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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 620 of 676

Negative / Null Result ReportOpen accessMedicine (General)

Permissible Outcomes of Lobe-Specific Lymph Node Dissection for Elevated Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Hiroaki Kuroda, Junji Ichinose, Katsuhiro Masago et al. · 2021 · Medicina

Background and Objectives : Lobe-specific nodal dissection (L-SND) is currently acceptable for the dissection of early-stage non-small cell lung cancer (NSCLC) but not for cancers of more advanced clinical stages. We aimed to assess the efficacy of L-SND, compared to systemic nodal dissection (SND). Materials and Methods : We retrospectively collected the clinical data of patients with carcinoembryonic antigen (CEA) abnormality who underwent complete resection of NSCLC via lobectomy or more in addition to either SND or L-SND at two cancer-specific institutions from January 2006 to December 201

View details →DOI: 10.3390/medicina57121365
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Clinical analysis of four serum tumor markers in 458 patients with ovarian tumors: diagnostic value of the combined use of HE4, CA125, CA19-9, and CEA in ovarian tumors

Chen F, Shen J, Wang J et al. · 2018 · Cancer Management and Research

Fawen Chen,1,2 Jing Shen,3 Jianwei Wang,1 Pengwei Cai,1 Yi Huang3 1Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, 2Department of Blood Transfusion, 3Department of Clinical Laboratory, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, People’s Republic of China Purpose: To investigate the diagnostic values of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) for ovarian tumors. Methods: The participants were divided into three gr

Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Understanding the Sensory Influences of Oak in the Production of Smoke-Affected Wines: A Case Study with Cabernet Sauvignon

Jenna A. Fryer, Elizabeth Tomasino · 2025 · Beverages

Wines produced from grapes exposed to wildfire smoke exhibit smoke-related flavors, such as smoky, burnt, and an ashy finish. While grapes are impacted on the vine, winemaking strategies can influence the perception of smoke-related properties in the resulting wine. This case study evaluated eight smoke-affected wines across three vintages from commercial production to assess how oak influences smoke-related flavors. Each vintage explored a different usage of oak, including oak origin, oak chips with carbon fining, and potential carryover of flavors through reused barrels. Wines were assessed

View details →DOI: 10.3390/beverages11040122
Negative / Null Result ReportOpen accessBusiness

Determinants of Technical Efficiency in Wheat Production in Ethiopia

Daniel Hailu · 2020 · International Journal of Agricultural Economics

Ethiopia is the second largest wheat producing countries in Sub-Saharan Africa and most people rely on rain fed agriculture for their livelihoods. Wheat production has increased from 2,176,603 tons in 2005 to 4,219,257 tons in 2016 with…

View details →DOI: 10.11648/j.ijae.20200505.19
Negative / Null Result ReportOpen accessInternal medicine

Hepatitis E virus infection results in acute graft failure after liver transplantation: a case report

Xiangyan Liu, Tian Shen, Zhuoyi Wang et al. · 2014 · Journal of Infection in Developing Countries

Hepatitis E virus (HEV) infection in most individuals is known as a self-limiting, acute, icteric hepatitis, but evidence shows HEV is responsible for choric hepatitis and rapid progressed liver cirrhosis in immuno-compromised patients. We present the case of a patient whose diagnosis of acute graft failure was due to a HEV infection 7 years after his first liver transplantation because of Wilson’s disease. The process showed severe jaundice with fatigue, poor appetite and continually rising serum aminopherase. The blood serum was found positive for the anti-HEV IgG antibody but negative for a

View details →DOI: 10.3855/jidc.3638
Negative / Null Result ReportOpen accessMedicine

The Novel New Jersey Eyewitness Instruction Induces Skepticism but Not Sensitivity.

Athan P Papailiou, David V Yokum, Christopher T Robertson · 2015 · PLoS ONE

In recent decades, social scientists have shown that the reliability of eyewitness identifications is much worse than laypersons tend to believe. Although courts have only recently begun to react to this evidence, the New Jersey judiciary has reformed its jury instructions to notify jurors about the frailties of human memory, the potential for lineup administrators to nudge witnesses towards suspects that they police have already identified, and the advantages of alternative lineup procedures, including blinding of the administrator. This experiment tested the efficacy of New Jersey's jury ins

View details →DOI: 10.1371/journal.pone.0142695
Negative / Null Result ReportOpen accessEducation

Critical Thinking of Medical Students: does it Change during the Study in Medical School?

