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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21368 results · page 643 of 713

Negative / Null Result ReportOpen accessMedicine

A Benchmark Side-by-Side Comparison of Two Well-Established Protocols for in vitro Hematopoietic Differentiation From Human Pluripotent Stem Cells

F. Gutiérrez-Agüera, Virginia C. Rodríguez-Cortez, P. Petazzi et al. · 2021 · Frontiers in Cell and Developmental Biology

The generation of transplantable hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) remains challenging. Current differentiation protocols from hPSCs generate mostly hematopoietic progenitors of the primitive…

View details →DOI: 10.3389/fcell.2021.636704
Negative / Null Result ReportMedicine

Which clinical factors and biochemical parameters differentiate major depressive disorder with versus without lifetime psychotic symptoms?

C. M. Esposito, F. Legnani, J. Barkin et al. · 2026 · International journal of psychiatry in clinical practice

OBJECTIVE Major depressive disorder (MDD) is a prevalent disabling condition, with psychotic features complicating its course and management. Purpose of the study is to identify clinical and biochemical factors differentiating psychotic…

View details →DOI: 10.1080/13651501.2025.2611928
Negative / Null Result Report

DIALECTIC BEHAVIOUR THERAPYAND ASSERTIVENESS TRAINING IN MANAGING CHALLENGES OF MENTAL HEALTH AMONG ADOLESCENTS WHO ABUSE SUBSTANCES IN PORT-HARCOURT METROPOLIS

Kienka, Kienka, · 2026 · Journal of Professional Counselling

One of the rapidly growing global concerns today is the abuse of various substances that are linked with mental health with significant threat to the psychosocial challenges common in Nigeria. One of the pertinent problems is the…

View details →DOI: 10.61955/iopjof
Negative / Null Result ReportOpen accessPsychology

The Effects of a Structured and Unstructured Kindergarten Program on the Readiness Scores of Children in Selected Public Schools in Lafayette Parish, Louisiana.

Mary Coletta mcdonough Newkome · 1974

The major purpose of this study was to determine if there was a significant difference in readiness test scores between students who participated in a structured kindergarten program and those who participated in an unstructured program.…

View details →DOI: 10.31390/gradschool_disstheses.2684
Negative / Null Result ReportOpen accessMedicine

Evaluation of the Effectiveness and Safety of a Multifaceted Computerized Antimicrobial Stewardship Intervention in Surgical Settings: A Single-center Cluster-randomized Controlled Trial.

Xin Yuan, Kai Chen, Jing Yuan et al. · 2023 · International Journal of Antimicrobial Agents

BACKGROUND Inappropriate antimicrobial use is common for patients undergoing surgery. Whether a multifaceted computerized antimicrobial stewardship program is effective and safe in reducing inappropriate antimicrobial use in surgical…

View details →DOI: 10.1016/j.ijantimicag.2023.106787
Negative / Null Result ReportOpen accessBiology

Effects of new polymorphisms in the bovine myocyte enhancer factor 2D (MEF2D) gene on the expression rates of the longissimus dorsi muscle

E. Juszczuk-Kubiak, R. Starzyński, T. Sakowski et al. · 2012 · Molecular Biology Reports

Myocyte enhancer factor 2D (MEF2D), a product of the MEF2D gene, belongs to the myocyte enhancer factor 2 (MEF2) protein family which is involved in vertebrate skeletal muscle development and differentiation during myogenesis. The aim of…

View details →DOI: 10.1007/s11033-012-1689-6
Negative / Null Result ReportOpen accessChemistry

Trehalose may prevent postsurgical adhesions in a rabbit model of hysterotomy.

H. Fujino, Soojung Lee, Shigeki Suzuki et al. · 2011 · Journal of Veterinary Medical Science

The adhesion-preventing effect of trehalose in visceral organs was evaluated in a rabbit model. All rabbits underwent a hysterotomy, during which mild abrasion and desiccation was induced on the surfaces of visceral organs. In the control…

View details →DOI: 10.1292/jvms.10-0342
Negative / Null Result ReportOpen accessMedicine

Physical activity-related injuries of college students in southern China: A 1-year prospective study

Dongchun Tang, Weicong Cai, Yang Gao et al. · 2020 · Scientific Reports

This prospective study was to describe the incidence and characteristics of physical activity-related injuries (PARI) among college students in southern China. Online questionnaires and telephone interviews were combined to investigate the…

View details →DOI: 10.1038/s41598-020-64317-5
Negative / Null Result ReportOpen accessMedicine

Medical management in locally advanced and metastatic prostate cancer: Does changes in treatment policy have any specific effect on PSA levels?

