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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 644 of 725

Negative / Null Result ReportOpen accessMedicine

LIPID PROFILES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA ON L-ASPARAGINASE THERAPY

Janan G. Hasan · 2010 · The Medical Journal of Basrah University

ABSTRACT Background: Abnormal blood lipid profiles have been associated with many malignant diseases especially in children with acute lymphoblastic leukemia on L-asparaginase therapy Objective: To investigate the frequency and clinical significance of altered lipid profiles in children with Acute lymphoblastic leukemia (ALL) on L-asparaginase therapy Patients and Methods: A prospective study was carried out between February 2008 till January 2009 on a total of 50 patients with recently diagnosed and non-treated acute lymphoblastic leukemia who were admitted to pediatric oncology unit at Basra

View details →DOI: 10.33762/mjbu.2010.49464
Negative / Null Result ReportOpen accessBiology (General)

Increased Circulating H3 Histone in Response to Repeated Bouts of Exercise Does Not Associate with Parallel Alterations of Cell-Free DNA

Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology

Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond

View details →DOI: 10.3390/biology10030181
Negative / Null Result ReportOpen accessPsychiatry

C-reactive protein levels and cognitive functions in patients with bipolar disorder

O. Elleuch, M. Maalej, W. Guidara et al. · 2023 · European Psychiatry

Introduction The pathophysiology of bipolar disorder (BD) is complex and remains uncertain to this day. Several hypotheses have been suggested, including the involvement of inflammatory mechanisms in its pathogenesis and in eventual cognitive impairment. C-reactive protein (CRP) is one of the most commonly used inflammatory markers. High-sensitivity CRP (hs- CRP) is a more sensitive marker. Objectives We aimed to examine hs-CRP levels in patients with BD, and to investigate its relationship with cognitive functions. Methods We conducted a cross-sectional study between June 2016 and July 2018 o

View details →DOI: 10.1192/j.eurpsy.2023.1482
Negative / Null Result ReportOpen accessMedicine

GSDM gene polymorphisms regulate the IgE level in asthmatic patients.

Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi et al. · 2022 · PLoS ONE

Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients. Objective In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C

View details →DOI: 10.1371/journal.pone.0274951
Negative / Null Result ReportOpen accessGeophysics. Cosmic physics

Magnesian clay minerals and their influence on pores in the first member of Middle Permian Maokou Formation, southern Sichuan Basin

Liyu ZHANG, Donghua YOU, Rong LI et al. · 2025 · Shiyou shiyan dizhi

In recent years, multiple wells in the Sichuan Basin have produced industrial gas from the marlstone/marl-bearing limestone strata in the first member of the Middle Permian Maokou Formation (Mao 1), demonstrating promising exploration potential. Previous studies have suggested that the marlstone/marl-bearing limestone in Mao 1 exhibits self-generation and self-storage characteristics, forming low-porosity, low-permeability fracture-porosity type tight carbonate reservoirs with diverse storage spaces. Notably, diagenetic shrinkage pores and fractures formed during the transformation of sepiolit

View details →DOI: 10.11781/sysydz2025050974
Negative / Null Result ReportOpen accessImmunologic diseases. Allergy

Comprehensive 18F-FDG PET-based radiomics in elevating the pathological response to neoadjuvant immunochemotherapy for resectable stage III non-small-cell lung cancer: A pilot study

Yingpu Cui, Yingpu Cui, Yaobin Lin et al. · 2022 · Frontiers in Immunology

PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with chemotherapy and underwent 18F-FDG PET/CT were enrolled. Baseline 18F-FDG PET/CT was performed before treatment, and preoperative 18F-FDG PET/CT was performed three weeks after the completion of neoadjuvant treatment. Surgical resection was performed 4–5 weeks after the completion of neoadjuvant treatm

View details →DOI: 10.3389/fimmu.2022.994917
Negative / Null Result ReportOpen accessMedicine

Correlation Between Exercise Frequency and Menstrual Cycle Characteristics in Perimenopausal Women Aged 45–50 Years

Ni Luh Kadek Alit Arsani, Luh Ari Arini, Luh Yenny Armayanti et al. · 2026 · Althea Medical Journal

Background: During perimenopause, declining estrogen levels often lead to altered menstrual patterns and other age-related health concerns. Consequently, the role of physical activity warrants closer examination. This study investigated the correlation between exercise frequency and menstrual cycle characteristics in premenopausal women Methods: A cross-sectional observational study was conducted in Singaraja City, Indonesia, from July to October 2024. A total of 150 premenopausal women aged 45–50 years were recruited through random sampling. Exercise frequency was measured using the World Hea

View details →DOI: 10.15850/amj.v13n2.4594
Negative / Null Result ReportOpen accessVeterinary medicine

The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate

Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery

Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between

View details →DOI: 10.1177/1098612x241266418
Negative / Null Result ReportOpen accessMedicine

