Negative / Null Result ReportOpen accessMedicine
Springer-Sapp CB, Ogbara OO, Addison O et al. · 2025 · The Journal of frailty & aging
Background The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of…
View details →DOI: 10.1016/j.tjfa.2025.100090 Negative / Null Result ReportMedicine
Connor JJ, Johnson-Agbakwu C, Harlow BL et al. · 2026 · Journal of sex research
Female genital cutting (FGC) results in a higher risk for sexual issues in impacted women. This study examined this impact in a sample of 300 women identifying as Somali and living in the United States. FGC is highly prevalent in Somalia,…
View details →DOI: 10.1080/00224499.2026.2638383 Failed Experiment ReportOpen accessMedicine
Miranda MC, Hyde J, Salazar K et al. · 2024 · microPublication biology
Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 ,…
View details →DOI: 10.17912/micropub.biology.001063 Negative / Null Result ReportOpen accessMedicine
Fusagawa H, Sato T, Naito A et al. · 2025 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Overuse-induced muscle disorders (OIMD) frequently occur in athletes due to excessive and improper use under high physical demand, often leading to muscle pain and weakness. Limited studies have shown intramuscular fibrosis in OIMD, with…
View details →DOI: 10.1002/jor.70076 Negative / Null Result ReportMedicine
Foster BA, Zhou C, Canty E et al. · 2023 · Hospital pediatrics
Background Tolerance of uncertainty may influence how physicians and other providers practice and make clinical decisions. We hypothesized that increased tolerance of uncertainty would be associated with an increased uptake of a quality…
View details →DOI: 10.1542/hpeds.2022-006674 Negative / Null Result Report
Steffen J, Fischbach PC, Gönner L et al. · 2022 · Preprint
ABSTRACT Background Etiological theories of addictive behavior postulate a key role for decision-making mechanisms. However, current research is lacking clear computational models for decision-making in multi-step forward planning…
View details →DOI: 10.1101/2022.11.21.517329 Negative / Null Result ReportMedicine
Yee CS, Demirdji M, Bailey KN et al. · 2026 · Osteoarthritis and cartilage
Objective Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression of osteocytic perilacunocanalicular remodeling…
View details →DOI: 10.1016/j.joca.2025.12.019 Negative / Null Result ReportOpen accessMedicine
Byg LM, Wang CA, Attia J et al. · 2026 · Communications medicine
Background Early life nutrition is associated with child behaviour; however, the interplay with genetic vulnerability is understudied. We hypothesised that psychiatric genetic risk interacted with early nutrition to predict behavioural…
View details →DOI: 10.1038/s43856-025-01339-y Negative / Null Result ReportOpen accessMedicine
Najberg H, Tapparel M, Holmann JN et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)
Response training, such as with the Go/NoGo task, reduces the value of trained items by requiring participants to repeatedly inhibit their responses to appetitive cues that typically elicit approach tendencies. This devaluation is thought…
View details →DOI: 10.1162/imag.a.1118 Negative / Null Result ReportMedicine
van Timmeren T, Piray P, Goudriaan AE et al. · 2023 · Addictive behaviors
The development of addictive behaviors has been suggested to be related to a transition from goal-directed to habitual decision making. Stress is a factor known to prompt habitual behavior and to increase the risk for addiction and…
View details →DOI: 10.1016/j.addbeh.2023.107628 Negative / Null Result ReportOpen accessMedicine
Eldesouky L, Gross JJ, English T · 2025 · Scientific reports
The ways people manage their emotions (emotion regulation; ER) have been found to affect their own well-being and the well-being of others. In the present research, we extended prior work by examining whether similarity between people's ER…
View details →DOI: 10.1038/s41598-025-08245-2 Negative / Null Result ReportOpen accessMedicine
Hernandez C, Jensen CD, Duraccio KM · 2025 · Sleep advances : a journal of the Sleep Research Society
Study objectives This secondary data analysis study was designed to evaluate demographic and socioeconomic characteristics that may increase the magnitude of the impact of experimentally induced shortened sleep on suboptimal eating…
View details →DOI: 10.1093/sleepadvances/zpaf050 Negative / Null Result ReportMedicine
McDonald MJ, Marsh ML, Fears SD et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)
Chronic exposure to shortened sleep is associated with an increased risk of Alzheimer's disease and dementia. Previous studies show insufficient (e.g., poor or fragmented) sleep impairs cerebrovascular reactivity to metabolic stress and…
View details →DOI: 10.1152/japplphysiol.00648.2024 Failed Experiment Report
Saeid S, Afshar PF · 2025 · Preprint
Abstract Background Frailty syndrome is increasingly prevalent among older adults. Early identification of frailty and assessment of associated risk factors—such as poor nutritional status and polypharmacy—are critical for mitigating its…
View details →DOI: 10.21203/rs.3.rs-7339190/v1 Negative / Null Result ReportOpen accessMedicine
Cagigas ML, Fiorito G, Bertozzi B et al. · 2024 · Biomarker research
Background Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear…
View details →DOI: 10.1186/s40364-024-00613-w Negative / Null Result ReportOpen accessMedicine
Saito S, Tsukamoto H, Karaki M et al. · 2025 · Experimental physiology