M. Bağcıoğlu, C. Surcel, S. Ozcan et al. · 2017 · Archivio Italiano di Urologia e Andrologia

OBJECTIVE Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of…

View details →DOI: 10.4081/aiua.2017.4.282
Negative / Null Result ReportOpen accessMedicine

No difference in anti-spike antibody and surrogate viral neutralization following SARS-CoV-2 booster vaccination in persons with HIV compared to controls (CO-HIV Study)

Kendall Kling, Patrick Janulis, A. Demonbreun et al. · 2023 · Frontiers in Immunology

Background Understanding the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination will enable accurate counseling and inform evolving vaccination strategies. Little is known about antibody response…

View details →DOI: 10.3389/fimmu.2022.1048776
Negative / Null Result Report

Performance and Carass Potential of Pantaneiro Lambs Supplemented with Saccharomyces cerevisiae

Rafaela Machado dos Santos, Simone Fernanda Nedel Pértile, Marcos Barbosa Ferreira et al. · 2024 · Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde

Abstract The aim of this study was to evaluate the effect of a feed additive for feedlot Pantaneiro lambs on weight gain, dry matter intake, carcass and meat characteristics, in addition to the comparison between males and females. Eleven…

View details →DOI: 10.17921/1415-6938.2024v28n2p203-208
Replication FailureOpen access

Effect of feeding low protein diets supplemented with selected essential amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets

N. Mohan, M. Dipu, K. Ally et al. · 2023 · Journal of Veterinary and Animal Sciences

A study was conducted to assess the effect of feeding low protein diets supplemented with selected amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets. Thirty Large White Yorkshire female piglets…

View details →DOI: 10.51966/jvas.2023.54.2.537-543
Negative / Null Result ReportOpen access

Association of β-Globin Gene Haplotypes with Haematological Parameters and Foetal Haemoglobin among Patients with Sickle Cell Disorder in Raipur, Chhattisgarh, India

S. Bhagat, A. Thakur · 2023 · Journal of Clinical and Diagnostic Research

Introduction: Sickle cell disease is caused by a single nucleotide substitution in the β-globin gene. The variations in Foetal Haemoglobin (HbF) levels, β-globin gene cluster haplotype have been used as predictors of disease severity in…

View details →DOI: 10.7860/jcdr/2023/58342.17445
Negative / Null Result ReportOpen accessMedicine

The Neonatal Congenital Anomalies: Incidence and Risk Factors Before and After the war at Al-Thawrah Hospital- Sana'a,Yemen.

F. M. Abol-Gaith, N. Ismail, A. Al-Mutawakel · 2019 · Assiut Scientific Nursing Journal

Background: Congenital anomalies (CAs) are structural or functional abnormalities that occur during intrauterine life and can be identified prenatally, at birth or may be detected in infancy later. Aim: To compare the incidence and risk…

View details →DOI: 10.21608/asnj.2019.69565
Negative / Null Result ReportOpen access

Pertumbuhan Transplan Karang Lunak Sinularia polydactyla dan S. asterolobata Berdasarkan Metode Tebar Dasar dan Penempelan Substrat Pada Lokasi yang Berbeda

I. G. A. B. K. Jayantika, I. Dharma, W. Widiastuti · 2021

Soft coral transplantations are widely used for rehabilitation of coral reef ecosystems and commercial needs with common method are substrated-attached and placed on the metal table frame. These methods are considered as costly. This study…

View details →DOI: 10.24843/jmrt.2021.v04.i01.p07
Negative / Null Result Report

EFFECT OF PILATES AND YOGA ON PRIMARY DYSMENORRHEA AMONG WOMEN WITH FIBROMYALGIA

E. Sen, Varsha Chorsiya, S.Savitha Priyanka et al. · 2023 · europeanchemicalbulletin

Background: Primary Dysmenorrhea (PD), depression, anxiety, and stress among women with Fibromyalgia (FM) and healthy females are the common problems seen these days. It is important to determine possible factors related to Primary…

View details →DOI: 10.48047/ecb/2023.12.si5a.0508
Negative / Null Result ReportOpen accessMedicine

“Customized Titanium Mesh versus Titanium Reinforced Membrane in localized Alveolar Ridge Augmentation with Simultaneously delayed implant placement” A randomized clinical study

Maha Shaikh, A. Gamal, Ahmed Amr · 2020

Aim: To compare two different alveolar ridge augmentation (ARA) approaches applied in conjunction with delayed dental implants regarding the enhancement of the buccolingual alveolar ridge width and the changes in alveolar crestal level…

View details →DOI: 10.21608/edj.2020.36620.1181
Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of subcutaneous vs. transvenous implantable defibrillator therapy in a polymorbid patient cohort

B. Kattih, F. Operhalski, F. Boeckling et al. · 2022 · Frontiers in Cardiovascular Medicine

Background The subcutaneous implantable cardioverter-defibrillator (S-ICD) has been designed to overcome lead-related complications and device endocarditis. Lacking the ability for pacing or resynchronization therapy its usage is limited…

View details →DOI: 10.3389/fcvm.2022.1008311
Negative / Null Result ReportOpen accessPsychology

