Negative / Null Result ReportEnvironmental Science
Di Tian, Christopher J. Martinez, W. D. Graham et al. · 2014 · Journal of Climate
Abstract This study compared two types of approaches to downscale seasonal precipitation (P) and 2-m air temperature (T2M) forecasts from the North American Multimodel Ensemble (NMME) over the states of Alabama, Georgia, and Florida in the…
View details →DOI: 10.1175/jcli-d-13-00481.1Cited by 40 Negative / Null Result ReportPsychology
Margaret‐Anne Mackintosh, James Niehaus, Casey T. Taft et al. · 2017 · Military Medicine
OBJECTIVE: Anger is a symptom of post-traumatic stress disorder (PTSD) associated with a range of clinical and functional impairments, and may be especially prevalent among veterans with PTSD. Effective anger management therapies exist but…
View details →DOI: 10.7205/milmed-d-17-00063Cited by 40 Negative / Null Result ReportOpen accessMedicine
Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →DOI: 10.3390/ijerph18041396Cited by 40 Negative / Null Result Report
Ariana L. Smith, Alan J. Wein · 2011 · BJU International
OBJECTIVE • To evaluate the statistical and clinical efficacy of the pharmacological treatments of nocturia using non‐antidiuretic agents. PATIENTS AND METHODS • A literature review of treatments of nocturia specifically addressing the…
View details →DOI: 10.1111/j.1464-410x.2010.09972.xCited by 40 Negative / Null Result Report
Ali Aminian, Mohammad Jamal, Toms Augustin et al. · 2015 · Diabetes Technology & Therapeutics
The metabolic profile of patients after a failed surgical weight loss procedure is unknown. Long-term clinical outcomes of 31 obese diabetes patients with post–bariatric surgery excess weight loss of ≤25% were assessed. At a median…
View details →DOI: 10.1089/dia.2015.0064Cited by 40 Negative / Null Result ReportOpen accessMedicine
Michael Huang, Kenneth G. Lucas · 2010 · Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.
View details →DOI: 10.1155/2011/863210Cited by 40 Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
View details →DOI: 10.1002/bjs.7703Cited by 40 Negative / Null Result ReportOpen accessMedicine
Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →DOI: 10.1371/journal.pone.0032048Cited by 40 Negative / Null Result ReportOpen accessMedicine
João Pedro Ferreira, Francisco Vasques‐Nóvoa, Diana Ferrão et al. · 2022 · Diabetes Care
OBJECTIVE: Patients with type 2 diabetes (T2D) have a high risk for developing heart failure (HF), which is associated with poor prognosis. Fenofibrate may reduce HF events through multiple mechanisms. We sought to study the effect of…
View details →DOI: 10.2337/dc21-1977Cited by 40 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tasia Amelia, Jacobus P. D. van Veldhoven, Matteo Falsini et al. · 2021 · Journal of Medicinal Chemistry
receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belonging to a class of dicyanopyridines, and amino…
View details →DOI: 10.1021/acs.jmedchem.0c01856Cited by 40 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst et al. · 2012 · International Journal of Inflammation
Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-
View details →DOI: 10.1155/2012/412178Cited by 40 Negative / Null Result ReportOpen accessMedicine
Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo‐Giang‐Huong et al. · 2013 · PLoS Medicine
BACKGROUND: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide a similar clinical outcome compared to the standard VL-based strategy in Thailand. METHODS AND FINDINGS: The Programs for HIV Prevention and Treatment (PHPT-3) non-inferiority randomized clinical trial compared a treatment switching strategy based on CD4-only (CD4) monitoring versus viral-load (VL
View details →DOI: 10.1371/journal.pmed.1001494Cited by 40 Negative / Null Result ReportOpen accessImmunology and Microbiology
Melony J. Sellars, M Rao, SJ Arnold et al. · 2011 · Diseases of Aquatic Organisms
Gill-associated virus (GAV) is a nidovirus that commonly infects Penaeus monodon (black tiger shrimp) in eastern Australia, causing morbidity and mortalities in the acute stage of disease. Here we explored the possibility of inhibiting GAV…
View details →DOI: 10.3354/dao02343Cited by 40 Negative / Null Result Report
Ann M. Mitchell, Lauren Terhorst · 2016 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Although bereavement is not usually considered the type of stressor associated with posttraumatic stress disorder (PTSD), a risk factor often associated with poorer bereavement outcomes is when a death is sudden and unexpected.…
View details →DOI: 10.1177/1078390316673716Cited by 40 Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →DOI: 10.1002/cpt.1783Cited by 40 Negative / Null Result ReportOpen accessComputer Science
Tarek Ali, Panos Kostakos, Saeid Sheikhi · 2026 · Telecom
Machine learning (ML) methods for network anomaly detection are emerging as effective proactive strategies in threat hunting, substantially reducing the time required for threat detection and response. However, the challenges in training and maintaining ML models, coupled with frequent false positives, diminish their acceptance and trustworthiness. In response, Explainable AI (XAI) techniques have been introduced to enable cybersecurity operations teams to assess alerts generated by AI systems more confidently. Despite these advancements, XAI tools have encountered limited acceptance from inci
View details →DOI: 10.3390/telecom7030073Cited by 40 Negative / Null Result ReportOpen accessSocial Sciences
Michael P. Vandenbergh, Paul C Stern · 2026
