A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 70 of 660
Elaine Ku, Dawei Xie, Michael G. Shlipak et al. · 2015 · Journal of the American Society of Nephrology
Measured GFR (mGFR) has long been considered the gold standard measure of kidney function, but recent studies have shown that mGFR is not consistently superior to eGFR in explaining CKD-related comorbidities. The associations between…
Deborah Gurewich, Michael Shwartz, Erin Beilstein-Wedel et al. · 2021 · Medical Care
Background: The 2014 Veterans Choice Program aimed to improve care access for Veterans through expanded availability of community care (CC). Increased access to CC could particularly benefit rural Veterans, who often face obstacles in…
Wen-Shan Wu, Li-Ru Chen, Kuo-Hu Chen · 2025 · International Journal of Molecular Sciences
Platelet-rich plasma (PRP) is an autologous blood-derived concentrate increasingly utilized in regenerative medicine for its ability to accelerate healing and tissue repair. PRP is broadly classified by leukocyte content, fibrin architecture, and platelet concentration, with classification systems developed to standardize characterization. Preparation methods, including single- or double-spin centrifugation and buffy coat techniques, influence the final composition of PRP, determining the relative proportions of platelets, leukocytes, plasma proteins, and extracellular vesicles. These componen
Mark J. Flannery · 2026
Many bank managers and owners have long complained that they are over-regulated by a plethora of government agencies. The thrust of their complaint is that they could do a better job - i.e. become more profitable or increase their bank’s…
Pedro Weslley Rosário, Alexandre Lemos Silva, Michelle Aparecida Ribeiro Borges et al. · 2015 · Archives of Endocrinology and Metabolism
The objective of this study was to evaluate whether Doppler ultrasound (DUS) is of additional value to gray-scale ultrasound (GSUS) in predicting the benign or malignant nature of thyroid nodules. A total of 1,502 solid thyroid nodules ≥ 10 mm were evaluated. Suspicious vascularity (predominantly or exclusively central blood flow) was observed in only 5% of the nodules. This finding showed 96% specificity, but only 15% sensitivity. GSUS alone showed sensitivity and specificity of 88.7% and 68.2%, respectively, which did not improve with the addition of DUS (sensitivity of 89.4% and specificity
Julia A. Bubis, Lev I. Levitsky, Mark V. Ivanov et al. · 2017 · Rapid Communications in Mass Spectrometry
Rationale Label‐free quantification (LFQ) is a popular strategy for shotgun proteomics. A variety of LFQ algorithms have been developed recently. However, a comprehensive comparison of the most commonly used LFQ methods is still rare, in…
Andreas Kuehnl, Pavlos Tsantilas, Christoph Knappich et al. · 2016 · Circulation Cardiovascular Interventions
BACKGROUND: Associations between hospital volume and the risk of stroke or death following carotid endarterectomy (CEA) and carotid artery stenting (CAS) on a national level in Germany were analyzed. METHODS AND RESULTS: Secondary data…
Jun Wu, Jing Wang, Qiang Su et al. · 2018 · OncoTargets and Therapy
Background: Traditional chemotherapy and molecular targeted therapy have shown modest effects on the survival of patients with pancreatic cancer. The current study aimed to investigate the antitumor effects of apatinib, Astragalus…
Jonás Fouz-González · 2018 · ReCALL
Abstract This study investigates the potential of a podcast-based approach aimed at helping foreign language learners improve their pronunciation of features that tend to be fossilised in their interlanguage. Training took place over a…
Jonathan E. Rosenberg, Se Hoon Park, Vadim Kozlov et al. · 2022 · Journal of Clinical Oncology
PURPOSE: Homologous recombination repair gene mutations (HRRm) are common in urothelial carcinoma (UC), rendering tumor cells sensitive to poly (ADP-ribose) polymerase (PARP) inhibition. We assessed efficacy and safety of durvalumab…
Danni Li, Jeffrey R. Misialek, Eric Boerwinkle et al. · 2016 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
INTRODUCTION: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a…
Stewart Kettle, Marco Hernandez, Mike Sanders et al. · 2017 · Behavioral Sciences
