effects of retest period, stimulus type, and demographics

Hilmar Zech, Philip A. Gable, W. van Dijk et al. · 2022 · Behavior Research Methods

The approach-avoidance task (AAT) is an implicit task that measures people's behavioral tendencies to approach or avoid stimuli in the environment. In recent years, it has been used successfully to help explain a variety of health problems (e.g., addictions and phobias). Unfortunately, more recent AAT studies have failed to replicate earlier promising findings. One explanation for these replication failures could be that the AAT does not reliably measure approach-avoidance tendencies. Here, we first review existing literature on the reliability of various versions of the AAT. Next, we examine

View details →DOI: 10.3758/s13428-022-01920-6Cited by 27
Negative / Null Result ReportOpen accessMedicine

Calcium intake and its relationship with risk of overweight and obesity in adolescents

Tamara Beres Lederer Goldberg, Carla Cristiane da Silva, Luciana Peres et al. · 2026 · Archivos Latinoamericanos de Nutrición

Adolescents' eating habits are determined by social, psychological, economic, political, and educational influences. They tend to prefer foods with inadequate nutritional value and high fat and carbohydrate content which leads to excessive…

View details →DOI: 10.37527/2009.59.1.002Cited by 27
Negative / Null Result ReportEconomics, Econometrics and Finance

Wettbewerb als Norm der Wettbewerbspolitik

Erich Hoppmann · 2026 · ORDO

Der Wirtschaftspolitische Ausschus des Deutschen Bundestages erklarte bei Erlas des Kartellgesetzes, er konne und wolle den Wettbewerbsbegriff nicht definieren, das sei eine Angelegen heit der zustandigen Fachdisziplin1. Diese Aufforderung…

View details →DOI: 10.1515/ordo-1801-2054Cited by 27
Negative / Null Result ReportOpen accessMedicine

Peptide‐Drug Conjugates: A New Hope for Cancer

Amy Armstrong, Fleur Coburn, Yanyamba Nsereko et al. · 2025 · Journal of Peptide Science

Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker, enabling precise drug delivery while sparing healthy tissue. Despite their potential, PDCs face challenges including metabolic instability, premature payload release and rapid clearance, limiting clinical success. Only Lutathera remains FDA-approved after Pepaxto's withdrawal, though Pepaxto retains EMA and MHRA approval-highlighting regulatory and technic

View details →DOI: 10.1002/psc.70040Cited by 27
Negative / Null Result ReportOpen accessPsychology

Performance similarities predict collective benefits in dyadic and triadic joint visual search

Basil Wahn, Artur Czeszumski, Peter König · 2018 · PLoS ONE

When humans perform tasks together, they may reach a higher performance in comparison to the best member of a group (i.e., a collective benefit). Earlier research showed that interindividual performance similarities predict collective benefits for several joint tasks. Yet, researchers did not test whether this is the case for joint visuospatial tasks. Also, researchers did not investigate whether dyads and triads reach a collective benefit when they are forbidden to exchange any information while performing a visuospatial task. In this study, participants performed a joint visual search task e

View details →DOI: 10.1371/journal.pone.0191179Cited by 27
Negative / Null Result ReportOpen accessMedicine

Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery

Dae-Sang Lee, Mi Yeon Lee, Chi-Min Park et al. · 2018 · PLoS ONE

Delirium is a common complication of vascular surgery. The protective effect of preoperative statins on delirium after vascular surgery is controversial. The authors hypothesized that preoperative statin administration would decrease the incidence of delirium after vascular surgery. From May 2010 to May 2015, 1,132 patients underwent vascular surgery. Postoperative delirium was diagnosed from patients' medical records. The incidence of delirium was 11.5%. The preoperative statin exposure was not associated with reduced delirium in the univariate analysis. After adjusting for covariates, preope

View details →DOI: 10.1371/journal.pone.0192841Cited by 27
Negative / Null Result ReportOpen accessNeuroscience

Local Information Processing in Adults with High Functioning Autism and Asperger Syndrome: The Usefulness of Neuropsychological Tests and Self-Reports

