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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 673 of 725

Negative / Null Result ReportMedicine

Redefining the role of carbon nanoparticles in colorectal cancer surgery: From lymph node yield to diagnostic paradox.

Lv Y, Wang F, Shen Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Accurate lymph node (LN) staging is critical in colorectal cancer (CRC). Carbon nanoparticles (CNPs), used as a tumor localization agent, incidentally stain LNs, creating uncertainty about their utility for improving staging and…

View details →DOI: 10.1016/j.ejso.2026.111782
Negative / Null Result ReportMedicine

The Opioid Safety Toolkit: An interactive prescription opioid safety toolkit to increase opioid safety literacy and behaviours among people prescribed opioids for pain-a randomised controlled trial.

Nielsen S, Fox F, Lam T et al. · 2026 · Addiction (Abingdon, England)

Background and aims Prescription opioid-related harm remains a significant public health concern. This study aimed to evaluate the efficacy of the Opioid Safety Toolkit, a co-designed, interactive online resource, in increasing naloxone…

View details →DOI: 10.1111/add.70412
Negative / Null Result ReportMedicine

Epidemiologic and Clinical Trends of Pediatric Human Rhinovirus Infections: A 2-year Comparative Analysis From a Single Center.

Yildirim Arslan S, Turanli E, Dinc F · 2026 · The Pediatric infectious disease journal

Background Human rhinovirus is one of the leading causes of pediatric respiratory infections worldwide. Its circulation patterns have shown notable changes in recent years. This study aimed to compare the epidemiologic, clinical and…

View details →DOI: 10.1097/inf.0000000000005171
Negative / Null Result ReportMedicine

Glucocorticoid dose at discharge and the risk of infectious complications and rehospitalization in renal diseases.

Yahata K, Seta K, Osaki K et al. · 2026 · Clinical and experimental nephrology

Background Glucocorticoids have diverse adverse effects, particularly infections that may be severe or opportunistic. Therefore, glucocorticoids are often initiated during hospitalization; however, the optimal glucocorticoid dose at…

View details →DOI: 10.1007/s10157-026-02868-z
Negative / Null Result ReportMedicine

Disinfection by-products in ballast water treated with oxidants - effects of treatment type, filter pre-treatment, test location, and salinity.

Sverdrup LE, Pollestad BM, Sigvaldsen I et al. · 2026 · Chemosphere

Ballast water is essential for ship stability during cargo operations and voyage, but its discharge can introduce invasive aquatic species to new environments. To mitigate this risk, ballast water is commonly treated with oxidants such as…

View details →DOI: 10.1016/j.chemosphere.2026.144899
Negative / Null Result ReportMedicine

Evaluation of a Clinical Practice Algorithm for Pediatric Complicated Pneumonia: A Retrospective, Observational, Single-Center Study.

Ostertag-Hill CA, Cummings OW, Renaud EJ · 2026 · Rhode Island medical journal (2013)

Objective The diagnostic evaluation, antibiotic treatment, and type and timing of surgical intervention for pediatric patients with complicated pneumonia is not standardized and may lead to increased length of stay, more radiation…

Negative / Null Result ReportMedicine

Comparison of Different Lighting Protocols on Female Cat Reproduction.

Lantermino A, Lapuente C, Blanco PG et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The aim of this study was to describe and compare the effect of different lighting protocols on sexual cyclicity and serum melatonin in domestic female cats. Additionally, anti-Müllerian hormone (AMH) concentrations and ultrasound or…

View details →DOI: 10.1111/rda.70177
Negative / Null Result ReportMedicine

Comparison of the somatic mutations in breast carcinomas in sporadic and BRCA1 carrier patients through targeted next generation sequencing.

Barron CR, Ramineni M, Finkelman BS et al. · 2026 · Human pathology

Objectives Women who carry a germline mutation in BRCA1 have an increased lifetime risk of developing breast cancer (BC). Prior Next-Generation Sequencing (NGS) studies on BCs from patients with germline BRCA1 mutations (gBRCA1) were…

View details →DOI: 10.1016/j.humpath.2026.106144
Negative / Null Result ReportMedicine

Heat-Killed <i>Enterococcus faecalis</i> EF-2001 Promotes Systemic Th1-Skewed Immune Activation Without Detectable Reduction of Influenza Viral Load in Mice.

