A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Berge M, Hultgren O, Hugosson S et al. · 2026 · Scientific reports
There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently no reliable biomarkers to predict which patients are likely to benefit from the…
Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…
Jobson I, Vo NTN, Kujawinski E et al. · 2025 · Bioelectronic medicine
Background In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocure™, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they extend median…
Johnson KV, Steenbergen L · 2025 · Npj mental health research
The burgeoning field of the microbiome-gut-brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more…
Nimkulrat SD, Wagner MR, Waters BJ et al. · 2025 · Scientific reports
RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic β cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to β cell failure in…
Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports
We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…
Cesanelli L, Venckunas T, Minderis P et al. · 2026 · Antioxidants (Basel, Switzerland)
Background/Objectives : This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli…
Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology
Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…
Caballero P, Prieto-Amador M, Martínez-Guitarte J · 2022 · Preprint
Abstract Pesticides are an environmental problem. The search for new pest control methods has focused on compounds with low or no toxic effects in non-target organisms. Analogs of the juvenile hormone (JH) interfere endocrine system of…
Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)
α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…
Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health
This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…
Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
Winter AL, Peter M, Thunell E et al. · 2026 · Neural plasticity
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent…
Chen P, Lv J · 2024 · Nephrology (Carlton, Vic.)
This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid…
Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal
Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…
Galante H, Lane SJ, Elderbrock EK et al. · 2026 · Integrative organismal biology (Oxford, England)
Organisms in natural environments often undergo life history stage transitions that optimize behaviors (i.e., migration, reproduction, and foraging) with environmental conditions. These changes in behavior are facilitated by changes in…
García MA, Aceituno A, Díaz NB et al. · 2025 · Pharmaceutics
Background/Objectives: The static in vitro permeability assay based on cell monolayers has been widely used in the pharmaceutical industry and recognized by regulatory agencies as a surrogate method for BCS classification. However, the…
Miskelly MG, Lindqvist A, Jujić A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Statin use is associated with increased risk of type 2 diabetes (T2D) and mild hyperglycemia. The underlying mechanisms are not well studied, and the effect of statin treatment on glucagon-like peptide 1 (GLP-1) secretion or…
Alam KA, Martí-Solans J, Schall D et al. · 2026 · ACS chemical neuroscience
Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current ( I Ks ) that is…
Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice
Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…
Uysal Yeler G, Sivaslıoğlu A, Gülsün T et al. · 2025 · International journal of molecular sciences
Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in the differentiation and maturation of preadipocytes. PPARγ promotes adipogenesis by inducing the expression of fatty acid-binding protein 4 (FABP4). Uncoupling…
Crucitta S, Cinacchi P, Bargagna I et al. · 2026 · Therapeutic advances in drug safety
Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…
Shah V, Pankratz VS, Cardona M et al. · 2024
Background Given the existence of firmly entrenched and rapidly increasing health disparities, novel approaches are needed to improve the health of socioeconomically disadvantaged groups, including American Indian communities. In a prior…
van Oosterwijk JG, Richer L, Beimfohr-Griffing LK et al. · 2026 · Parasites & vectors
Background The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease…
Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology
Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…
Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research
We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…
Tseng M, Middleton SJ, Farah A et al. · 2025 · Pain reports
Introduction Hyperexcitability, particularly of DRG neurons, is a key driver of persistent pain states including neuropathic pain. Contactin-associated protein-like 2 (CASPR2) is transmembrane protein known to interact and regulate the…
Poljo A, Reichl JJ, Bürgi S et al. · 2025 · Obesity surgery
Background Obesity, a chronic disease with serious associated medical problems, remains a global health challenge. While metabolic bariatric surgery (MBS) is the most effective treatment for weight loss, GLP-1 receptor agonists (RAs) are…
Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity
Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…