e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20289 results in Negative / Null Result Report · page 650 of 677

Negative / Null Result ReportMedicine

SARS-CoV-2 spike-directed T cells and anti-receptor-binding-domain antibodies in hematological patients receiving three mRNA COVID-19 vaccine doses.

Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)

Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…

View details →DOI: 10.1016/j.eimce.2026.503146
Negative / Null Result Report

Choriodecidual Ureaplasma parvum infection induces fetal lung inflammation prior to intra-amniotic infection in a nonhuman primate model

Tripathy S, Crilley N, Morgan TK et al. · 2026 · Preprint

ABSTRACT Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity. Intrauterine infection-driven chorioamnionitis is strongly associated with preterm labor, fetal inflammatory response syndrome,…

View details →DOI: 10.64898/2026.06.06.730594
Negative / Null Result ReportMedicine

Short-term effects of static stretching versus myofascial release on hamstring tightness and lower extremity function in sedentary IT professionals: a randomized controlled trial.

Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation

Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…

View details →DOI: 10.1186/s13102-026-01818-2
Negative / Null Result ReportOpen accessMedicine

Does mRNA-based COVID-19 vaccination in the subacute phase lead to microstructural brain changes? A prospective pilot MRI study using T1 relaxometry.

Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports

Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…

View details →DOI: 10.1038/s41598-026-56181-6
Negative / Null Result Report

Turnip mosaic virus-based gRNA delivery system for plant genome editing

Khwanbua E, Lappe RR, Bierl AA et al. · 2026 · Preprint

Plant virus-based gRNA delivery systems offer a rapid alternative to stable transformation for CRISPR-mediated genome editing, but potyvirus-based platforms in Cas9-expressing plants are still underexplored. Here, we developed a turnip…

View details →DOI: 10.64898/2026.04.22.720221
Negative / Null Result ReportMedicine

Contact Allergy to Topical Corticosteroids in Atopic Dermatitis: Diagnostic Gaps in Baseline Patch Testing.

Zaryczańska A, Sokołowska-Wojdyło M, Wilkowska A et al. · 2026 · Contact dermatitis

Background Chronic exposure to topical corticosteroids (TCS) in patients with atopic dermatitis (AD) may increase the risk of allergic contact dermatitis (ACD), which can mimic flares of the underlying disease and remain underrecognized.…

View details →DOI: 10.1111/cod.70192
Negative / Null Result ReportMedicine

Prospective Study of Cytomegalovirus Reactivation in Patients With Multiple Myeloma Receiving Anti-CD38 and BCMA Therapies.

Baneman E, Jacobs SE, Rana M et al. · 2026 · Clinical lymphoma, myeloma & leukemia

Background Cytomegalovirus (CMV) is an opportunistic pathogen that causes infection in certain immunocompromised hosts, but the risk of clinically significant CMV infection in patients with multiple myeloma (MM) is not well understood.…

View details →DOI: 10.1016/j.clml.2026.05.008
Negative / Null Result ReportMedicine

Comprehensive evaluation of reference miRNA for extracellular miRNA quantification in CKD.

Srivastava A, Maienschein-Cline M, Pabalan A et al. · 2026 · Methods (San Diego, Calif.)

MicroRNAs (miRNAs) are promising biomarkers and therapeutic targets; however, reliable extracellular miRNA quantification by RT-qPCR depends on appropriate normalization, and no universal endogenous reference has been established. This…

View details →DOI: 10.1016/j.ymeth.2026.05.010
Negative / Null Result ReportOpen accessMedicine

X-rays and gamma rays do not differ in their effectiveness for sterilizing pupae and adults of the mosquito Aedes aegypti (Diptera: Culicidae).

Chen C, Qualls WA, Xue RD et al. · 2026 · Journal of economic entomology

The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.)…

View details →DOI: 10.1093/jee/toaf030
Negative / Null Result ReportOpen accessMedicine

Association between anti-Mullerian hormone and antithyroid antibodies detectability and positivity in women assisted at a fertility clinic.

Oliveira YIL, Couto A, Sá PG et al. · 2025 · JBRA assisted reproduction

Objective To evaluate the association between antithyroid antibodies detectability and positivity and ovarian reserve. Additionally, we aimed to evaluate the correlation between TSH levels and parameters of ovarian reserve [anti-Mullerian…

View details →DOI: 10.5935/1518-0557.20250032
Negative / Null Result Report

Assessing the Reliability and Minimal Detectable Change of Frontal Plane Projection Angles During Single-leg Tasks in Individuals with Patellofemoral Pain

Nagahori H, Liang JN, Keefer I et al. · 2026 · Preprint

Abstract This study conducted a secondary analysis of a previous study to evaluate the test-retest reliability, standard error of measurement (SEM), and minimal detectable change (MDC) of frontal plane projection angles across five…

View details →DOI: 10.21203/rs.3.rs-8183647/v1
Negative / Null Result ReportMedicine

Detection capabilities of a single dried blood spot for recombinant erythropoietin micro-dose testing in sport.

Requena-Tutusaus L, Anselmo I, Coll S et al. · 2026 · Journal of pharmacological and toxicological methods

Objectives Dried blood spot (DBS) micro-sampling is gaining prominence in anti-doping testing, particularly for the detection of erythropoietin-receptor agonists (ERAs) such as recombinant erythropoietin (rEPO). However, detecting…

View details →DOI: 10.1016/j.vascn.2026.108423
Negative / Null Result ReportOpen accessMedicine

Early Transplantation After Pretransplant Reduction of <i>TP53</i>-Altered Clones and Prolonged Dose-Adjusted Azacitidine Maintenance: A Three-Case Series.

