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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 633 of 725

Negative / Null Result ReportMedicine

Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level.

Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…

View details →DOI: 10.1002/smi.70167
Negative / Null Result ReportMedicine

Lack of association between Helicobacter pylori and pediatric atopy: Evidence from a Latin American multicenter cohort.

Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…

View details →DOI: 10.1002/jpn3.70237
Negative / Null Result ReportMedicine

Spatial Association between Air Pollution and Non-communicable Diseases and their Distribution in India.

Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…

View details →DOI: 10.4103/ijcm.ijcm_209_25
Negative / Null Result Report

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · Preprint

Abstract Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy, and to determine whether therapeutic…

View details →DOI: 10.21203/rs.3.rs-8673450/v1
Negative / Null Result ReportMedicine

The lack of association between cumulative MTX dose and liver fibrosis in PsA: a cohort study.

Kharouf F, Mehta P, Carrizo Abarza V et al. · 2025 · Rheumatology (Oxford, England)

Objectives Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic…

View details →DOI: 10.1093/rheumatology/keaf282
Negative / Null Result ReportMedicine

Quantitative assessments of ultrasound-based rotator cuff muscle quality.

Nasr AJ, Wang H, Khazzam M et al. · 2026 · PM & R : the journal of injury, function, and rehabilitation

Background Fatty infiltration and muscle atrophy strongly influence clinical outcomes in patients with rotator cuff tears. Emerging quantitative techniques integrated with brightness-mode ultrasound and shear wave elastography (SWE) have…

View details →DOI: 10.1002/pmrj.70097
Negative / Null Result ReportOpen accessMedicine

Lack of association between G6PD variants and Parkinson disease.

Chifamba LV, Parlar SC, Liu L et al. · 2026 · HGG advances

Oxidative stress has been implicated in Parkinson disease (PD). Genes involved in PD, such as PRKN, PINK1, and PARK7, contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase,…

View details →DOI: 10.1016/j.xhgg.2025.100555
Negative / Null Result ReportMedicine

Association of Psychotropic and Opioid Medication Use With Physical Function in Hospitalized Older Adults With Dementia.

Kim N, Resnick B, Galik E et al. · 2026 · Journal of gerontological nursing

Purpose To examine whether psychotropic medications (antipsychotics, sedatives, antiseizures, antidepressants, and anxiolytics) and opioids were associated with physical function in hospitalized older adults with dementia. Method A…

View details →DOI: 10.3928/00989134-20251104-01
Negative / Null Result ReportMedicine

Impact of Selective Serotonin Reuptake Inhibitors on Bleeding Rates in HeartMate 3 Left Ventricular Assist Device Patients Not Taking Aspirin.

Ganter M, Bowyer M, Relic E et al. · 2026 · Artificial organs

Background Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) therapy have been associated with increased bleeding risk in left ventricular assist device (LVAD) patients receiving warfarin…

View details →DOI: 10.1111/aor.70078
Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

View details →DOI: 10.1053/j.jrn.2025.06.003
Negative / Null Result ReportMedicine

Postoperative Fever Following Pelvic and Acetabular Fixation: Incidence, Risk Factors, and Lack of Association With Surgical Site Infection.

Ayoub M, Curtis E, Vue Y et al. · 2025 · Orthopedics

Background Despite numerous studies showing postoperative fever can be a common and benign occurrence, there is still a significant and costly workup when fevers occur after surgery, including for orthopedic patients with pelvic ring and…

View details →DOI: 10.3928/01477447-20250506-01
Negative / Null Result Report

CD44v6 Promotes Proliferation, Migration, and Invasion in Cholangiocarcinoma Cells, but Lacks Independent Prognostic Significance

Myint KZ, Rattanasinganchan P, Moolthiya P et al. · 2025 · Preprint

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile duct epithelium. Alt-hough the CD44v6 splice variant is implicated in the progression of numerous cancers, its functional role and clinical relevance in CCA remain poorly…

View details →DOI: 10.20944/preprints202509.1220.v1
Negative / Null Result ReportMedicine

SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study.

Velez MP, Treacy K, Shellenberger J et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18-44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from…

View details →DOI: 10.1016/j.jogc.2025.103159
Negative / Null Result ReportMedicine

25-Hydroxyvitamin D levels are associated with mortality and cardiovascular events in systemic lupus erythematosus.

