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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19906 results in Negative / Null Result Report · page 631 of 664

Negative / Null Result ReportMedicine

Comparative analysis of PTH Washout and 99mTc-MIBI SPECT/CT in presurgical localization for patients with primary hyperparathyroidism.

Cieślewicz M, Szczepanek-Parulska E, Witowska A et al. · 2026 · Journal of endocrinological investigation

Purpose Our study aimed to evaluate the performance and concordance of parathyroid hormone wash-out (PTHw) and 99m Tc-MIBI+SPECT/CT (MIBI) in preoperative localization for patients with primary hyperparathyroidism (PHPT), and assess…

View details →DOI: 10.1007/s40618-026-02873-9
Negative / Null Result ReportMedicine

'White autopsies': an overview of cases with inconclusive results of post-mortem examinations in the Department of Forensic Medicine of the Jagiellonian University Medical College in Kraków, Poland.

Zwierzewicz Z, Szpakowska A, Bistroń D et al. · 2025 · Archiwum medycyny sadowej i kryminologii

The aim of the study The aim of the study was to accurately determine the incidence of white autopsies and to identify possible conditions responsible for such autopsies by means of analyzing confirmed causes of death in the same age…

View details →DOI: 10.4467/16891716amsik.25.008.22186
Negative / Null Result ReportMedicine

COMPARING THE ABILITY OF GENETIC TESTING TO PROVIDE A DEFINITIVE DIAGNOSIS IN PATIENTS WITH PERIPHERAL AND MACULAR INHERITED RETINAL DISEASE.

Dones AM, Bou Ghanem G, Kessler C et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose We performed a retrospective cross-sectional study to determine whether there is a significant difference in the percentage of patients with diagnosed inherited macular or peripheral disease who receive more definitive genetic…

View details →DOI: 10.1097/iae.0000000000004732
Negative / Null Result ReportMedicine

Robotic arm-assisted <sup>18</sup>F-FDG PET/CT-guided biopsy in febrile patients with biopsy accessible FDG-avid lesions: a single-centre experience.

Aggarwal P, Singh H, Kumar R et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose Fever of unknown origin (FUO) is a prolonged fever with unknown etiology after an extensive outpatient or inpatient workup. 18 F-Flurodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT) has shown a…

View details →DOI: 10.1007/s00259-026-07928-w
Negative / Null Result ReportMedicine

Enteral When Compared With IV Magnesium Replacement in the Critically Ill: A Noninferiority Randomized Clinical Trial.

Nguyen CD, Panganiban HP, Karahalios A et al. · 2026 · Critical care medicine

Objectives Enteral magnesium replacement may be as effective as IV replacement while being a cheaper and more environmentally sustainable intervention. The primary objective was to evaluate whether enteral magnesium is noninferior to IV…

View details →DOI: 10.1097/ccm.0000000000007174
Negative / Null Result ReportMedicine

Development and validation of a nomogram model for predicting negative/indeterminate HIV-1 antibody confirmation: a strategy to streamline the diagnostic pathway.

Liao G, Zhang S, Wei Y et al. · 2026 · BMC medical informatics and decision making

Background The standard HIV diagnostic algorithm comprises sequential serological screening, confirmatory antibody testing, and nucleic acid confirmation when necessary. This multi-step process often causes diagnostic delays, particularly…

View details →DOI: 10.1186/s12911-026-03546-6
Negative / Null Result ReportMedicine

Effect of re-biopsy and re-vitrification on clinical outcomes in preimplantation genetic testing for aneuploidy.

Wu H, Wang H, Liang Y et al. · 2025 · Journal of assisted reproduction and genetics

Purpose To investigate whether re-biopsy and re-vitrification affect embryo developmental potential and clinical outcomes. Methods Embryos that underwent preimplantation genetic testing for aneuploidy (PGT-A) and single embryo transfer…

View details →DOI: 10.1007/s10815-025-03675-3
Negative / Null Result ReportMedicine

Changes in Attitudes After Suicide Prevention Media Campaigns in Three Norwegian Regions.

