Lack of Replication of the GRIN2A-by-Coffee Interaction in Parkinson Disease
Ismaïl Ahmed; Pei‐Chen Lee; Christina M. Lill; Susan Searles Nielsen; Fanny Artaud; Lisa G. Gallagher; Marie‐Anne Loriot; Claire Mulot · 2014 · PLoS Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The etiology of Parkinson disease (PD) involves both genetic susceptibility and environmental exposures. In particular, coffee consumption is inversely associated with PD but the mechanisms underlying this intriguing association are unknown. According to a recent genome-wide gene-environment interaction study, the inverse coffee-PD association was two times stronger among carriers of the T allele of SNP rs4998386 in gene GRIN2A than in homozygotes for the C allele. We attempted to replicate this result in a similarly sized pooled analysis of 2,289 cases and 2,809 controls from four independent
Abstract by Ismaïl Ahmed; Pei‐Chen Lee; Christina M. Lill; Susan Searles Nielsen; Fanny Artaud; Lisa G. Gallagher; Marie‐Anne Loriot; Claire Mulot, PLoS Genetics (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pgen.1004788