Negative / Null Result ReportOpen accessPsychology
Matt Field, Lisa Di Lemma, Paul Christiansen et al. · 2016 · Psychology of Addictive Behaviors
Alcohol dependence is characterized by conflict between approach and avoidance motivational orientations for alcohol that operate in automatic and controlled processes. This article describes the first study to investigate the predictive validity of these motivational orientations for relapse to drinking after discharge from alcohol detoxification treatment in alcohol-dependent patients. One hundred twenty alcohol-dependent patients who were nearing the end of inpatient detoxification treatment completed measures of self-reported (Approach and Avoidance of Alcohol Questionnaire; AAAQ) and auto
View details →DOI: 10.1037/adb0000232Cited by 28 Negative / Null Result ReportOpen accessDecision Sciences
Anton Olsson-Collentine, Robbie C. M. van Aert, Marjan Bakker et al. · 2023 · Psychological Methods
-hacking) from this "multiverse" of outcomes can inflate effect size estimates and false positive rates. We studied the effects of researcher degrees of freedom and selective reporting using empirical data from extensive multistudy…
View details →DOI: 10.1037/met0000559Cited by 28 Negative / Null Result ReportOpen accessPsychology
Paweł A. Atroszko, Bartosz Atroszko, Edyta Charzyńska · 2021 · International Journal of Environmental Research and Public Health
Background: Relatively strong theoretical assumptions and previous studies concerning co-occurring addictive behaviors suggest a subpopulation representing general proclivity to behavioral addictions (BAs), and there are gender-specific subpopulations. This study aimed to compare latent profile analysis (LPA) and latent class analysis (LCA) as the methods of investigating different clusters of BAs in the general student population and among students positively screened for at least one BA. Participants and procedure: Analyses of six BAs (study, shopping, gaming, Facebook, pornography, and food
View details →DOI: 10.3390/ijerph18168590Cited by 28 Negative / Null Result ReportOpen accessMedicine
David Baumeister, Wolfgang Eich, Silvia Saft et al. · 2019 · Scientific Reports
There has been a surging interest in the putative role of peripheral growth factors in the pathophysiology of fibromyalgia, specifically in the peripheral sensitization that occurs in chronic pain disorders. This cross-sectional study set out to assess and compare brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in plasma samples from fibromyalgia patients and healthy controls. Plasma BDNF and NGF were measured in 89 fibromyalgia patients and 36 pain-free controls, and compared using ANCOVA controlling for potential confounders, as well as Bayesian methods for parameter e
View details →DOI: 10.1038/s41598-019-49403-7Cited by 28 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ismaïl Ahmed, Pei‐Chen Lee, Christina M. Lill et al. · 2014 · PLoS Genetics
The etiology of Parkinson disease (PD) involves both genetic susceptibility and environmental exposures. In particular, coffee consumption is inversely associated with PD but the mechanisms underlying this intriguing association are unknown. According to a recent genome-wide gene-environment interaction study, the inverse coffee-PD association was two times stronger among carriers of the T allele of SNP rs4998386 in gene GRIN2A than in homozygotes for the C allele. We attempted to replicate this result in a similarly sized pooled analysis of 2,289 cases and 2,809 controls from four independent
View details →DOI: 10.1371/journal.pgen.1004788Cited by 28 Negative / Null Result ReportOpen accessMedicine
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson et al. · 2022 · European Heart Journal - Cardiovascular Pharmacotherapy
AIMS: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the…
View details →DOI: 10.1093/ehjcvp/pvac070Cited by 28 Negative / Null Result ReportOpen accessMedicine
Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →DOI: 10.1186/s12887-019-1441-7Cited by 28 Negative / Null Result Report
Bisakha Sen, Justin Blackburn, Michael A. Morrisey et al. · 2012 · Health Services Research
Objective To explore whether health care utilization changed among enrollees in Alabama's CHIP program, ALL Kids, following copayment increases at the beginning of fiscal year 2004. Data Sources Data on all ALL Kids enrollees over…
View details →DOI: 10.1111/j.1475-6773.2012.01384.xCited by 28 Negative / Null Result ReportOpen accessMedicine
Andreas Carus, Howard Gurney, Val Gebski et al. · 2013 · Journal of Translational Medicine
Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear. We evaluated baseline and nadir neutrophils in 111 patients (pts.) with non-small cell lung cancer (NSCLC) and 118 pts. with ovarian cancer (OC) treated with chemotherapy administered with dose-individualization to achieve nadir neutropenia of 1.5. We used predefined baseline neutrophil cut-offs 4.5 × 109/L (NSCLC) and 3.9 × 109/L (OC). Absence of chemotherapy-induced nadir neutropenia (CTCAE grade 0, neutrophils ≥ LLN) was seen in 23% of OC and
