A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 90 of 674
So-Yeon Kim, Kelly S. Giovanello · 2011 · Journal of Cognitive Neuroscience
Numerous studies have documented that older adults (OAs) do not perform as well as young adults (YAs) when task demands require the establishment or retrieval of a novel link between previously unrelated information (relational memory:…
Alexis Dunkle, Ivan Dzhagalov, Y-W He · 2011 · Cell Death and Disease
Myeloid cell leukemia sequence-1 (Mcl-1) is a critical anti-apoptotic factor in T lymphocytes. However, in spite of the many pro-apoptotic proteins with proposed binding to Mcl-1, the specific interactions by which Mcl-1 regulates primary T-cell survival under different conditions have not been fully explored. Further, how different trophic cytokines modulate the specific role(s) of Mcl-1 is unknown. Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes. Using the inducible Mcl-1-floxed estrogen receptor-Cre fusion protein (Mcl-1(f/f)ERCre) deletion system in
Sun-Hwa Shin, Won-Seok Choi · 2021 · Food Science of Animal Resources
This study examined the measurement conditions of the texture profile analysis (TPA) experiments that are typically used to measure the physical properties of sausage. As the measurement conditions (compression ratio and cross-head speed)…
David H. Howard, Carolyn Kenline, Hillard M. Lazarus et al. · 2011 · Health Services Research
OBJECTIVE: In 1999, three randomized controlled trials concluded that high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HDC/HCT) is no better than conventional chemotherapy for women with breast cancer.…
Marie‐Ève Nadeau, Barbara E. Kitchell · 2011 · PubMed
This retrospective study compared the efficacy of surgery alone versus surgery in combination with chemotherapy in the treatment of canine thyroid carcinoma; potential prognostic factors were evaluated. Forty-four dogs with…
Raquel Ajub Moysés, Rossana Veronica Mendoza López, Patrı́cia Maluf Cury et al. · 2013 · Clinics
OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: T
Fabian A. Soto · 2018 · Journal of Experimental Psychology General
In a recent article, Maes et al. (2016) report the results from 15 experiments in the blocking effect, all of which failed to replicate the basic phenomenon. Whereas Maes et al. did not dispute the reality of the blocking effect, they…
Aditi Mathur, Matthew H. Law, Ian L. Megson et al. · 2010 · Psychiatric Genetics
OBJECTIVES: A number of studies have reported a genetic association of the AKT1 gene with schizophrenia, although some have failed to replicate the AKT1 association. This study was undertaken to further explore the AKT1 association with…
Matthew J. Fisher, Luis A Marcos Raymundo, Melinda Monteforte et al. · 2020 · International Journal of Infectious Diseases
OBJECTIVES: The purpose of this study is to evaluate clinical outcomes in patients with critical COVID-19 pneumonia requiring invasive mechanical ventilation who were treated with tocilizumab DESIGN: Single-center retrospective cohort…
Xiaoyu Chen, Dongli Wei, Mårten S. G. Ahlquist · 2021 · Organometallics
A CoPc/CNT system has been only recently reported to transform CO2 to methanol via electrochemical reductions, despite the fact that catalyst has been studied extensively since the 1980s. The explanation of high methanol selectivity lies behind the fact that in the new report CoPc exists mainly as a monomer, while in earlier works aggregates dominate. Here, we have studied the reactivity of monomeric and dimeric CoPc by DFT. The mechanism involves rate-limiting CO2 association, with the C–O cleavage step having very similar activation free energy. Once the Co–CO– intermediate is formed, the re
Francesco Giuseppe De Rosa, Silvia Corcione, Giovanni Di Perri et al. · 2015 · PubMed
Tigecycline, the first member of the glycylcyclines, has been approved for complicated skin and soft tissue infections (cSSTIs) and complicated intra-abdominal infections (cIAIs). It has a wide range of activity against Gram-positive and…
Michael Weller, Michael Lim, Ahmed Idbaïh et al. · 2021 · Neuro-Oncology
Abstract BACKGROUND Novel therapies are needed in newly diagnosed glioblastoma as nearly all patients experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ), including patients with tumors with methylated…
Liangzhi Zhong, Lu Chen, Shengqing Lv et al. · 2019 · Radiation Oncology
PURPOSE: Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) combined with temozolomide (TMZ) for the postoperative treatment of GBM. MATERIALS AND METHODS: From February 2012 to February 2018, 80 patients with newly diagnosed and histologically confirmed GBM in our institute were reviewed retrospectively. All patients underwent complete resection or partial resection
C. Gianna Hoffman-Luca, Chao-Yie Yang, Jianfeng Lü et al. · 2015 · PLoS ONE
SAR405838 is a potent and specific MDM2 inhibitor currently being evaluated in Phase I clinical trials for the treatment of human cancer. Using the SJSA-1 osteosarcoma cell line which harbors an amplified MDM2 gene and wild-type p53, we have investigated the acquired resistance mechanisms both in vitro and in vivo to SAR405838. Treatment of SJSA-1 cells with SAR405838 in vitro leads to dose-dependent cell growth inhibition, cell cycle arrest and robust apoptosis. However, prolonged treatment of SJSA-1 cells in vitro with SAR405838 results in profound acquired resistance to the drug. Analysis o
Mingqiu Chen, Minmin Shen, Yu Lin et al. · 2018 · Radiation Oncology
BACKGROUND: The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT). METHODS: The clinical data of patients with ESCC treated with chemoradiotherapy with or without AC were collected and retrospectively reviewed. The overall survival (OS), locoregional failure-free survival (LFFS) and distant failure-free survival (DFFS) rates were analyzed statistically. RESULTS: A total of 187 patients fulfilled the inclusion criteria, 98 of whom were treated with CRT-alone