Assawasaksakul T, Fava A, Goldman D et al. · 2026 · Annals of the rheumatic diseases

Objectives We assessed the association between 25-hydroxyvitamin D (25(OH)D) levels and rates of mortality and cardiovascular events (stroke, myocardial infarction, angina/bypass) in patients with systemic lupus erythematosus (SLE).…

View details →DOI: 10.1016/j.ard.2025.10.013
Negative / Null Result ReportMedicine

The role of susceptibility weighted imaging as a substitute to post-contrast T1-weighed images in detection of active multiple sclerosis lesions.

Rashad Ali F, Teiba MK, Sheha AS et al. · 2026 · Clinical radiology

Background and purpose Magnetic susceptibility levels of multiple sclerosis plaques increase as they convert from the active enhancing stage to the chronic or inactive nonenhancing stages. The purpose of our study was to discern whether a…

View details →DOI: 10.1016/j.crad.2025.107127
Negative / Null Result ReportOpen accessMedicine

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy.

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · CVIR endovascular

Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy and to determine whether therapeutic success is…

View details →DOI: 10.1186/s42155-026-00713-8
Negative / Null Result ReportMedicine

The Value of Anti-Drug Antibody Detection in Discriminating Patients from Healthy Controls and Predicting the Gross Motor Functional State in Patients with Pompe Disease.

Aziz-Ahari S, Aminian M, Rahimian A et al. · 2026 · Iranian journal of allergy, asthma, and immunology

Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection…

View details →DOI: 10.18502/ijaai.v25i2.20800
Negative / Null Result ReportMedicine

Early Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study.

Kardon A, Ren H, Gerard E et al. · 2026 · Neurocritical care

Background Headache is nearly ubiquitous in the immediate aftermath of nontraumatic, aneurysmal pattern subarachnoid hemorrhage (SAH); however, pain experiences vary significantly throughout the intensive care unit (ICU) course across…

View details →DOI: 10.1007/s12028-025-02396-w
Negative / Null Result ReportOpen accessMedicine

Radiolucent lines after robotic-assisted surface-matching kinematically aligned UKA: short-term incidence and lack of association with tibial alignment.

Itou J, Kuwasawa A, Nihei K et al. · 2026 · Archives of orthopaedic and trauma surgery

Purpose This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints.…

View details →DOI: 10.1007/s00402-026-06335-y
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Middle Cerebral Artery Diastolic Deceleration Area and Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)

Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…

View details →DOI: 10.3390/medicina62050957
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between COL1A1 rs1800012 Polymorphism and Anterior Open Bite Malocclusion in a Turkish Case-Control Cohort.

Polat T, Yılmaz ÖÖ, Önem Özbilen E et al. · 2025 · Genes

Background/objectives Anterior open bite is a multifact orial malocclusion influenced by genetic and environmental factors. Variants in the Collagen type I, alpha 1 ( COL1A1 ) gene, particularly rs1800012, have been implicated in bone…

View details →DOI: 10.3390/genes16101122
Negative / Null Result ReportMedicine

Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.

Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care

PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…

View details →DOI: 10.1177/26350106251361363
Negative / Null Result ReportMedicine

Habitual Worry, Cognitive Control, and Heart Rate Variability in Adult ADHD.

Längle A, Reyes Del Paso GA, Ettinger U et al. · 2025 · Psychophysiology

Adult attention-deficit/hyperactivity disorder (ADHD) is associated with substantial impairments in well-being and quality of life. In addition to cognitive and behavioral symptoms, emotional dysregulation characterizes the disorder. This…

View details →DOI: 10.1111/psyp.70110
Negative / Null Result ReportMedicine

Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study.

Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery

Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…

View details →DOI: 10.1016/j.avsg.2025.11.008
Negative / Null Result ReportMedicine

Epigenetic alterations of serotonergic but not dopaminergic signalling in compulsive sexual behaviour disorder.

Androvičová R, Jahn K, Engel J et al. · 2026 · Behavioural brain research

Rationale The compulsive sexual behaviour disorder (CSBD) is a recent addition to the ICD-11 diagnostic manual under the chapter of impulse control disorders. Though there is a wealth of different theoretical viewpoints regarding the…

View details →DOI: 10.1016/j.bbr.2025.115872