A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21374 results · page 673 of 713
Sugawara J, Ogoh N, Watanabe H et al. · 2024 · Frontiers in physiology
Background Accumulative excessive physical load elevates central arterial stiffness and smooth muscular tone of peripheral vascular beds in endurance athletes. The aim of this study was to test the hypothesis that a brief series of soccer…
Harmon KK, Pourhatami Z, Malinowski D et al. · 2025 · Journal of functional morphology and kinesiology
Background : Knee joint immobilization is common after surgery or injury. Whether remaining physically active during immobilization preserves muscle strength and size has not been studied. Objectives : This observational study examined…
Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity
Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…
Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…
Marin TC, Oliveira GF, Azevêdo LM et al. · 2025 · Chronobiology international
We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL…
Song Y, Hupfeld KE, Davies-Jenkins CW et al. · 2023 · Preprint
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA),…
Rigó M, Weyers S · 2024 · Children (Basel, Switzerland)
Background COVID-19 pandemic has influenced all children's motor development. We examine whether this differs by social circumstances. We hypothesise that socially disadvantaged children experienced more pronounced motor problems compared…
Bae H, Hensch TK · 2023 · Preprint
1 Neprilysin (Nep) is a membrane-bound zinc-dependent endopeptidase that cleaves a wide variety of small peptides in the body. In the brain, it has gained fame as an important endogenous degrader of amyloid beta peptide, responsible for…
Welch JE, Luo W, Ambroise KJ et al. · 2024 · Journal of psychiatric research
Depression and some other illnesses are associated with increased self-reference and negative emotion in language. Research findings on lexical patterns in Borderline Personality Disorder (BPD) have been inconsistent. We conducted two…
Boparai ES, Lee JK, Zhu S et al. · 2023 · The American journal of gastroenterology
Occult colorectal cancer (CRC) has historically driven recommendations for colectomy in patients with inflammatory bowel disease with dysplasia . We defined the contemporary risk of occult CRC at colectomy among 93 patients with…
Ishibashi HK, Sasaki E, Chiba D et al. · 2025 · Orthopaedic journal of sports medicine
Background Ramp lesions (RLs) associated with anterior cruciate ligament (ACL) injury increase knee instability. However, whether RLs should be treated surgically remains unclear. Purpose/hypothesis This study aimed to investigate the…
Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science
[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…
Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience
Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…
Young J, Seeberg KA, Aakre KM et al. · 2024 · Clinical biochemistry
Background Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would be predictive of…
Kodama M, Yamazaki R, Hayakawa J et al. · 2023 · Preprint
Abstract Symbiosis includes commensalism, mutualism, and parasitism, however in many symbiotic relationships, it is difficult to determine which type they are in. Since trophic-linkage is a necessary factor to determine this, data on…
Ranzini M, Romeo Z, Zorzi M et al. · 2023 · Preprint
Exogenous orienting of attention can affect the mental processing of time, suggesting the existence of a spatial representation for temporal durations, with shorter and longer durations represented on the left and on the right of a mental…
Azam MB, Singh SI · 2026 · BMC medical informatics and decision making
Background Heart rate variability (HRV) derived from electrocardiogram (ECG) signals offers a promising non-invasive window into glycemic status; however, existing studies frequently combine distinct glucose measurements and employ…
Williams AC, Content VG, Alexander LM · 2025 · American journal of physiology. Heart and circulatory physiology
Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some…
Nanashima A, Hiyoshi M, Imamura N et al. · 2025 · Translational cancer research
Background Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim…
Aney P, Zeng S, Kensinger EA et al. · 2025 · Neuropsychologia
Background Human memory tends to bias negative over neutral information. Recent evidence suggests that this bias may be due to a categorical effect of emotionally salient information, which diminishes when negative information is less…
Chida K, Oshi M, Roy AM et al. · 2024 · Breast cancer research and treatment
Purpose While comprehensive research exists on the mutation of the DNA repair gene BRCA1, limited information is available regarding the clinical significance of BRCA1 gene expression. Given that cancer cell proliferation is aggrevated by…
Troha R, Lee SLT, Anam M et al. · 2025 · Frontiers in systems neuroscience
The hippocampus plays a prominent role in spatial navigation and memory. However, differences exist along the hippocampus longitudinal axis in function and connectivity. The current study focuses on the dorsal and intermediate subregions…
Vallesi V, Galléa C, Sritharan J et al. · 2025 · Brain communications
Functional paralysis (FP), a subtype of functional neurological disorder (FND), is characterized by symptoms of paralysis without clinically evident damage to the nervous system. Previous research has reported impaired inhibitory control…
Erickson MG, Zanton GI, Wattiaux MA · 2023 · Journal of dairy science
Limited research has examined the interaction between dietary crude protein (CP) level and CP feeding pattern. We tested CP level (low protein [LP], 13.8%; high protein [HP], 15.5% CP, dry matter [DM] basis) and CP feeding pattern (OF =…
Speed LJ, de Valk J, Croijmans I et al. · 2023 · Cognitive science
Odor and color are strongly associated. Numerous studies demonstrate consistent odor-color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test…
Goldway N, Markovits T, Fine N et al. · 2026 · Biological psychiatry global open science
Background Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of posttraumatic stress disorder (PTSD). Despite its significance, the…
Højsgaard Chow H, Talbot J, Lundell H et al. · 2023 · Multiple sclerosis and related disorders
Introduction Dimethyl fumarate treatment is approved in Europe for patients with relapsing-remitting multiple sclerosis (MS) and in the US for relapsing forms of MS. We recently published the results of the first randomized…
Goel S, Jovanović B, Chu X et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Cyclin-dependent kinase 4/6 inhibitors can significantly extend survival when given in combination with endocrine therapy in patients with hormone receptor-positive metastatic breast cancer. However, their activity has been…
Buchtele N, Schörgenhofer C, Schwameis M et al. · 2022 · American journal of respiratory and critical care medicine
Rationale: Prostaglandin E 1 (alprostadil; PGE 1 ), in addition to low-dose unfractionated heparin, increases the biocompatibility of extracorporeal systems and enhances the efficacy of artificial organs without increasing bleeding risk.…
Zhu J, Li Z, Song D et al. · 2026 · BMC health services research
Background The IMforte trial had supported lurbinectedin as a recommended first-line maintenance therapy for patients with extensive-stage small-cell lung cancer (ES-SCLC), while its cost-effectiveness remains uncertain for patients and…