Negative / Null Result ReportOpen accessMedicine
Pradeesh Sivapalan, Charlotte Suppli Ulrik, Thérèse Lapperre et al. · 2021 · European Respiratory Journal
Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with the latter also having in vitro antiviral properties. This may improve outcomes in patients hospitalised for coronavirus…
View details →DOI: 10.1183/13993003.00752-2021Cited by 48 Negative / Null Result ReportOpen accessMedicine
Hiroki Nishikawa, Akira Arimoto, Tomoko Wakasa et al. · 2012 · International Journal of Oncology
The aim of the present study was to evaluate the influence of preoperative transcatheter arterial chemoembolization (TACE) on survival after surgical resection (SR) for hepatocellular carcinoma (HCC). Two hundred and thirty-five HCC…
View details →DOI: 10.3892/ijo.2012.1711Cited by 48 Negative / Null Result ReportOpen accessMedicine
Maria Juárez, Nieves Díaz, Geoffrey I. Johnston et al. · 2020 · Lara D. Veeken
OBJECTIVES: This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary…
View details →DOI: 10.1093/rheumatology/keaa410Cited by 48 Negative / Null Result ReportMedicine
Wei Qiu, Sonja Raven, Jing-Kun Wu et al. · 2010 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols. METHODS: Brain cMRI (1.5 Tesla) scans of 105 Caucasian patients with classical MS (50 with…
View details →DOI: 10.1136/jnnp.2009.198192Cited by 48 Negative / Null Result ReportOpen accessMedicine
Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić et al. · 2023 · Blood Cancer Journal
Currently, the International Prognostic Index (IPI) is the most used and reported model for prognostication in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). IPI-like variations have been proposed, but only a few have been validated in different populations (e.g., revised IPI (R-IPI), National Comprehensive Cancer Network IPI (NCCN-IPI)). We aimed to validate and compare different IPI-like variations to identify the model with the highest predictive accuracy for survival in newly diagnosed DLBCL patients. We included 5126 DLBCL patients treated with immunochemotherapy wit
View details →DOI: 10.1038/s41408-023-00930-7Cited by 48 Negative / Null Result ReportOpen accessMedicine
Antoine Bouquegneau, Emmanuelle Vidal‐Petiot, François Vrtovsnik et al. · 2013 · Nephrology Dialysis Transplantation
BACKGROUND: Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation of glomerular filtration rate (GFR) is thus important in these patients. We tested the…
View details →DOI: 10.1093/ndt/gft329Cited by 48 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fabio Morgante, Wen Huang, Peter Sørensen et al. · 2020 · G3 Genes Genomes Genetics
Abstract The ability to accurately predict complex trait phenotypes from genetic and genomic data are critical for the implementation of personalized medicine and precision agriculture; however, prediction accuracy for most complex traits is currently low. Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. We found that expression levels (r
View details →DOI: 10.1534/g3.120.401847Cited by 48 Negative / Null Result Report
Swati Agarwal, Faisal A Alzahrani, Asif Ahmed · 2018 · International Journal of Molecular Sciences
Background: Throughout history, menopause has been regarded as a transition in a woman’s life. With the increase in life expectancy, women now spend more than a third of their lives in menopause. During these years, women may experience…
View details →DOI: 10.3390/ijms19103160Cited by 48 Negative / Null Result Report
Madeleine Selvander, Peter Åsman · 2012 · Acta Ophthalmologica
Abstract. Purpose: To investigate construct validity for modules hydromaneuvers and phaco on the Eyesi surgical simulator. Methods: Seven cataract surgeons and 17 medical students performed capsulorhexis, hydromaneuvers, phaco, navigation,…
View details →DOI: 10.1111/j.1755-3768.2012.02440.xCited by 48 Negative / Null Result Report
Haiyang Yang, Amitava Chattopadhyay, Kuangjie Zhang et al. · 2012 · Journal of Consumer Psychology
Abstract Recent research suggests that unconscious thought is superior to conscious thought in many cognitive domains. In this article, we show that the duration of unconscious thought has an inverted‐U shaped relationship with creativity…
View details →DOI: 10.1016/j.jcps.2012.04.002Cited by 47 Negative / Null Result Report
Masaaki Sadakiyo, Teppei Yamada, Kenichi Kato et al. · 2016 · Chemical Science
We conducted a systematic study of the control of selective adsorption behaviour through the type of central metals in a series of analogous MOFs that show closed-open structural transformations.
