Negative / Null Result ReportMedicine
Wang Y, Kong X, Wei H et al. · 2025 · Haemophilia : the official journal of the World Federation of Hemophilia
Introduction The Bethesda assay (BA) and the Nijmegen-Bethesda assay (NBA) are commonly used to measure inhibitors in patients with haemophilia A (HA). The laboratory results of inhibitor assays have been demonstrated to be highly…
View details →DOI: 10.1111/hae.70084 Negative / Null Result Report
Malinowska K, Wawrzynowicz M, Markowska K et al. · 2025 · Preprint
Conservation decision-making requires accurate identification of causes of population changes. Ecologists often rely on analytical protocols that aggregate high-dimensional monitoring data. We hypothesise that compressing data - either…
View details →DOI: 10.1101/2025.05.17.654658 Negative / Null Result Report
Jena S, Kim D, Lee AM et al. · 2025 · Preprint
Abstract Background: Disease heterogeneity across a diverse patient cohort poses challenges to cancer drug development due to inter-patient variability in treatment responses. However, current preclinical models fail to depict…
View details →DOI: 10.21203/rs.3.rs-6590535/v1 Failed Experiment Report
Caldwell MW, Brownstein CD, Meyer DL et al. · 2025 · Preprint
Accurate reconstruction of the timescale of organismal evolution requires placement of extinct representatives among living branches. In this way, the fossil record has the capacity to revise hypotheses of organismal evolution by producing…
View details →DOI: 10.1101/2025.04.18.649532 Negative / Null Result ReportMedicine
Hall AD, Whitehurst DA, Mortensen JE et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Malaria remains a significant public health concern in sub-Saharan Africa, particularly in Ethiopia where Plasmodium falciparum and Plasmodium vivax are co-endemic. Most cases in the United States are acquired abroad and imported.…
View details →DOI: 10.1016/j.jiac.2025.102777 Negative / Null Result ReportMedicine
Atencia S, Mateu N, Rodríguez-Cobos A et al. · 2025 · Veterinary research communications
Bordetella bronchiseptica (Bb) is a frequent pathogen in dogs and a component of the Canine Infectious Respiratory Disease Complex (CIRDC). However, it can also be detected in the lower respiratory tract of healthy animals, complicating…
View details →DOI: 10.1007/s11259-025-10826-5 Negative / Null Result Report
Kaiser A, Resasco J, Dee L · 2025 · Preprint
Abstract As urban populations grow, conserving biodiversity within cities is increasingly vital and of global policy interest. However, urban environments pose unique challenges for understanding drivers of biodiversity change, as…
View details →DOI: 10.21203/rs.3.rs-6213868/v1 Negative / Null Result ReportOpen accessMedicine
Hellingman A, Göttle NL, Walz A et al. · 2026 · ACS infectious diseases
Malaria remains a major global health threat, and the emergence of partial artemisinin resistance challenges current treatment regimens. Reliable antimalarial screening assays are therefore essential for identifying new drug candidates.…
View details →DOI: 10.1021/acsinfecdis.5c00924 Negative / Null Result ReportOpen accessMedicine
Zhang C, Li J, Zhuang W · 2026 · Frontiers in oncology
Background Acute myeloid leukemia (AML) is an acute leukemia characterized by aberrant proliferation of myeloid blasts in the bone marrow. Auer bodies are identifiable in the blasts of certain AML subtypes, but their "faggot-like"…
View details →DOI: 10.3389/fonc.2026.1791126 Negative / Null Result ReportOpen accessMedicine
Hashimoto G, Tsukagoshi Y, Saito A et al. · 2026 · JACC. Case reports
Background Inferior sinus venosus (SV) atrial septal defect (ASD) is a rare interatrial communication, found near the inferior vena cava (IVC)-right atrial (RA) junction, that may be overlooked on transesophageal echocardiography (TEE).…
View details →DOI: 10.1016/j.jaccas.2026.107644 Negative / Null Result ReportOpen accessMedicine
Cutarelli A, De Falco F, Brunetti R et al. · 2024 · Frontiers in veterinary science
Virological evaluation was performed on equine semen to detect the presence of papillomaviruses (PVs) using droplet digital polymerase chain reaction (ddPCR) as the aim of this study was to investigate whether the sperm from asymptomatic…
View details →DOI: 10.3389/fvets.2024.1427370 Negative / Null Result ReportMedicine
Thakur M, Mewara A, Lakshmi P et al. · 2025 · Diagnostic microbiology and infectious disease
Ascariasis, caused by Ascaris lumbricoides, is a widespread parasitic infection. Traditional diagnostic methods, such as microscopy, can miss infections with low worm burdens, leading to false negatives. This study compares four diagnostic…
View details →DOI: 10.1016/j.diagmicrobio.2025.116808 Negative / Null Result ReportMedicine
Wilk B, Lim H, Hicks J et al. · 2025 · JACC. Clinical electrophysiology
Background Atrial fibrillation is associated with abnormal synchronization of left atrial electrical activity and substantially increased risk of myocardial infarction, stroke and heart failure. Objectives This study sought to investigate,…
View details →DOI: 10.1016/j.jacep.2025.02.012 Negative / Null Result ReportMedicine
Fukuta K, Shimada Y, Nagamatu Y et al. · 2025 · European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Objectives The advantages of preoperative three-dimensional (3D) image simulations, which require enhanced computed tomography (ECT), for anatomical lung resection are well documented. However, the necessity for contrast agent presents a…
