Failed Experiment ReportOpen accessComputer Science
Sándor Kisfaludi-Bak, Jesper Nederlof, Erik Jan van Leeuwen · 2018 · arXiv
The Planar Steiner Tree problem is one of the most fundamental NP-complete problems as it models many network design problems. Recall that an instance of this problem consists of a graph with edge weights, and a subset of vertices (often called terminals); the goal is to find a subtree of the graph of minimum total weight that connects all terminals. A seminal paper by Erickson et al. [Math. Oper. Res., 1987] considers instances where the underlying graph is planar and all terminals can be covered by the boundary of $k$ faces. Erickson et al. show that the problem can be solved by an algorithm
Failed Experiment ReportOpen accessMedicine
Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →DOI: 10.1371/journal.pone.0266901 Failed Experiment ReportMedicine
Harder K, Thöle M · 2026 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Objective The aim of this study was to evaluate the therapeutic success of a conservative treatment approach for macrodontic molars in guinea pigs. To this end, longitudinal data from conservative management were analyzed and parameters of…
View details →DOI: 10.1055/a-2773-8335 Failed Experiment ReportMedicine
Day M, Kearney S · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To explore methods of evaluating success of optical myopia control interventions, and to apply these methods retrospectively to a clinical population. Methods A retrospective cohort study was conducted on pediatric patients…
View details →DOI: 10.1002/ovs2.70075 Failed Experiment ReportMedicine
Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
View details →DOI: 10.1186/s13019-026-04483-1 Failed Experiment ReportMedicine
Afuh R, Ashinze P, Banerjee S et al. · 2026 · Discover oncology
Melanoma remains one of the most aggressive cutaneous malignancies, accounting for a disproportionate share of skin cancer-related mortality despite relatively lower incidence. Over the past decade, immune checkpoint inhibitors (ICIs) have…
View details →DOI: 10.1007/s12672-026-05202-x Failed Experiment ReportMedicine
Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
View details →DOI: 10.1371/journal.pone.0352418 Failed Experiment ReportOpen accessMedicine
Çimen Ş, Altındağ N, Erginöz E et al. · 2026 · International journal of molecular sciences
The relationship between biochemical severity parameters and adenoma burden in primary hyperparathyroidism (PHPT) has been widely studied, although some variability across studies persists. This relationship is clinically relevant for…
View details →DOI: 10.3390/ijms27115034 Failed Experiment ReportMedicine
Knapper, Thomas, Hills et al. · 2026 · Blood
We assessed the addition of the tyrosine kinase inhibitor Quizartinib, following intensive chemotherapy and as maintenance, in patients aged >60 years with AML or high-risk MDS, regardless of FLT3 mutation status. 463 patients (median age…
View details →DOI: 10.1182/blood.2025032681 Failed Experiment ReportMedicine
Ren, Nan, Li et al. · 2026 · Annals of medicine
To evaluate the analgesic efficacy of thoracic paravertebral block (TPVB) with different doses of liposomal bupivacaine (LB) or ropivacaine in patients undergoing single-port thoracoscopic lung surgery. A total of 105 patients scheduled…
View details →DOI: 10.1080/07853890.2026.2687941 Failed Experiment ReportMedicine
Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
View details →DOI: 10.1002/prp2.70277 Failed Experiment ReportOpen accessComputer Science
Carmine Abate, Arthur Azevedo de Amorim, Roberto Blanco et al. · 2018 · arXiv
We propose a new formal criterion for evaluating secure compilation schemes for unsafe languages, expressing end-to-end security guarantees for software components that may become compromised after encountering undefined behavior---for example, by accessing an array out of bounds. Our criterion is the first to model dynamic compromise in a system of mutually distrustful components with clearly specified privileges. It articulates how each component should be protected from all the others---in particular, from components that have encountered undefined behavior and become compromised. Each comp
Failed Experiment Report
Isaac Unah · 2026 · SSRN Electronic Journal
