Negative / Null Result ReportMedicine
Olanders G, Testa G, Tibo A et al. · 2024 · Journal of chemical information and modeling
In the realm of biomedical research, understanding the intricate structure of proteins is crucial, as these structures determine how proteins function within our bodies and interact with potential drugs. Traditionally, methods like X-ray…
View details →DOI: 10.1021/acs.jcim.4c01475 Negative / Null Result ReportMedicine
Hirsch MS, Hildebrand CB, Geltinger F et al. · 2024 · American journal of respiratory cell and molecular biology
The mortality associated with acute lung injury (ALI) increases with age. Alveolar epithelial type II (AEII) cells are the progenitor cells of the alveolar epithelium and are crucial for repair after injury. We hypothesize that telomere…
View details →DOI: 10.1165/rcmb.2024-0054oc Negative / Null Result ReportOpen accessMedicine
Ohyama K, Isumi A, Doi S et al. · 2025 · Medicine
Although increasing coronavirus disease (COVID-19) vaccination coverage is a measure to prevent the spread of severe acute respiratory syndrome coronavirus 2, a certain percentage of people refuse to be vaccinated (i.e., vaccine hesitancy…
View details →DOI: 10.1097/md.0000000000043614 Negative / Null Result ReportOpen accessMedicine
Sanders GJ, Bennett M, Kollock RO et al. · 2026 · Muscles (Basel, Switzerland)
Background : The study examined sex differences in countermovement jump (CMJ) force plate metrics and neuromuscular responses to a standardized dynamic warm-up in physically active college students. Methods : Forty-one participants (21…
View details →DOI: 10.3390/muscles5010004 Negative / Null Result ReportOpen accessMedicine
Ascione M, Carulla-Roig M, Meschberger-Annweiler FA et al. · 2026 · Clinical psychology & psychotherapy
Anorexia nervosa (AN) is a severe psychiatric disorder characterized by intense fear of gaining weight and persistent body image disturbance. Virtual reality-based mirror exposure therapy (VR-MET) may reduce body-related fear through…
View details →DOI: 10.1002/cpp.70273 Negative / Null Result ReportMedicine
Verkaar AJCF, van Damme I, van Veldhuisen ER et al. · 2026 · Journal of sleep research
Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted…
View details →DOI: 10.1111/jsr.70311 Negative / Null Result ReportMedicine
Hannig L, Braunger BM, Kleefeldt N et al. · 2026 · Cell and tissue research
CEACAM1 (CC1) is an important mediator of cell proliferation and adhesion and serves as an angiogenic factor through interaction with VEGF. Although the role of CC1 has been extensively studied in organs such as the heart, liver and lung…
View details →DOI: 10.1007/s00441-026-04087-0 Negative / Null Result ReportMedicine
Magrin GL, Michels R, Gil ACK et al. · 2026 · Journal of periodontal research
Aim This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the…
View details →DOI: 10.1111/jre.70127 Negative / Null Result ReportMedicine
Nguyen E, Rusu DN, Dolan JL et al. · 2026 · Practical radiation oncology
Purpose/objective(s) - This retrospective study determines if uniform fasting protocols successfully limit stomach volume variation and proximity to the planning target volume (PTV) throughout radiation treatment. Materials/methods - 74…
View details →DOI: 10.1016/j.prro.2026.05.013 Negative / Null Result ReportMedicine
Naemura N, Fukuda Y · 2026 · [Nihon koshu eisei zasshi] Japanese journal of public health
Objectives Improving the screening rates in specific health checkups and guidance represents a challenge for health insurance providers and local governments nationwide. In this study, we evaluated SMS-based health checkup encouragement…
View details →DOI: 10.11236/jph.25-133 Replication FailureMedicine
Hyman AC, Albins MA, Curtis JS et al. · 2026 · Scientific reports
Biological invasions threaten ecosystems worldwide, with invasive predators such as lionfish (Pterois spp.) altering marine communities through predation, competition, and habitat disruption. Since their introduction to the western…
View details →DOI: 10.1038/s41598-026-54653-3 Replication FailureMedicine
Ludwig DR, Zhang F, Minor B et al. · 2026 · Academic radiology
Rationale and objectives To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic…
View details →DOI: 10.1016/j.acra.2026.05.017 Replication FailureMedicine
Islam AM, Baldwin RB, Dyer BJ et al. · 2026 · Facial plastic surgery & aesthetic medicine
Background Patients with orbital floor fractures are frequently transferred between facilities for suspected clinical need, although many of these transfers may be unnecessary. Objective To compare the characteristics among patients with…
View details →DOI: 10.1177/26893614261441472 Replication FailureMedicine
Pentland DR, Treder N, Najjar S et al. · 2026 · Hearing research
WHRN gene mutations underlie several forms of deafness in humans and mice. It is not known whether WHRN-associated hearing loss can be reversed after its onset and we aimed to address this using a genetic approach. We show that a knockdown…
View details →DOI: 10.1016/j.heares.2026.109682 Replication FailureMedicine