Annelies Spek, Evert Scholte, Ina A. van Berckelaer‐Onnes · 2010 · Journal of Autism and Developmental Disorders

Local information processing in 42 adults with high functioning autism, 41 adults with Asperger syndrome and 41 neurotypical adults was examined. Contrary to our expectations, the disorder groups did not outperform the neurotypical group…

View details →DOI: 10.1007/s10803-010-1106-8Cited by 27
Negative / Null Result ReportOpen accessMedicine

Application of Machine Learning for Tumor Growth Inhibition – Overall Survival Modeling Platform

Phyllis Chan, Xiaofei Zhou, Nina Wang et al. · 2020 · CPT Pharmacometrics & Systems Pharmacology

Machine learning (ML) was used to leverage tumor growth inhibition (TGI) metrics to characterize the relationship with overall survival (OS) as a novel approach and to compare with traditional TGI-OS modeling methods. Historical dataset…

View details →DOI: 10.1002/psp4.12576Cited by 27
Negative / Null Result Report

One chiral fingerprint to find them all

Markus Orsi, Jean-Louis Reymond · 2024 · Journal of Cheminformatics

Abstract Molecular fingerprints are indispensable tools in cheminformatics. However, stereochemistry is generally not considered, which is problematic for large molecules which are almost all chiral. Herein we report MAP4C, a chiral…

View details →DOI: 10.1186/s13321-024-00849-6Cited by 27
Negative / Null Result Report

Predicting clinically significant change in an inpatient program for people with severe mental illness

Talia Gonda, Frank P Deane, Ganapathi Murugesan · 2012 · Australian & New Zealand Journal of Psychiatry

Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to…

View details →DOI: 10.1177/0004867412445527Cited by 27
Negative / Null Result Report

Invasive crayfish outperform Potamonautid crabs at higher temperatures

Takudzwa C. Madzivanzira, Josie South, Olaf L. F. Weyl · 2021 · Freshwater Biology

Abstract Data on ecological impacts of freshwater crayfish invasions in Africa are scarce but invasion history suggests the likelihood of negative implications for biodiversity. To evaluate the potential for ecological impacts we describe…

View details →DOI: 10.1111/fwb.13691Cited by 27
Negative / Null Result Report

Do compassionate firms outperform? The role of organizational learning

Jacob Guinot, Sandra Miralles, Alma Rodríguez-Sánchez et al. · 2020 · Employee Relations: The International Journal

Purpose Based on a new management paradigm rooted on care and compassion, this study explores the consequences of compassion at work on organizational learning and firm performance. Design/methodology/approach Structural equation modeling…

View details →DOI: 10.1108/er-07-2019-0275Cited by 27
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Significant association of XRCC4 single nucleotide polymorphisms with childhood leukemia in Taiwan.

Kang‐Hsi Wu, Chung-Hsing Wang, Yung‐Li Yang et al. · 2010 · PubMed

BACKGROUND: The DNA repair gene XRCC4, a member of the protein family involved in non-homologous end-joining repair pathway, plays a major role in repairing DNA double-strand breaks. XRCC4 is important in maintaining the overall genome…

View details →Cited by 27
Negative / Null Result ReportOpen accessArts and Humanities

The Impact of Peer Scaffolding through Process Approach on EFL Learners’ Academic Writing Fluency

Masoud Khalili Sabet, Abdorreza Tahriri, Parastou Gholami Pasand · 2013 · Theory and Practice in Language Studies

This paper aimed to examine the impact of peer scaffolding through process approach on writing fluency of EFL learners. To this end, a Nelson Proficiency Test was administered to 49 EFL learners studying at University of Guilan, based on…

View details →DOI: 10.4304/tpls.3.10.1893-1901Cited by 27
Negative / Null Result Report

Simple questionnaires outperform behavioral tasks to measure socio-emotional skills in students

Mélusine Boon-Falleur, Adrien Bouguen, Axelle Charpentier et al. · 2022 · Scientific Reports

Abstract Recent empirical research has shown that improving socio-emotional skills such as grit, conscientiousness and self-control leads to higher academic achievement and better life outcomes. However, both theoretical and empirical…

