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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 623 of 713

Negative / Null Result Report

Impact of Delayed Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study

Yanowitz T, Patel A · 2025 · Preprint

Abstract OBJECTIVE: To evaluate whether delayed cord clamping (DCC) duration predicts hyperbilirubinemia and phototherapy days among preterm infants of different gestational ages. STUDY DESIGN: In this retrospective cohort study, 2,421…

View details →DOI: 10.21203/rs.3.rs-8158705/v1
Negative / Null Result ReportOpen accessMedicine

Prognostic value of magnetic resonance imaging in pediatric-onset primary sclerosing cholangitis.

Vanhanen EJ, Lehtimäki TE, Kolho KL et al. · 2026 · Therapeutic advances in gastroenterology

Background The prognostic value of magnetic resonance imaging (MRI) in pediatric-onset primary sclerosing cholangitis (PSC) remains poorly studied. The MRI-based ANALI scores with and without gadolinium (ANALI Gd and ANALI NoGd ) have…

View details →DOI: 10.1177/17562848261426258
Negative / Null Result ReportMedicine

Sex-Specific Prognostic Patterns of Sarcopenia Components in Patients With Heart Failure.

Habaguchi A, Katano S, Yano T et al. · 2026 · Circulation journal : official journal of the Japanese Circulation Society

Background Whether the components of sarcopenia provide sex-specific prognostic information in heart failure (HF) remains uncertain. Methods and results We enrolled 604 patients with HF (259 women; median age, 73 years) undergoing…

View details →DOI: 10.1253/circj.cj-25-0714
Negative / Null Result Report

Psychology at the screen: The flaws of the current VAR protocol

Walker D, Staniforth CE, Thomas J et al. · 2025 · Preprint

The English Premier League claim that the introduction of the Video Assistant Referee (VAR) has led to more correct decisions. However, the psychological mechanisms of the current protocol have yet to be explored, and the current study…

View details →DOI: 10.31234/osf.io/jgcbw_v2
Negative / Null Result Report

The Bidirectional Relationship Between Sleep Disturbance and Exposure-Based Treatment for Social Anxiety Disorder: A Multi-Method Examination

McGrory CM, Fireman GD, Bottary RM et al. · 2025 · Preprint

Abstract Background . Individuals with Social Anxiety Disorder (SAD) often experience poor sleep, which may influence treatment outcomes. Although theoretical models link sleep and fear extinction mechanisms, findings are equivocal and…

View details →DOI: 10.21203/rs.3.rs-7121721/v1
Negative / Null Result ReportMedicine

Examining links between somatosensation and cognition in children with hemiplegic cerebral palsy.

Hewitt KM, Bayliss DM, McLean BA et al. · 2026 · Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

Children with cerebral palsy (CP) are at increased risk of impaired somatosensation and cognition. Among children with hemiplegia, approximately three-quarters have impaired somatosensation and one-third have intellectual impairment. While…

View details →DOI: 10.1080/09297049.2026.2621691
Negative / Null Result ReportOpen accessMedicine

Does Bone Quality Predict Pseudarthrosis, Subsidence, or Loss of Lordosis After Anterior Cervical Discectomy and Fusion? Minimum 5-Year Cohort Study.

Kim S, Park S, Ahn DK et al. · 2026 · Global spine journal

Study DesignRetrospective cohort study.ObjectivesTo determine whether preoperative cervical bone quality assessed by computed tomography Hounsfield units (CT HU) predicts pseudarthrosis, cage subsidence, or loss of cervical lordosis after…

View details →DOI: 10.1177/21925682261424749
Negative / Null Result ReportMedicine

Chicken or the egg: The relationship between cognitive deficits and negative symptoms in first episode psychosis.

Au-Yeung C, Christophe NK, Lavigne KM et al. · 2026 · Schizophrenia research

Background Cognitive impairments and negative symptoms (NS) represent an unmet therapeutic need in psychotic disorders. Both NS and cognitive impairments, are key predictors of functioning. Both also appear during the illness prodrome,…

View details →DOI: 10.1016/j.schres.2026.02.008
Negative / Null Result Report

Social Attunement and Alcohol Use: The Role of Age and Gender

Romein C, Colyer-Patel K, Kroon E et al. · 2025 · Preprint

Background: Alcohol use typically peaks during adolescence and early adulthood, when its social reinforcement value is high, and then decreases as individuals take on more adult-like responsibilities. The present study investigates whether…

View details →DOI: 10.31234/osf.io/srk3e_v2
Negative / Null Result Report

The time course of neural activity predictive of self-initiated movement

Jeay-Bizot L, Basbug M, Maoz U et al. · 2025 · Preprint

Decades of research have shown that early ramping activity is a very reliable antecedent of self-initiated movement. However, the dominant paradigm has been to only analyze data epochs culminating in movement, which discounts how often…

View details →DOI: 10.31234/osf.io/vdbg8_v3
Negative / Null Result Report

Cannabis Use, Affect, and Emotion Regulation in Daily Life: A 3-Week Experience Sampling Method Study in People Who Smoke Cannabis Almost Daily

Donate APG, Cousijn J, Kroon E et al. · 2026 · Preprint

Background and Aims: Although many people who use cannabis report mood-enhancing effects, affective responses are thought to vary within and between individuals. This study examined the bidirectional associations between momentary affect…

View details →DOI: 10.31234/osf.io/w5fd3_v1
Negative / Null Result ReportMedicine

On how people describe paintings with mirrors.

