A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 608 of 664
· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
Wu F, Wu R, Chen L et al. · 2026 · New biotechnology
Enhancing enzyme thermostability is crucial for industrial applications requiring robust performance under extreme conditions. Structure-based protein design models excel at improving thermal stability but often compromise enzymatic…
Liu X, Wang Y, Medina AA et al. · 2026 · Pharmacological research
Gut-liver axis disturbance is the unifying pathogenesis of cholestatic liver diseases. The purpose of this study was to explore the underlying mechanisms of the probiotic Lactobacillus amylovorus (LA) and its secreted extracellular…
Sohal P, Gupta K, Kaushal S et al. · 2025 · Preprint
ABSTRACT Objective Acute isoniazid toxicity causes refractory seizures due to pyridoxine deficiency-mediated gamma-aminobutyric acid depletion. While pyridoxine is the established antidote, its limited availability in emergency settings…
Huchthausen C, Shi M, Sousa GL et al. · 2025 · Preprint
Abstract Radiomics-based machine learning models have the potential to detect lung cancer at inception from CT scans and transform patient outcomes. Low malignancy rates in early-development pulmonary nodules (PNs) and variable image…
Timimi S · 2025 · Child and adolescent mental health
Because definitions of mental disorder are inescapably subjective, they can be continuously expanded in response to commercial, guild and social interests and pressures. In this article, I argue that this has resulted in young people…
Moncheaux A, Guimond A, Spiegelhalter C et al. · 2025 · Preprint
ABSTRACT Background Mutations in CAV3 , encoding caveolin-3, cause caveolinopathies, rare genetic disorders affecting both skeletal and cardiac muscle. Caveolin-3 contributes to T-tubule formation and excitation-contraction coupling. BIN1…
Fujii T, Nogami Y, Seo T · 2026 · BMJ open
Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…
Simeonova L, Leseva M, Stoyanov K et al. · 2025 · Biochimica et biophysica acta. Molecular basis of disease
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator…
Jackson CB, Xue W, Gupta AA et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose To evaluate local failure (LF) rates for patients with intermediate-risk rhabdomyosarcoma treated on the Children's Oncology Group ARST1431 clinical trial, the first and largest international, phase 3 randomized study to use FOXO1…
Chow WD, Spinner RJ, Amrami KK et al. · 2026 · Journal of neurosurgery. Case lessons
Background Bertolotti syndrome is an underrecognized cause of chronic low back pain. Back pain generated from Bertolotti syndrome is believed to result from altered weight dissipation mechanics and/or instability of the pseudoarticulation,…
Boda A, Bandey IN, Chowdhury S et al. · 2025 · Preprint
Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported…
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary anaesthesia and analgesia
Objective To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. Study design A crossover,…
Jacob A, He J, Peck A et al. · 2025 · Heliyon
Sjögren's (SS) involves salivary and lacrimal gland dysfunction. These studies examined metabolic profiles in the B6. Il14α transgene mouse model of SS and a cohort of human SS patients at different stages of disease. In B6. Il14α mice,…
Pae Y, Park H, Lee H et al. · 2024 · Preprint
Abstract Background Hyperhidrosis is the secretion of excess sweat beyond what the body needs for homeostatic regulation. Secondary hyperhidrosis is usually related to an underlying cause, mostly a medical condition, or extrinsic factors…
Kateh Shamshiri M, Vakili-Ghartavol R, Aiyelabegan HT et al. · 2025 · Cytokine
While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows…
Lamboley Q, Fourcade Y · 2024 · Journal of biogeography
AIM: The continuous development of statistical tools applied to ecology has contributed to great advances for modelling species' niches and distributions from opportunistic observations. However, as these observations are subject to biases…
Alghizzi TM, Alshahrani TM · 2024 · Heliyon
Despite considerable evidence that supports the use of grading rubrics (GRs) as tools for written corrective feedback, there is a paucity of research that investigates which of the different types of GRs best develops learners'…
Siegrist H, Spieler A, Peters AS et al. · 2024 · Preprint
There is currently no clinically valid biomarker for predicting the growth and prognosis of abdominal aortic aneurysms (AAA). The most promising candidates with highest diagnostic values are plasma D-dimers and markers of activated…
Lefebvre C, Tiffay A, Breemeersch C et al. · 2024 · Preprint
Rationale Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. Glutamine (Gln) supplementation previously showed beneficial effects on gut…
Bousamaki J, Maciag G, Petersen AG et al. · 2026 · Basic & clinical pharmacology & toxicology
Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three…
Güngör HS, Łabuz G, Yildirim TM et al. · 2024 · Journal of refractive surgery (Thorofare, N.J. : 1995)
Purpose To investigate how varying levels of longitudinal chromatic aberration (LCA) affect visual quality in patients with trifocal intraocular lenses (IOLs). Methods Twenty-nine patients implanted with trifocal IOLs were assessed for…
Hui Q, Xiang T, Qinglan X et al. · 2026 · Food science & nutrition
The link between Vitamin D (Vit D) deficiency and sudden sensorineural hearing loss (SSNHL), especially regarding recurrence and age-related disparities, remains unclear. Recurrence and age-specific risks of SSNHL are under addressed,…
Tanabe S, Shi Y · 2024 · The American journal of case reports
BACKGROUND Retained products of conception (RPOC) is a rare complication following second-trimester delivery or pregnancy termination, often leading to significant hemorrhage. Diagnosed via ultrasound or CT, RPOC requires surgical…
Hyun J, Cerino ES, Katz MJ et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and…
Story BD, Thomasy SM, Randolph MW et al. · 2024 · Frontiers in veterinary science
Sjogren's disease, well-described in people, is rarely identified in veterinary species. In people, Sjogren's disease is one of the most common systemic autoimmune disorders with an incidence of 0.5% in the female population. The hallmark…
Sood M, Hegde V, Prabhu N et al. · 2026 · Journal of Indian Prosthodontic Society
Aim This study aimed to assess the shear bond strength between three-dimensional (3D)-printed acrylic denture base resin and 3D-printed teeth with and without ridge lap surface modifications. Materials and methods The investigation…
Li W, Shi M, Zhou P et al. · 2024 · Preprint
Background: The outcome of extramedullary infiltration (EMI) in pediatric acute myeloid leukemia (AML) is controversial, and little is known about the implications of stem cell transplantation (SCT) and gemtuzumab ozogamicin (GO) treatment…