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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 678 of 725

Negative / Null Result ReportMedicine

Rectus Femoris Neuromechanical Responses to Exercise-Induced 3% Body Mass Loss by Baseline Hydration Status: A Randomized Group Comparison.

Skotniczny K, Terbalyan A, Linek P et al. · 2026 · Nutrients

Background Acute dehydration impairs performance, but its effects on resting neuromuscular and tissue mechanics are unclear. We tested whether baseline hydration status and exercise-induced sweat loss alter the resting neuromechanical…

View details →DOI: 10.3390/nu18122015
Negative / Null Result ReportMedicine

Experience With Performing Rheocarna Therapy via the Single-Needle Method for Treatment of Chronic Limb-Threatening Ischemia.

Yamauchi Y, Tanaka R, Kawahira R et al. · 2026 · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Introduction This study investigated the safety and efficacy of single-needle Rheocarna therapy for chronic limb-threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization…

View details →DOI: 10.1002/1744-9987.70161
Negative / Null Result ReportMedicine

Effects of High-Impact Exercise on Bone Marker Concentrations During Controlled Low Energy Availability in Recreational Female Runners.

Sterringer T, Sale C, Morozov A et al. · 2026 · Calcified tissue international

Exposure to low energy availability (LEA) can stimulate metabolic adaptations that have been shown to disrupt bone remodeling as suggested by suppressed markers of bone formation and/or increased markers of bone resorption. Previous…

View details →DOI: 10.1007/s00223-026-01564-0
Negative / Null Result ReportMedicine

Observation of Altered Iron Status Development During Noncompetitive Season Training in NCAA Division I Female Acrobatics and Tumbling Athletes.

Pickler MC, Funderburk LK, Lee KM et al. · 2026 · Journal of strength and conditioning research

Abstract Pickler, MC, Funderburk, LK, Lee, KM, Bolden, LK, Chapman-Lopez, TJ, Heileson, JL, and Gallucci, AR. Observation of altered iron status development during noncompetitive season training in NCAA Division I female acrobatics &…

View details →DOI: 10.1519/jsc.0000000000005584
Negative / Null Result Report

Metabolic Dynamics During Cardiopulmonary Bypass: Oxygen Delivery, Carbon Dioxide Production, and Lactate Response Despite Preserved Global Perfusion

J D, J JA, S S et al. · 2026 · Preprint

Abstract Objective To analyze intraoperative metabolic parameters from carbon dioxide during cardiopulmonary bypass (CPB) and their association with postoperative hyperlactatemia in elective cardiac surgery. Methods This study observed 26…

View details →DOI: 10.21203/rs.3.rs-9702308/v1
Negative / Null Result ReportMedicine

Voice and Swallowing in Professional Voice Users: The Effect of Therapy Methods.

Özcan Ulubeli P, Aydoğan Z, Karakaya Gojayev E et al. · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This study aimed to evaluate pain complaints, as well as voice and swallowing functions, in professional voice users, and to compare the effectiveness of three therapeutic approaches: vocal hygiene (VH), vocal function…

View details →DOI: 10.1159/000550481
Negative / Null Result ReportMedicine

A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.

Wang X, Xu Y, Lin X et al. · 2026 · Scientific reports

Left ventricular-arterial (V-A) coupling is a key determinant of cardiovascular performance, which integrates intrinsic myocardial contractility with ventricular afterload. Septic shock frequently disrupts this coupling, and norepinephrine…

View details →DOI: 10.1038/s41598-026-56605-3
Negative / Null Result ReportMedicine

Analysis of mechanical dynamics in acoustofluidics: assessing the impact of frequency sweeping on PZT performance and acoustic phenomena.

Maisto A, Sanders RGP, de Hemptinne A et al. · 2026 · Ultrasonics

In this work, we combine acoustic streaming measurements, direct vibration measurements and the theory of wave dispersion to interpret changes in acoustic streaming. The vibration dynamics of the PZT are studied under frequency sweeping…

View details →DOI: 10.1016/j.ultras.2026.108182
Negative / Null Result Report

Redox potential in animal andrology: An experimental study on boar semen

Pintus E, Scaringi M, Engelen J et al. · 2026 · Preprint

Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…

View details →DOI: 10.64898/2026.05.21.726780
Negative / Null Result ReportOpen accessMedicine

Acid-base balance and respiratory mechanics during robotic-assisted surgery: an observational study.

Pitimada M, Chiumello D, Monte A et al. · 2026 · Journal of robotic surgery

To evaluate changes in acid-base equilibrium in plasma and urine according to the Stewart’s approach, in gas exchange and in respiratory mechanics during robotic-assisted surgery. Prospective observational study on patients undergoing…

View details →DOI: 10.1007/s11701-026-03392-8
Negative / Null Result ReportMedicine

Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial.

Dunseath GJ, Cheung WY, Luzio SD et al. · 2026 · Diabetes care

Objective To determine whether less invasive C-peptide tests, urine C-peptide-to-creatinine ratio (UCPCR) and dried blood spot (DBS), could replace the mixed-meal tolerance test (MMTT) in the context of an interventional clinical trial…

View details →DOI: 10.2337/dc25-2896
Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

Negative / Null Result ReportMedicine

Behavioral Adaptation to Neck Radio-Collars and Its Relations with Temperament in Two Neotropical Psittacid Species.

de Almeida GN, de Jesus LG, Branco MEC et al. · 2026 · Journal of applied animal welfare science : JAAWS

Track devices can cause behavioral, physical, and physiological adverse effects, with individuals varying in how quickly they adapt to them. We examined behavioral effects of replica radio-collars on two captive psittacid species,…

View details →DOI: 10.1080/10888705.2026.2681557
Negative / Null Result ReportMedicine

Impact of tighter glycaemic targets on pregnancy outcomes in a multi-ethnic cohort with gestational diabetes: A retrospective, single centre observational study.