We report results from a large online randomised tax experiment in Guatemala. The trial involves short messages and choices presented to taxpayers as part of a CAPTCHA pop-up window immediately before they file a tax return, with the aim of priming honest declarations. In total our sample includes 627,242 taxpayers and 3,232,430 tax declarations made over four months. Treatments include: honesty declaration; information about public goods; information about penalties for dishonesty, questions allowing a taxpayer to choose which public good they think tax money should be spent on; or questions
Richard B. Felson, Brendan Lantz · 2015 · Aggressive Behavior
Data from the National Incident-Based Reporting System (NIBRS) are used to examine the tendency for victims of physical assault, sexual assault, and robbery to refuse to cooperate with the police (N= 3,856,171). Analyses of physical…
Kai Schreiber, Bart Krekelberg · 2013 · PLoS ONE
The goal of multi-voxel pattern analysis (MVPA) in BOLD imaging is to determine whether patterns of activation across multiple voxels change with experimental conditions. MVPA is a powerful technique, its use is rapidly growing, but it poses serious statistical challenges. For instance, it is well-known that the slow nature of the BOLD response can lead to greatly exaggerated performance estimates. Methods are available to avoid this overestimation, and we present those here in tutorial fashion. We go on to show that, even with these methods, standard tests of significance such as Students' T
Patience Njina Soneka, Jackson Phiri · 2019 · Open Journal of Business and Management
The objective of this study was to assess the factors that influence the level of e-tax systems adoption in Zambia. The study focused on TaxOnline system used by domestic taxes division in Zambia. The study was conducted in rural Zambia. In this study, the researcher used Technology Acceptance Model (TAM). The sample size was purposively selected from various taxpayers who were coming through to Zambia Revenue Authority Solwezi internet bureau. 100 semi structured survey questionnaires were distributed with 100% response. The data collected was analyzed using descriptive statistics. The result
Prakash Raj Timilsena, Eric Wafula, Craig F. Barrett et al. · 2022 · Frontiers in Plant Science
We assess relationships among 192 species in all 12 monocot orders and 72 of 77 families, using 602 conserved single-copy (CSC) genes and 1375 benchmarking single-copy ortholog (BUSCO) genes extracted from genomic and transcriptomic datasets. Phylogenomic inferences based on these data, using both coalescent-based and supermatrix analyses, are largely congruent with the most comprehensive plastome-based analysis, and nuclear-gene phylogenomic analyses with less comprehensive taxon sampling. The strongest discordance between the plastome and nuclear gene analyses is the monophyly of a clade com
Joanna Lankester, Daniela Zanetti, Erik Ingelsson et al. · 2021 · PLoS ONE
Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighte
Leah Wetherill, Arpana Agrawal, Manav Kapoor et al. · 2014 · Addiction Biology
Alcohol and drug use disorders are individually heritable (50%). Twin studies indicate that alcohol and substance use disorders share common genetic influences, and therefore may represent a more heritable form of addiction and thus be…
János Kálmán, Loes M. Olde Loohuis, Annabel Vreeker et al. · 2021 · The British Journal of Psychiatry
BACKGROUND: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. AIMS: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. METHOD: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of on
Aneet S. Toor, Orr Limpisvasti, Hansel Ihn et al. · 2018 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: While hamstring autograft is a popular option for the general population, BTB autograft is still significantly more popular among professional athletes due to concerns of altering knee kinematics with hamstring harvest. This study…
Evie Stergiakouli, K. Langley, Hywel Williams et al. · 2011 · Genes Brain & Behavior
Deletions encompassing the X-linked STS gene (encoding steroid sulfatase) have been observed in subjects with neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD). Recently, two single nucleotide…
Jinke Li, Zhongxue Li · 2011 · Natural Resources