Ohashi T, Hagihara M, Asai N et al. · 2026 · Microorganisms

Heat-killed Enterococcus faecalis EF-2001 (EF-2001) is a postbiotic preparation reported to modulate host immunity. However, its specific impact on host immune responses and virological outcomes during the early phase of influenza…

View details →DOI: 10.3390/microorganisms14020316
Negative / Null Result Report

Assessment of Heavy Metals in Organic and Non-Organic Vegetables Post Severe Tropical Cyclone Gabrielle: A cross-sectional comparative analysis.

Dearing C, Ye Z, Robertshaw G · 2025 · Preprint

Abstract* Background Heavy metals such as cadmium, lead, and mercury are ubiquitous in the environment, accumulating in plants, animals, water and human food. Human exposure through the consumption of vegetable crops is a global concern…

View details →DOI: 10.12688/f1000research.175538.1
Negative / Null Result ReportMedicine

Impact of neoadjuvant immunotherapy on postoperative cardiac adverse events in NSCLC: insights from a bidirectional cohort.

Yan C, Zhang X, Hu S et al. · 2026 · International journal of surgery (London, England)

The impact of neoadjuvant chemo-immunotherapy (nCIT) on perioperative cardiac safety in patients undergoing lung cancer resection remains unclear. This study aimed to evaluate the incidence and risk factors of postoperative cardiac adverse…

View details →DOI: 10.1097/js9.0000000000004846
Negative / Null Result ReportMedicine

Effect of acute intraperitoneal injection of methylglyoxal on organ injury and oxidative stress in chicks (Gallus gallus domestics).

Okino M, Makino R, Aoki M et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Methylglyoxal (MGO) is an α-dicarbonyl compound and produced from several metabolic pathways, including glucose metabolism. This compound induces oxidative stress and organ damage in mammals and is associated with various diseases,…

View details →DOI: 10.1016/j.cbpa.2026.111975
Negative / Null Result Report

Glucose coating tunes the catalytic reactivity of FeO@Fe 3 O 4 for biomedical applications: safety assessment using a 3D hepatic in vitro model

Ovalle MAM, Rozman I, Winkler EL et al. · 2026 · Preprint

Abstract Iron-oxide magnetic nanoparticles (MNPs) have been extensively investigated as magnetically actuable nanocatalysts for diagnostic and therapeutic applications. However, because wüstite/magnetite/maghemite phases can interconvert,…

View details →DOI: 10.21203/rs.3.rs-8474662/v1
Negative / Null Result Report

The Safety of Low-Molecular-Weight Heparin Bridging Therapy in Patients Receiving Preoperative Oral Antithrombotic Drugs During Spinal Fusion Surgery

Yan W, Che Z, Deng H et al. · 2026 · Preprint

Abstract 【Purpose】 To evaluate whether preoperative oral antithrombotic drugs increase perioperative bleeding risk in spinal fusion patients receiving low-molecular-weight-heparin (LMWH) bridging therapy, and compare bleeding risk with…

View details →DOI: 10.21203/rs.3.rs-8344022/v1
Negative / Null Result ReportMedicine

Shortening the perioperative prophylactic antimicrobial duration in pediatric ventriculoperitoneal (VP) shunt insertion.

Tada A, Ihara S, Suwa J et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Background Perioperative antimicrobial therapy is important to prevent central nervous system (CNS) infections following cerebrospinal fluid (CSF) shunt insertion, but the optimal duration remains unclear. This study aimed to evaluate the…

View details →DOI: 10.1111/ped.70372
Negative / Null Result ReportOpen accessMedicine

Impact of offset polyethylene liners on acetabular component loosening : an Australian Orthopaedic Association National Joint Replacement Registry-based analysis.

Shafiei SH, Latorre MR, Shimmin A · 2026 · Bone & joint open

Aims Restoring native hip biomechanics is essential for the long-term success of total hip arthroplasty (THA). Lateralized (offset) acetabular liners were developed to increase global offset and improve soft-tissue tension, but their…

View details →DOI: 10.1302/2633-1462.76.bjo-2026-0033.r1
Negative / Null Result ReportMedicine

Effectiveness of a Remote Physical Activity Intervention in Individuals with Alzheimer's Disease and their Caregivers: Results from a Randomized Trial.

Ptomey LT, Helsel BC, Montgomery RN et al. · 2026 · Medicine and science in sports and exercise

Purpose Individuals with Alzheimer's disease and related dementias (ADRD) and their caregivers often experience reduced physical activity (PA), diminished functional fitness, and heightened health risks. Remotely delivered PA interventions…

View details →DOI: 10.1249/mss.0000000000003974
Negative / Null Result ReportMedicine

Atherosclerotic Cardiovascular Risk in Patients with Chronic Hepatitis B: Tenofovir Disoproxil Fumarate Vs. Tenofovir Alafenamide: A Korean Nationwide Study.

