Hematopoietic stem cell transplantation is effective in achieving long-term survival for post-aplastic anemia myeloid neoplasms: the EBMT Severe Aplastic Anemia Report
Pedro Henrique Prata; Dirk-Jan Eikema; Brian Piepenbroek; Austin Kulasekararaj; Beatrice Drexler; Jennifer M-L. Tjon; Krista Vaht; Mahmoud Aljurf · 2025 · Haematologica
WASTE classifies this as Failed Experiment Report · AI classification, approximate
An experimental approach did not work as intended — learn what to avoid before investing the same effort.
Abstract
Aplastic anemia (AA) transformation into myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) is associated with a dismal prognosis. Hematopoietic stem cell transplant offers the sole possibility of cure, but data on long-term survival are scarce. We retrospectively analyzed 270 patients transplanted for MDS, AML, or an isolated cytogenetic abnormality after a diagnosis of AA or paroxysmal nocturnal hemoglobinuria reported to the EBMT. The median age at transplantation was 39 years. The 5-year overall survival (OS) rate was 64%, unaffected by chromosome 7 abnormalities, age at trans
Abstract by Pedro Henrique Prata; Dirk-Jan Eikema; Brian Piepenbroek; Austin Kulasekararaj; Beatrice Drexler; Jennifer M-L. Tjon; Krista Vaht; Mahmoud Aljurf, Haematologica (2025) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Outcomes of autologous transplantation for multiple myeloma according to different induction regimens
Negative / Null Result ReportPreparation quality control and clinical application observation of pooled platelets with leukocytes reduced
Negative / Null Result ReportValidation of a pulmonary embolism risk assessment model in gynecological inpatients
Negative / Null Result ReportA retrospective cohort analysis on the association between blood donation intervals and adverse reactions to blood donation in Shenzhen, China
Negative / Null Result ReportModulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study
Negative / Null Result ReportPROGNOSTIC VALUE OF BRAIN AND ACUTE LEUKEMIA CYTOPLASMIC GENE EXPRESSION IN EGYPTIAN CHILDREN WITH ACUTE MYELOID LEUKEMIA
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.3324/haematol.2024.287205