Negative / Null Result ReportOpen accessMedicine
Miklós Lipcsey, Mia Furebring, Sten Rubertsson et al. · 2010 · Upsala Journal of Medical Sciences
BACKGROUND: Renal dysfunction is associated with increased morbidity and mortality in intensive care patients. In most cases the glomerular filtration rate (GFR) is estimated based on serum creatinine and the Modification of Diet in Renal Disease (MDRD) formula, but cystatin C-estimated GFR is being used increasingly. The aim of this study was to compare creatinine and MDRD and cystatin C-estimated GFR in intensive care patients. METHODS: Retrospective observational study was performed, on patients treated within the general intensive care unit (ICU) during 2004-2006, in a Swedish university h
View details →DOI: 10.3109/03009734.2010.526724Cited by 33 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Simran Thakkar, Aditi Chopra, Lakshmi Nagendra et al. · 2023 · touchREVIEWS in Endocrinology
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterized by the irreversible destruction of the β cells of the pancreas, which leads to a lifelong dependency on exogenous insulin. Despite the advancements in insulin…
View details →DOI: 10.17925/ee.2023.19.2.7Cited by 33 Negative / Null Result ReportOpen accessMedicine
John Ly, David Minarik, Lars Edenbrandt et al. · 2019 · EJNMMI Research
The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mi
View details →DOI: 10.1186/s13550-019-0536-3Cited by 33 Negative / Null Result ReportOpen accessMedicine
Terence Fullerton, Brendon Binneman, William David et al. · 2018 · Alzheimer s Research & Therapy
Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in humans at a dose of 30 mg. This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial evaluating the efficacy and safety of SAM-760 30 mg once daily (QD) for 12 weeks in subjects with AD on a stable regimen of donepezil 5 to 10 mg QD. The study included an interim analysis with stopping rules for futility or efficacy after 180 subjects comp
View details →DOI: 10.1186/s13195-018-0368-9Cited by 33 Negative / Null Result ReportOpen accessMedicine
Péter Kupó, T Riesz, László Sághy et al. · 2023 · Journal of Cardiovascular Electrophysiology
INTRODUCTION: Routine ultrasound (US) guidance for femoral venous access to decrease vascular complications of atrial fibrillation (AF) ablation procedures has been advocated. However, the benefit has not been unequivocally demonstrated by randomized-trial data. METHODS: Consecutive patients undergoing pulmonary vein isolation (PVI) on uninterrupted anticoagulant treatment were included. A quasi-random allocation to either US-guided or conventional puncture group was based on which of the two procedure rooms the patient was scheduled in, with only one of the rooms equipped with a US machine in
View details →DOI: 10.1111/jce.15893Cited by 33 Negative / Null Result ReportOpen accessSocial Sciences
Stefan Stieger, Sabine Wunderl · 2022 · Computers in Human Behavior
In adolescence, smartphone use in general and social media use in particular has often been associated with negative effects, such as higher anxiety levels and body dissatisfaction. Other outcomes – such as fundamental cognitive abilities and skills (e.g., intelligence, information processing, spatial perception) – have rarely been the focus of research. Here, we analysed data from a large sample of adolescents (12–16 years; N > 12,000) who performed a series of psychometric tests ranging from intelligence, spatial perception, and information processing, to practical numeracy, and compared the
View details →DOI: 10.1016/j.chb.2022.107358Cited by 33 Negative / Null Result Report
Igor Calzada · 2020 · Smart Cities
This article addresses the problem of replication among smart cities in the European Commission’s Horizon 2020: Smart Cities and Communities (EC-H2020-SCC) framework programme. This article initially sets the general policy context by…
View details →DOI: 10.3390/smartcities3030049Cited by 33 Negative / Null Result Report
David Houdoux, Axelle Amon, David Marsan et al. · 2021 · Communications Earth & Environment
Abstract Memory effects in seismology—such as the occurrence of aftershock sequences—are implicitly assumed to be governed by the time since the main event. However, experiments are yet to identify if memory effects are structural or…
View details →DOI: 10.1038/s43247-021-00147-1Cited by 33 Negative / Null Result ReportMedicine
Sarah Moody, Leire Escudero‐Ibarz, Ming Wang et al. · 2017 · The Journal of Pathology
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends…
View details →DOI: 10.1002/path.4933Cited by 33 Negative / Null Result ReportOpen accessMedicine
Janet M. Boekhout, Brenda Berendsen, Denise A. Peels et al. · 2018 · International Journal of Environmental Research and Public Health
This study explores the effectiveness of the Active Plus65 intervention designed to stimulate physical activity among single older adults with a chronic physical impairment. A quasi-experimental pre-test post-test study was performed. The intervention group (n = 411; mean age = 76.75; SD = 7.75) was assessed at baseline, three months, and six months. Data of comparable older adults who completed the original Active Plus intervention served as reference group (n = 87; mean age = 74.36; SD = 6.26). Multilevel regression analyses were applied: outcome measures were weekly minutes of moderate to v
View details →DOI: 10.3390/ijerph15020346Cited by 33 Negative / Null Result ReportOpen accessMedicine
Chao Gao, Bin Zhu, Fan Ouyang et al. · 2025 · BMJ
Abstract Objectives To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons. Design Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).…