Abstract Government laws and policies have produced substantial gains in environmental quality, but they have failed to achieve climate mitigation goals. Elinor Ostrom explored how resource users developed nongovernmental institutions to…
View details →DOI: 10.1093/9780197809198.003.0030Cited by 40 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi et al. · 2025 · Biomarker Research
Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates. KMT2A-r, found in 3-10% of adult AML cases, disrupt epigenetic regulation by forming chimeric proteins that activate oncogenic pathways like HOXA and MEIS1. These fusion proteins recruit cofactors such as Menin and DOT1L, driving leukemogenesis through abnormal histone methylation. Diagnosing KMT2A-r AML requires precision, with traditional methods like FISH and RT-PCR b
View details →DOI: 10.1186/s40364-025-00786-yCited by 39 Negative / Null Result ReportOpen accessMedicine
Virve I. Enne, Susan Stirling, Julie Barber et al. · 2025 · Intensive Care Medicine
PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP). METHODS: This pragmatic multicentre, open-label RCT…
View details →DOI: 10.1007/s00134-024-07772-2Cited by 39 Negative / Null Result ReportOpen accessMedicine
Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
View details →DOI: 10.3324/haematol.2013.087650Cited by 39 Negative / Null Result Report
Nicole Sneath · 2010 · Neonatal Network
Background: Peripherally inserted central catheters (PICCs) are commonly used in NICUs. Although they have many benefits, they also have many potential complications. Confirming catheter tip position is essential to decreasing…
View details →DOI: 10.1891/0730-0832.29.1.23Cited by 39 Negative / Null Result Report
Shoichi Kuramitsu, Hitoshi Matsuo, Tomohiro Shinozaki et al. · 2020 · Circulation: Cardiovascular Interventions
Background: The safety of fractional flow reserve (FFR)-based deferral of revascularization remains to be fully established in real-world practice. We sought to assess clinical outcomes after deferral of revascularization based on FFR.…
View details →DOI: 10.1161/circinterventions.119.008355Cited by 39 Negative / Null Result ReportOpen accessMedicine
Ellen W. Demerath, Nikki Lynn Rogers, Derek Reed et al. · 2010 · Annals of Human Biology
BACKGROUND: Elevated visceral adiposity is strongly predictive of cardiometabolic disease, but, due to the high cost of biomedical imaging, assessment of factors contributing to normal variation in visceral (VAT) and subcutaneous (SAT)…
View details →DOI: 10.3109/03014460.2010.524893Cited by 39 Negative / Null Result ReportNeuroscience
Annika Melinder, Svein Magnussen · 2014 · Psychology Crime and Law
Expert witnesses have various tasks that frequently include issues of memory. We tested if expert witnesses outperform other practitioners on memory issues of high relevance to clinical practice. We surveyed psychiatrists and psychologists…
View details →DOI: 10.1080/1068316x.2014.915324Cited by 39 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Osval A. Montesinos‐López, J. Cricelio Montesinos-López, P. K. Singh et al. · 2020 · G3 Genes Genomes Genetics
The paradigm called genomic selection (GS) is a revolutionary way of developing new plants and animals. This is a predictive methodology, since it uses learning methods to perform its task. Unfortunately, there is no universal model that can be used for all types of predictions; for this reason, specific methodologies are required for each type of output (response variables). Since there is a lack of efficient methodologies for multivariate count data outcomes, in this paper, a multivariate Poisson deep neural network (MPDN) model is proposed for the genomic prediction of various count outcome
View details →DOI: 10.1534/g3.120.401631Cited by 39 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sofia G. Seabra, Inês Fragata, Marta A. Antunes et al. · 2017 · Molecular Biology and Evolution
Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genome-wide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory. We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously
View details →DOI: 10.1093/molbev/msx247Cited by 39 Negative / Null Result ReportOpen accessNeuroscience
David D. Aguilar, Robert E. Strecker, Radhika Basheer et al. · 2019 · Journal of Neurophysiology
The type 5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced…
View details →DOI: 10.1152/jn.00532.2019Cited by 39 Negative / Null Result ReportEnvironmental Science
Robert N. Meroney, David E. Neff · 2010
Numerical calculations of wind loads on solar photovoltaic collectors were used to estimate drag, lift and overturning moments on different collector support systems. These results were compared with direct force measurement tests obtained…
Negative / Null Result ReportHealth Professions
Richard D. Lennox, David A. Sharar, Eileen Schmitz et al. · 2010 · Journal of Workplace Behavioral Health
This article describes the development and validation of a five-item scale Workplace Outcome Suite designed as an open access instrument aimed at facilitating empirical research on Employee Assistance Program (EAP) interventions. The suite…
View details →DOI: 10.1080/15555241003760995Cited by 39 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theocharis Ispoglou, D. A. O’Kelly, Athanasia Angelopoulou et al. · 2015 · The Journal of Strength and Conditioning Research
Mouth rinsing with carbohydrate (CHO) solutions during cycling time trials results in performance enhancements; however, most studies have used approximately 6% CHO solutions. Therefore, the purpose of this study was to compare the…
View details →DOI: 10.1519/jsc.0000000000000882Cited by 39 