View details →DOI: 10.1186/1479-5876-11-189Cited by 28 Negative / Null Result ReportOpen accessSocial Sciences
Irene Mosca, Bláithín Ní Bhuachalla, Rose Anne Kenny · 2013 · BMC Cardiovascular Disorders
BACKGROUND: To assess prevalence rates of subjective and objective reports of two cardiovascular disorders (hypertension and hypercholesterolemia) for the same subset of respondents in a large-scale study. To determine whether and the extent to which the socioeconomic health gradient differed in the subjective and objective reports of the two cardiovascular disorders. METHODS: Data from the first wave (2009/2011) of The Irish Longitudinal Study on Ageing were used (n = 4,179). This is a nationally representative study of community-dwelling adults aged 50+ residing in Ireland. Subjective measur
View details →DOI: 10.1186/1471-2261-13-64Cited by 28 Negative / Null Result ReportOpen accessMedicine
Natalie Kashefi, Jonathan I. Nathan, Sharmila Dissanaike · 2014 · Plastic & Reconstructive Surgery Global Open
BACKGROUND: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization…
View details →DOI: 10.1097/gox.0000000000000121Cited by 28 Negative / Null Result ReportOpen accessMedicine
Fang He, Huai‐Qiang Ju, Yi Ding et al. · 2020 · British Journal of Cancer
BACKGROUND: For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS: The pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by Kaplan-Meier and log-rank test. RESULTS: In total, 1041 pCR individuals were identified from 5567 LARC cases.
View details →DOI: 10.1038/s41416-020-0989-1Cited by 28 Negative / Null Result ReportOpen accessMedicine
Weikun Li, Murat Yalçın, Dhruba J. Bharali et al. · 2019 · Scientific Reports
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
View details →DOI: 10.1038/s41598-019-44979-6Cited by 28 Negative / Null Result ReportOpen accessMedicine
Nilgün Mendil, Şahin Temel, Recep Civan Yüksel et al. · 2021 · TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18–86) ye
View details →DOI: 10.3906/sag-2007-228Cited by 28 Negative / Null Result ReportAgricultural and Biological Sciences
Patrick J. McIntyre, Sharon Y. Strauss · 2017 · Evolution
The geographic distributions of polyploids suggest they can have distinct and sometimes broader niches compared to diploids. However, relatively few field experiments have investigated whether range differences are associated with local…
View details →DOI: 10.1111/evo.13288Cited by 28 Negative / Null Result ReportPsychology
Natalie L. Wilver, Jesse R. Cougle · 2018 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The current study extended upon previous research efforts by evaluating the utility and feasibility of an 8-session Internet-based interpretation bias modification (IBM) training protocol targeting evaluation- and…
View details →DOI: 10.1037/ccp0000372Cited by 28 Negative / Null Result ReportOpen accessMedicine
Wouter M. IJgosse, Harry van Goor, Camiel Rosman et al. · 2020 · JMIR Serious Games
Background Surgical residents underutilize opportunities for traditional laparoscopic simulation training. Serious gaming may increase residents’ motivation to practice laparoscopic skills. However, little is known about the effectiveness of serious gaming for laparoscopic skills training. Objective The aim of this study was to establish construct validity for the laparoscopic serious game Underground. Methods All study participants completed 2 levels of Underground. Performance for 2 novel variables (time and error) was compared between novices (n=65, prior experience <10 laparoscopic proc
View details →DOI: 10.2196/17222Cited by 28 Negative / Null Result ReportOpen accessImmunology and Microbiology
D. Beaujean, Fedor Gassner, A Wong et al. · 2016 · BMC Public Health
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren. METHODS: A total of 887 children, aged 9-13 years and attending the two final years of primary
View details →DOI: 10.1186/s12889-016-3811-5Cited by 28 Negative / Null Result ReportMedicine
Shahar Shelly, Pritikanta Paul, Hong‐Yan Bi et al. · 2020 · Neurology
OBJECTIVE: To improve myasthenia gravis (MG) autoantibody testing. METHODS: MG serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All…
View details →DOI: 10.1212/wnl.0000000000010910Cited by 28 Negative / Null Result Report
Erik Litonius, Tomohisa Niiya, Pertti J. Neuvonen et al. · 2011 · Basic & Clinical Pharmacology & Toxicology
Abstract: Intravenous lipid emulsion has been used in the resuscitative treatment of intoxications caused by local anaesthetics and tricyclic antidepressants with seemingly beneficial results. We studied the effect of intravenous lipid…
View details →DOI: 10.1111/j.1742-7843.2011.00826.xCited by 28 Negative / Null Result ReportOpen accessDecision Sciences
Gillian Pepper, Deirdre Corby, Rachel Bamber et al. · 2017 · PeerJ