Reza sharifinia, Abdolhussein Shakurnia · 2022 · Journal of Medical Education Development

Background & Objective: Critical thinking (CT) is essential in medical education and improves physicians' clinical ability and competency. The present study aimed to determine the CT level and the trend of its changes in medical education at Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, in 2021. Materials & Methods: In this cross-sectional descriptive study, the CT levels of 165 medical students in three curricular phases, namely basic sciences, externship, and internship courses were examined. The data collection tool was the California Critical Thinking Skills Questionnaire

View details →DOI: 10.52547/edcj.15.45.26
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Effect of fermented oyster (Crassostrea gigas) extracts and regular walking on muscle strength and mass in older adults with relatively low muscle mass: A randomized controlled trial

Ye Li Lee, Sang Yeoup Lee, Sang Yeoup Lee et al. · 2022 · Frontiers in Nutrition

IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized cont

View details →DOI: 10.3389/fnut.2022.935395
Negative / Null Result ReportOpen accessVeterinary medicine

Effect of Shearing for Improving the Thermoregulatory Responses of Crossbred Sheep During Heat Stress

Lina Fernanda Pulido-Rodríguez, Alfredo Manuel Franco Pereira, Fábio Luís Henrique et al. · 2025 · Veterinary Sciences

Shearing to improve heat dissipation is common in sheep farming. This study evaluated the influence of shearing on thermoregulatory responses of crossbred sheep from adapted breeds exposed to heat stress. Ten ewes were kept in a climate chamber exposed to heat stress (10–13 h), reaching 37 ± 1.0 °C for nine days, during two consecutive periods, without shearing, and then at 14 days after shearing, evaluating all variables. Rectal temperature, respiration rate, sweating rate, ocular surface temperature, and skin temperature were analyzed at 7, 10, 13, 17, and 20 h, and blood cortisol was analyz

View details →DOI: 10.3390/vetsci12040358
Negative / Null Result ReportOpen accessOphthalmology

Comparison of intravitreal injection of ranibizumab, steroids, and pars plana vitrectomy for chronic persistent nonimproving diabetic macular edema with nontractional epiretinal membrane

Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology

Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography

View details →DOI: 10.4103/djo.djo_36_25
Negative / Null Result ReportOpen accessMedicine

Treating social cognition impairment with the online therapy 'SoCoBo': A randomized controlled trial including traumatic brain injury patients.

Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE

Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des

View details →DOI: 10.1371/journal.pone.0294767
Negative / Null Result ReportOpen accessVeterinary medicine

Effect of Combining a Prebiotic (Autolyzed Yeast from Saccharomyces cerevisiae ) and Probiotic ( Bacillus subtilis ) Added in a High-Energy Diet on Growth Performance, Dietary Energetics, and Carcass Traits of Fattening Hairy Lambs

Jesús A. Quezada-Rubio, Alfredo Estrada-Angulo, Beatriz I. Castro-Pérez et al. · 2026 · Animals

Due to their specific properties, the autolyzed yeast Saccharomyces cerevisiae (SC) and bacterial Bacillus subtilis (BS) theoretically can have a synergistic effect when combined and offered in ruminant diets. Thus, the aim of this experiment was to evaluate the effect of their combination as feed additives on growth performance, dietary energy, carcass traits, and visceral organ mass in finishing lambs. For this reason, 48 Pelibuey × Katahdin lambs (98 ± 17 d age; initial weight = 20.25 ± 3.37 kg) were used in a feeding trial lasting 83 d. Lambs were blocked by weight and assigned to 24 pens.

