Negative / Null Result ReportMedicine
Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal
The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…
View details →DOI: 10.22037/iej.v21i1.46586 Failed Experiment ReportMedicine
Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
View details →DOI: 10.1002/prp2.70277 Negative / Null Result ReportMedicine
Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence
Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…
View details →DOI: 10.2147/ppa.s596598 Negative / Null Result ReportMedicine
Coşansu, Osoria, Juneja · 2026 · Journal of food protection
This study investigated the effects of sodium chloride (NaCl), grape seed extract (GSE), and cooling duration on the growth of Clostridium perfringens in cooked ground beef during slow exponential cooling. Meat samples containing…
View details →DOI: 10.1016/j.jfp.2026.100828 Negative / Null Result ReportMedicine
MacInnes, Ferrer-Vicens, Hancock et al. · 2026 · Blood advances
The RNA-binding protein IMP1 is a developmentally expressed, post-transcriptional regulator involved in mRNA stability and translation. In the erythroid lineage, IMP1 was found expressed in fetal, but repressed in adult erythroid cells,…
View details →DOI: 10.1182/bloodadvances.2025019406 Negative / Null Result ReportMedicine
Guendouz, Devriendt · 2026 · Molecular immunology
In livestock species such as pigs, antibiotics are frequently used during weaning, a period of increased susceptibility to infections. However, the emergence and spread of antimicrobial resistance necessitate alternative strategies to…
View details →DOI: 10.1016/j.molimm.2026.06.002 Negative / Null Result ReportMedicine
Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine
To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…
View details →DOI: 10.1007/s41999-026-01519-6 Negative / Null Result ReportMedicine
da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…
View details →DOI: 10.1080/19440049.2026.2683670 Negative / Null Result ReportMedicine
Hu, El-Sappah, Chen et al. · 2026 · Frontiers in plant science
Understanding the temperature sensitivity ( Q 10 ) of soil respiration (RS) and its response to nitrogen (N) and phosphorus (P) fertilization is essential for predicting soil carbon dynamics under climate change. However, seasonal…
View details →DOI: 10.3389/fpls.2026.1795072 Negative / Null Result ReportMedicine
Ziltzer, Bulbul, Barry et al. · 2026 · The Laryngoscope
To investigate whether routine involvement of the medical hospitalist service (MHS) in postoperative medical management of head and neck cancer (HNC) patients undergoing major ablative head and neck surgery with free tissue transfer (FTT)…
View details →DOI: 10.1002/lary.70659 Negative / Null Result ReportMedicine
Wang, Li, Zhang et al. · 2026 · Child development
This study examines how center-based parenting interventions aimed at improving early child development in rural China affect the mental health of caregivers. Data from an analytic sample of 615 caregiver-child dyads (children aged 6 to 24…
View details →DOI: 10.1093/chidev/aacag099 Negative / Null Result ReportMedicine
Gurcay, Bilgin, Sert et al. · 2026 · Advances in skin & wound care
Frailty, resulting from physical and psychological factors, may lead to the development of care dependency in people diagnosed with diabetic foot. This study was conducted to determine frailty and care dependency in patients diagnosed with…
View details →DOI: 10.1097/asw.0000000000000461 Negative / Null Result ReportMedicine
Molnes, Vinje, Opheim et al. · 2026 · Translational animal science
In June 2023, an incident at a Norwegian feed mill caused pig feed being over-supplemented with sodium selenite (NaSe), resulting in feed selenium concentrations ranging from 2.47 to 4.70 mg Se/kg feed from sodium selenite (NaSe),…
View details →DOI: 10.1093/tas/txag048 Negative / Null Result ReportMedicine
Cui, Luo, Tajika et al. · 2026 · Journal of affective disorders
This study aimed to examine the effectiveness of smartphone-delivered cognitive behavioral therapy (CBT) in participants with subthreshold depression, considering the potential influence of physical comorbidities. In this secondary…
View details →DOI: 10.1016/j.jad.2026.121954 Negative / Null Result ReportMedicine
Bai, Kim, Cao et al. · 2026 · Social psychiatry and psychiatric epidemiology
Universal Credit (UC) is a major UK welfare reform that consolidates six means-tested benefits into a single monthly payment, aiming to simplify benefits delivery and incentivize labor market participation. However, concerns have emerged…
View details →DOI: 10.1007/s00127-026-03108-1 Negative / Null Result ReportMedicine
Sun, Gong, Liu et al. · 2026 · Molecules (Basel, Switzerland)
A novel urea complexation technology was developed based on the agglomeration phenomenon induced by ambient-temperature agitation of a ternary system consisting of urea, water and fatty acid ethyl esters (EEs). The agglomeration phenomenon…
View details →DOI: 10.3390/molecules31091452 Negative / Null Result ReportMedicine
Guleria, Horijan, Kumar et al. · 2026 · Scientific reports
