Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication
Han Wu; Xiang Zhao; Fei Wang; Qian Jiang; Lili Shi; Maolei Gong; Weihua Liu; Bo Gao · 2017 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages. In contrast, MuV did not replicate in male GC. Notably, testicular ce
Abstract by Han Wu; Xiang Zhao; Fei Wang; Qian Jiang; Lili Shi; Maolei Gong; Weihua Liu; Bo Gao, Frontiers in Immunology (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2017.00117