View details →DOI: 10.1136/bmj-2024-082945Cited by 33 Negative / Null Result ReportOpen accessComputer Science
Anne Lohr, Michael Sailer, Matthias Stadler et al. · 2024 · Teaching and Teacher Education
We investigated factors that are potentially associated with teaching and learning with digital technology, by replicating and extending Sailer, Murböck, and Fischer's (2021) study with a representative sample of 407 German secondary school teachers. In line with the replicated study, teachers' technology-related teaching skills were crucial for different forms of students' active learning, whereas the digital technology equipment available in a school was less important. School support was positively related to successful digital teaching and learning at schools. The success of Bring-Your-Own
View details →DOI: 10.1016/j.tate.2024.104788Cited by 33 Replication FailureOpen accessNeuroscience
Joost de Winter, Sebastiaan M. Petermeijer, Lars Kooijman et al. · 2021 · International Journal of Psychophysiology
Several papers by Eckhard Hess from the 1960s and 1970s report that the pupils dilate or constrict according to the interest value, arousing content, or mental demands of visual stimuli. However, Hess mostly used small sample sizes and undocumented luminance control. In a first experiment (N = 182) and a second preregistered experiment (N = 147), we replicated five studies of Hess using modern equipment. Our experiments (1) did not support the hypothesis of gender differences in pupil diameter change with respect to baseline (PC) when viewing stimuli of different interest value, (2) showed tha
View details →DOI: 10.1016/j.ijpsycho.2021.03.003Cited by 33 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Oisín Ryan, Jonas M B Haslbeck, Lourens Waldorp · 2025 · Multivariate Behavioral Research
Time series analysis is increasingly popular across scientific domains. A key concept in time series analysis is stationarity, the stability of statistical properties of a time series. Understanding stationarity is crucial to addressing frequent issues in time series analysis such as the consequences of failing to model non-stationarity, how to determine the mechanisms generating non-stationarity, and consequently how to model those mechanisms (i.e., by differencing or detrending). However, many empirical researchers have a limited understanding of stationarity, which can lead to the use of in
View details →DOI: 10.1080/00273171.2024.2436413Cited by 33 Negative / Null Result ReportPsychology
Yongliang Wang, Yumeng Guo · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background The rise of artificial intelligence (AI) has reshaped English as Foreign Language (EFL) instruction, offering new opportunities for language learning. While much of the existing research focuses on AI integration in…
View details →DOI: 10.1002/jcal.70189Cited by 33 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ahmed Samour, Riza Radmehr, Ernest Baba Ali et al. · 2024 · Heliyon
Given the alarming level of climate change, policymakers across the globe are seeking strategies to mitigate environmental pollution to achieve sustainable development. In this context, renewable energy and technological advancements have…
View details →DOI: 10.1016/j.heliyon.2024.e39970Cited by 33 Negative / Null Result ReportOpen accessMedicine
Christof A. Leicht, Victoria L. Goosey‐Tolfrey, Nicolette C. Bishop · 2026 · PubMed
A spinal cord injury (SCI) can increase the risk of infection by impacting on many aspects of immune function; one particularly well-documented observation is a reduction in lymphocyte numbers. The vast majority of lymphoid cells express…
View details →DOI: 10.22029/eir.2013.1683Cited by 33 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Bo Zou, Dan Zhao, Shuang Zhou et al. · 2025 · Frontiers in Nutrition
Emerging evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) are essential structural and functional nutrients that significantly influence the composition and function of the gut microbiota, a key mediator of host health. Although evidence suggests that increasing tissue Omega-3 levels through dietary intervention may optimize gut microbiota-host interaction through modulation of composition, metabolite production, and the intestinal mucus barrier, some studies have reported inconsistent findings regarding these protective effects. Studies indicate that a high Omega-6/Omega-3 r
View details →DOI: 10.3389/fnut.2025.1575323Cited by 32 Negative / Null Result ReportOpen accessMathematics
Jeremy P. Gygi, Cole Maguire, Ravi K. Patel et al. · 2024 · Journal of Clinical Investigation
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes for some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation of molecular and cellular profiles over the full disease course can link immune programs and their coordination with progression heterogeneity.METHODSWe performed deep immunophenotyping and conducted longitudinal multiomics modeling, integrating 10 assays for 1,152 Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study participants and identif
View details →DOI: 10.1172/jci176640Cited by 32 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Walter Acevedo, Bijan Fallah, Sebastian Reich et al. · 2017 · Climate of the past
Abstract. Paleoclimate data assimilation (DA) is a promising technique to systematically combine the information from climate model simulations and proxy records. Here, we investigate the assimilation of tree-ring-width (TRW) chronologies into an atmospheric global climate model using ensemble Kalman filter (EnKF) techniques and a process-based tree-growth forward model as an observation operator. Our results, within a perfect-model experiment setting, indicate that the "online DA" approach did not outperform the "off-line" one, despite its considerable additional implementation complexity. On