Characteristics of atmospheric dustfall fluxes and particle size in an open pit coal mining area and surrounding areas

Yayuan Deng, Hongxuan Wu, Tingning Zhao et al. · 2025 · Scientific Reports

Abstract Atmospheric dustfall is solid air pollutant, which is mainly influenced by local sources, so it has a major impact on the local environment and the health of local residents. The objective of this study was to investigate the distribution characteristics of dustfall fluxes and particle size, and the meteorological factors affected them. Atmospheric dustfall was collected in an open-pit coal mining area and surrounding areas in the arid desert area of Northwest China from March to December 2018. Dustfall fluxes was measured, particle size was measured by using graphical methods and gra

View details →DOI: 10.1038/s41598-025-94161-4
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

The role of suction drainage in the management of peri-operative bleeding in Total and Unicomcompartmental knee arthroplasty: a retrospective comparative study

Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders

Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o

View details →DOI: 10.1186/s12891-021-04868-4
Negative / Null Result ReportOpen accessVeterinary medicine

Exploring the relationship between calcitonin, ionized calcium, and bone turnover in cats with and without naturally occurring hypercalcemia

Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science

ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.

View details →DOI: 10.3389/fvets.2024.1399942
Replication Failure

PENGARUH PENDIDIKAN KARYAWAN DAN PELATIHAN KARYAWAN TERHADAP KUALITAS KERJA KARYAWAN (Studi Kasus Karyawan PT. Anugrah Mandiri Sejaterah

Anisatul Fauziah · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary

Persaingan dalam lingkungan kerja saat ini semakin ketat, ini menuntut perusahaan terus menerus mengembangkan usahanya untuk dapat bersaing dengan perusahaan lain. Oleh karena itu dibutuhkan pengelola manajemen perusahaan yang biasa…

View details →DOI: 10.62668/significant.v2i02.863
Negative / Null Result ReportOpen accessMedicine

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients.

M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology

BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…

View details →DOI: 10.1016/j.ijcard.2016.04.064
Negative / Null Result ReportOpen accessMedicine

Grading angiogenesis in oral squamous cell carcinoma: a histomorphometric study.

V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research

CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…

View details →DOI: 10.4103/0970-9290.156792
Negative / Null Result ReportOpen access

Microscale Dynamics of Larval Fish Assemblages in the Straits of Malacca Nearshore Coincided with Lunar Phases

Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science

Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…

View details →DOI: 10.47836/pjtas.46.4.18
Negative / Null Result ReportOpen accessMedicine

Cardiac Effects of in utero Exposure to Antiretroviral Therapy in HIV-Uninfected Children Born to HIV-Infected Mothers

S. Lipshultz, Paige L. Williams, B. Zeldow et al. · 2015 · AIDS (London)

Objectives:We evaluated the potential cardiac effects of in-utero exposures to antiretroviral drugs in HIV-exposed but uninfected (HEU) children. Design and methods:We compared echocardiographic parameters of left ventricular function…

View details →DOI: 10.1097/qad.0000000000000499
Negative / Null Result ReportMedicine

Reappraisal of Electrocardiographic Criteria for Localization of Idiopathic Outflow Region Ventricular Arrhythmias.

James K. Gabriels, M. Abdelrahman, Lakshmi Nambiar et al. · 2021 · Heart Rhythm

BACKGROUND Electrocardiographic (ECG) criteria have been proposed to localize the site of origin (SOO) of outflow region ventricular arrhythmias (VAs). Many factors influence the QRS morphology of VAs and may limit the accuracy of these…

View details →DOI: 10.1016/j.hrthm.2021.08.003
Negative / Null Result ReportMedicine

Trial of Electronic Medical Record Integrated Next-Generation Sequencing Ordering in Veterans Affairs Cancer Care

J. Stoeckle, S. Poland, H. Maynard et al. · 2024 · JCO Precision Oncology

PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New…

View details →DOI: 10.1200/po.23.00463
Negative / Null Result ReportOpen accessMedicine

Successful weight loss maintenance in relation to method of weight loss

Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity

This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…

View details →DOI: 10.1038/oby.2008.364
Negative / Null Result ReportMedicine

Comparative Pathologic Analysis of Breast Cancers Classified as HER2/neu-Amplified by FISH Using a Standard HER2/CEP17 Dual Probe and an Alternative Chromosome 17 Control Probe

Somaye Y. Zare, Leo I. Lin, Abrar Alghamdi et al. · 2018 · American Journal of Surgical Pathology

At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an…

View details →DOI: 10.1097/pas.0000000000001106
Negative / Null Result ReportOpen accessMedicine

Sex differences in uric acid and NT-pro BNP assessments during coronary severity

Guofeng Guo, Zhaoqi Huang, Shixiang Wang et al. · 2020 · Medicine

Abstract To investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and coronary artery severity in acute coronary syndrome patients of different sexes. A total of 134 patients…

View details →DOI: 10.1097/md.0000000000019653
Negative / Null Result ReportMedicine

Accuracy comparison of 3D printed tooth-supported implant surgical guides: A prospective observational clinical study.

