Negative / Null Result ReportOpen accessMedicine
Marjolein M Iversen, Giesje Nefs, Grethe S Tell et al. · 2016 · PLoS ONE
Aim To examine whether elevated anxiety and/or depressive symptoms are related to all-cause mortality in people with Type 2 diabetes, not using insulin. Methods 948 participants in the community-wide Nord-Trøndelag Health Survey conducted during 1995-97 completed the Hospital Anxiety and Depression Scale with subscales of anxiety (HADS-A) and depression (HADS-D). Elevated symptoms were defined as HADS-A or HADS-D ≥8. Participants with type 2 diabetes, not using insulin, were followed until November 21, 2012 or death. Cox regression analyses were used to estimate associations between baseline e
View details →DOI: 10.1371/journal.pone.0160861 Negative / Null Result ReportOpen accessPathology
Yeganeh Shekari, Zahra Mahmoodi, Mohammadtaghi Ghorbani Hesari et al. · 2026 · Molecular Pain
Background: Chronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene polymorphism (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype. Methods: This case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40–80 years. Participants were assessed for
View details →DOI: 10.1177/17448069261439611 Negative / Null Result ReportMedicine
Stokbro, Liebregts, Baan et al. · 2026 · Scientific reports
The aim of this study was to evaluate the influences of surgical sequencing on the postoperative occlusion in bimaxillary osteotomies. Patients who underwent bimaxillary surgery without maxillary segmentation, based on a virtual surgical…
View details →DOI: 10.1038/s41598-026-52284-2 Negative / Null Result ReportOpen accessPediatrics
Claire Howarth, Christian Mifsud, Christian Mifsud et al. · 2024 · Frontiers in Pediatrics
IntroductionThere is significant uncertainty regarding the role that anaemia or red blood cell transfusion (RBCT) plays in the development of gut injury in preterm infants. This study evaluated Near Infrared Spectroscopy (NIRS) together with a range of known biomarkers of gut inflammation to identify their relationship with anaemia and RBCT.MethodA prospective observational study of preterm infants born at <30 weeks gestation was conducted from birth until either 36 weeks post conceptional age or discharge home. Gut perfusion and biomarkers of gut injury were assessed weekly by: 60 min NIRS me
View details →DOI: 10.3389/fped.2024.1440537 Negative / Null Result ReportOpen accessTheory and practice of education
Chatelaine M. Wansi · 2026 · International Journal of Multidisciplinary Educational Research and Innovation
Physics and engineering are like two peas in a pod; one cannot be complete without the other. Physics is an integral part of the engineering curricula as the latter is founded on principles of our physical world. Thus, understanding the level of physics conceptual comprehension and mathematical proficiency of civil engineering students as well as identifying factors that affect it helps educators, academic institutions, and policy-makers better serve and prepare students as reliable future civil engineers. This research utilized a quantitative research design, specifically a predictive correla
View details →DOI: 10.64637/709619 Negative / Null Result ReportOpen accessMedicine
Haure Osman Muhammad Hamadamin, Samir Mahmood Othman · 2026 · Zanco Journal of Medical Sciences
Background and objective: Obesity is a chronic, multifactorial condition characterized by an excessive accumulation of body fat that presents significant health risks. Community pharmacists, for instance, are highly accessible and often serve as the first point of contact for patients seeking advice on weight management. This study aims to fill a research gap by evaluating community pharmacists’ knowledge, attitudes, and practices related to obesity and weight management. Methods: A cross-sectional study was carried out among 331 community pharmacists among different pharmacy settings in Erbil
View details →DOI: 10.15218/zjms.2026.003 Negative / Null Result ReportOpen accessPublic aspects of medicine
Hatice Özyılmaz, Serdar Bağlar · 2026 · BMC Public Health
Abstract Background Adolescence is a critical milestone in the transition to adulthood. Factors affecting oral health, an essential component of general health during this period, also influence public health. This study investigates the potential impact of parental education level (PEL) and daily total daily screen time (DTST) on adolescent oral health using a large sample size. Methods A total of 1300 adolescents aged 17 and 18 from Ordu Province were included in this study. A structured questionnaire was used to assess PEL, DTST, and other habits that may influence dental caries. Oral healt
View details →DOI: 10.1186/s12889-025-25923-y Negative / Null Result ReportOpen accessMedicine
Michinobu Umakoshi, Akiko Nakamura, Hiroyuki Tsuchie et al. · 2023 · Scientific Reports