View details →DOI: 10.3390/ani16040610
Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid

The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats

Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke et al. · 2021 · Intensive Care Medicine Experimental

Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w

View details →DOI: 10.1186/s40635-021-00389-5
Negative / Null Result ReportOpen accessBusiness

ANALISIS PENGGUNAAN PEMBIAYAAN MUDHARABAH DAN PEMBIAYAAN MUSYARAKAH TERHADAP PROFITABILITAS DI BANK UMUM SYARIAH PERIODE 2015-2018

H. M. Zakaria, Gusganda Suria Manda, Arif Rakhman · 2020

This study is aiming to determine the effect of mudharabah financing on the profitability (ROA) in Sharia Commercial Banks (BUS) for the 2015-2018 period, the effect of musyarakah financing on the profitability (ROA) on Sharia Commercial…

View details →DOI: 10.34308/eqien.v7i2.146
Negative / Null Result ReportOpen accessMedicine

Survival from methicillin-sensitive Staphylococcus aureus bloodstream infections over 20 years: a cohort of 1328 patients

Benedikt J. Wiggli, Reno Frei, Reto Laffer et al. · 2017 · Swiss Medical Weekly

PURPOSE Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years. OBJECTIVE To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors

View details →DOI: 10.4414/smw.2017.14508
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Sleep Regularity Index After Stroke: Change Over Time and Its Association With Recovery: A Longitudinal Observational Study

George D. Fulk, Regina Bell, Keenan Batts et al. · 2026 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Sleep–wake disruption is common after stroke and may impede recovery. The Sleep Regularity Index (SRI) quantifies the probability that an individual is in the same sleep or wake state at the same clock time on consecutive days. This study evaluates SRI during poststroke recovery, estimating associations with stroke outcomes and characterizing transitions between SRI states over time. Methods We analyzed data from 71 participants who were part of a larger ongoing study exploring the impact of nonobstructive sleep apnea sleep disorders post stroke. Data were collected at 10, 60, and 9

View details →DOI: 10.1161/jaha.125.048392
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])

A. DeMichele, A. C. Dueck, D. Hlauschek et al. · 2025 · Breast Cancer Research

Abstract Background The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer recurrence. This pre-specified analysis was conducted to determine whether adjuvant palbociclib benefited patients diagnosed with lower risk stage IIA disease compared to those with higher stage disease. Methods PALLAS was an international, multicenter, randomized, open-label, phase III trial, representing a public–private partnership between Pfizer, the Austrian Breast Cancer Study Group, and the U.S. ALLIANCE Foundation. Patients diagnosed with stage II

View details →DOI: 10.1186/s13058-024-01941-3
Negative / Null Result ReportOpen accessMedicine

Cost-effectiveness of follow-up invasive coronary angiography after percutaneous coronary stenting: a real-world observational cohort study in Japan

Hiroyuki Daida, Tomoyuki Takura, Tetsuya Shiina et al. · 2022 · BMJ Open

Objectives Follow-up invasive coronary angiography (FUICA) after percutaneous coronary intervention (PCI) has been shown to increase the rate of early coronary revascularisation without reducing the incidence of subsequent myocardial infarction or death. However, no studies have evaluated the cost-effectiveness of FUICA in patients after coronary stenting. Therefore, this study aimed to evaluate the cost-effectiveness of FUICA after PCI.Design Retrospective observational cohort study.Setting 497 hospitals.Participants and interventions Overall, 558 patients who underwent coronary artery stenti

View details →DOI: 10.1136/bmjopen-2022-061617
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

The Diagnostic and Grading Accuracy of 68Ga-DOTATATE and 18F-FDG PET/MR for Pancreatic Neuroendocrine Neoplasms

Jinxin Zhou, Runze Zhao, Yu Pan et al. · 2022 · Frontiers in Oncology

Accurate diagnosis and grading are critical for pancreatic neuroendocrine neoplasm (pNEN) management. This study compares the diagnostic and grading value of 68Ga-DOTATATE PET/MR and 18F-FDG PET/MR for pNENs separately as well as in combination. A total of 36 patients with histologically confirmed pNENs, who underwent both 68Ga-DOTATATE PET/MR and 18F-FDG PET/MR within 2 weeks from 2020 to 2021, were retrospectively collected and analyzed. The maximum standardized uptake values of 68Ga-DOTATATE (G-SUVmax) and 18F-FDG (F-SUVmax) on PET and the minimum values of apparent diffusion coefficient (A