A. Rezaei, Farnoush Fotovat, Ali Heidari et al. · 2026 · The Journal of prosthetic dentistry (Print)

STATEMENT OF PROBLEM Implant-supported prostheses provide a reliable method of replacing missing teeth. To avoid complications, their accurate placement is critical. Advances in static computer-aided implant surgery (sCAIS), which uses…

View details →DOI: 10.1016/j.prosdent.2025.12.026
Negative / Null Result ReportOpen accessMedicine

UBLED AF study for safety and efficacy between uninterrupted edoxaban, warfarin and rivaroxaban for AF/Fl ablation patients

N. Kumar, N. Elbanhawy, S. Chalil et al. · 2021

Type of funding sources: None. Catheter ablation in patients with atrial fibrillation (AF)/atrial flutter carries a risk of thromboembolism and major bleeding. Oral anticoagulation is advised for prevention of thromboembolic complications.…

View details →DOI: 10.1093/europace/euab116.559
Negative / Null Result ReportMedicine

Impact of Moderate‐Intensity Multicomponent Training on Cardiometabolic Health‐Related Outcomes in Older Adults With Overweight and Obesity: A 9‐Month Quasi‐Experimental Single‐Arm Pretest‐Posttest Study

Enzo Berbery, Vitor de Salles Painelli, Paulo Vitor Suto Aizava et al. · 2026 · Australasian Journal on Ageing

ABSTRACT Objective The aim of this study was to investigate the effects of a moderate‐intensity multicomponent training (MCT) program on body composition, physical function, glycaemic control and lipid profiles in overweight and obese…

View details →DOI: 10.1111/ajag.70176
Negative / Null Result ReportOpen accessMedicine

Perbandingan Pemberian Informasi Verbal dengan Presentasi Video Terhadap Pengetahuan Prosedur Anestesi Umum pada Pasien yang Akan Menjalani Operasi di RSUP DR Hasan Sadikin Bandung

Yodi Suryo Arnanto, Ruli Herman Sitanggang, Nurita Dian Kestriani Saragi Sitio · 2018 · Jurnal Anestesi Perioperatif

Informasi mengenai indikasi, tujuan, prosedur, risiko, manfaat, dan alternatif tindakan anestesi yang akan dilakukan harus disampaikan kepada pasien. Pemberian informasi dilakukan secara verbal atau lisan pada saat proses persetujuan…

View details →DOI: 10.15851/jap.v6n3.1351
Negative / Null Result ReportOpen accessMedicine

The effect of photobiomodulation on histamine and Mucuna pruriens-induced pruritus, hyperknesis and alloknesis in healthy volunteers: A double-blind, randomized, sham-controlled study

K. Lang-Illievich, C. Klivinyi, Heike Schulze-Bauer et al. · 2024 · PLoS ONE

Background Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom. Objectives This study investigated the efficacy of…

View details →DOI: 10.1371/journal.pone.0307034
Negative / Null Result ReportOpen accessMedicine

Repeatability of Pentacam-derived intraocular lens decentration measurements and the level of agreement with OPD-Scan III: A prospective observational case series

Xiaobao Liu, Wenjie Wu, Yulong Huang et al. · 2024 · PLoS ONE

Purpose This study aimed to assess the repeatability of intraocular lens (IOL) decentration measurements obtained through Pentacam, based on corneal topographic axis (CTA) and pupillary axis (PA), and to evaluate the level of agreement…

View details →DOI: 10.1371/journal.pone.0299064
Negative / Null Result ReportMedicine

Static and dynamic effects of customized insoles on attenuating arch collapse with pregnancy: A randomized controlled trial.

N. Segal, Lauren N. Neuman, Maria C Hochstedler et al. · 2018 · The Foot

INTRODUCTION Anthropometric changes to the feet with pregnancy may increase risk for musculoskeletal disease. Customized arch-supportive orthoses to prevent anthropometric changes could potentially provide an inexpensive means to prevent…

View details →DOI: 10.1016/j.foot.2018.07.007
Negative / Null Result ReportOpen access

Haematology profile of dogs with primary uterine inertia

P. Magnus, C. Jayakumar, N. Thomas et al. · 2023 · Journal of Veterinary and Animal Sciences

Primary uterine inertia is the inherent inability of the uterus to contract and expel a fully grown foetus after the end of the gestation period, through a normal birth canal, in the absence of obstructive dystocia.There are conflicting…

View details →DOI: 10.51966/jvas.2023.54.1.7-12