Abstract Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-posit
View details →DOI: 10.1038/s41598-023-28024-1 Negative / Null Result ReportOpen accessMedicine
N Bushra Thasneem, Resmi S. Kaimal, Abdul Hakeem Thengu Murichathil · 2025 · Journal of Family Medicine and Primary Care
Introduction: Anaemia is one of the significant public health problems faced by developing countries. It occurs more frequently in women of childbearing age. Anaemia causes poor work capacity, and severe forms may even cause cardiac failure. In pregnant women, anaemia may lead to preterm labour, low-birth-weight babies, and increased risk of maternal mortality due to post-partum haemorrhage. Even though there are national programmes to supply iron free of cost and other measures to tackle anaemia, it is still prevalent in our country. Anaemia prevalence has increased between NFHS-4 and NFHS-5,
View details →DOI: 10.4103/jfmpc.jfmpc_1456_24 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Mylène Duivon, Joy Perrier, Carine Segura-Djezzar et al. · 2022 · Frontiers in Neuroscience
BackgroundPrevious studies have revealed both sleep alterations and prospective memory (PM) impairments in breast cancer (BC) patients. PM refers to memory of intended actions and is crucial for daily living tasks and treatment compliance. As sleep is known to favor memory consolidation, one may expect that changes in sleep quality related to BC would have an impact on PM performance. This study aimed at assessing sleep-dependent consolidation of intentions using an ecological, virtual reality-based PM task in BC patients not treated with chemotherapy.Materials and methodsThirty-seven early st
View details →DOI: 10.3389/fnins.2022.908268 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Guglielmo Arzilli, Lorenzo Stacchini, Virginia Casigliani et al. · 2023 · Human Vaccines & Immunotherapeutics
The decline in children’s vaccination coverage and the resurgence of preventable infectious diseases draw attention to parents’ vaccine hesitancy. Our study introduces two validated tools to independently assess vaccine hesitancy and health literacy among parents with school-age children. We developed a Vaccine Confidence Index (VCI) from 10 Likert items, exploring their relationships through exploratory and confirmatory factor analyses. We modified the IMETER (Italian medical term recognition test) to measure health literacy. We assessed the internal consistency of the modified IMETER and the
View details →DOI: 10.1080/21645515.2023.2271765 Negative / Null Result ReportOpen accessDermatology
Das Nilay, Ghosh Pramit, Das Suchibrata et al. · 2008 · Indian Journal of Dermatology
Background: Onychomycosis manifests itself in various forms, notably onychodystrophy, onycholysis, subungual hyperkeratosis, or nail-plate discoloration. Not necessarily nail changes mentioned here should always be of fungal origin. Objective: The present study is planned to get an idea about etiological agent and clinical correlation in fingernail onychomycosis. Materials and Methods: Nail-clipping and subungual debris of patients with above mentioned nail changes were subjected to KOH preparation. Culture was done on SDA and SDCCA media. Species identification was done by colony character, p
Negative / Null Result ReportOpen accessCytology
Weijie Cao, Xingang Li, Xiaoyu Zhang et al. · 2019 · Cells
Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide m
View details →DOI: 10.3390/cells8020159 Negative / Null Result ReportOpen accessPublic aspects of medicine
Batoul Ghosn, Leila Azadbakht, Mohammad Reza Monazzam Esmaeilpour et al. · 2024 · BMC Public Health
Abstract Background Despite numerous studies that have explored the association between individual antioxidants or specific combinations and the risk of hearing loss, there is lack of information regarding the relationship between dietary total antioxidant capacity (dTAC) and hearing loss. The conflicting results on this association further highlight the need for more research in this area. This study aims to investigate the association between overall dietary antioxidant intake and the risk of hearing loss among Iranian adults. Methods This cross-sectional study recruited 3443 adult participa
View details →DOI: 10.1186/s12889-024-18108-6 Negative / Null Result ReportOpen accessMedicine
Muhammad Hussain Iqbal, Tanveer Hussain, Fariha Khalid et al. · 2020 · Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of diastasis recti abdominis and its associated risk factors in postpartum women. Study Design: Cross-sectional study. Place and Duration of Study: Omar Medical Center Lahore, Yaseen Medical Center Lahore and Social Security Hospital Lahore, from Sep 2019 to Dec 2019. Methodology: This study included 128 participants fulfilling the eligibility criteria. The assessment of diastasis recti abdominis was done manually by a female physiotherapist using single finger, double finger and three finger methods on abdomen at three levels: at the umbilicus, 4.5 cm bel
Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Mohammad Mehrazmay, Ensi Khalili Pouya, Elham Keshavarz · 2021 · Journal of Kerman University of Medical Sciences
Background: Breast cancer is a major health problem in Iran with increasing incidence in the recent years. Breast density is one of the most important risk factors for developing breast cancer. Metabolic syndrome that is defined by the presence of multiple clinical and lab data findings has also been shown to be related with breast cancer.Methods: A sample of 246 cases who referred to Mahdiyeh hospital in Tehran were selected according to the inclusion criteria and a form was prepared including breast density in the screening mammogram done in our center and recent lab tests including FBS, HDL
View details →DOI: 10.22062/jkmu.2021.91831 Negative / Null Result ReportOpen accessDentistry
Song Cai, SiYu Li, YaShi Zhou et al. · 2024 · BMC Oral Health
Abstract Background Sedentary behavior (SB) may contribute to obesity and lower extremity fluid retention, which may favor the development of obstructive sleep apnea (OSA). However, linking sedentary behavior to OSA is unclear. The purpose of this study was to determine if there is an association between SB and OSA. Methods Three typical questions in the NHANES questionnaire(①The frequency of feeling excessively sleepy per month. ②The frequency of gasping, snorting or stopping breathing per week. ③The frequency of snoring per week.) have been used for the assessment of OSA. A physical activity
View details →DOI: 10.1186/s12903-024-03960-0 Negative / Null Result ReportOpen accessDermatology
Jie Gao, Linting Wei, Xinghan Liu et al. · 2017 · Kidney & Blood Pressure Research
Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between
View details →DOI: 10.1159/000473889 Negative / Null Result ReportOpen accessMedicine
Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
View details →DOI: 10.7860/jcdr/2022/55267.16473 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sung Ui Jung, Kwang Kuk Park, Song I Yang et al. · 2014 · Korean Journal of Clinical Oncology
Purpose: Mutations in the p53 gene and accumulation of p53 protein are the most common genetic events in gastric carcinomas. This study evaluates the association of p53 gene expression with clinicopathologic findings and prognosis of gastric cancer patients who underwent curative resection. Methods: Retrospective analysis was performed on 236 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between December 2011 and September 2012. Nuclear p53 expression was detected by immunohistochemistry. Results: p53 expression was detected in 213 patie
View details →DOI: 10.14216/kjco.14003 Negative / Null Result ReportOpen accessMedicine
Zoya maqsood , Shahid Jamal Siddiqui, Nimarta Bai et al. · 2025 · Journal of the Dow University of Health Sciences
Objective: To determine the frequency of raised intraocular pressure (IOP) following neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy in pseudophakic patients and to compare outcomes between high- and low-energy procedures. Methods: This descriptive cross-sectional study was conducted at the Department of Ophthalmology, Khairpur Medical College / Civil Hospital, Khairpur Mirs, Pakistan from April to September 2024. A total of 139 pseudophakic patients with posterior capsular opacification (PCO) undergoing Nd:YAG capsulotomy were enrolled. Baseline demographic and clinical dat
Negative / Null Result ReportOpen accessOphthalmology
Sepehr Feizi, Mohammad Ali Javadi · 2019 · Journal of Ophthalmic & Vision Research
Purpose: To evaluate the effects of donor graft thickness on postoperative best spectacle-corrected visual acuity (BSCVA), refractive outcomes, endothelial cell density (ECD) and function, intraocular pressure (IOP), and postoperative complications after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This retrospective, interventional case series enrolled 77 eyes of 64 patients who underwent DSAEK with or without simultaneous cataract surgery. Clinical outcomes, including BSCVA, refraction, keratometric astigmatism, IOP, and ECD were assessed at the final follow-up exa
View details →DOI: 10.4103/jovr.jovr_55_17 Negative / Null Result ReportOpen accessIndustrial safety. Industrial accident prevention
Ridha Ramayanti · 2017 · The Indonesian Journal of Occupational Safety and Health
ABSTRACT Work fatigue is condition which some factors have interaction with the workers. Fatigue may occur in the workforce by various factors, such as nutritional status and work climate. This study was conducted to analyze the relationship between nutritional status and work climate with work fatigue in Hikmah Food Catering. This was an observational analytic study using a cross sectional design. Samples size 43 peoples were taken by simple random sampling method. The correlation between the dependent and independent variables were analyzed by spearman correlation test (α = 0,05). Work clima