Comportamentos de Fair Play e Antiesportivos: Avaliação dos Árbitros Fair Play and Unsporting Behavior: Evaluation of Referees Comportamientos de Fair Play y No-deportivos: Evaluación del Juez

Marcella Andressa Bosquetti, Amanda Oliveira de Morais, Leandro Ricardo Altimari et al. · 2017

This study aimed to investigate fair play behaviors and anti-sports in futsal games Sub 9 and Sub 15 categories, through the referees' evaluation. Participated 17 referees who refereed games in 1o division of a futsal championship in a…

View details →DOI: 10.18761/pac.2015.6.1.a05
Negative / Null Result ReportOpen accessMedicine

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation

Olga Mineeva-Sangwo, Joan Martí-Carreras, E. Cleenders et al. · 2022 · Viruses

BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.…

View details →DOI: 10.3390/v14071533
Negative / Null Result ReportMedicine

Factors affecting long-term prognosis in adult patients with psychogenic non-epileptic seizures.

Turksever Meliha, Guldiken Baburhan, Ozkan Hulya et al. · 2024 · Ideggyógyászati Szemle

Background and purpose Among epileptic patients who are monitored using the video-electroencephalography monitoring (VEM) technique, in some patients a psychogenic non-epileptic seizure (PNES) can be identified as a definitive diagnosis.…

View details →DOI: 10.18071/isz.77.0021
Negative / Null Result ReportOpen accessBiology

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

J. Hoozemans, E. S. van Haastert, Robert Veerhuis et al. · 2005 · Journal of Neuroinflammation

Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still…

View details →DOI: 10.1186/1742-2094-2-27
Negative / Null Result ReportMedicine

Metabolic and Nutritional Outcomes After Sleeve Gastrostomy and Gastric Bypass in Adolescents: A Cohort Study with 1-Year Follow-Up

Faraneh Zolfaghari, M. Barzin, M. Mahdavi et al. · 2025 · Hormone and Metabolic Research

Abstract We conducted this study to compare the anthropometric and metabolic outcomes and nutritional status, after sleeve gastrostomy (SG) and gastric bypass (GB) in adolescents with severe obesity. We selected 219 adolescents with severe…

View details →DOI: 10.1055/a-2679-9676
Negative / Null Result ReportOpen accessMedicine

Open simple prostatectomy and robotic simple prostatectomy for large benign prostatic hyperplasia: Comparison of safety and efficacy

J. Cho, K. T. Moon, J. Lee et al. · 2021 · Prostate International

Background To compare the safety and efficacy of open simple prostatectomy (OSP) and robotic simple prostatectomy (RSP) for the treatment of large benign prostatic hyperplasia (BPH). Materials and methods We retrospectively reviewed the…

View details →DOI: 10.1016/j.prnil.2020.11.004
Negative / Null Result ReportMedicine

Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.

R. Khazanchi, K. Nandoliya, Maryam N. Shahin et al. · 2024 · Journal of Neurosurgery

OBJECTIVE Whether obesity is associated with meningioma and the impact of obesity by gender has been debated. The primary objective of this study was to investigate differences in BMI between male and female patients undergoing craniotomy…

View details →DOI: 10.3171/2023.11.jns23732
Negative / Null Result Report

Pemberian POC Urine Ternak Berbeda Konsentrasi Terhadap Pertumbuhan dan Serapan Kalium Tanaman Jagung Manis (Zea Mays L.)

Dhanu Pangestu Anggi Dinata, Anis Sholihah · 2024 · Folium : Jurnal Ilmu Pertanian

Livestock urine is one of the potential raw materials for for making potential liquid organic fertilizer (POC). Livestock urine contains various important nutrients, such as nitrogen, phosphorus, and potassium. Research This research was…

View details →DOI: 10.33474/folium.v8i2.22351
Negative / Null Result Report

Relationship Between Work-life Balance and Quality of Life among Millennials and Generation Z: a Correlation and Independent T Test Study

Nachaal S, M. R, Kavyaprabha N · 2026 · International Journal For Multidisciplinary Research

The present study aimed to investigate the relationship between Work-Life Balance (WLB) and Quality of Life (QOL) among Millennials and Generation Z employees through a quantitative correlational research design. To achieve this purpose,…

View details →DOI: 10.36948/ijfmr.2026.v08i02.74785
Negative / Null Result ReportMedicine

Safety and efficacy of anifrolumab therapy in systemic lupus erythematosus in real-world clinical practice: LOOPS registry.

Y. Miyazaki, M. Funada, S. Nakayamada et al. · 2023 · Rheumatology

OBJECTIVES To determine the safety and efficacy of anifrolumab in patients with systemic lupus erythematosus (SLE) classified based on the Lupus Low Disease Activity State (LLDAS) in real-world clinical practice. METHODS This retrospective…

View details →DOI: 10.1093/rheumatology/kead568