A Systems Biology Analysis of Apoptosome Formation and Apoptosis Execution Supports Allosteric Procaspase-9 Activation
Maximilian L. Würstle; Markus Rehm · 2014 · Journal of Biological Chemistry
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Abstract
The protease caspase-9 is activated on the apoptosome, a multiprotein signal transduction platform that assembles in response to mitochondria-dependent apoptosis initiation. Despite extensive molecular research, the assembly of the holo-apoptosome and the process of caspase-9 activation remain incompletely understood. Here, we therefore integrated quantitative data on the molecular interactions and proteolytic processes during apoptosome formation and apoptosis execution and conducted mathematical simulations to investigate the resulting biochemical signaling, quantitatively and kinetically. I
Abstract by Maximilian L. Würstle; Markus Rehm, Journal of Biological Chemistry (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1074/jbc.m114.590034