View details →DOI: 10.20473/ijosh.v4i2.2015.177-186 Negative / Null Result ReportOpen accessMedicine (General)
Margaret Diana , Deviana Soraya Riu, Fatmawati Madya et al. · 2025 · Obgynia
Objective: This study aimed to investigate the impact of SHS exposure on fetal biometry and umbilical artery flow at 24 – 28 weeks of gestation. Methods: This cross-sectional study included 110 pregnant women, divided into a study group (55 passive) smokers and a control group (55 non-passive smokers). Serum cotinine levels were measured using ELISA. Fetal biometry (biparietal diameter, head circumference, abdominal circumference, and femur length) and umbilical artery flow (pulsatility and resistance indices) were assessed via ultrasound and Doppler ultrasonography. Group comparisons were con
View details →DOI: 10.24198/obgynia.v8i3.956 Negative / Null Result ReportOpen accessDermatology
Souvik Sardar, Somenath Sarkar, Indrashis Podder et al. · 2022 · Indian Journal of Dermatology
Background: Primary scarring alopecias (PSAs) are a rare group of dermatological disorders with overlapping clinical features. They result in permanent hair loss and significant psychological morbidity. Aims: To analyze the clinico-epidemiology of PSAs of the scalp, along with clinico-pathological correlation. Methods: We conducted a cross sectional, observational study including 53 histopathologically confirmed cases of PSA. Clinico-demographic parameters, hair care practices, and histologic characteristics were noted and statistically analyzed. Results: Among 53 patients (mean age 30.9 ± 8.1
View details →DOI: 10.4103/ijd.ijd_540_21 Negative / Null Result ReportOpen accessBiology (General)
Brajušković G., Nikolić Zorana, Kojić A. et al. · 2013 · Archives of Biological Sciences
Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS identified 8q24 as one of the most significant PCa-associated regions. The aim of this study was to evaluate the association of SNP rs378854 at 8q24 with PCa risk in the Serbian population. The study population included 261 individua
View details →DOI: 10.2298/abs1302475b Negative / Null Result ReportOpen accessMedicine
Nissar Shaikh, Huda Al Mahdi, Anant Pai et al. · 2022 · Annals of Medicine
Introduction COVID-19 patients presenting with ocular manifestations are from 0.8% to 32% of patients seen in the ED. The available literature is scarce regarding COVID-19 patients presenting with ocular manifestations from the Middle Eastern region. Purpose This study aims to report the incidence of ocular signs and symptoms in COVID-19 patients and find any correlation between the occurrence of ocular manifestations and patients’ comorbidities. Methods All patients having the primary diagnosis of COVID-19 infection and concurrent ocular manifestations on admission to our tertiary COVID-19 he
View details →DOI: 10.1080/07853890.2022.2029554 Negative / Null Result ReportOpen accessMedicine
Kiho Sung, Junsol Kim, Yeong-Ran Park et al. · 2026 · Scientific Reports
Abstract Cardiovascular disease (CVD) is prevalent among older adults, but studies often focus on individual spouses rather than couple dynamics. This study examines how interplay between spouses—specifically discordance in gender role attitudes—relates to CVD risk biomarkers, using couple-matched data from the Korean Social Life, Health, and Aging Project (KSHAP) on 308 older married couples (616 individuals). Actor-partner interdependence models (APIM) reveal that discordant gender role attitudes are significantly associated with higher CVD risk markers—higher systolic blood pressure, higher
View details →DOI: 10.1038/s41598-026-41697-8 Negative / Null Result ReportOpen accessGeriatrics
Han SB · 2017 · Clinical Interventions in Aging
Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED) in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designe
Negative / Null Result ReportOpen accessPublic aspects of medicine
Chen Zhang, Yuanyuan Wang, Wei Xie et al. · 2024 · BMC Public Health
Abstract Background Hypertension is one of the major public health problems in China. Limited evidence exists regarding sex differences in the association between hypertension and air pollutants, as well as the impact of dietary factors on the relationship between air pollutants and hypertension. The aim of this study was to investigate the sex-specific effects of dietary patterns on the association between fine particulate matter (PM2.5), ozone(O3) and hypertension in adults residing in Jiangsu Province of China. Methods A total of 3189 adults from the 2015 China Adult Chronic Disease and Nut
View details →DOI: 10.1186/s12889-024-18620-9 