Here, we report three attempts to replicate a finding from an influential psychological study (Griskevicius et al., 2011b). The original study found interactions between childhood SES and experimental mortality-priming condition in predicting risk acceptance and delay discounting outcomes. The original study used US student samples. We used British university students (replication 1) and British online samples (replications 2 and 3) with a modified version of the original priming material, which was tailored to make it more credible to a British audience. We did not replicate the interaction b
View details →DOI: 10.7717/peerj.3580Cited by 28 Negative / Null Result ReportOpen accessSocial Sciences
Jan G. Voelkel, Mark J. Brandt, Matteo Colombo · 2018 · Comprehensive Results in Social Psychology
People are prejudiced toward groups they perceive as having a worldview dissimilar from their own. This link between perceived attitudinal dissimilarity and prejudice is so stable that it has been described as a psychological law. The current research tests whether reducing people’s (over-)confidence in their own understanding of policies by puncturing their illusion of explanatory depth in the political domain will reduce the link between perceived attitudinal dissimilarity and prejudice. In an initial pre-registered experiment (N = 296), we did not find support for our hypothesis, but explor
View details →DOI: 10.1080/23743603.2018.1464881Cited by 28 Negative / Null Result ReportOpen accessComputer Science
Shervin Malmasi, Joel Tetreault, Mark Dras · 2015
We examine different ensemble methods, including an oracle, to estimate the upper-limit of classification accuracy for Native Language Identification (NLI). The oracle outperforms state-of-the-art systems by over 10% and results indicate that for many misclassified texts the correct class label receives a significant portion of the ensemble votes, often being the runner-up. We also present a pilot study of human performance for NLI, the first such experiment. While some participants achieve modest results on our simplified setup with 5 L1s, they did not outperform our NLI system, and this perf
View details →DOI: 10.3115/v1/w15-0620Cited by 28 Negative / Null Result ReportOpen accessPsychology
Leon Y. Xiao, Tullia C. Fraser, Philip Newall · 2022 · Journal of Gambling Studies
Loot boxes are quasi-gambling virtual products in video games that provide randomised rewards of varying value. Previous studies in Western contexts have identified a positive correlation between loot box purchasing and problem gambling severity. A preregistered survey of People's Republic of China (PRC) video game players (N = 879) failed to replicate this correlation. We observed statistically significant but weak positive correlations between loot box expenditure and past-year gambling participation, and between loot box expenditure and impulsiveness. This study cannot prove that loot boxes
View details →DOI: 10.1007/s10899-022-10148-0Cited by 27 Negative / Null Result ReportOpen accessNeuroscience
Annelies Spek, Evert Scholte, Ina A. van Berckelaer‐Onnes · 2010 · Journal of Autism and Developmental Disorders
Local information processing in 42 adults with high functioning autism, 41 adults with Asperger syndrome and 41 neurotypical adults was examined. Contrary to our expectations, the disorder groups did not outperform the neurotypical group…
View details →DOI: 10.1007/s10803-010-1106-8Cited by 27 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ahmad Karimi, Yuna Min, C. Lu et al. · 2012 · Poultry Science
A total of 540 one-day-old male broiler chicks were used to evaluate the potential enhancing effects of a mixture of 2 commercial carbohydrase preparations on phytase efficacy. A nonphytate phosphorus (nPP) deficient diet (0.15%) was…
View details →DOI: 10.3382/ps.2012-02558Cited by 27 Negative / Null Result ReportOpen accessMedicine
Albert J. Auguste, Rose M. Langsjoen, Danielle L. Porier et al. · 2021 · Virology
We describe the isolation and characterization of a novel insect-specific flavivirus (ISFV), tentatively named Aripo virus (ARPV), that was isolated from Psorophora albipes mosquitoes collected in Trinidad. The ARPV genome was determined…
View details →DOI: 10.1016/j.virol.2021.07.004Cited by 27 Negative / Null Result ReportOpen accessMedicine
Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao et al. · 2021 · Biomedicines
Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide
View details →DOI: 10.3390/biomedicines9010088Cited by 27 Negative / Null Result ReportOpen accessPsychology
Kathryn J. Lester, Susanna Roberts, Robert Keers et al. · 2015 · The British Journal of Psychiatry
BACKGROUND: We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive…
View details →DOI: 10.1192/bjp.bp.114.154997Cited by 27 Negative / Null Result ReportOpen accessEnvironmental Science
William L. Baker, Mark A. Williams · 2018 · Ecological Applications
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western United States remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration…
View details →DOI: 10.1002/eap.1688Cited by 27 