View details →DOI: 10.1039/c5sc03325jCited by 47 Negative / Null Result ReportOpen accessMedicine
Marie Fallon, Maciej Sopata, Erika Dragon et al. · 2023 · The Oncologist
BACKGROUND: This phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid…
View details →DOI: 10.1093/oncolo/oyad188Cited by 47 Negative / Null Result ReportOpen accessMedicine
Mark Thalgott, Thomas Horn, Matthias Heck et al. · 2014 · Journal of Hematology & Oncology
BACKGROUND: Patients with locally advanced and high-risk prostate cancer (LAPC) are prone to experience biochemical recurrence despite radical prostatectomy (RP). We evaluated feasibility, safety and activity of a neoadjuvant chemohormonal therapy (NCHT) with 3-weekly full dose docetaxel and complete androgen blockade (CAB) in locally advanced and high-risk prostate cancer patients (LAPC) undergoing RP. METHODS: Patients (n = 30) were selected by Kattans' preoperative score and received trimestral buserelin 9,45 mg, bicalutamide 50 mg/day and 3 cycles docetaxel (75 mg/m²) followed by RP. Prima
View details →DOI: 10.1186/1756-8722-7-20Cited by 47 Negative / Null Result ReportOpen accessMedicine
Akiyoshi Hagiwara, Noriko Tanaka, Tatsuki Uemura et al. · 2016 · BMJ Open
OBJECTIVE: To determine whether treatment with recombinant human thrombomodulin (rhTM) increases survival among patients with severe septic-induced disseminated intravascular coagulation (DIC). DESIGN: Single-centre, open-label, randomised…
View details →DOI: 10.1136/bmjopen-2016-012850Cited by 47 Negative / Null Result ReportOpen accessMedicine
Sara Galimberti, Mario Petrini, Claudia Baratè et al. · 2020 · Frontiers in Oncology
SARS-CoV-2 is the viral agent responsible for the pandemic that in the first months of 2020 caused about 400,000 deaths. Among compounds proposed to fight the SARS-CoV-2-related disease (COVID-19), tyrosine kinase inhibitors (TKIs), already effective in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML), have been proposed on the basis of their antiviral action already demonstrated against SARS-CoV-1. Very few cases of COVID-19 have been reported in Ph+ ALL and in CML Italian cohorts; authors suggested that this low rate of infections might depend f
View details →DOI: 10.3389/fonc.2020.01428Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Marco Roccetti, Giovanni Delnevo, Luca Casini et al. · 2021 · Journal Of Big Data
Abstract Deep learning models are tools for data analysis suitable for approximating (non-linear) relationships among variables for the best prediction of an outcome. While these models can be used to answer many important questions, their utility is still harshly criticized, being extremely challenging to identify which data descriptors are the most adequate to represent a given specific phenomenon of interest. With a recent experience in the development of a deep learning model designed to detect failures in mechanical water meter devices, we have learnt that a sensible deterioration of the
View details →DOI: 10.1186/s40537-021-00428-8Cited by 47 Negative / Null Result ReportOpen accessNeuroscience
Colin Quirk, Kirsten Adam, Edward K. Vogel · 2020 · eNeuro
Visual working memory is the ability to hold visual information temporarily in mind. A key feature of working memory is its starkly limited capacity, such that only a few simple items can be remembered at once. Prior work has shown that this capacity limit cannot be circumvented by providing additional encoding time, whether providing just 200 ms or up to 1300 ms, capacity is still limited to only three to four items. In contrast, Brady et al. (2016) hypothesized that real-world objects, but not simple items used in prior research, benefit from additional encoding time and are not subject to t
View details →DOI: 10.1523/eneuro.0150-20.2020Cited by 47 Negative / Null Result ReportPsychology
Stephen R. Shirk, Anne P. DePrince, Patrice S. Crisostomo et al. · 2013 · Psychotherapy
Four clinical trials have shown that a history of interpersonal trauma is associated with diminished response to cognitive-behavioral therapy (CBT) for adolescent depression. An efficacious CBT protocol for adolescent depression was…
View details →DOI: 10.1037/a0034845Cited by 47 Negative / Null Result ReportOpen accessSocial Sciences
Alexis V. Knaub, Kathleen Foote, Charles Henderson et al. · 2016 · International Journal of STEM Education
The characteristics of the classroom environment play an important role in shaping teaching practices and supporting research-based instructional strategies. One instructional strategy that has reimagined the classroom is the Student-Centered Active Learning Environment with Upside-Down Pedagogies (SCALE-UP). SCALE-UP uses studio-style instruction to facilitate student collaboration. Although there is significant interest in studio-style instruction, there is not much research-based guidance available for institutions interested in setting up a classroom, especially for secondary users interes
View details →DOI: 10.1186/s40594-016-0042-3Cited by 47 Negative / Null Result ReportOpen accessMedicine
Kayleigh N. McCarty, David H. Morris, Laura E. Hatz et al. · 2017 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: The UPPS-P model posits that impulsivity comprises five factors: positive urgency, negative urgency, lack of planning, lack of perseverance, and sensation seeking. Negative and positive urgency are the traits most consistently…
View details →DOI: 10.15288/jsad.2017.78.617Cited by 47 Negative / Null Result ReportOpen accessMedicine