View details →DOI: 10.3389/fonc.2022.796391
Negative / Null Result ReportOpen accessPsychiatry

The Post-Discharge Network Coordination Programme (PDNC-P): A randomised controlled trial to evaluate the efficacy of an intervention aimed at reducing rehospitalisations and improving mental health

Michael Pascal Hengartner, Silvia ePassalacqua, Gisela eHeim et al. · 2016 · Frontiers in Psychiatry

Purpose: To evaluate the efficacy of a post-discharge intervention for psychiatric inpatients aimed at preventing hospital readmissions and at improving patients’ mental health and psychosocial functioning. Methods: RCT using parallel group block randomisation including 151 patients with ≤3 hospitalisations within the last three years, a GAF score ≤60, and aged 18–64 years, assessed at two psychiatric hospitals from the canton of Zurich, Switzerland, between September 2011 and February 2014. Primary outcomes were rate and duration of rehospitalisation; secondary outcomes were mental health and

View details →DOI: 10.3389/fpsyt.2016.00027
Negative / Null Result ReportOpen accessEnvironmental sciences

The effectiveness of Biofumigants from Brassicaceae and Non-Brassicaceae to control root knot Nematodes on tomato

Habriantono Bakhroini, Wagiyana Wagiyana, Alfarisy Fariz Kustiawan · 2023 · E3S Web of Conferences

Root-knot nematodes (Meloidogyne spp.) are considered as one of the main limiting factors in crop production systems. Currently, several eco-friendly root-knot nematodes control technologies have been developed, one of which is biofumigants. The purpose of this study was to determine the effectiveness of biofumigants from Brassicaceae and Non-Brassicaceae to control root-knot nematodes. The study was conducted using a one-factor Completely Randomized Design (CRD) with 5 treatments. The results showed that the application of biofumigants from both brassicaceae and non-brassicaceae had no signif

View details →DOI: 10.1051/e3sconf/202337307003
Negative / Null Result ReportOpen accessAgriculture

Energy content of hybrid Rumex patienta L. x Rumex tianschanicus A. Los. (Rumex OK 2) samples from autumn months

Michal Rolinec, Dzhamal Rakhmetov, Daniel Bíro et al. · 2018 · Acta Fytotechnica et Zootechnica

Aim of this experiment was to determine the gross energy concentration of fresh, wilted and ensiled hybrid of Rumex patientia L. x Rumex tianschanicus A. Los. (Rumex OK 2). Samples were collected in autumn months of the year 2017. The plant of Rumex OK 2 consist during autumn months only from rosette of leaves. The height of leaves was in autumn months following, September 56.68±13.80 cm; October 59.29±11.93 cm and November 55.98±10.80 cm. Rumex OK 2 silage was made from wilted matter, with or without of addition of dried molasses. Gross energy was determined as the heat released after combust

View details →DOI: 10.15414/afz.2018.21.01.20-23
Negative / Null Result ReportOpen accessSurgery

Efficacy of Low Level Laser Therapy in Lumbar Discopathy Pain (Randomized Controlled Study)

A. Samarbakhsh, M. Shojaeei, M. Hami · 2014 · Global Spine Journal

Introduction Finding evidence based and effective method of managing low back pain (LBP) has been always a major dilemma in the field of neuromusculoskeletal system. The focus of this investigation is to establish a treatment regime for the discopathy origin of LBP using low level laser (LLL). This type of LBP is the cause of a significant number of days of sick leave in many countries. LLLT has not yet been fully adopted as a treatment method. Results of studies on LLL suggest that it reduces pain by a range of physiologic responses, such as increase in b-endorphins and depolarization blockag

View details →DOI: 10.1055/s-0034-1376737
Negative / Null Result ReportOpen accessMedicine

A randomized comparative study to estimate the safety and effectiveness between laryngeal mask airway supreme and I-gel in patients undergoing elective surgeries

Kaushal Kabir , Keshav Middha , Arora KK et al. · 2023 · Asian Journal of Medical Sciences