Bertamini M, Lucia M, Diaz S et al. · 2025 · British journal of psychology (London, England : 1953)

Since antiquity humans have been fascinated by mirrors; yet, when asked to predict what is made visible in the reflection, or to interpret a scene with a mirror, observers make systematic errors. Many observers claim that a character in a…

View details →DOI: 10.1111/bjop.70042
Negative / Null Result Report

Dynamics of Torque Teno Virus DNA Load in Bronchoalveolar Lavage in COVID-19 associated Acute Respiratory Distress Syndrome

Bumberger AM, Kastner M, Rüsing L et al. · 2026 · Preprint

Background: Torque teno virus (TTV) DNA load has been proposed as a surrogate marker of the net state of immunosuppression. While plasma TTV levels have been associated with infection risk and adverse outcomes, the clinical relevance of…

View details →DOI: 10.22541/au.176770094.44860022/v1
Negative / Null Result Report

Predicting AI Anxiety: An Existential Perspective

Gobet F, Evans N, Chatfield-Jouin F et al. · 2025 · Preprint

Artificial Intelligence (AI) is transforming many aspects of daily life and improving efficiency and outcomes in various sectors, ranging from healthcare to education. However, this rapid integration also introduces significant anxiety…

View details →DOI: 10.31234/osf.io/h7zje_v1
Negative / Null Result ReportMedicine

Temperature and precipitation mismatches increase infection risk in amphibians.

Thumsová B, Martínez-Silvestre A, Pérez-Vallejo M et al. · 2025 · Current biology : CB

The thermal mismatch hypothesis (TMH), the notion that cool- and warm-adapted hosts have higher infection risk during unusually warm and cool spells, respectively, was recently proposed to explain how temperature shifts driven by climate…

View details →DOI: 10.1016/j.cub.2025.07.053
Negative / Null Result ReportMedicine

ICANS mitigation in high-risk elderly patients treated with CD28 co-stimulatory anti-CD19 CAR-T cells using a standardization protocol: a pilot study.

Fridberg G, Amit O, Sherf Y et al. · 2026 · Haematologica

CAR-T has transformed relapsed/refractory LBCL treatment, with CD28-based products yielding rapid responses but higher ICANS rates. With Axicabtagene-ciloleucel and Brexucabtagene-autoleucel, overall and severe ICANS reach 78% and 35%,…

View details →DOI: 10.3324/haematol.2025.288954
Negative / Null Result ReportMedicine

Does Red Cell Distribution Width Have a Predictive Role in Anastomotic Leak after Right Hemicolectomy for Colon Cancer?

Sevik HO, Aytepe O, Kilic MK et al. · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Introduction Red cell distribution width (RDW) has recently emerged as a potential biomarker reflecting nutritional and inflammatory status in surgical oncology. While anastomotic leakage (AL) remains a devastating complication after right…

View details →DOI: 10.1177/10926429251410882
Negative / Null Result Report

Return of Threat Expectancy Likelihood After an Exposure Exercise as Dynamic Predictor of Intervention Outcome in Fear of Public Speaking

Bouwman V, Pittig A, Engelhard I et al. · 2025 · Preprint

Although exposure-based Cognitive Behavioral Therapy is generally effective for anxiety disorders, many people do not benefit. A better understanding of treatment predictors is required. This study investigated whether the dynamics of…

View details →DOI: 10.31234/osf.io/6s23z_v2
Negative / Null Result Report

Precision of reaches and proprioception in motor control and adaptation

Henriques DY, Gastrock RQ, Hart BM' · 2025 · Preprint

Abstract How do precision of movement and proprioception influence motor control and adaptation? Several theories—such as the exploration-exploitation hypothesis—propose that variability plays a key role in motor performance and learning.…

View details →DOI: 10.21203/rs.3.rs-7713663/v1
Negative / Null Result Report

Bridging Perspectives: The Impact of Teacher and Student Ratings of Social-Emotional and Instructional Characteristics on Student Outcomes

Scheirlinckx J, Dupré S, De Fruyt F · 2025 · Preprint

Teachers' social-emotional and instructional (SEI) characteristics shape classroom functioning and student outcomes, yet most research relies exclusively on teacher self-reports, potentially overlooking discrepancies between teachers'…

View details →DOI: 10.31234/osf.io/3tm2f_v1
Negative / Null Result ReportMedicine

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Reyna NC, Hamilton DA · 2026 · Hippocampus

Alzheimer's disease (AD) is characterized by irreversible neurobiological deterioration and cognitive impairment. AD patients exhibit stress system abnormalities including upregulation of the corticotropin releasing factor type 1 receptor…

View details →DOI: 10.1002/hipo.70103