Failed Experiment ReportMedicine
Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
View details →DOI: 10.1186/s13019-026-04483-1 Failed Experiment ReportOpen accessMedicine
Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports
Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles
View details →DOI: 10.1038/s41598-022-12374-3 Failed Experiment ReportMedicine
Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
View details →DOI: 10.1371/journal.pone.0352418 Failed Experiment ReportOpen accessPublic aspects of medicine
Susan C. Wright, Titilayo T. Biya, Majapi E. Chokwe · 2014 · Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Pregnancy-related health education conveys basic information regarding healthy lifestyle choices and preventive healthcare in order to promote the health of the mother and foetus. Verbal education is supplemented frequently by means of healthpromotion leaflts. A pregnancy-related leaflt used in primary care clinics in Tshwane, South Africa titled: ‘Are you pregnant or planning to have a baby?’ was the focus of this research. Objectives: The study had two objectives, the fist of which was to explore whether the English pregnancy leaflt improved the knowledge of young female adults w
View details →DOI: 10.4102/hsag.v19i1.764 Failed Experiment ReportMedicine
Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
View details →DOI: 10.1002/prp2.70277 Failed Experiment ReportOpen accessOphthalmology
Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD et al. · 2025 · Ophthalmology Science
Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro
View details →DOI: 10.1016/j.xops.2024.100650 Failed Experiment ReportOpen accessComputer Science
Carmine Abate, Arthur Azevedo de Amorim, Roberto Blanco et al. · 2018 · arXiv
We propose a new formal criterion for evaluating secure compilation schemes for unsafe languages, expressing end-to-end security guarantees for software components that may become compromised after encountering undefined behavior---for example, by accessing an array out of bounds. Our criterion is the first to model dynamic compromise in a system of mutually distrustful components with clearly specified privileges. It articulates how each component should be protected from all the others---in particular, from components that have encountered undefined behavior and become compromised. Each comp
Failed Experiment ReportMedicine
Lertwiram P, Fuangfa P, Kijkunasathian C et al. · 2026 · Scientific reports
Arthroscopic rotator cuff repair (ARCR) generally improves clinical outcomes, but the impact of pre-existing glenohumeral osteoarthritis (GHOA) severity on these outcomes remains unclear. This study aims to evaluate the correlation between…
View details →DOI: 10.1038/s41598-026-58506-x Failed Experiment Report
Isaac Unah · 2026 · SSRN Electronic Journal
The paper argues that Eritrea's Constitution — ratified after a costly independence struggle and designed to establish democracy, rule of law, and human rights — has never been implemented in nearly 30 years. The failure is attributed…
View details →DOI: 10.2139/ssrn.6289978 Failed Experiment ReportMedicine
Elattar S, Basha NR, Salem A et al. · 2025 · Cardiology in review
Pulmonary arterial hypertension (PAH), a subset of pulmonary hypertension (PH), remains a progressive and debilitating disease marked by vascular remodeling and elevated pulmonary vascular resistance. Tadalafil, a phosphodiesterase type 5…
View details →DOI: 10.1097/crd.0000000000001036 Failed Experiment ReportOpen accessComputer Science
Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv
Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}
Failed Experiment ReportOpen accessMedicine
Comeau MO, Gascon F, Corbeil M et al. · 2025 · Acta neurochirurgica
Purpose Meningioma resection remains partial in over 25% of cases, with few known predictors of residual disease progression. This study aims to assess if dural attachment, identified on postoperative imaging, influences meningioma…
View details →DOI: 10.1007/s00701-025-06734-x Failed Experiment ReportOpen accessComputer Science
Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv
A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model
Failed Experiment ReportOpen accessComputer Science
Alan Lee, Harry Tong · 2025 · arXiv
We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2
Failed Experiment ReportOpen accessComputer Science
Xinzhe Chen, Jianjiang Li · 2023 · arXiv
The escalating surge in data generation presents formidable challenges to information technology, necessitating advancements in storage, retrieval, and utilization. With the proliferation of artificial intelligence and big data, the "Data Age 2025" report forecasts an exponential increase in global data production. The escalating data volumes raise concerns about efficient data processing. The paper addresses the predicament of achieving a lower compression ratio while maintaining or surpassing the compression performance of state-of-the-art techniques. This paper introduces a lossy compressio
Failed Experiment ReportOpen accessPlant culture
Laura Cabero-Moreno, Ignacio Landeras-López, María Victoria Bravo-Navas et al. · 2025 · Frontiers in Plant Science
Abies pinsapo is an endangered species, endemic to southern Spain. Somatic embryogenesis and cryopreservation constitute important biotechnological tools, which can be used in order to improve the management and conservation of threatened species. The objective of this work was to develop somatic embryogenesis and cryopreservation protocols for A. pinsapo. Somatic embryogenesis was induced from mature zygotic embryos of A. pinsapo cultured on solid MS medium with macroelements at half-strength and supplemented with 20 g L-1 sucrose and 5 mg L-1 6-benzylaminopurine (BA). Embryogenic cultures su
View details →DOI: 10.3389/fpls.2025.1535113 Failed Experiment ReportOpen accessComputer Science