Background: Supreme laryngeal mask airway (SLMA) and i-gel airway devices are second generation supraglottic airway devices (SAD) and are good alternatives to intubation during elective surgeries. Aims and Objectives: This study was conducted with the objective of comparing the two SAD with respect to ease of insertion, number of attempts of insertion, insertion time, ease of gastric tube insertion, accompanying hemodynamic changes, incidence of adverse effects like regurgitation, lip and dental trauma, post-operative sore throat, dysphagia, and hoarseness. Materials and Methods: This study wa

View details →DOI: https://doi.org/10.3126/ajms.v14i9.52692
Negative / Null Result ReportOpen access

The Influence of Building Quality, Facilities and Location of Flats on the Level of Occupant Satisfaction in Islamic Boarding School Flats in the Jambi Region

Sujono, Firdaus · 2024 · Jurnal Multidisiplin Madani

The aim of this research is to determine the quality of buildings, facilities and location of flats on the level of satisfaction of flats residents in the area, namely the As'ad Islamic Boarding School and Sa'adatuddaren Flats. The sample…

View details →DOI: 10.55927/mudima.v4i11.11659
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

Early weight-bearing after anterior cruciate ligament reconstruction with hamstring grafts induce femoral bone tunnel enlargement: a prospective clinical and radiographic study

Takuya Tajima, Nami Yamaguchi, Makoto Nagasawa et al. · 2019 · BMC Musculoskeletal Disorders

Abstract Background Bone tunnel enlargement following primary anterior cruciate ligament (ACL) reconstruction with soft tissue graft might be a severe disadvantage for revision surgery. The postoperative rehabilitation protocol including the non-weight-bearing periods were different depending on the surgeon or institute. To determine the relationship between femoral bone tunnel enlargement and the postoperative non-weight-bearing period after double-bundle ACL reconstruction with hamstring grafts. Methods Forty-two patients who underwent primary double-bundle ACL reconstruction with hamstring

View details →DOI: 10.1186/s12891-019-2653-6
Negative / Null Result ReportOpen access

PENGARUH STRUKTUR AKTIVA TERHADAP NILAI PERUSAHAAN DENGAN STRUKTUR MODAL SEBAGAI VARIABEL INTERVENING PADA PERUSAHAAN SUB SEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI TAHUN 2017-2020

D. Widayanti, Ika Wahyuni, Triska Dewi Pramitasari · 2022 · Jurnal Mahasiswa Entrepreneurship (JME)

Food and beverage companies are one of the business sectors that continue to experience growth. Food and beverage companies are also in great demand by investors because they are a sector that can survive in the midst of Indonesia's…

View details →DOI: 10.36841/jme.v1i4.2112
Negative / Null Result ReportOpen access

A STUDY TO ASSESS THE EFFECTIVENESS OF PRAYANAMA TO RELIEVE STRESS AMONG THE PEOPLE OF SELECTED AREAS OF AHMEDABAD

Hari Mohan Singh, V. Patel, Group C · 2021 · International Journal of Advanced Research

Aim: To assess the effectiveness of pranayama to relieve stress at selected areas. Methodology: study design: one group pre-test post–test research design1. Place and duration of study: The study was conducted in selected areas of…

View details →DOI: 10.21474/ijar01/13733
Negative / Null Result ReportOpen access

Pengaruh Jumlah Unit Usaha, Investasi Dan Output UMKM Terhadap Kemiskinan

Sri Oktavani, Y. Yulhendri · 2021 · Jurnal Ecogen

This study aims to analyzed the effect of the number of business units, investment and output of MSMEs on poverty in West Sumatra. The object of this research is the Regency / City in West Sumatra Province. This study uses the Least Square…

View details →DOI: 10.24036/jmpe.v4i3.11341
Negative / Null Result ReportOpen accessMedicine

Effects of Recreational Boating on Microbial and Meiofauna Diversity in Coastal Shallow Ecosystems of the Baltic Sea

S. Iburg, Dandan Izabel-Shen, Å. Austin et al. · 2021 · Msphere

With the increase of recreational boating activity and development of boating infrastructure in shallow, wave-protected areas, there is growing concern for their impact on coastal ecosystems. In order to properly assess the effects and…

View details →DOI: 10.1128/msphere.00127-21