Mohn C, Haga E, Nilsson HSW et al. · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Background In a recent Norwegian regional suicide prevention media campaign, we found small and inconclusive results regarding changes in attitudes to suicide and help-seeking. In this exploratory study we add the data from two other…

View details →DOI: 10.1080/13811118.2026.2624605
Negative / Null Result Report

Identification of a Pathogenic BRCA2 Variant by Multigene Panel Testing in a Blood Group Chimera/Mosaic Case Unclassifiable by Conventional BRCA1/2 Testing

GONDA K, Ozaki A, Ito S et al. · 2026 · Preprint

Abstract In the setting of blood group chimerism/mosaicism, conventional BRCA1/2 genetic testing may yield inconclusive results. Multigene panel testing (MGPT) may overcome this limitation. We report a case in which BRCA2 pathogenic…

View details →DOI: 10.21203/rs.3.rs-8494624/v1
Negative / Null Result ReportMedicine

Biomagnetism of oral tissues and external magnetic field interactions with cell membranes, oral microflora, and orthodontic magnetic therapies: A review.

Itabaiana Sobrinho S, Meira-Belo LC, Mohallem NDS · 2026 · Progress in biophysics and molecular biology

Various rare earth magnets have been successfully applied in clinical orthodontics; however, their interactions with the oral environment remain only partially understood. Various controversies remain regarding magnetic fields (MFs) in…

View details →DOI: 10.1016/j.pbiomolbio.2026.01.003
Negative / Null Result ReportMedicine

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Vieira FT, Deng Z, Muller MJ et al. · 2026 · Obesity reviews : an official journal of the International Association for the Study of Obesity

Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat-free mass and fat mass losses) and mass-independent adaptations in EE (e.g., hormones). Glucagon-like peptide-1 receptor…

View details →DOI: 10.1111/obr.70116
Negative / Null Result ReportMedicine

Intraoperative biopsy challenges: Cavernous sinus meningioma mimic.

Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia

We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…

View details →DOI: 10.1016/j.neucie.2025.500739
Negative / Null Result ReportMedicine

Lost in submission? Investigating publication bias in regional anaesthesia: A pilot case study of the erector spinae plane block.

De Cassai A, Dost B, Karapinar YE et al. · 2026 · Revista espanola de anestesiologia y reanimacion

Background The Erector Spinae Plane (ESP) block is a regional anaesthesia technique with a growing range of clinical applications due to its short learning curve, low complication rate, and effectiveness. However, publication bias can…

View details →DOI: 10.1016/j.redare.2026.501995
Negative / Null Result ReportMedicine

Radiation necrosis mimicking tumor recurrence after chemoradiation for vaginal squamous cell carcinoma.

Di Noia D, Maiorano MFP, Sanasi A et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Radiation necrosis is a rare but serious complication of pelvic chemoradiotherapy that may closely mimic tumor recurrence on both imaging and clinical examination. We describe the case of a 43-year-old woman with FIGO stage II vaginal…

View details →DOI: 10.1016/j.jogoh.2026.103129
Negative / Null Result ReportOpen accessMedicine

Glomerular Yield in Ultrasound-Guided Native Kidney Biopsies in Pediatric and Adult Populations With Age-Stratified Subgroups.

Ravizzini PC, Lino HA, de Faria Castro Fleury E et al. · 2025 · Cureus

Background This study compares the glomerular yield, mean number of biopsy cores, and complication rates between pediatric and adult populations undergoing ultrasound-guided native kidney biopsies. Additionally, the adult population was…

View details →DOI: 10.7759/cureus.91202
Negative / Null Result ReportMedicine

Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.

Mayer A, Bresesti I, Francescato G et al. · 2025 · European journal of pediatrics

The amount of fluid to give in preterm infants with patent ductus arteriosus (PDA) is still highly debated, with no robust evidence that fluid restriction provides a clear benefit. The aim of the study is to evaluate if spontaneous closure…

View details →DOI: 10.1007/s00431-025-06651-2
Negative / Null Result ReportMedicine

Assessing Blood Pressure, Mental Health, and HRV Responses to Integrated Acupuncture in Hypertensive Patients: A Pilot Randomized Controlled Trial.