View details →DOI: 10.1093/ejcts/ezae449 Negative / Null Result ReportOpen accessMedicine
Hes C, Gui LT, Bay A et al. · 2025 · Molecular metabolism
Objective Growth differentiation factor 15 (GDF15) acts on the receptor dimer of GDNF family receptor alpha-like (GFRAL) and Rearranged during transfection (RET). While Gfral-expressing cells are known to be present in the area postrema…
View details →DOI: 10.1016/j.molmet.2024.102070 Failed Experiment ReportOpen accessMedicine
Janse van Vuuren R, Martel PO, Narbonne P · 2025 · microPublication biology
In C. elegans hermaphrodites, the distal tip cells (DTCs) capping the gonad arms provide a Notch ligand, the niche signal that maintains germline stem cell pools. Using fixed germlines, it was recently shown that the transcription of a…
View details →DOI: 10.17912/micropub.biology.001908 Negative / Null Result ReportMedicine
Clifton J, Woodward S, Hardcastle S et al. · 2025 · International journal of obstetric anesthesia
Background Disparities in labor epidural analgesia (LEA) management could reduce maternal satisfaction and increase risk. We compared times from the first administration of breakthrough pain medication (top-up) to LEA replacement to…
View details →DOI: 10.1016/j.ijoa.2024.104327 Negative / Null Result ReportMedicine
Allahham M, Rennert W, Miller KM et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Background Rotavirus (RV) and Adenovirus (AdV) gastroenteritis affect children worldwide. The sensitivity and specificity of the AMP Rapid Test ROTA/ADENOVIRUS [AMP-RA] for the detection of RV and AdV were compared against qPCR Allplex™…
View details →DOI: 10.1007/s10096-025-05042-7 Negative / Null Result ReportMedicine
Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)
Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…
View details →DOI: 10.1152/japplphysiol.00178.2025 Negative / Null Result ReportMedicine
Pires RHM, Simon S, Buzier R et al. · 2025 · Journal of hazardous materials
Excess of trace elements (TE) significantly alters the performances of anaerobic digestors (AD). Due to interactions with organic matter in particular, only a small fraction of TE can effectively interact with the biomass. However,…
View details →DOI: 10.1016/j.jhazmat.2024.136995 Negative / Null Result ReportOpen accessMedicine
Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…
View details →DOI: 10.3390/diagnostics16020259 Negative / Null Result ReportMedicine
Gaeta R, Giuffra V, Maixner F et al. · 2024 · International journal of paleopathology
Objective The aim of this study is to investigate potential evidence of tuberculosis in mummified remains. Materials The natural mummy of an anonymous friar from the mortuary chapel of the church of Santa Maria della Grazia in Comiso…
View details →DOI: 10.1016/j.ijpp.2024.11.001 Negative / Null Result ReportMedicine
Gonullu-Rotman D · 2024 · American journal of medical genetics. Part C, Seminars in medical genetics
This piece narrates the journey of Maria (name of the mother has been altered to protect the family's privacy), a new mother confronting her newborn's unexpected diagnosis of very long chain acyl-CoA dehydrogenase (VLCAD) deficiency,…
View details →DOI: 10.1002/ajmg.c.32109 Negative / Null Result ReportOpen accessMedicine
Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports
The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…
View details →DOI: 10.1038/s44319-026-00740-5 Negative / Null Result ReportOpen accessMedicine
Ağar ET, Yüksel C · 2026 · Journal of surgical case reports
The pyramidal lobe (PL) of the thyroid gland is a common embryological remnant; however, the presence of double PLs is an exceptionally rare anatomical variation. Failure to recognize this anomaly may result in incomplete thyroidectomy,…
View details →DOI: 10.1093/jscr/rjag049 Negative / Null Result ReportMedicine
Arega TW, Bricq S, Meriaudeau F · 2025 · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
In real-world scenarios, medical image segmentation models encounter input images that may deviate from the training images in various ways. These differences can arise from changes in image scanners and acquisition protocols, or even the…
View details →DOI: 10.1016/j.compmedimag.2024.102476 Negative / Null Result ReportMedicine
Hsu AL, Wu CW, Huang CM et al. · 2025 · Journal of psychiatric research
Late-life depression (LLD) is a heterogeneous mental disorder with a high risk of suicide, often linked to abnormalities in brain networks, particularly the prefrontal cortex. While transcranial magnetic stimulation targeting the dorsal…
View details →DOI: 10.1016/j.jpsychires.2025.04.053 Failed Experiment ReportOpen accessMedicine
Tanglay O, Jhunjhnuwala D, Huynh W · 2025 · Frontiers in human neuroscience
Introduction Post-stroke cognitive impairment (PSCI) is common and often under-recognized, particularly in the acute phase. Most cognitive screening tools provide only a global score, overlooking domain-specific deficits that influence…
View details →DOI: 10.3389/fnhum.2025.1678230 Negative / Null Result ReportMedicine
Ito S, Takano C, Hoque SA et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect…
View details →DOI: 10.1016/j.jiac.2025.102626 Negative / Null Result ReportOpen accessMedicine
Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters
The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…
View details →DOI: 10.3892/ol.2026.15647 