The study aimed to evaluate fumigation and repellent properties of essential oils (EOs) from Juniperus macropoda leaves and cedarwood, Cedrus deodara against storage pests viz., Tribolium castaneum and Callosobruchus maculatus. Further,…
View details →DOI: 10.1038/s41598-026-52009-5 Negative / Null Result ReportMedicine
Heidari, Amiri, Mobarakeh · 2026 · Journal of speech, language, and hearing research : JSLHR
Age-related hearing loss (ARHL) has been associated with cognitive decline. Although bilingualism may influence cognitive performance, its interaction with hearing loss remains unclear. This study aimed to investigate the effects of ARHL…
View details →DOI: 10.1044/2026_jslhr-25-00649 Negative / Null Result ReportMedicine
Wang, Lv, Zeng et al. · 2026 · Neurocritical care
This study compared the effectiveness of noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC) in preventing reintubation among neurosurgical intensive care patients following extubation. A retrospective…
View details →DOI: 10.1007/s12028-026-02495-2 Negative / Null Result ReportMedicine
Aouimeur, Sagnial, Travers et al. · 2026 · Scientific reports
Primary human corneal endothelial cell (CEC) culture is a key step toward developing cell-based therapies for corneal endothelial diseases, yet its success remains highly variable, particularly when using tissues from older donors. This…
View details →DOI: 10.1038/s41598-026-52213-3 Negative / Null Result ReportMedicine
Kizuki, Kaneko, Taniguchi et al. · 2026 · Sleep and biological rhythms
We previously found that seasonal changes in sleep duration were affected by sex, residential area, and age in Japanese community residents. This study aimed to determine whether these factors also affect the seasonality of…
View details →DOI: 10.1007/s41105-025-00621-9 Negative / Null Result ReportMedicine
Yang, Jang, Park et al. · 2026 · Veterinary ophthalmology
To evaluate the clinical efficacy of a newly developed adhesive tissue sealant, gelatinized cornea-derived decellularized extracellular matrix (Cod-ECM) for the treatment of stromal ulcers in dogs. This study included 60 eyes of 56 dogs…
View details →DOI: 10.1111/vop.70181 Negative / Null Result ReportMedicine
Campbell, Wilson, Du Plessis et al. · 2026 · Journal of neurotrauma
Following a mild traumatic brain injury (mTBI), up to 30% of individuals will experience persisting symptoms beyond 3 months. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has shown…
View details →DOI: 10.1177/08977151261440773 Negative / Null Result ReportMedicine
Antoniou, Yang, Juurlink et al. · 2026 · Clinical pharmacology and therapeutics
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co-administration with CYP3A4-inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the…
View details →DOI: 10.1002/cpt.70267 Negative / Null Result ReportMedicine
Huggins, Martinez, Baird et al. · 2026 · Journal of neurotrauma
Mild traumatic brain injury (mTBI), a common health burden among combat veterans, has been associated with alterations in brain structure. Moreover, post-traumatic stress disorder (PTSD), frequently comorbid with mTBI, is linked to smaller…
View details →DOI: 10.1177/08977151261438986 Negative / Null Result ReportMedicine
Abdolahi, Li, Zou et al. · 2026 · Translational vision science & technology
To assess the performance of an artificial intelligence deep learning (DL) model compared with neuro-ophthalmologists for the classification of subjects with elevated intracranial pressure (ICP) and papilledema versus control subjects,…
View details →DOI: 10.1167/tvst.15.4.2 Negative / Null Result ReportMedicine
Gozen, Sezgin, Yavuzer et al. · 2026 · Frontiers in pharmacology
Propofol is a short-acting intravenous hypnotic anesthetic widely used for sedation and the induction and maintenance of general anesthesia. Although it reliably produces unconsciousness, its intrinsic analgesic efficacy remains a subject…
View details →DOI: 10.3389/fphar.2026.1773526 Negative / Null Result ReportMedicine
Schmeisk-Rosa, Andersen, Cordeiro et al. · 2026 · Plant and soil
In highly weathered soils of central Amazonia, where nutrients such as phosphorus (P) and base cations are scarce, fertilization experiments have demonstrated above- and belowground effects on total net primary productivity (NPP). This…
View details →DOI: 10.1007/s11104-026-08303-2 Negative / Null Result ReportMedicine
Yigitbay, Kural, Tanrıverdi et al. · 2026 · Foot & ankle specialist
ObjectiveThis study aimed to identify the possible risk factors for the development of partial bridging and synostosis in the distal tibiofibular joint following surgically treated ankle fracture-dislocations and to examine the effects of…
View details →DOI: 10.1177/19386400261426837 Negative / Null Result ReportMedicine
Bacchetta, Vacchelli, Pica et al. · 2026 · Ecotoxicology (London, England)
Micro- and nanoplastic toxicity is a growing environmental concern, especially in aquatic ecosystems. This study investigates the acute and chronic effects of polypropylene microfibers (PP MFs), derived from artificially aged surgical face…
View details →DOI: 10.1007/s10646-026-03077-w 