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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19915 results in Negative / Null Result Report · page 659 of 664

Negative / Null Result ReportOpen accessMedicine

Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study.

Jing Zhang, Vikash Vikash, Ping Wang et al. · 2019 · International Journal of Ophthalmology

AIM To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil (5-FU) for open angle glaucoma (OAG) patients after filtration surgery. METHODS As a prospective randomized interventional trial, 36…

View details →DOI: 10.18240/ijo.2019.02.08
Negative / Null Result ReportOpen access

Stress Response and Analgesia During and after Robotic-Assisted Pelvic Exenteration

A. D. Lifanova, A. A. Grazhdankin, I. Lutfarakhmanov · 2024 · Creative Surgery and Oncology

Introduction. Thoracic epidural analgesia or thoracic epidural anaesthesia (TEA) and opioid-based intravenous multimodal analgesia (MMA) provide adequate control of perioperative pain, however, comparative data are still to be gathered.…

View details →DOI: 10.24060/2076-3093-2024-14-2-105-115
Negative / Null Result ReportOpen accessMedicine

Is the Serum Vitamin D Level at the Time of Hospital-Acquired Acute Kidney Injury Diagnosis Associated with Prognosis?

Lingyun Lai, Jing Qian, Yanjiao Yang et al. · 2013 · PLoS ONE

Background Low circulating vitamin D levels have been suggested to potentially contribute to acute complications in critically ill patients. However, in patients with acute kidney injury (AKI), whether vitamin D deficiency occurs and is a…

View details →DOI: 10.1371/journal.pone.0064964
Negative / Null Result ReportOpen accessMedicine

Efficacy of a multiple-component and multifactorial personalized fall prevention program in community-dwelling older adults at moderate-to-high fall risk: The PRE.C.I.S.A. Randomized Controlled Trial

Fabio La Porta, S. Caselli, G. Lullini et al. · 2022 · medRxiv

Background: The fall risk in the elderly is a major public health issue due to the immediate injury-related consequences and the risk of associated long-term disability. However, the delivery of effective interventions for fall prevention…

View details →DOI: 10.1101/2022.03.26.22272987
Negative / Null Result ReportMedicine

Low-intensity versus high-intensity home-based treadmill training and walking attainment in young children with spastic diplegic cerebral palsy.

K. Mattern-Baxter, J. Looper, Chuan Zhou et al. · 2020 · Archives of Physical Medicine and Rehabilitation

OBJECTIVE To compare the effect of low-intensity (LI) versus high-intensity (HI) TT on walking attainment and overall walking activity in children with cerebral palsy (CP). DESIGN Prospective, multi-site, randomized controlled trial…

View details →DOI: 10.1016/j.apmr.2019.09.015
Negative / Null Result ReportOpen accessMedicine

Hypoparathyroidism: what is the best calcium carbonate supplementation intake form?

Loraine Gollino, M. Biagioni, Nathalia Regina Sabatini et al. · 2017 · Brazilian Journal of Otorhinolaryngology

Introduction In hypoparathyroidism, calcium supplementation using calcium carbonate is necessary for the hypocalcemia control. The best calcium carbonate intake form is unknown, be it associated with feeding, juice or in fasting. Objective…

View details →DOI: 10.1016/j.bjorl.2017.10.010
Negative / Null Result ReportMedicine

How does variation of the bag volume in inert gas rebreathing cardiac output measurements influence the reproducibility in patients with pulmonary diseases?

F. Trinkmann, F. Kraus, M. Borggrefe et al. · 2011 · European Respiratory Journal

Background: Cardiac output (CO) is an important hemodynamic parameter, however its determination is difficult in daily clinical routine. Non-invasive inert gas rebreathing (IGR) showed promising results in recent investigations with the…

View details →DOI: 10.1183/13993003/erj.38.suppl_55.p1526
Negative / Null Result ReportOpen accessMedicine

Assessment of proprioceptive exercises in the treatment of rotator cuff disorders in nursing professionals: a randomized controlled clinical trial.