Alisa M. Higgins, Sandra Peake, Rinaldo Bellomo et al. · 2019 · Critical Care Medicine
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. DESIGN: Prospective, randomized, parallel-group trial. SETTING: Fifty-one hospitals in Australia, New Zealand, Finland, Hong Kong, and the…
Vivian E. Strong, Sam S. Yoon · 2013 · World Journal of Surgery
Much debate still exists regarding the appropriate extent of lymphadenectomy for gastric adenocarcinoma. In high incidence countries in Eastern Asia, more extensive (e.g. D2) lymphadenectomies are standard, and these surgeries are…
Amy Thomas, Khaled Dajani, John P. Neoptolemos et al. · 2010 · Digestive Diseases
Pancreatic cancer is one of the major causes of cancer death in Europe with a 5-year survival rate of less than 5%. Although surgery cannot guarantee a cure, the 5-year survival does improve to around 10% following resection and increases…
Shiow‐Ching Shun, Kun‐Huei Yeh, Jin‐Tung Liang et al. · 2013 · Oncology nursing forum
PURPOSE/OBJECTIVES: To explore the association between supportive care needs and type D personality, and to identify personality traits, including negative affectivity (NA) and social inhibition (SI), and their influence on the supportive…
Otto A. Sanchez, Elizabeth A. Copenhaver, Christopher P. Elder et al. · 2010 · Magnetic Resonance in Medicine
Abstract Blood oxygenation level dependent (BOLD) contrast in skeletal may reflect the contributions of both intravascular and extravascular relaxation effects. The purpose of this study was to determine the significance of the…
Arjen Alink, Hunar Abdulrahman, Richard N. Henson · 2018 · Nature Communications
Abstract Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to…
Hsi‐Chin Wu, Chao‐Hsiang Chang, Ru-Yin Tsai et al. · 2010 · PubMed
Prostate cancer is the most common cause of cancer death in men and is a major health problem worldwide. Methylene tetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is also an important source of DNA…
Chun-Yu Kuo, Yang-Ming Huang, Yei‐Yu Yeh · 2018 · Frontiers in Psychology
Cognitive training and social engagement are two of the routes that potentially improve cognitive functions in older adults. The former targets specific functions so that an intervention can trigger the plasticity and efficiency of the underpinning neural systems, and the latter also provides an environment supportive of social and emotional needs. We investigated whether an integration of the two routes could enhance cognitive functions related to executive control, because no prior research has adopted a theory-driven approach to design a group-based cognitive training program for executive
Ullrich K. H. Ecker, Caitlin X. M. Sharkey, Briony Swire-Thompson · 2023 · PLOS ONE
Individuals often continue to rely on misinformation in their reasoning and decision making even after it has been corrected. This is known as the continued influence effect, and one of its presumed drivers is misinformation familiarity.…
Thibaut Vaulet, M. Al‐Memar, H. Fourie et al. · 2021 · Computer Methods and Programs in Biomedicine
BACKGROUND: Clinical models to predict first trimester viability are traditionally based on multivariable logistic regression (LR) which is not directly interpretable for non-statistical experts like physicians. Furthermore, LR requires…
Amanda E. Haponski, Diarmaid Ó Foighil · 2019 · PeerJ
The genus Corbicula consists of estuarine or freshwater clams native to temperate/tropical regions of Asia, Africa, and Australia that collectively encompass both sexual species and clonal (androgenetic) lineages. The latter have become…
Alejandro Gella, Mònica Segura, Núria Durany et al. · 2011 · BMC Psychiatry
BACKGROUND: Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder. Another SNP in ANK3 (rs10761482) was associated with schizophrenia in a large European sample. Within the debate on common susceptibility genes for schizophrenia and bipolar disorder, we tried to investigate common findings by analyzing association of ANK3 with schizophrenia, bipolar disorder and unipolar depression. METHODS: We genotyped three single nucleotide polymorphisms (SNPs) in ANK3 (rs9804190, rs10994336,
Maximilian L. Würstle, Markus Rehm · 2014 · Journal of Biological Chemistry
The protease caspase-9 is activated on the apoptosome, a multiprotein signal transduction platform that assembles in response to mitochondria-dependent apoptosis initiation. Despite extensive molecular research, the assembly of the holo-apoptosome and the process of caspase-9 activation remain incompletely understood. Here, we therefore integrated quantitative data on the molecular interactions and proteolytic processes during apoptosome formation and apoptosis execution and conducted mathematical simulations to investigate the resulting biochemical signaling, quantitatively and kinetically. I
Steven Masson, Benjamin Marrow, Stuart Kendrick et al. · 2014 · Transplant International
Return to drinking after liver transplantation for alcoholic liver disease (ALD) remains a source of unease with varying reported rates of return to drinking and impact this has on graft function. In 2005, the UK Transplant liver advisory…
L. A. Temitope · 2013 · Journal of Economics and Behavioral Studies
This paper adopts the Toda-Yamamoto technique of causality in order to examine the direction of causality between employment and economic growth. This is to investigate whether the increase in the Gross Domestic Product (GDP) translates into increased employment or not and vice versa, in South Africa, using quarterly data from 2000Q1 to 2012Q3. South Africa has been experiencing high and increased growth for the past decade, yet the rate of employment is not significantly high. Meanwhile, the objective of the government, since the first democratic election in 1994, was to increase economic gro