e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 624 of 713

Negative / Null Result ReportMedicine

Differential Antioxidant Capacities of Human Endometriotic and Endometrial Cell Models Under H<sub>2</sub>O<sub>2</sub> Exposure.

Coelho JA, Gomes KS, Cerchiaro G · 2026 · International journal of molecular sciences

Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in 2D…

View details →DOI: 10.3390/ijms27094131
Negative / Null Result ReportMedicine

Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration after Axotomy.

Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…

View details →DOI: 10.1523/jneurosci.0112-26.2026
Negative / Null Result ReportMedicine

Persistence of Campylobacter fetus subsp. venerealis in the reproductive tract of vaccinated heifers after experimental infection: Insights into vaginal mucosal immunity in heifers.

Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology

Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…

View details →DOI: 10.1016/j.vetimm.2026.111131
Negative / Null Result ReportMedicine

Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling.

Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology

The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…

View details →DOI: 10.1016/j.molpha.2026.100123
Negative / Null Result ReportMedicine

Using Telehealth in End-of-Life Palliative Care: A Multimethod Randomized Controlled Trial.

Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine

Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…

View details →DOI: 10.1177/10966218261444643
Negative / Null Result ReportMedicine

Anemia Following One Anastomosis Gastric Bypass: A Comparative Study of Diabetic and Non-Diabetic Patients.

AhmadQaderi F, Pazouki A, Pishgahroudsari M et al. · 2026 · Obesity surgery

BACKGROUND: Metabolic-bariatric surgery (MBS) is recognized as the most effective long-term intervention for obesity and its associated conditions, including type 2 diabetes mellitus (T2DM) One-anastomosis gastric bypass (OAGB), the third…

View details →DOI: 10.1007/s11695-026-08632-2
Negative / Null Result ReportMedicine

Relaxation of Guinea Pig Aorta Induced by 5-HT<sub>2B</sub> Receptor. Exploration of Potential Mechanisms.

Del-Ángel-Monroy S, Rodríguez-Márquez A, Orozco-Suárez S et al. · 2026 · Basic & clinical pharmacology & toxicology

Vascular relaxation induced by 5-HT 2B receptor is thought to be mediated by stimulation of endothelial nitric oxide synthase (eNOS), but this assumption still requires investigation. To investigate potential mechanisms, BW723C86 (5-HT 2B…

View details →DOI: 10.1111/bcpt.70236
Negative / Null Result ReportMedicine

Synergism of TNF and IFNγ promotes cell death, but TNF drives innate immune-mediated colitis independent of IFNγ.

Torres-Huerta A, Ruley-Haase K, Boger-May A et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)

The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that…

View details →DOI: 10.1093/jimmun/vkag111
Negative / Null Result ReportOpen accessMedicine

Suffocating neck hematoma in thyroidectomy: use of drains and perioperative risk factors in 1,334 surgeries.

Aragone L, Burbano P, Cameron A et al. · 2026 · Annals of surgical treatment and research

Purpose A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies…

View details →DOI: 10.4174/astr.2026.110.3.144
Negative / Null Result ReportMedicine

Deep brain stimulation or best medical treatment for Parkinson's disease patients: 36-month longitudinal neuropsychological and motor assessment - a prospective case-control study.

Szlufik S, Duszyńska-Wąs K, Koźmińska A et al. · 2026 · Neurologia i neurochirurgia polska

Introduction Bilateral subthalamic nucleus deep brain stimulation (DBS STN) is a very effective surgical method of treating motor symptoms in Parkinson's disease (PD) patients. The long-term cognitive outcome after the surgery is still…

View details →DOI: 10.5603/pjnns.107017
Negative / Null Result ReportMedicine

SUPERROOT1 is not the only C-S lyase capable to contribute to glucosinolate biosynthesis in Arabidopsis thaliana.

Piślewska-Bednarek M, Czerniawski P, Kuczewska S et al. · 2026 · Phytochemistry

Glucosinolates (GLs) are sulfur-containing specialized metabolites from plants representing the Brassicales order. They can be derived from several amino acids through a complex biosynthetic pathway. The majority of steps on this pathway…

View details →DOI: 10.1016/j.phytochem.2026.114872
Negative / Null Result ReportMedicine

Impact of oral nutritional supplements on nutritional outcomes and survival in post-gastrectomy patients receiving chemotherapy.

Wang X, Xi Q, Zhuang Q et al. · 2026 · Clinical nutrition ESPEN

Background & aims Malnutrition complicates recovery in gastrectomy patients, worsened by adjuvant chemotherapy and linked to poorer outcomes. However, evidence regarding the influence of Oral Nutritional Supplements (ONS) on skeletal…

View details →DOI: 10.1016/j.clnesp.2026.103263
Negative / Null Result ReportMedicine

Exogenous Carbohydrate Oxidation Is Higher When Consuming Glucose + Fructose Compared with Glucose Alone during Endurance Exercise Regardless of Energy Status.