Yamagata F, Yoshihara K, Nannya Y et al. · 2026 · EJHaem

TP53 -altered myeloid neoplasms are associated with an extremely high risk of relapse even after allogeneic hematopoietic cell transplantation (allo-HCT), and the optimal pretransplant and posttransplant strategies remain undefined. We…

View details →DOI: 10.1002/jha2.70315
Negative / Null Result ReportOpen accessMedicine

Liver Transplantation for HBV-Related Disease in France: NUC Type Before LT Is Associated With Patient Survival.

Bienvenue I, Roux O, Coilly A et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed…

View details →DOI: 10.1111/liv.70737
Negative / Null Result ReportMedicine

Reliability of Inertial Sensors for Measuring Scapular Kinematics in Individuals With Shoulder Pain and Scapular Dyskinesis.

Oliveira FADS, Santos LRH, Silva HAD et al. · 2026 · Journal of sport rehabilitation

Context Scapular dyskinesis is frequently associated with subacromial pain syndrome (SAPS), and clinicians increasingly use inertial sensors as a portable, low-cost option to assess scapular kinematics. However, the reliability of these…

View details →DOI: 10.1123/jsr.2026-0055
Negative / Null Result ReportOpen accessMedicine

Occurrence of Ochratoxin A in Edible Pig Tissues (Kidneys, Liver, Muscle and Fat) in Greece Determined by HPLC-FD.

Vlachou M, Solomakos N, Govaris A et al. · 2026 · Toxins

This study aimed to assess the occurrence and contamination levels of OTA in edible tissues of slaughtered pigs in Greece using high-performance liquid chromatography with fluorescence detection (HPLC-FD). Kidney, liver, muscle, and fat…

View details →DOI: 10.3390/toxins18040181
Negative / Null Result ReportOpen accessMedicine

Pattern-Matched Powered Gait Orthosis Training in Patients with Neurological Gait Impairment: A Multicenter Prospective Pilot Study of Hip and Knee-Ankle-Foot Orthoses.

Yun YJ, Moon C, Kim KH et al. · 2026 · Journal of clinical medicine

Background : Wearable powered gait orthoses offer a clinically flexible alternative to treadmill-based robotic systems, yet evidence on different device configurations matched to the site of neuromuscular impairment remains limited.…

View details →DOI: 10.3390/jcm15103580
Negative / Null Result ReportMedicine

Detectable global temperature responses to wildfires and volcanic eruptions.

Li Y, Santer BD, Solomon S et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Large volcanic eruptions and intense wildfires perturb Earth's atmospheric temperature. Understanding the climate response to such natural forcings is essential for obtaining reliable estimates of its response to anthropogenic greenhouse…

View details →DOI: 10.1073/pnas.2525500123
Negative / Null Result ReportOpen accessMedicine

Association of caffeine levels with myocardial perfusion during pharmacological stress cardiac magnetic resonance imaging.

Iribarren A, Obrutu O, Maughan J et al. · 2026 · American heart journal plus : cardiology research and practice

Background Caffeine, a nonselective adenosine A2 receptor antagonist, blunts adenosine-induced coronary hyperemia. Despite recommended abstinence before adenosine stress cardiac magnetic resonance imaging (CMRi), residual caffeine may…

View details →DOI: 10.1016/j.ahjo.2025.100709
Negative / Null Result ReportMedicine

Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.

Sivanandam P, Syenina A, Chan YF et al. · 2026 · Communications medicine

Background Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown if systemically administered…

View details →DOI: 10.1038/s43856-026-01678-4
Negative / Null Result ReportOpen accessMedicine

Concurrent chemoradiotherapy plus nimotuzumab versus chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma with a suboptimal response to induction chemotherapy: a randomized phase 2 trial.

Liu LT, Sun XS, Quan TT et al. · 2026 · Nature communications

Induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (LA-NPC); however, patients with a suboptimal response to IC, defined as detectable…

View details →DOI: 10.1038/s41467-026-71019-5
Negative / Null Result ReportOpen accessMedicine

Pre-Post Motor-Cognitive and Shooting Performance Patterns in Security-Force Applicants During a Fixed-Order Acute-Load Protocol: A Descriptive Pilot Study.

Němá K, Kačúr P, Kozák T et al. · 2026 · Journal of functional morphology and kinesiology

Background: Operational performance in security-force settings depends on maintaining accurate motor-cognitive and shooting performance under acute physical strain. This descriptive pilot study examined pre-post performance patterns during…

View details →DOI: 10.3390/jfmk11020183
Negative / Null Result ReportOpen accessMedicine

Interrater Reliability of the Ankylosing Spondylitis Performance Index in Patients With Axial Spondyloarthritis.

Rasmussen CA, Mink SB, Primdahl J et al. · 2026 · Musculoskeletal care

Introduction In recent years, the Ankylosing Spondylitis Performance Index (ASPI) has emerged as a new objective measure of physical function in patients with axial spondyloarthritis (axSpA). So far, only the relative interrater…

View details →DOI: 10.1002/msc.70224