Individuals who experience prolonged sitting daily are reported to be at risk of developing cerebrovascular disease, which is associated, in part, with attenuation in cerebral blood flow regulation. However, the effect of prolonged sitting…
View details →DOI: 10.1113/ep092178 Negative / Null Result ReportOpen accessMedicine
Suzuki K, Kamijo F, Nishinaka N · 2025 · Journal of physical therapy science
[Purpose] The purpose of this study was to compare the trunk displacement and ground reaction force during hand-behind-back (HBB) movements between the right and left hands. [Participants and Methods] Twenty healthy right-handed men…
View details →DOI: 10.1589/jpts.37.274 Negative / Null Result ReportMedicine
Williams CD, Sobolewski CM, Cage J et al. · 2026 · Journal of American college health : J of ACH
Black American women are disproportionately affected by diseases, such as obesity, heart disease, and cancer, and risks are reduced by better physical activity and nutrition. Given these disparities, it is particularly important to…
View details →DOI: 10.1080/07448481.2025.2611274 Negative / Null Result Report
Iaquinta MR, Lanzillotti C, Tognon M et al. · 2026 · Preprint
ABSTRACT Background The effects of dexamethasone during in vitro human osteogenesis present a complex picture. On one side, dexamethasone promotes the osteogenic differentiation of human bone marrow mesenchymal stromal cells (BMSCs) by…
View details →DOI: 10.64898/2026.02.04.703935 Negative / Null Result Report
Collins C, Cobb AR, Sukri RS et al. · 2026 · Preprint
Abstract Aims Tropical peatlands have a globally important role as carbon sinks. How their waterlogged conditions and low nutrient status impact plant litter decomposition is not well-understood, despite decomposition processes…
View details →DOI: 10.21203/rs.3.rs-8416081/v1 Failed Experiment Report
Salgado-Roa F, Stuart-Fox D, Ospina-Rozo L et al. · 2025 · Preprint
The presence of multiple colour variants within a single population, known as colour polymorphism, is a striking example of intraspecific phenotypic variation and a model for studying evolutionary processes. These processes depend on the…
View details →DOI: 10.32942/x2vs9q Negative / Null Result ReportMedicine
Campos KL, Rolim GG, Silva RS et al. · 2026 · Entomologia Experimentalis et Applicata.
The boll weevil, Anthonomus grandis grandis Boh., presents significant management challenges due to its persistent presence and prolonged cropping season. One hypothesis posits that favorable factors, such as host availability and climatic…
Negative / Null Result Report
Barresi G, Viana KMP, Hermansen TK et al. · 2025 · Preprint
Peer action coordination in middle childhood is thought to benefit from socio-cognitive abilities such as emotion understanding and inhibitory control, but empirical evidence for their role is limited. This study replicates and extends a…
View details →DOI: 10.20944/preprints202512.0218.v1 Negative / Null Result ReportOpen accessMedicine
Czyżowska-Froemling A, Xu H, Harold K et al. · 2026 · Physiological reports
Age-related loss of innervation in skeletal muscle is a key driver of sarcopenia. We investigated the role of calcium-dependent phospholipase A 2 (cPLA 2 ) in denervation-atrophy. cPLA 2 mediates the release of polyunsaturated fatty acid…
View details →DOI: 10.14814/phy2.70906 Negative / Null Result ReportOpen accessMedicine
Lancup-Gauthier A, Brassard D, Côté M et al. · 2022 · Current developments in nutrition
Objectives While there is evidence that the early lockdown due to COVID-19 pandemic may have had small positive impacts on several populations’ dietary habits, the longer term effects remain largely unknown. The aim of this study was to…
Failed Experiment ReportMedicine
Chao AM, Agarwal K, Zhou Y et al. · 2024 · The International journal of eating disorders
Objective Adults with binge-eating disorder (BED), compared with those without BED, demonstrate higher blood-oxygen-level-dependent (BOLD) response to food cues in reward-related regions of the brain. It is not known whether cognitive…
View details →DOI: 10.1002/eat.24244 Negative / Null Result ReportMedicine
Sørensen TT, Rod NH, Nguyen TL et al. · 2023 · European journal of epidemiology
Out-of-home care has been linked to excess mortality across the lifespan. We examined whether this association is modified by the age at first out-of-home care placement and the number of placements. In this population-based cohort study,…
View details →DOI: 10.1007/s10654-022-00959-1 Negative / Null Result Report
van Timmeren T, Piray P, Goudriaan A et al. · 2022 · Preprint
The development of addictive behaviors has been suggested to be related to a transition from goal-directed to habitual decision making. Stress is a factor known to prompt habitual behavior and to increase the risk for addiction and…
View details →DOI: 10.31234/osf.io/pcund Negative / Null Result ReportOpen accessMedicine
Veregge M, Hirsch CD, Moscou MJ et al. · 2025 · mSystems
Goss's wilt and leaf blight of maize is an economically important disease caused by the Gram-positive bacterium, Clavibacter nebraskensis ( Cn ). Little is known about the ecology and pathogenesis of this bacterium. Here, we used…
View details →DOI: 10.1128/msystems.01355-24 Negative / Null Result ReportOpen accessMedicine
Kim MJ, Kim S, Kim J et al. · 2025 · Scientific reports
Unanticipated postural control measures may better identify mechanisms of ankle sprains in real-life situations. The purpose of this study was to identify directional deficits in reactive postural control during unanticipated horizontal…
View details →DOI: 10.1038/s41598-025-98913-0 