The paper argues that Eritrea's Constitution — ratified after a costly independence struggle and designed to establish democracy, rule of law, and human rights — has never been implemented in nearly 30 years. The failure is attributed…
View details →DOI: 10.2139/ssrn.6289978 Failed Experiment ReportOpen accessOrthopedic surgery
Karthikeyan Chinnakkannu MD, John E Femino MD, Natalie Glass PhD et al. · 2019 · Foot & Ankle Orthopaedics
Category: Ankle, Arthroscopy, Hindfoot, Sports Introduction/Purpose: Posterior ankle/hindfoot arthroscopy (PAHA) is an established surgical option for treating pathologies, of posterior ankle and subtalar joints, which otherwise would require open incisions. Arthroscopic procedures are less invasive, provide magnified visualization and allow earlier rehabilitation and return to activity. Many studies have reported outcomes after PAHA, however only two studies have reported complications in larger cohorts. Although posterior ankle impingement (PAI) is a common indication for PAHA, it is a non-s
View details →DOI: 10.1177/2473011419s00018 Failed Experiment ReportOpen accessComputer Science
Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv
Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}
Failed Experiment ReportOpen accessComputer Science
Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv
A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model
Failed Experiment ReportOpen accessComputer Science
Alan Lee, Harry Tong · 2025 · arXiv
We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2
Failed Experiment ReportOpen accessMedicine
Fernando Naclerio, Eneko Larumbe-Zabala, Robert Cooper et al. · 2015 · PLoS ONE
We investigated the effects of ingesting a multi-ingredient (53 g carbohydrate, 14.5 g whey protein, 5 g glutamine, 1.5 g L-carnitine-L-tartrate) supplement, carbohydrate only, or placebo on intermittent performance, perception of fatigue, immunity, and functional and metabolic markers of recovery. Sixteen amateur soccer players ingested their respective treatments before, during and after performing a 90-min intermittent repeated sprint test. Primary outcomes included time for a 90-min intermittent repeated sprint test (IRS) followed by eleven 15 m sprints. Measurements included creatine kina
View details →DOI: 10.1371/journal.pone.0125188 Failed Experiment ReportOpen accessComputer Science
Xinzhe Chen, Jianjiang Li · 2023 · arXiv
The escalating surge in data generation presents formidable challenges to information technology, necessitating advancements in storage, retrieval, and utilization. With the proliferation of artificial intelligence and big data, the "Data Age 2025" report forecasts an exponential increase in global data production. The escalating data volumes raise concerns about efficient data processing. The paper addresses the predicament of achieving a lower compression ratio while maintaining or surpassing the compression performance of state-of-the-art techniques. This paper introduces a lossy compressio
Failed Experiment ReportOpen accessComputer Science
Liyun Zhang, Jiayi Guo · 2026 · arXiv
We document an empirical phenomenon in chain-of-thought and ReAct agents driven by ten large language models from seven architecture families: meaning-bearing perturbations (e.g., paraphrase, synonym) alter final answers more often than presentation perturbations (e.g., formatting, reordering) of comparable severity. Across 68 cells spanning GSM8K, MATH, and HotpotQA (1,530 originals and $\sim$11,150 variants), the inconsistency gap averages +19.69 pp after severity matching (paired $t=9.58$, $p<0.0001$), with 64/68 cells positive. The gap survives four severity-proxy audits and remains signif
Failed Experiment ReportOpen accessPhysics
Nicolas Tancogne-Dejean, Martin Lüders, Carsten A. Ullrich · 2023 · arXiv
We extend some of the well established self-interaction correction (SIC) schemes of density-functional theory to the case of systems with noncollinear magnetism. Our proposed SIC schemes are tested on a set of molecules and metallic clusters in combination with the widely used local spin-density approximation. As expected from the collinear SIC, we show that the averaged-density SIC works well for improving ionization energies but fails to improve more subtle quantities like the dipole moments of polar molecules. We investigate the exchange-correlation magnetic field produced by our extension
Failed Experiment ReportOpen accessImmunologic diseases. Allergy
