A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19798 results in Negative / Null Result Report · page 87 of 660
Shuichi Matsuda, Hideki Mizu‐uchi, Shingo Fukagawa et al. · 2010 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract A prospective study was performed to compare the clinical and radiological results of mobile‐ and fixed‐bearing total knee arthroplasty with specific attention to rotational alignment and range of motion. Sixty‐one knees were…
Marjorie L. McCullough, Rebecca A. Hodge, Peter T. Campbell et al. · 2021 · Metabolites
Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Condi
Tomer Fekete, Andrey R. Nikolaev, Floris De Knijf et al. · 2018 · Frontiers in Neuroscience
Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by administering alternating current through a multi-electrode montage (mtACS), while va
Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
Tien‐Yu Yang, Tsan-Wen Huang, Po‐Yao Chuang et al. · 2018 · BMC Musculoskeletal Disorders
BACKGROUND: Displaced transverse fractures of the body of the patella are usually associated with disruption of extensor mechanism and should be fixed surgically. The most common method is a tension band wiring (TBW) technique. Some surgeons concurrently employ an augmented circumferential cerclage wiring (ACCW) technique to help fracture stabilization and aid in fracture healing; however, its role and effect on the treatment outcomes is unclear. METHODS: We performed a STROBE-compliant retrospective observational cohort study on all cases of acute closed patella fracture that were treated at
Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
Jade Chapman, Elliott Rees, Denise Harold et al. · 2012 · Human Molecular Genetics
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the Genetic and…
Anna A. Stec, T. Richard Hull, David Purser et al. · 2014 · Fire Safety Science
In a fire, normally non-hazardous thermoplastic materials can produce lethal concentrations of toxic effluents in the smoke. The toxic product yields of the asphyxiants carbon monoxide (CO) and hydrogen cyanide (HCN) from developed fires…
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
Cyril Messaraa, Nicola J. Robertson, Melissa Walsh et al. · 2019 · Journal of Cosmetic Dermatology
BACKGROUND: The use of a skin care routine is commonly promoted by the cosmetic industry, yet there is a lack of clinical evidence to support this practice over the use of a single skin care product. AIMS: In the present study, we aimed at…
Jeremy P. Gygi, Cole Maguire, Ravi K. Patel et al. · 2024 · Journal of Clinical Investigation
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes for some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation of molecular and cellular profiles over the full disease course can link immune programs and their coordination with progression heterogeneity.METHODSWe performed deep immunophenotyping and conducted longitudinal multiomics modeling, integrating 10 assays for 1,152 Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study participants and identif
K.E. Giller, Euan K. James, Julie Ardley et al. · 2024 · Plant and Soil
Abstract Background Despite more than 50 years of research, no robust evidence suggests that inoculation of cereals and other non-legumes with free-living and/or endophytic bacteria leads to fixation of agronomically significant quantities of dinitrogen gas (N 2 ) from the atmosphere. A plethora of new products claims to increase the growth and yields of major cereals and other crops through stimulating N 2 -fixation by inoculating with bacteria. Scope We review the literature on N 2 -fixation by bacteria in the rhizosphere and as endophytes in non-legume plants. We find no unequivocal evidenc
J. M. Górriz, R. Martin-Clemente, F. Segovia et al. · 2026 · Information Fusion
As a technique that can compactly represent complex patterns, machine learning has significant potential for predictive inference in multi-source and heterogeneous information fusion scenarios. K-fold cross-validation (CV) is the most common approach for ascertaining the likelihood that a machine learning outcome is generated by chance and frequently outperforms conventional hypothesis testing. This improvement arises from measures directly obtained from machine learning classifications, such as accuracy, that do not have a parametric description. To approach a frequentist analysis within fusi
The First Waters · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper develops government structural reference infrastructure for AI and AGI environments. It addresses the need for public institutions to preserve reference continuity across public records, citizen submissions, administrative documents, authority-condition references, state histories, seal-reference contexts, role accountability records, economic references, and propagation-sensitive records without becoming dependent on a single AI provider, platform, model, or cloud environment. The framework does not perform public decision-making, grant authority, issue permits, approve benefits, c
Bo Zou, Dan Zhao, Shuang Zhou et al. · 2025 · Frontiers in Nutrition
Emerging evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) are essential structural and functional nutrients that significantly influence the composition and function of the gut microbiota, a key mediator of host health. Although evidence suggests that increasing tissue Omega-3 levels through dietary intervention may optimize gut microbiota-host interaction through modulation of composition, metabolite production, and the intestinal mucus barrier, some studies have reported inconsistent findings regarding these protective effects. Studies indicate that a high Omega-6/Omega-3 r
Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov et al. · 2025 · Nature Communications
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics if clinicians over or under rely on AI. To investigate such collaborative decision-making process, we conducted a Human-AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. We investigated two levels of collaborative behavior: model-agnostic and model-specific; and found that Human-AI
Han Wu, Xiang Zhao, Fei Wang et al. · 2017 · Frontiers in Immunology
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages. In contrast, MuV did not replicate in male GC. Notably, testicular ce
Walter Acevedo, Bijan Fallah, Sebastian Reich et al. · 2017 · Climate of the past
Abstract. Paleoclimate data assimilation (DA) is a promising technique to systematically combine the information from climate model simulations and proxy records. Here, we investigate the assimilation of tree-ring-width (TRW) chronologies into an atmospheric global climate model using ensemble Kalman filter (EnKF) techniques and a process-based tree-growth forward model as an observation operator. Our results, within a perfect-model experiment setting, indicate that the "online DA" approach did not outperform the "off-line" one, despite its considerable additional implementation complexity. On
Mohsen Mehrara, H Abrishami, Mostafa Boroujli et al. · 2013 · International Letters of Social and Humanistic Sciences
This paper examines causal relationships between Government Recurrent Expenditure (GRE) and GDP for Iran using annual data over the period 1970-2010. The Gregory-Hansen (1996) cointegration technique, allowing for the presence of potential structural breaks in data, is applied to empirically examine the long-run co-movement between these variables. The results suggest that there is a long-run relationship between these variables. The Granger Causality test indicates strong unidirectional effects from GDP to GRE. But there is no evidence that TRE promotes long-term economic growth. Moreover, th
Jung Sun Kim, Eun Joo Kang, Dae Sik Kim et al. · 2018 · BMC Cancer
BACKGROUND: This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. METHODS: A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. RESULTS: VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed p
Felix Chopra, Ingar Haaland, Christopher Roth et al. · 2023 · The Economic Journal
Abstract We examine how the evaluation of research studies in economics depends on whether a study yielded a null result. Studies with null results are perceived to be less publishable, of lower quality, less important and less precisely…
Urko M. Marigorta, Óscar Lao, Ferrán Casals et al. · 2011 · BMC Genomics
BACKGROUND: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of
Janna N. Vrijsen, Ben Grafton, Ernst H. W. Koster et al. · 2024 · Behaviour Research and Therapy
Cognitive bias modification (CBM) has evolved from an experimental method testing cognitive mechanisms of psychopathology to a promising tool for accessible digital mental health care. While we are still discovering the conditions under which clinically relevant effects occur, the dire need for accessible, effective, and low-cost mental health tools underscores the need for implementation where such tools are available. Providing our expert opinion as Association for Cognitive Bias Modification members, we first discuss the readiness of different CBM approaches for clinical implementation, the
Kirsty Kitto, Ben Hicks, Simon Buckingham Shum · 2023 · British Journal of Educational Technology
Abstract An extraordinary amount of data is becoming available in educational settings, collected from a wide range of Educational Technology tools and services. This creates opportunities for using methods from Artificial Intelligence and…
Mikko T. Holmberg, Aleksi Tornio, Maria Paile‐Hyvärinen et al. · 2018 · Clinical Pharmacology & Therapeutics
CYP3A enzymes participate in the elimination of ticagrelor and the bioactivation of clopidogrel and prasugrel. We studied the effects of functional CYP3A genetic variants (CYP3A4*22; rs35599367 and CYP3A5*3; rs776746) on the…
Guohao Xie, Glenn C Duff, L.W. Hall et al. · 2013 · Journal of Animal Science
The effects of bacitracin methylene disalicylate (BMD) and scours on the fecal microbiome, animal performance, and health were studied in Holstein bull calves. Holstein bull calves (n = 150) were obtained from a single source at 12 to 24 h…
William H.B. McAuliffe · 2018 · Thinking & Reasoning
The past few decades of moral psychology research have yielded empirical anomalies for rationalist theories of moral judgments. An increasing number of psychologists and philosophers argue that these anomalies are explained well by…
Frank Kreienkamp, Philip Lorenz, Tobias Geiger · 2020 · Atmosphere
Climate modelling output that was provided under the latest Coupled Model Intercomparison Project (CMIP6) shows significant changes in model-specific Equilibrium Climate Sensitivity (ECS) as compared to CMIP5. The newer versions of many…
on behalf of the Pediatric Imaging Neurocognition Genetics study, John D. Eicher, Angela Montgomery et al. · 2015 · Brain Imaging and Behavior
Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examin
Federica Albanese, Daniela Mercatelli, Luca Finetti et al. · 2021 · Neurobiology of Disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…