View details →DOI: 10.1038/s41598-021-04046-5Cited by 26
Negative / Null Result Report

Photovoltaic fields largely outperform afforestation efficiency in global climate change mitigation strategies

Rafael Stern, Jonathan D Muller, Eyal Rotenberg et al. · 2023 · PNAS Nexus

Abstract Suppression of carbon emissions through photovoltaic (PV) energy and carbon sequestration through afforestation provides complementary climate change mitigation (CCM) strategies. However, a quantification of the “break-even time”…

View details →DOI: 10.1093/pnasnexus/pgad352Cited by 26
Negative / Null Result ReportEngineering

Systematic Strategy for Obtaining a Dividing-Wall Column Applied to an Extractive Distillation Process

Gardênia Marinho Cordeiro, M.F. Figueirêdo, Wagner Brandão Ramos et al. · 2017 · Industrial & Engineering Chemistry Research

Currently, process intensification using dividing-wall columns (DWCs) is one of the most promising alternatives for reducing the costs of the distillation process. However, for extractive distillation, there are still questions regarding…

View details →DOI: 10.1021/acs.iecr.6b05047Cited by 26
Negative / Null Result Report

Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial

Jean-Philippe Hauzeur, Chantal Lechanteur, Etienne Baudoux et al. · 2019 · Clinical Orthopaedics & Related Research

Abstract Background In patients with nontraumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow aspirate concentrate (BMAC) could delay the progression of osteonecrosis and improve symptoms in pre-fracture ONFH.…

View details →DOI: 10.1097/corr.0000000000001107Cited by 26
Negative / Null Result Report

An intraoperative load sensor did not improve the early postoperative results of posterior‐stabilized TKA for osteoarthritis with varus deformities

Sang Jun Song, Se Gu Kang, Yeon Je Lee et al. · 2018 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose In the present study, the early results of sensor‐assisted versus manually balanced posterior‐stabilized total knee arthroplasty (TKA) for osteoarthritis with varus deformities were prospectively compared. Methods Fifty…

View details →DOI: 10.1007/s00167-018-5314-7Cited by 26
Negative / Null Result Report

Intracranial Pressure Changes following Traumatic Brain Injury in Rats: Lack of Significant Change in the Absence of Mass Lesions or Hypoxia

Levon Gabrielian, Luke W. Willshire, Stephen C. Helps et al. · 2011 · Journal of Neurotrauma

Traumatic brain injury (TBI) often causes raised intracranial pressure (ICP), with >50% of all TBI- related deaths being associated with this increase in ICP. To date, there is no effective pharmacological treatment for TBI, partly because…

View details →DOI: 10.1089/neu.2011.1785Cited by 26
Negative / Null Result ReportMedicine

Significant association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis

Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Lara D. Veeken

OBJECTIVES: To elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV). METHODS: Peripheral blood from 36 patients with active AAV and 18 healthy controls was…

View details →DOI: 10.1093/rheumatology/kez327Cited by 26
Negative / Null Result ReportOpen accessComputer Science

Resolving data bias improves generalization in binding affinity prediction

David Graber, Peter Stockinger, Fabian Meyer et al. · 2025 · Nature Machine Intelligence

The field of computational drug design requires accurate scoring functions to predict binding affinities for protein-ligand interactions. However, train-test data leakage between the PDBbind database and the Comparative Assessment of Scoring Function benchmark datasets has severely inflated the performance metrics of currently available deep-learning-based binding affinity prediction models, leading to overestimation of their generalization capabilities. Here we address this issue by proposing PDBbind CleanSplit, a training dataset curated by a new structure-based filtering algorithm that elim

View details →DOI: 10.1038/s42256-025-01124-5Cited by 26
Negative / Null Result ReportOpen accessMedicine

Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis

John K. Forrest, Steven J. Yakubov, G. Michael Deeb et al. · 2026 · Journal of the American College of Cardiology

BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary…

View details →DOI: 10.1016/j.jacc.2026.02.5063Cited by 26
Negative / Null Result ReportOpen accessMedicine

Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies

Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics

Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa

View details →DOI: 10.1016/j.neurot.2025.e00601Cited by 26