Singh D, Kodali PB, Sharma G et al. · 2025 · Medical acupuncture

Abstract This study aimed to investigate the effects of an integrated acupuncture (IA) protocol on blood pressure (BP), depression, anxiety, stress scores, and heart rate variability (HRV) in hypertensive patients. Abstract The study was a…

View details →DOI: 10.1089/acu.2024.0065
Negative / Null Result ReportMedicine

The VGLUT3 positive neurons of the median raphe region promote long-term spatial memory through time-dependent mechanisms.

Fazekas CL, Török B, Szabó A et al. · 2026 · Progress in neurobiology

Episodic memory and related forms of learning depend critically on the hippocampus, whose activity is regulated by brainstem inputs that remain incompletely understood. The midbrain median raphe region (MRR) is a key regulator of forebrain…

View details →DOI: 10.1016/j.pneurobio.2026.102904
Negative / Null Result ReportOpen accessMedicine

Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report.

Li SH, Niu WW, Huo XX et al. · 2025 · World journal of gastroenterology

Background Gastric mucosa-associated lymphoid tissue (MALT) lymphoma presents with various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological…

View details →DOI: 10.3748/wjg.v31.i38.111549
Negative / Null Result ReportOpen accessMedicine

Post-Traumatic Chest Wall Abscess Associated with <i>Gordonia sputi</i> in an Immunocompetent Patient: A Case Report.

Soda M, Motoyama H, Adachi T et al. · 2026 · Surgical case reports

Introduction Gordonia species are rare aerobic Gram-positive actinomycetes and opportunistic pathogens. Their clinical manifestations and optimal management remain poorly defined. Gordonia sputi is an especially uncommon cause of…

View details →DOI: 10.70352/scrj.cr.26-0054
Negative / Null Result ReportOpen accessMedicine

Nationwide seroprevalence of SARS-CoV-2 during the COVID-19 pandemic and prepandemic periods in Lao PDR.

Phommasone K, Souksakhone C, Chanthongthip A et al. · 2025 · PloS one

Background Lao PDR reported a low number of confirmed SARS-CoV-2 cases until the introduction of COVID-19 vaccines in April 2021. This raised doubts about whether the reported number reflected the true situation and questioned about…

View details →DOI: 10.1371/journal.pone.0336239
Negative / Null Result ReportOpen accessMedicine

Impact of 18F-choline PET-CT or PET-MRI on surgical strategy in patients with primary hyperparathyroidism.

Carrillo Lizarazo JL, Cecchin D, Camozzi V et al. · 2025 · BJS open

Background Accurate preoperative localization is essential for successful, focused, minimally invasive surgery in primary hyperparathyroidism (PHPT). New imaging techniques have recently been proposed. This study evaluated the impact of…

View details →DOI: 10.1093/bjsopen/zraf069
Negative / Null Result ReportMedicine

Serum 25-Hydroxyvitamin D Levels and Longitudinal Changes in Muscle Mass and Function in Peritoneal Dialysis Patients: A Prospective Cohort Study.

Wang L, Xue C, Zhu B et al. · 2026 · Journal of nutritional science and vitaminology

Data regarding to how serum 25 hydroxyvitamin D (25(OH)D) levels affect muscle mass and function in end-stage renal disease (ESRD) patients have led to inconclusive results. The main goal of this research was to examine the relationship…

View details →DOI: 10.3177/jnsv.72.1
Negative / Null Result Report

Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery

Song P, Su J, Vraa CLK et al. · 2025 · Preprint

Lipid nanoparticles (LNPs) have proven to be an effective delivery system for RNA therapeutics. The chemical composition of LNPs determines their functional delivery efficiency and targeting properties, which vary between in vitro and in…

View details →DOI: 10.1101/2025.09.02.673705
Negative / Null Result ReportMedicine

Methionine PET Findings in the Diagnosis of Brain Tumors and Nontumorous Mass Lesions: A Single-Center Report on 426 Cases.

Shiba Y, Aoki K, Ohka F et al. · 2025 · AJNR. American journal of neuroradiology

Background and purpose Differentiating between a brain tumor and a nontumorous lesion remains a diagnostic challenge, particularly when conventional imaging modalities such as CT and MRI provide inconclusive results. While 11 C-methionine…

View details →DOI: 10.3174/ajnr.a8871