China and India are the two countries with the strongest economic growth in the world. Meanwhile they consume much of the global coal to fuel their economic development. With coal burning as a major factor contributing to global greenhouse gas emissions, China and India are confronted with a dilemma of economic growth and environment protection. Will coal consumption reduction cause economic shocks? Is there a causal relationship between coal consumption and economic growth in China and India? In this paper Granger causality tests were used to examine the relationship between coal consumption
Sarah Jordan, Laure Brimbal, David B. Wallace et al. · 2019 · Journal of Investigative Psychology and Offender Profiling
Abstract The purpose of the study was to examine the effectiveness of the micro‐expressions training tool (METT) in identifying and using micro‐expressions to improve lie detection. Participants ( n = 90) were randomly assigned to receive…
John C. Morrill, Tetsuro Ikegami, Naoko Yoshikawa-Iwata et al. · 2010 · PLoS ONE
BACKGROUND: Rift Valley fever virus (RVFV), a member of the genus Phlebovirus within the family Bunyaviridae, is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, while in livestock it causes fever and high abortion rates. METHODOLOGY/PRINCIPAL FINDINGS: Sequence analysis showed that a wild-type RVFV ZH501 preparation consisted of two major viral subpopulations, with a single nucleotide heterogeneity at nucleotide 847 of M segment (M847); one had a G residue at M847 encoding glycine in a major
Marcello Tiseo · 2010 · Drug Design Development and Therapy
Most patients with non-small-cell lung cancer (NSCLC) present with advanced disease and their long-term prognosis remains poor. Epidermal growth factor receptor (EGFR)-targeted therapies, such as gefitinib, have been subjected to…
Juliano Rodrigues Sangalli, Marcos Roberto Chiaratti, Tiago Henrique Camara De et al. · 2014 · PLoS ONE
Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. In this regard, most factors that promote chromatin decondensation, including histone deacetylase inhibitors (HDACis), have been found to increase nuclear reprogramming efficiency, making their use common to improve SCNT rates. Herein we used valproic acid (VPA) in SCNT to test whether the treatment
Witoon Purahong, Dolaya Sadubsarn, Benjawan Tanunchai et al. · 2019 · Microorganisms
Mangrove forest trees play important ecological functions at the interface between terrestrial and marine ecosystems. However, despite playing crucial roles in plant health and productivity, there is little information on microbiomes of the tree species in mangrove ecosystems. Thus, in this study we aimed to characterize the microbiome in soil (rhizosphere) and plant (root, stem, and leaf endosphere) compartments of the widely distributed mangrove tree Rhizophora stylosa. Surprisingly, bacterial operational taxonomic units (OTUs) were only confidently detected in rhizosphere soil, while fungal
Hamzah Abu‐Sbeih, Cynthia N. Tran, Phillip S. Ge et al. · 2019 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint inhibitors (ICIs) represent a promising novel class of cancer therapy, but immune-mediated adverse events can complicate ICI treatment. Acute cholecystitis in patients receiving ICI therapy has not been characterized. We aimed to describe the clinical features of patients who developed ICI-related cholecystitis. METHODS: We evaluated a case series of patients at a tertiary cancer center who received ICI therapy and developed cholecystitis, diagnosed by clinical presentation and diagnostic imaging, during 2010-2018. Patients with a history of chronic cholecystitis
Andrea Botticelli, Silvia Mezi, Giulia Pomati et al. · 2020 · Frontiers in Immunology
Backgrounds. Clinical trials showed that only a subset of patients benefits from immunotherapy suggesting the need to identify new predictive biomarker of resistance.. Indolamine 2,3-dioxygenase (IDO) has been proposed as a mechanism of resistance to anti-PD1 treatment and serum kyn/trp ratio represent a possible marker of IDO activity. Methods. Metastatic NSCLC, RCC and HNSCC treated in second line with nivolumab were included in this prospective study. Baseline serum kynurenine and tryptophan levels were measured by high-performance liquid chromatography to define the kyn/trp ratio. The 2–t
Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu et al. · 2019 · Critical Care
BACKGROUND: Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors. METHODS: In a multicenter prospective cohort study of 400 critically ill septic patients, we derived and validated thresholds for each marker and expressed prognostic enrichment using risk differences (RD) of 30-day mortal