Brigitte Leeners, Tillmann H. C. Krüger, Kirsten Geraedts et al. · 2017 · Frontiers in Behavioral Neuroscience
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational multisite study comprised data of n=88 menstruating women from Hannover, Germany, and Zurich, Switzerland, assessed during a first cycle and n=68 re-assessed during a second cycle to rule out practice effects and false-positive chance findings. We assessed visuospatial working memory, attention, cognitive bias and hormone levels at four consec
View details →DOI: 10.3389/fnbeh.2017.00120Cited by 47 Negative / Null Result ReportOpen accessMedicine
Agatha Lenartowicz, Holly Truong, Giulia C. Salgari et al. · 2019 · Journal of Child Psychology and Psychiatry
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in…
View details →DOI: 10.1111/jcpp.13042Cited by 47 Negative / Null Result ReportOpen accessMedicine
Charles Sharp, Huzaifa Adamali, Ann Millar · 2017 · ERJ Open Research
Idiopathic pulmonary fibrosis (IPF) has an unpredictable course and prognostic factors are incompletely understood. We aimed to identify prognostic factors, including multidimensional indices from a significant IPF cohort at the Bristol…
View details →DOI: 10.1183/23120541.00096-2016Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Xinsong Du, John Novoa-Laurentiev, Joseph M. Plasek et al. · 2024 · EBioMedicine
BACKGROUND: Large language models (LLMs) have shown promising performance in various healthcare domains, but their effectiveness in identifying specific clinical conditions in real medical records is less explored. This study evaluates LLMs for detecting signs of cognitive decline in real electronic health record (EHR) clinical notes, comparing their error profiles with traditional models. The insights gained will inform strategies for performance enhancement. METHODS: This study, conducted at Mass General Brigham in Boston, MA, analysed clinical notes from the four years prior to a 2019 diagn
View details →DOI: 10.1016/j.ebiom.2024.105401Cited by 47 Negative / Null Result ReportOpen accessMedicine
Karin Bammann, Nicola K. Thomson, Birte Marie Albrecht et al. · 2021 · PLoS ONE
The study of physical activity in older adults is becoming more and more relevant. For evaluation of physical activity recommendations, intensity-specific accelerometer cut-points are utilized. However, research on accelerometer cut-points for older adults is still scarce. The aim of the study was to generate placement-specific cut-points of ActiGraph GT3X+ activity counts and raw measures of acceleration to determine physical activity intensity in older adults. A further aim was to compare the validity of the generated cut-points for a range of different physical activities. The study was a s
View details →DOI: 10.1371/journal.pone.0252615Cited by 47 Negative / Null Result ReportMedicine
Soenke Böettger, David García Núñez, Rafael Meyer et al. · 2017 · Palliative & Supportive Care
BACKGROUND: In the intensive care setting, delirium is a common occurrence that comes with subsequent adversities. Therefore, several instruments have been developed to screen for and detect delirium. Their validity and psychometric…
View details →DOI: 10.1017/s1478951516001176Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Zongyao Li, Kazuhiro Kitajima, Kenji Hirata et al. · 2021 · EJNMMI Research
Abstract Background To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[ 18 F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep-learning technologies. Materials and methods Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[ 18 F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. We designed and trained a
View details →DOI: 10.1186/s13550-021-00751-4Cited by 47 Negative / Null Result Report
Rajesh R. Shrestha, Daniel L. Peters, Markus A. Schnorbus · 2013 · Hydrological Processes
Abstract It is a common practice to employ hydrologic models for assessing alterations to streamflow as a result of anthropogenically driven changes, such as riverine, land use, and climate change. However, the ability of the models to…
View details →DOI: 10.1002/hyp.9997Cited by 46 Negative / Null Result ReportOpen accessMedicine
Michael Mullerad, Jonatan R. A. Aguinaga, Tareq Aro et al. · 2017 · Rambam Maimonides Medical Journal
OBJECTIVE: High-power Holmium Laser (120H) has a unique modulated pulse mode, Moses™ technology. Moses technology modulates the laser pulse to separate the water (vapor bubble), then deliver the remaining energy through the bubble. Proprietary laser fibers were designed for the Moses technology. Our aim was to compare stone lithotripsy with and without the Moses technology. METHODS: We designed a questionnaire for the urologist to fill immediately after each ureteroscopy in which the Lumenis 120H was used. We compared procedures with (n=23) and without (n=11) the use of Moses technology. Surge
View details →DOI: 10.5041/rmmj.10315Cited by 46 Negative / Null Result ReportOpen accessMedicine
Phitsinee Thipubon, Chairat Uthaipibull, Sumalee Kamchonwongpaisan et al. · 2015 · Malaria Journal
BACKGROUND: Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes. Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC). Iron chelators are widely used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are non-toxic to mammalian cells. METHODS: Inhibitory effect of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green
View details →DOI: 10.1186/s12936-015-0910-1Cited by 46 