Liyun Zhang, Jiayi Guo · 2026 · arXiv
We document an empirical phenomenon in chain-of-thought and ReAct agents driven by ten large language models from seven architecture families: meaning-bearing perturbations (e.g., paraphrase, synonym) alter final answers more often than presentation perturbations (e.g., formatting, reordering) of comparable severity. Across 68 cells spanning GSM8K, MATH, and HotpotQA (1,530 originals and $\sim$11,150 variants), the inconsistency gap averages +19.69 pp after severity matching (paired $t=9.58$, $p<0.0001$), with 64/68 cells positive. The gap survives four severity-proxy audits and remains signif
Failed Experiment ReportOpen accessPhysics
Nicolas Tancogne-Dejean, Martin Lüders, Carsten A. Ullrich · 2023 · arXiv
We extend some of the well established self-interaction correction (SIC) schemes of density-functional theory to the case of systems with noncollinear magnetism. Our proposed SIC schemes are tested on a set of molecules and metallic clusters in combination with the widely used local spin-density approximation. As expected from the collinear SIC, we show that the averaged-density SIC works well for improving ionization energies but fails to improve more subtle quantities like the dipole moments of polar molecules. We investigate the exchange-correlation magnetic field produced by our extension
Failed Experiment ReportOpen accessComputer Science
Frits de Nijs, Daan Wilmer · 2012 · arXiv
The goal of this paper is to critically evaluate a heuristic algorithm for the Inverse Banzhaf Index problem by Laruelle and Widgrén. Few qualitative results are known about the approximation quality of the heuristics for this problem. The intuition behind the operation of this approximation algorithm is analysed and evaluated. We found that the algorithm can not handle general inputs well, and often fails to improve inputs. It is also shown to diverge after only tens of iterations. We present three alternative extensions of the algorithm that do not alter the complexity but can result in up t
Failed Experiment Report
Abdulrida FM · 2026 · Preprint
Abstract Background: The Hepatitis B (HBV) and Hepatitis C (HCV) viruses remain significant global health challenges, contributing to chronic liver disease and life-threatening complications. This study aimed to investigate the genetic…
View details →DOI: 10.21203/rs.3.rs-9748714/v1 Failed Experiment ReportOpen accessPhysics
Khadijeh Najafi, M. A. Rajabpour · 2017 · arXiv
In a recent letter, J. Cardy, Phys. Rev. Lett. \textbf{112}, 220401 (2014), the author made a very interesting observation that complete revivals of quantum states after quantum quench can happen in a period which is a fraction of the system size. This is possible for critical systems that can be described by minimal conformal field theories (CFT) with central charge $c<1$. In this article, we show that these complete revivals are impossible in microscopic realizations of those minimal models. We will prove the absence of the mentioned complete revivals for the critical transverse field Ising
Failed Experiment Report
· 2015 · Strategic Direction
Purpose – This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach – This briefing is prepared by an…
View details →DOI: 10.1108/sd-12-2014-0178 Failed Experiment Report
Kyle Admire, Stephen Gegick · 2026 · BMJ Case Reports
Tumours within the pulmonary arteries provide a diagnostic challenge due to their similar appearance to pulmonary emboli. Often, the decision to sample is multidisciplinary and the best approach to take is often unknown. Here we describe a…
View details →DOI: 10.1136/bcr-2025-268157 Failed Experiment ReportMedicine
Wyganowska ML, Klewin-Steinböck S, Ao P · 2026 · Life (Basel, Switzerland)
Background This randomized controlled clinical study aimed to evaluate changes in salivary secretion following injections of a hyaluronic acid and amino acid solution in patients with hyposalivation. Materials and methods A total of 100…
View details →DOI: 10.3390/life16060887 Failed Experiment Report
J. Stöhr, L. Maurer, B. Zimmer et al. · 2016 · Reproduction, Fertility and Development
In humans, intracytoplasmic sperm injection (ICSI) has become widely applied to overcome infertility. In addition to its clinical usefulness, ICSI is also a valuable research tool for studying fundamental aspects of gamete interaction…
View details →DOI: 10.1071/rdv29n1ab128 Failed Experiment ReportMedicine
Rançon A, Rançon U, Ivek T et al. · 2026 · Physical review. E
We explore how minimal neural networks can invert the renormalization group (RG) coarse-graining procedure in the two-dimensional Ising model, effectively dreaming up microscopic configurations from coarse-grained states. This task,…
View details →DOI: 10.1103/3njc-5tlx Failed Experiment ReportMedicine
Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…
View details →DOI: 10.1016/j.euroneuro.2026.112771 Failed Experiment ReportOpen accessMedicine
Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery
Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…
View details →DOI: 10.1093/icvts/ivag039 Failed Experiment Report
Adam Wilson · 2012 · Journal of Petroleum Technology
This article, written by Editorial Manager Adam Wilson, contains highlights of paper SPE 151518, ’Automated Managed-Pressure Drilling Allows Identification of New Reserves in an HP/HT Exploration Well in SB Field, Offshore Malaysia,’ by…
View details →DOI: 10.2118/0912-0113-jpt Failed Experiment Report
Omar S. Aljitawi, Jeff Radel, Bruce Kimler et al. · 2011 · Blood
Abstract Abstract 4695 Introduction: UCB is also an attractive stem cell source for transplantation because of the ease of procurement, the absence of donor risks, and reduced risk of transmissible infections. Unfortunately, outcomes of…
View details →DOI: 10.1182/blood.v118.21.4695.4695 