Huda MS, Margari N, Islam N et al. · 2026 · Obstetric medicine

Aims To determine the impact of tighter glycaemic targets for gestational diabetes. Methods Retrospective data analysis before and after introducing tighter glucose targets. Results In 2265 pregnancies there was no change in…

View details →DOI: 10.1177/1753495x261445509
Negative / Null Result ReportMedicine

An evaluation of anatomical and functional outcomes in patients undergoing retinectomy for proliferative vitreoretinopathy.

Uzlu D, Erdöl H, Bulanık ÖB et al. · 2026 · BMC ophthalmology

Background The objective of this study was to evaluate the anatomical and functional outcomes of patients who underwent relaxing retinotomy or retinectomy for retinal detachment complicated by proliferative vitreoretinopathy. Methods The…

View details →DOI: 10.1186/s12886-026-04904-8
Negative / Null Result ReportMedicine

Mental rotation performance after acute stress.

Richardson AE, VanderKaay Tomasulo MM · 2026 · BMC psychology

Background The need to mentally rotate objects is common in everyday activities (e.g., driving, loading suitcases in a car, playing 3D video games) and in specific professions (e.g., air traffic controllers, mechanics, pilots, surgeons).…

View details →DOI: 10.1186/s40359-026-04818-6
Negative / Null Result ReportMedicine

The Importance of Objective Functional and Balance Testing in Pediatric Anterior Cruciate Ligament Reconstruction for a Safe Return-To-Sport: A Two-Year Prospective Study.

Crippa M, Turati M, Flumian C et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Pediatric anterior cruciate ligament reconstruction (ACLR) outcomes, particularly long-term functional recovery and return-to-sport (RTS), remain debated and have not been well characterized in skeletally immature…

View details →DOI: 10.1016/j.jisako.2026.101149
Negative / Null Result ReportMedicine

Antifungal susceptibility of genital yeast isolates, Auckland, 2016-2025.

Morris AJ, McKinney WP, Roberts SA · 2026 · The New Zealand medical journal

Aim Our aim was to record current susceptibility results of genital yeast isolates and to compare the results to the previous report covering the period 2001-2015. Methods Genital yeast isolates had their antifungal susceptibility…

View details →DOI: 10.26635/6965.7444
Negative / Null Result ReportMedicine

Sono-anatomy of the supraclavicular region for ultrasound-guided subclavian vein catheterization: revaluation of a former method.

Berk AZ, Balaban O, Eman A et al. · 2026 · BMC anesthesiology

BACKGROUND/OBJECTIVE: Ultrasound-guided subclavian vein (SCV) catheterization offers an alternative approach to the classical jugular vein catheterization for central venous catheter placement. The objective of this study was to evaluate…

View details →DOI: 10.1186/s12871-026-03857-1
Negative / Null Result ReportOpen accessMedicine

Changes in macular structure after removal of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium.

Lee CH, Kim KH, Choi YJ et al. · 2026 · Scientific reports

This study investigates the effect of epiretinal membrane (ERM) removal in the combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) patients. In this retrospective, comparative case series, 15 CHRRPE patients were…

View details →DOI: 10.1038/s41598-026-39124-z
Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

View details →DOI: 10.1080/13625187.2025.2596612
Negative / Null Result ReportMedicine

Quantification of Changes in Bifidobacteria and Lactobacilli Colony-forming Units During Rifaximin Treatment and Synbiotic Gel in Healthy Volunteers.

Cassís-Nosthas ML, Vorácková FV, Dzib FT et al. · 2026 · Journal of visualized experiments : JoVE

Although the gut microbiota is generally stable, it can be influenced by antibiotic treatment. Rifaximin, which is used to treat gastrointestinal disorders, is frequently administered with probiotics to reduce the risk of dysbiosis.…

View details →DOI: 10.3791/70201
Negative / Null Result ReportMedicine

Cerebral physiology following general anaesthesia with sevoflurane or propofol in healthy volunteers - a randomised, single-blind cross-over trial.

Madsen SS, Asghar MS, Lindberg U et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Although general anaesthesia is a very common medical procedure, knowledge of how the brain physiologically recovers remains limited. In this randomized cross-over trial, we investigated brain physiology during recovery from general…

View details →DOI: 10.1152/japplphysiol.01169.2025
Negative / Null Result ReportMedicine

Diurnal Rhythm in Blood Pressure Is Preserved in Hypertensive Mice Despite Therapy With Mineralocorticoid Receptor Antagonists.

Usai DS, Kudryavtseva O, Thomsen MB · 2026 · Journal of cardiovascular pharmacology

Abstract Human arterial blood pressure follows a circadian rhythm, where pressure is highest during the day and lowest during the night. Patients with hypertension can have either a preserved rhythm or a dampened rhythm with a lower…

View details →DOI: 10.1097/fjc.0000000000001812