Jessica J. Harrison, Wilson Nguyen, Mahali S. Morgan et al. · 2024 · npj Vaccines
Abstract In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current approved human and veterinary vaccines are derived from genotype (G) III JEV strains, we used the recently described insect-specific Binjari virus (BinJV) chimeric flavivirus vaccine technology to produce a JEV GIV vaccine candidate. Herein we describe the production of a chimeric virus displaying the structural prM and E proteins of a JEV GIV
View details →DOI: 10.1038/s41541-024-00903-2 Failed Experiment ReportOpen accessComputer Science
Frits de Nijs, Daan Wilmer · 2012 · arXiv
The goal of this paper is to critically evaluate a heuristic algorithm for the Inverse Banzhaf Index problem by Laruelle and Widgrén. Few qualitative results are known about the approximation quality of the heuristics for this problem. The intuition behind the operation of this approximation algorithm is analysed and evaluated. We found that the algorithm can not handle general inputs well, and often fails to improve inputs. It is also shown to diverge after only tens of iterations. We present three alternative extensions of the algorithm that do not alter the complexity but can result in up t
Failed Experiment ReportOpen accessPhysics
Khadijeh Najafi, M. A. Rajabpour · 2017 · arXiv
In a recent letter, J. Cardy, Phys. Rev. Lett. \textbf{112}, 220401 (2014), the author made a very interesting observation that complete revivals of quantum states after quantum quench can happen in a period which is a fraction of the system size. This is possible for critical systems that can be described by minimal conformal field theories (CFT) with central charge $c<1$. In this article, we show that these complete revivals are impossible in microscopic realizations of those minimal models. We will prove the absence of the mentioned complete revivals for the critical transverse field Ising
Failed Experiment Report
· 2015 · Strategic Direction
Purpose – This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach – This briefing is prepared by an…
View details →DOI: 10.1108/sd-12-2014-0178 Failed Experiment ReportOpen accessDiseases of the blood and blood-forming organs
Pedro Henrique Prata, Dirk-Jan Eikema, Brian Piepenbroek et al. · 2025 · Haematologica
Aplastic anemia (AA) transformation into myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) is associated with a dismal prognosis. Hematopoietic stem cell transplant offers the sole possibility of cure, but data on long-term survival are scarce. We retrospectively analyzed 270 patients transplanted for MDS, AML, or an isolated cytogenetic abnormality after a diagnosis of AA or paroxysmal nocturnal hemoglobinuria reported to the EBMT. The median age at transplantation was 39 years. The 5-year overall survival (OS) rate was 64%, unaffected by chromosome 7 abnormalities, age at trans
View details →DOI: 10.3324/haematol.2024.287205 Failed Experiment Report
Kyle Admire, Stephen Gegick · 2026 · BMJ Case Reports
Tumours within the pulmonary arteries provide a diagnostic challenge due to their similar appearance to pulmonary emboli. Often, the decision to sample is multidisciplinary and the best approach to take is often unknown. Here we describe a…
View details →DOI: 10.1136/bcr-2025-268157 Failed Experiment Report
J. Stöhr, L. Maurer, B. Zimmer et al. · 2016 · Reproduction, Fertility and Development
In humans, intracytoplasmic sperm injection (ICSI) has become widely applied to overcome infertility. In addition to its clinical usefulness, ICSI is also a valuable research tool for studying fundamental aspects of gamete interaction…
View details →DOI: 10.1071/rdv29n1ab128 Failed Experiment Report
Adam Wilson · 2012 · Journal of Petroleum Technology
This article, written by Editorial Manager Adam Wilson, contains highlights of paper SPE 151518, ’Automated Managed-Pressure Drilling Allows Identification of New Reserves in an HP/HT Exploration Well in SB Field, Offshore Malaysia,’ by…
View details →DOI: 10.2118/0912-0113-jpt Failed Experiment Report
Omar S. Aljitawi, Jeff Radel, Bruce Kimler et al. · 2011 · Blood
Abstract Abstract 4695 Introduction: UCB is also an attractive stem cell source for transplantation because of the ease of procurement, the absence of donor risks, and reduced risk of transmissible infections. Unfortunately, outcomes of…
View details →DOI: 10.1182/blood.v118.21.4695.4695 