L. V. Martins, M. Marziale · 2012 · Brazilian Journal of Physical Therapy

BACKGROUND Shoulder pain in nursing professionals may lead to limitations in occupational and daily activities and consequently interfere with quality of life. OBJECTIVE To compare the effects of two physical therapy programs which…

View details →DOI: 10.1590/s1413-35552012005000057
Negative / Null Result Report

СООТНОШЕНИЕ МЕЖДУ ГЕНДЕРНЫМИ ПСИХОЭМОЦИОНАЛЬНЫМИ ХАРАКТЕРИСТИКАМИ И ШКОЛЬНОЙ УСПЕВАЕМОСТЬЮ В РАННЕМ ПОДРОСТКОВОМ ВОЗРАСТЕ

А.И. Боравова · 2024 · Асимметрия

В работе проведен сравнительный анализ психоэмоциональных особенностей учащихся средней школы. Установлены достоверно значимые различия эмоциональных личностных характеристик между мальчиками и девочками подросткового возраста в…

View details →DOI: 10.25692/asy.2024.18.1.003
Negative / Null Result Report

Comparison of Sickle Cell Disease Patient Experiences in Developed and Developing Countries: Insights from UK and India Patient Cohorts

Ashley Lai, Kim Z Summers, Orlando Agrippa et al. · 2024 · Blood

Background Sickle cell disease (SCD) is the most common genetic blood disorder, affecting millions globally with 300,000 new cases annually. ~14,000 people live with SCD in the UK, while the number exceeds 20 million in India. Differences…

View details →DOI: 10.1182/blood-2024-210767
Negative / Null Result ReportOpen access

Correlation of Problem Based Learning Model and Discovery Learning Model with the Development of Creativity and Motivation of Students

Jaka Sayidina Ali, A. Pambudi, Stefanus Prasetyo Yudi Susanto · 2024 · International journal of multidisciplinary research and analysis

This study aims to determine the correlation of Problem-Based Learning Model and Discovery Learning Model with students' creativity and learning motivation. This research uses a quantitative approach of correlation type. . The sample in…

View details →DOI: 10.47191/ijmra/v7-i01-21
Negative / Null Result ReportOpen accessMedicine

Влияние экзогенных сурфактантов на показатели газового состава крови у новорождённых с респираторным дистресс-синдромом

A. A. Перепелица, Array М Голубев, Array В. Мороз · 2007

Objective: to study the effects of the surfactants Surfactant-BL and Curosurf on pulmonary oxygenizing properties in preterm neonatal infants with respiratory distress syndrome (RDS). The studies were performed in 81 preterm neonates with…

View details →DOI: 10.15360/1813-9779-2007-3-59
Negative / Null Result Report

Auto-Induced, Radiofrequency, Downlink Exposure Focused at the Human Ear

Hanne Herssens, Arno Thielens · 2023 · European Microwave Conference

A numerical study is performed to determine the auto-induced downlink exposure due to 5G New Radio (NR) networks at 3.5 GHz. The exposure scenario consists of a subject situated in the far-field of the base station (BS) equipped with…

View details →DOI: 10.23919/eumc58039.2023.10290507
Negative / Null Result ReportMedicine

Concepts of care for people with dementia

N. Rieckmann, C. Schwarzbach, M. Nocon et al. · 2009 · GMS Health Technology Assessment

Introduction Today there are approximately one million people with dementia in Germany. If current demographic trends continue, this number is likely to rise substantially in the coming years. In the older population, dementia is the most…

View details →DOI: 10.3205/hta000063
Negative / Null Result ReportOpen accessMedicine

Ivermectin treatment of demodicosis in 56 hamsters.

K. Tani, T. Iwanaga, K. Sonoda et al. · 2001 · Journal of Veterinary Medical Science

Fifty-six hamsters with demodicosis were treated with daily oral administration of ivermectin (0.3 mg/kg). Thirty-three cases (58.9%) were cured and 6 cases (10.7%) had improved clinically but needed to continue treatment. Of 5 cases…

View details →DOI: 10.1292/jvms.63.1245
Negative / Null Result ReportMedicine

Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe.

N. Matinhira, N. Soko, T. Bandason et al. · 2019 · International Journal of Pediatric Otorhinolaryngology

OBJECTIVE Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent thrust of the Zimbabwean government to reduce incidence of HPV related…

View details →DOI: 10.1016/j.ijporl.2018.10.036
Negative / Null Result ReportOpen accessMedicine

Vaccination counseling with and without excipient skin testing in patients with suspected allergic reactions to mRNA COVID-19 vaccines and patients with atopy

Dilawar Khokhar, K. O’Shea, C. Akin et al. · 2022 · Journal of Allergy and Clinical Immunology: Global

Background Allergic reactions have been reported with mRNA vaccines for COVID-19 prevention. Patients perceived to be at higher risk for a reaction may be referred to an allergist, although evaluation strategies may differ between…

View details →DOI: 10.1016/j.jacig.2022.05.012
Negative / Null Result ReportMedicine

Exploratory safety investigations in normal, freely moving Göttingen minipigs using telemetry: Pharmacological validation.