Yang J, Lim J, Kim YJ et al. · 2026 · Journal of medical virology

Tenofovir alafenamide (TAF) exhibits antiviral efficacy comparable to tenofovir disoproxil fumarate (TDF). Nonetheless, concerns persist regarding TAF's impact on the lipid profile and potential atherosclerotic cardiovascular disease…

View details →DOI: 10.1002/jmv.70829
Negative / Null Result ReportMedicine

The Effect of High-Intensity Interval Training on Neuroplasticity-Related Proteins in the Cerebrum of Postnatally Growth-Restricted Mice.

Kim SH, Quinn MA, Ananyev J et al. · 2026 · Medicine and science in sports and exercise

Introduction Childhood growth restriction can lead to lasting developmental changes, increasing susceptibility to chronic diseases and neurodegenerative conditions in adulthood. High-intensity interval training (HIIT) elevates…

View details →DOI: 10.1249/mss.0000000000003964
Negative / Null Result ReportMedicine

A randomized trial of I-SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions.

Sunderrajan A, Cursio J, Mason N et al. · 2026 · Journal of hospital medicine

Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in…

View details →DOI: 10.1002/jhm.70273
Negative / Null Result ReportOpen accessMedicine

Effect of ruminally protected lysine on growth and nitrogen balance of grain-finished beef cattle fed diets of decreasing protein concentration.

Herzog DS, Jo J, Nakajima D et al. · 2026 · Translational animal science

Two experiments were conducted to determine the effect of ruminally protected lysine (AjiPro-L) supplementation on performance and nitrogen (N) balance of feedlot cattle fed decreasing concentrations of dietary protein. Diets contained (DM…

View details →DOI: 10.1093/tas/txag076
Negative / Null Result ReportMedicine

Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.

Medina Muñoz M, Gallego Campillo S, Martín Peinador Y et al. · 2026 · Indian pediatrics

Objective Lower respiratory tract infections (LRTIs) are a common cause of primary care visits in infants. This study was done to evaluate the course of LRTIs before-and-after the introduction of nirsevimab and to identify the associated…

View details →DOI: 10.1007/s13312-026-00385-6
Negative / Null Result ReportMedicine

The association between skin-suturing technique, prolonged healing and recurrence after Bascom's Cleft lift surgery.

Larsen MB, Faurschou IK, Haas S · 2026 · Techniques in coloproctology

Background The optimal treatment for complex Pilonidal Sinus Disease (PSD) is still debated. Despite great advances with the introduction of off-midline closure techniques, healing problems and recurrence remain challenges. We aimed to…

View details →DOI: 10.1007/s10151-026-03377-7
Negative / Null Result ReportMedicine

Impacts of temporal discrepancies between basal sap flow and canopy transpiration on estimating canopy ozone uptake in a warm temperate coniferous forest.

Tanaka R, Tokai S, Oi N et al. · 2026 · The Science of the total environment

Sap flow measured at basal trunk (Fd_base) has been used to estimate canopy transpiration and ozone uptake in forests. Although diurnal patterns of Fd_base do not always correspond to those of canopy transpiration, little is known about…

View details →DOI: 10.1016/j.scitotenv.2026.181975
Negative / Null Result ReportMedicine

The effect of Sebia's CZE IFCC-converted results on carbohydrate-deficient transferrin (CDT) interpretation in driver's license assessments.

Debunne N, De Letter K, Delanghe J et al. · 2026 · Clinical chemistry and laboratory medicine

Objectives Carbohydrate-deficient transferrin (CDT) is a specific biomarker for chronic excessive alcohol consumption. The IFCC Working Group on CDT Standardization recommends 2-sialo-transferrin (2-sialo-Tf) as the sole measurand, with a…

View details →DOI: 10.1515/cclm-2026-0346
Negative / Null Result ReportMedicine

Surgical complications after therapeutic lymph node dissection in stage III-IV melanoma: impact of neoadjuvant immunotherapy.

Lytchiér JVC, Okur MI, Rutkowski W et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Neoadjuvant immune checkpoint inhibitors (ICI) have recently entered clinical practice in management of melanoma, yet its impact on surgical outcomes remains unclear. This study evaluated the influence of neoadjuvant ICI on…

View details →DOI: 10.1016/j.ejso.2026.111403