Replication FailureMedicine
Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
View details →DOI: 10.1097/xcs.0000000000001749 Negative / Null Result ReportMedicine
Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
View details →DOI: 10.1007/s00421-026-06227-4 Negative / Null Result ReportMedicine
Kemp LT, Smeets T, Jansen A et al. · 2026 · Journal of behavior therapy and experimental psychiatry
While studying appetitive and aversive conditioning is common in psychopathology research, studies that measure both types of learning simultaneously are rare. To gain insight into the role of appetitive and aversive learning in the…
View details →DOI: 10.1016/j.jbtep.2025.102071 Negative / Null Result ReportMedicine
Del Grosso SJ, Nichols KL, Delgado JA et al. · 2025 · Nutrient cycling in agroecosystems.
Grassland soils managed with livestock grazing can act as sources and sinks for methane (CH₄) and nitrous oxide (N₂O), but, in aggregate, are typically a source of N₂O and a sink for CH₄. Previously, we observed higher N₂O losses from…
Negative / Null Result ReportMedicine
Arriero-Cabañero A, Díaz-Rubio N, Talabán-Rocha C et al. · 2025 · Molecular neurobiology
Pyruvate kinases are key enzymes of glycolytic metabolism of neurons and glia. One of them, pyruvate kinase M2 (PKM2) can also act as a transcriptional regulator and in this function has been implicated in several neurodegenerative…
View details →DOI: 10.1007/s12035-025-05508-x Negative / Null Result ReportMedicine
Moreau AL, Rappaport BI, Saturday ML et al. · 2026 · Journal of psychiatric research
Intolerance of uncertainty (IU) is an individual difference dimension reflecting negative cognitive, emotional, and behavioral responses to uncertainty. IU is an important etiological and maintaining mechanism of internalizing…
View details →DOI: 10.1016/j.jpsychires.2025.12.019 Negative / Null Result ReportMedicine
Elster A, Ron L · 2026 · Journal of personality
Introduction Behavior is not solely determined by individual dispositions or situational demands, but by the dynamic interplay between them. The current research investigates the contextual sensitivity of behavioral determinants by…
View details →DOI: 10.1111/jopy.70018 Replication FailureMedicine
Ye J, Hoàng DĐ, Liu X et al. · 2025 · Biochemical and Biophysical Research Communications
Schisandrin B (SchB), a natural lignan with reported organ-protective effects, was hypothesized to ameliorate severe acute pancreatitis (SAP). We investigated the effects of SchB (30 and 60 mg/kg) in a caerulein-induced mouse model of SAP…
Negative / Null Result ReportOpen accessMedicine
Raidl P, Vogl A, Dreisörner A et al. · 2026 · Psychophysiology
Prior evidence suggests that individuals with higher fitness exhibit attenuated endocrine and autonomic responses to acute psychological and physical stressors. However, it remains unclear whether this stress-buffering effect depends on…
View details →DOI: 10.1111/psyp.70350 Negative / Null Result ReportMedicine
Varden Gjerde K, Bartz-Johannessen C, Løberg EM et al. · 2026 · Schizophrenia research
Background Schizophrenia patho-etiology may involve endothelial inflammation and blood-brain barrier (BBB) dysregulation with cellular adhesion molecules (CAMs) as important mediators. CAMs are essential for cellular integrity but can show…
View details →DOI: 10.1016/j.schres.2026.01.021 Negative / Null Result ReportOpen accessMedicine
Chhabra BR, Madan AK, Tichansky DS · 2025 · Cureus
Introduction Relationships with industry may create a potential conflict of interest (COI). Disclosure of COI is essential for integrity of educational programming. In 2013, Center for Medicare and Medicaid Services (CMS) developed the…
View details →DOI: 10.7759/cureus.98417 Negative / Null Result Report
Lin X, Lee JB, Phua HP et al. · 2025 · Preprint
Introduction Migrants are drawn to high-income countries (HICs) for employment, often in sectors deemed difficult, risky, and low paying. However, they experience more injuries and deaths and face barriers to healthcare. The World Health…
View details →DOI: 10.1101/2025.10.23.25338532 Negative / Null Result Report
Hashimoto C, Yoshino A, Hida S et al. · 2025 · Preprint
Abstract Background With the increasing diversity of nationalities in Japan, the number of foreign patients with limited Japanese language proficiency is growing. While various multilingual support resources have been developed in recent…
View details →DOI: 10.21203/rs.3.rs-7097925/v1 Negative / Null Result Report
Spacey OG, Jones OR, Record S et al. · 2025 · Preprint
The population dynamics and life histories of macroparasites are fundamental to examine their impacts on hosts and ecosystems. Still, macroparasite population models often ignore parasite individual heterogeneity and are rarely applied to…
View details →DOI: 10.1101/2025.05.09.653086 Negative / Null Result ReportMedicine
Brink KJ, Wiles TM, Stergiou N et al. · 2025 · Human movement science
The Optimal Movement Variability Hypothesis posits that healthy movements exhibit an optimal structure of variability, characterized by fractal patterns, which confer both stability and flexibility in motor control. This optimal,…
View details →DOI: 10.1016/j.humov.2025.103368 Negative / Null Result ReportMedicine
Weber RE, Schulze KM, Kenney NJ et al. · 2025 · American journal of cancer research
Breast cancer patients' maximal O 2 uptake (V̇O 2 max) values average 60-80% of age-predicted values which is often attributed to adjuvant therapy rather than risk factors, comorbidities, or the tumor and associated factors (e.g.,…