Julie Jacobsen, Berit Ø. Christoffersen · 2025 · Journal of pharmacological and toxicological methods

INTRODUCTION Adverse cardiovascular (CV) effects is a major cause of drug attrition. Early assessment of CV risk for new drug candidates may be warranted for early de-risking of the further development. Predictive animal models and a…

View details →DOI: 10.1016/j.vascn.2025.108395
Negative / Null Result ReportOpen accessMedicine

Evaluation of Health Literacy and Associated Factors Among Adults Living in Saudi Arabia: A Cross-Sectional Study

Yaser M. Alahmadi · 2023 · Inquiry : a journal of medical care organization, provision and financing

In this westernized culture, maintaining a healthy lifestyle has become a major health concern internationally. Health literacy is an emerging concept and requires effective measures and reform to improve the health status and health of…

View details →DOI: 10.1177/00469580231161428
Negative / Null Result ReportOpen accessMedicine

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

Jingjing Cai, Chengwen Yang, Qiuhong Wei et al. · 2023 · Pakistan Journal of Medical Sciences

Objective: To observe the therapeutic effect of natamycin combined with voriconazole in the treatment of fungal keratitis (FK). Methods: This is a retrospective study. The subjects of this study were 64 patients with FK who were admitted…

View details →DOI: 10.12669/pjms.39.3.6908
Negative / Null Result ReportMedicine

PP27 Pre-hospital lactate monitoring: a worthy adjunct to systolic blood pressure and shock index in triggering blood product administration in patients with suspected traumatic haemorrhage?

J. Griggs, M. Sherriff, J. Leung et al. · 2019 · Emergency Medicine Journal

Introduction Pre-hospital identification of patients with suspected occult traumatic haemorrhage is problematic. Physiological parameters and clinical gestalt are inadequate surrogates for ongoing haemorrhage. Lactate monitoring may hold…

View details →DOI: 10.1136/emermed-2019-999.27
Negative / Null Result ReportMedicine

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.

T. Aleman, Rachel M. Huckfeldt, Leona W. Serrano et al. · 2022 · Ophthalmology (Rochester, Minn.)

PURPOSE To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM). DESIGN Prospective, open-label, non-randomized,…

View details →DOI: 10.1016/j.ophtha.2022.06.006
Negative / Null Result ReportOpen accessMedicine

Potential effects of angiogenesis-related factors on the severity of APAC and surgical outcomes of trabeculectomy

Jing Wang, Ming-shui Fu, Min Zhou et al. · 2020 · BMC Ophthalmology

Background EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle closure (APAC) results…

View details →DOI: 10.1186/s12886-021-02051-w
Negative / Null Result Report

Production of recombinant pepsin, pancreatic lipase and colipase from Pichia pastoris as feed additive

F. Liu · 2014 · Recent progress in swine breeding and raising technologies and cutting-edge reproductive technologies and perspectives for their usage in swine

Enzyme feed additives are always added in animal nutrition to improve the quality of feeds, or to improve the animals’ growth performance and health through intensifying digestibility of the feed ingredients. This study investigated the…

View details →DOI: 10.56669/mrtp9486
Negative / Null Result ReportOpen accessPsychology

Organizational Culture and Job Satisfaction of Greek Banking Institutions

Dimitrios Belias, A. Koustelios, G. Vairaktarakis et al. · 2015

The purpose of this study is to investigate the relation between organizational culture and job satisfaction. In particular, the research hypothesis is that the type of organization culture in a specific institution is able to predict the…

View details →DOI: 10.1016/j.sbspro.2015.01.1206
Negative / Null Result Report

MODERASI KEBIJAKSANAAN DALAM HUBUNGAN IDENTITAS DIGITAL DAN PERBANDINGAN SOSIAL PADA GENERASI Z PENGGUNA LINKEDIN

Riana Sahrani, Cherry Delfina Setiawan, Callista Chandra et al. · 2026 · CENDEKIA: Jurnal Ilmu Pengetahuan

ABSTRACT Digital identity is a self-representation built through online activities and has become a crucial aspect for Generation Z, who grew up amidst technological advancements. One widely used platform is LinkedIn, which functions not…

View details →DOI: 10.51878/cendekia.v6i1.8256
Negative / Null Result ReportOpen accessMedicine

Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis

Jonathan Yun, Jingyan Yang, Michael Cloney et al. · 2017 · Frontiers in Neurology

Background Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern…

View details →DOI: 10.3389/fneur.2017.00478