View details →DOI: 10.5194/cp-13-545-2017Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Han Wu, Xiang Zhao, Fei Wang et al. · 2017 · Frontiers in Immunology
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages. In contrast, MuV did not replicate in male GC. Notably, testicular ce
View details →DOI: 10.3389/fimmu.2017.00117Cited by 32 Negative / Null Result ReportOpen accessComputer Science
The First Waters · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper develops government structural reference infrastructure for AI and AGI environments. It addresses the need for public institutions to preserve reference continuity across public records, citizen submissions, administrative documents, authority-condition references, state histories, seal-reference contexts, role accountability records, economic references, and propagation-sensitive records without becoming dependent on a single AI provider, platform, model, or cloud environment. The framework does not perform public decision-making, grant authority, issue permits, approve benefits, c
View details →DOI: 10.5281/zenodo.20371945Cited by 32 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mohsen Mehrara, H Abrishami, Mostafa Boroujli et al. · 2013 · International Letters of Social and Humanistic Sciences
This paper examines causal relationships between Government Recurrent Expenditure (GRE) and GDP for Iran using annual data over the period 1970-2010. The Gregory-Hansen (1996) cointegration technique, allowing for the presence of potential structural breaks in data, is applied to empirically examine the long-run co-movement between these variables. The results suggest that there is a long-run relationship between these variables. The Granger Causality test indicates strong unidirectional effects from GDP to GRE. But there is no evidence that TRE promotes long-term economic growth. Moreover, th
View details →DOI: 10.18052/www.scipress.com/ilshs.11.76Cited by 32 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
K.E. Giller, Euan K. James, Julie Ardley et al. · 2024 · Plant and Soil
Abstract Background Despite more than 50 years of research, no robust evidence suggests that inoculation of cereals and other non-legumes with free-living and/or endophytic bacteria leads to fixation of agronomically significant quantities of dinitrogen gas (N 2 ) from the atmosphere. A plethora of new products claims to increase the growth and yields of major cereals and other crops through stimulating N 2 -fixation by inoculating with bacteria. Scope We review the literature on N 2 -fixation by bacteria in the rhizosphere and as endophytes in non-legume plants. We find no unequivocal evidenc
View details →DOI: 10.1007/s11104-024-07001-1Cited by 32 Negative / Null Result ReportOpen accessComputer Science
Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov et al. · 2025 · Nature Communications
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics if clinicians over or under rely on AI. To investigate such collaborative decision-making process, we conducted a Human-AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. We investigated two levels of collaborative behavior: model-agnostic and model-specific; and found that Human-AI
View details →DOI: 10.1038/s41467-024-55259-xCited by 32 Negative / Null Result ReportOpen accessComputer Science
J. M. Górriz, R. Martin-Clemente, F. Segovia et al. · 2026 · Information Fusion
As a technique that can compactly represent complex patterns, machine learning has significant potential for predictive inference in multi-source and heterogeneous information fusion scenarios. K-fold cross-validation (CV) is the most common approach for ascertaining the likelihood that a machine learning outcome is generated by chance and frequently outperforms conventional hypothesis testing. This improvement arises from measures directly obtained from machine learning classifications, such as accuracy, that do not have a parametric description. To approach a frequentist analysis within fusi
View details →DOI: 10.1016/j.inffus.2026.104404Cited by 32 Negative / Null Result ReportPsychology
Chung-Yuan Hsu, Chin‐Chung Tsai · 2012 · Interactive Learning Environments
Abstract Educational researchers have indicated that although computer games have the potential to promote students' motivation and engagement, the work on how to design effective games that fulfil educational purposes is still in its…
View details →DOI: 10.1080/10494820.2012.705850Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Sugie, Shoichiro Mukai, Koji Yamasaki et al. · 2016 · PubMed
BACKGROUND/AIM: Up-regulation of caveolin (CAV)-1 is associated with aggressive prostate cancer. Recently, it has been inferred that CAV2, a co-factor sub-type of CAV1, cross-talks with CAV1 and promotes tumor growth. We previously…
Negative / Null Result ReportNeuroscience
Fanxing Meng, Cristy Ho, Rob Gray et al. · 2014 · Ergonomics
Three experiments were conducted to assess the effectiveness of dynamic vibrotactile warning signals with different spatial patterns and to compare dynamic towards-torso and towards-head vibrotactile warnings in a simulated driving task.…
View details →DOI: 10.1080/00140139.2014.976278Cited by 32 Negative / Null Result Report
Timothy J. Layton, Andrew M. Ryan · 2015 · Health Services Research
Objective To evaluate the effects of the size of financial bonuses on quality of care and the number of plan offerings in the Medicare Advantage Quality Bonus Payment Demonstration. Data Sources Publicly available data from CMS from 2009…
View details →DOI: 10.1111/1475-6773.12409Cited by 32 