View details →DOI: 10.62347/qccz2316 Negative / Null Result Report
Chang DS, Littlepage-Saunders M, Hochstein MJ et al. · 2023 · Preprint
Convergent lines of evidence from animal models suggest that disrupted metabotropic glutamate receptor 2 (mGlu 2 ) function promotes high levels of drug consumption for a variety of psychoactive drugs including alcohol, opioids, and…
View details →DOI: 10.1101/2023.09.15.558004 Negative / Null Result ReportMedicine
Erickson MG, Reinhardt LA, Svaren L et al. · 2024 · Journal of dairy science
Reducing dietary CP is a well-established means to improve N use efficiency. Yet, few studies have considered if transient restrictions in dietary CP could reduce the environmental footprint of late-lactation cows. We hypothesized that the…
View details →DOI: 10.3168/jds.2023-24150 Negative / Null Result ReportOpen accessMedicine
Colomer-Poveda D, Mera-González I, Marcos-Frutos D et al. · 2026 · European journal of applied physiology
PURPOSE: The aim of this triple-blind, placebo-controlled study was to determine the effects of anodal transcranial direct current stimulation (a-tDCS) applied over the primary motor cortex (M1) and the dorsolateral prefrontal cortex…
View details →DOI: 10.1007/s00421-026-06186-w Negative / Null Result Report
Turan G, Spiertz V, Bein O et al. · 2023 · Preprint
The human brain is postulated to function as a prediction machine, constantly comparing incoming sensory input to predictions based on past experiences. When an event contradicts these predictions, it results in a prediction error (PE),…
View details →DOI: 10.22541/au.168663255.58375954/v1 Negative / Null Result ReportOpen accessMedicine
Agir M, Sahin K, Pulatkan A et al. · 2026 · JSES international
Background Rotator cuff tears are a leading cause of shoulder pain, with high rerupture rates despite advancements in surgical techniques. Tendon-to-bone healing failure is often attributed to insufficient fibrocartilage regeneration at…
View details →DOI: 10.1016/j.jseint.2025.101425 Negative / Null Result ReportOpen accessMedicine
Meier K, van Hoeken D, Kager CCM et al. · 2025 · The International journal of eating disorders
Objective This study examined the impact of the COVID-19 pandemic on incidence rates of anorexia nervosa (AN) and bulimia nervosa (BN) in Dutch primary care by comparing pre-pandemic (2015-2019) and in-pandemic (2020-2022) periods. We…
View details →DOI: 10.1002/eat.24431 Negative / Null Result ReportOpen accessMedicine
Haucke M, Heinz A, Heinzel S et al. · 2025 · European archives of psychiatry and clinical neuroscience
Adverse alcohol consumption is a major public health concern, which might have been further increased by the COVID-19 pandemic. In this study we investigated the impact of a lockdown stage on the association between alcohol consumption,…
View details →DOI: 10.1007/s00406-024-01941-6 Negative / Null Result ReportOpen accessMedicine
Kim SH, Heo JH, Cunanan K et al. · 2026 · Journal of the Endocrine Society
Context While popular weight-loss medications have raised concerns about lean mass loss, the normative effects of nonpharmacologic weight loss on body composition remain unclear. Objective We assessed how the extent of weight loss from…
View details →DOI: 10.1210/jendso/bvag015 Failed Experiment Report
Seetahul Y, Greitemeyer T · 2025 · Preprint
Objective: With two experiments (N = 1,576), we examine the causal effect of frustration on the immediate inclination to play violent video games (VVGs) and the moderating role of long-term VVG exposure. Method: Frustration was…
View details →DOI: 10.31234/osf.io/pwkny_v2 Failed Experiment ReportMedicine
Ogawa M, Matsumoto K, Aoyama K et al. · 2025 · IEEE transactions on visualization and computer graphics
Virtual reality (VR) enables beyond-real interactions (BRI) that transcend physical constraints, offering effective user experiences like extending a hand to grasp distant objects. However, adapting to novel mappings of BRI often reduces…
View details →DOI: 10.1109/tvcg.2025.3549562 Failed Experiment ReportOpen accessMedicine
Cong YQ, Yurdum L, Fischer A et al. · 2025 · Journal of nonverbal behavior
The ingroup advantage refers to the phenomenon of emotions being more accurately recognised when expressors and perceivers share the same cultural background. Though well-documented in studies using posed facial expressions, whether the…
View details →DOI: 10.1007/s10919-025-00492-1 Failed Experiment ReportMedicine
Sabino-Carvalho JL, Guerrero RV, Teixeira AL et al. · 2025 · Autonomic neuroscience : basic & clinical
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by non-motor symptoms and marked altered sympathetic and parasympathetic activity. However, it is currently unclear if inappropriate autonomic adjustments are…
View details →DOI: 10.1016/j.autneu.2025.103311 Negative / Null Result ReportMedicine
Parsowith EJ, Herring E, Cohen B et al. · 2025 · Experimental gerontology
Background Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of the underlying mechanisms hinders the…
View details →DOI: 10.1016/j.exger.2025.112803 Negative / Null Result ReportMedicine
Rubino M, Fan R', Kulesz PA et al. · 2026 · The Laryngoscope
Objectives Complete or relative voice rest is recommended following phonomicrosurgery. Primarily, adherence to rest has been measured using patient reports, but their validity is unknown. Instrumental measures of rest adherence are…
View details →DOI: 10.1002/lary.70432 