Barney DE Jr, Panik KN, Michalak J et al. · 2026 · The Journal of nutrition

Background When glucose (GLU) is consumed during endurance exercise in an energy deficit state (DEF), exogenous carbohydrate oxidation is lower than in energy balance (BAL). Whether consuming multiple transportable carbohydrates, such as…

View details →DOI: 10.1016/j.tjnut.2026.101593
Negative / Null Result ReportMedicine

Concomitant prophylactic trochanteric epiphysiodesis may not be an effective procedure for Perthes varus surgery.

Agarwal A, Iqbal MZ, Bhalla S · 2026 · Journal of clinical orthopaedics and trauma

Background Prophylactic trochanteric epiphyseodesis is commonly performed with proximal femoral varus osteotomy in Perthes disease to reduce relative trochanteric overgrowth. However, its effectiveness, particularly in children at the…

View details →DOI: 10.1016/j.jcot.2026.103379
Negative / Null Result ReportMedicine

Maternal SARS-CoV-2 Antibodies in Mink Kits: Dynamics of Passive Immunity and Implications for Silent Farm-Wide Transmission Following Virus Re-Incursion.

Thomou Z, Dovas CI, Poutahidis T et al. · 2026 · Viral immunology

Maternal antibodies protect mink kits early in life, but their duration and impact on subsequent SARS-CoV-2 exposure remain unclear. We longitudinally characterized passive immunity in kits born to mothers previously infected with lineage…

View details →DOI: 10.1177/08828245261444539
Negative / Null Result ReportMedicine

Influence of Barrier Membrane and Peri-Implantitis-Like Bone Defect Configurations on Graft Stability.

Suárez F, Couso-Queiruga E, Osorio J et al. · 2026 · Clinical implant dentistry and related research

Objectives The objective of this ex vivo investigation was to study the significance of barrier membrane application on graft stability across different peri-implantitis-related bone defect configurations. Materials and methods Fresh pig…

View details →DOI: 10.1111/cid.70140
Negative / Null Result ReportMedicine

Exposure to a high-fat diet compromises gut health, behavior, and HPA axis function, with partial reversal when limited to adolescence.

Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin

High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…

View details →DOI: 10.1016/j.brainresbull.2026.111883
Negative / Null Result ReportMedicine

Impact of 14 days of head-down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults.

Lagacé JC, St-Martin P, Avino M et al. · 2026 · Experimental physiology

Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals…

View details →DOI: 10.1113/ep093524
Negative / Null Result ReportMedicine

Magnesium supplements, sleep quality, and nocturnal leg cramps: a combination of cross-sectional and prospective studies.

Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition

PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…

View details →DOI: 10.1007/s00394-026-03910-2
Negative / Null Result ReportMedicine

Evaluation of Nicotinamide Riboside in Prevention of Small Nerve Fiber Axon Degeneration and Promotion of Nerve Regeneration.

Thomas S, Ben-Davies R, Cetinkaya-Fisgin A et al. · 2026 · Journal of the peripheral nervous system : JPNS

Background and aims Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD + ) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD + levels are associated with axonal…

View details →DOI: 10.1111/jns.70101
Negative / Null Result ReportMedicine

Dasatinib and quercetin prevent alveolar bone loss in aged mice.

Battistelli LS, Moraes RM, Santos YC et al. · 2026 · Journal of periodontology

Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage.…

View details →DOI: 10.1002/jper.70115
Negative / Null Result ReportMedicine

Long‐term comparison shows protected and non‐protected forests differ in harvesting, but not in wildfires or drought‐driven dieback

Espelta JM, Viana‐Soto A, Molowny‐Horas R et al. · 2026 · Journal of Applied Ecology.

While disturbances are essential for biodiversity, their escalation driven by climate change may threaten forest ecosystems. Contrasting approaches to adapt forests to disturbances-intensifying management versus encouraging natural…

Negative / Null Result ReportMedicine

The effects of amblyopia on simulated driving behavior in an urban setting.

Al-Haddad C, Kobeissi H, Wehbi Z et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Purpose To assess the driving performance and visual attention of amblyopic drivers using a driving simulator integrated with eye tracking technology in an urban setting. Methods A total of 30 participants were enrolled: 14 amblyopic…

View details →DOI: 10.1016/j.jaapos.2026.104738
Negative / Null Result ReportMedicine

Effects of rostral fluid shift on small airway narrowing in asthma before and after bronchodilation.

Cao X, Francisco CO, TaghiBeyglou B et al. · 2026 · Sleep & breathing = Schlaf & Atmung

PURPOSE: The recumbent posture during sleep increases small airway narrowing and nocturnal asthma despite optimal asthma treatment. Fluid accumulation in the chest can narrow the airway lumen, contributing to small airway narrowing. We…

View details →DOI: 10.1007/s11325-026-03607-0