Arslan B, Güdül KF · 2026 · BMC oral health
Aim The aim of this study is to assess whether coloured resin composites undergo greater colour changes following exposure to a colouring solution after the use of a whitening mouthwash. Materials and methods Sixty composite discs (2 × 8…
View details →DOI: 10.1186/s12903-026-08495-0 Negative / Null Result ReportMedicine
de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal
Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…
View details →DOI: 10.1007/s00192-026-06686-5 Negative / Null Result ReportMedicine
Vermedal H, Hellings IR, Fretheim-Kelly ZL et al. · 2026 · Equine veterinary journal
Background Exercise-related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings.…
View details →DOI: 10.1002/evj.70211 Negative / Null Result ReportMedicine
Okutan AE, Kehribar L, Gürün E et al. · 2026 · International orthopaedics
Purpose To evaluate 1-year clinical and functional outcomes, as well as donor-site morbidity based on quadriceps muscle morphology, after primary single-bundle ACLR using a quadrupled RF tendon autograft. Methods Patients who underwent…
View details →DOI: 10.1007/s00264-026-06886-0 Negative / Null Result ReportOpen accessMedicine
Jabba SV, Erythropel HC, Anastas PT et al. · 2026 · Tobacco prevention & cessation
Since late 2022, the sale of most flavored tobacco products has been prohibited in California, including menthol cigarettes. Tobacco companies responded by introducing 'non-menthol' cigarettes in which menthol was replaced with WS-3, an…
View details →DOI: 10.18332/tpc/217322 Negative / Null Result Report
Rehman MU · 2026 · Preprint
Abstract The X-ray repair cross-complementing protein 1 (XRCC1) is a central scaffold protein involved in DNA single-strand break repair (SSBR), coordinating the assembly of multi-protein repair complexes. Its activity is regulated by…
View details →DOI: 10.21203/rs.3.rs-9455541/v1 Negative / Null Result ReportMedicine
Kaw R, Shekhar S, Mehra R et al. · 2026 · Chest
Background Heart failure (HF) is common in obesity hypoventilation syndrome (OHS). We explored the impact of HF on in-hospital outcomes of patients with or at risk of OHS who were treated with mechanical ventilation (MV), noninvasive…
View details →DOI: 10.1016/j.chest.2025.11.039 Negative / Null Result Report
Jerabek S, Kim J, Sung J et al. · 2026 · Preprint
ABSTRACT Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9 result in frequent aneuploidy and…
View details →DOI: 10.64898/2026.05.30.728989 Negative / Null Result ReportMedicine
Berge T, Vuletić F, Bøe B · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To compare clinical and radiological outcomes 1 year after Arthroscopic Latarjet procedure, using two different fixation techniques: screw or suture button fixation. Methods This retrospective comparative cohort study included 75…
View details →DOI: 10.1002/ksa.70426 Negative / Null Result ReportMedicine
Graetz C, Löwe C, Übermuth S et al. · 2026 · International journal of dental hygiene
Objective Bristle splaying may be associated with reduced cleaning efficacy; however, the relationship between the bristle splaying index (BSI) and contact pressure (CP) during brushing with a powered toothbrush (PT) with real-time CP…
View details →DOI: 10.1111/idh.70101 Negative / Null Result Report
Copps M, Solmi F, Viding E et al. · 2026 · Preprint
BackgroundIrritability is a distressing and disabling transdiagnostic symptom of emotion dysregulation. Despite some obvious links between irritability and eating behaviours this relationship is rarely studied.AimsWe examined longitudinal…
View details →DOI: 10.31234/osf.io/7zye9_v1 Negative / Null Result Report
Yamaguchi H, Arioka M · 2026 · Preprint
Abstract We previously reported that in the filamentous fungus Aspergillus oryzae entire nuclei were degraded by autophagy when cells are exposed to nutrient starvation. In this study we investigated the roles of vacuolar proteases in…
View details →DOI: 10.21203/rs.3.rs-8802980/v1 Negative / Null Result ReportMedicine
Vrba J, Havlasek J, Dostalova K et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cannabidiol (CBD) is known to activate aryl hydrocarbon receptor (AhR) and expression of cytochromes P450 (CYP) 1A. This study examined the effect of cannabigerol (CBG) on the AhR/CYP1A pathway in HepG2 cells, human hepatocytes, and normal…
View details →DOI: 10.1016/j.fct.2026.116156 Negative / Null Result ReportMedicine
Negrila A, Radu RA, Terecoasa EO et al. · 2026 · Journal of neurointerventional surgery
Background Endovascular thrombectomy (EVT) is a time-sensitive treatment for acute ischemic stroke, and hub-and-spoke systems have expanded patient access to this intervention. However, overcrowding at comprehensive stroke centers (CSCs)…
View details →DOI: 10.1136/jnis-2026-025430 Negative / Null Result ReportMedicine
Kuznetsova DA, Kuznetsov DM, Lyubina AP et al. · 2026 · Biochimica et biophysica acta. Biomembranes
The design of effective non-viral nucleic acid delivery systems based on cationic amphiphilic compounds remains a major challenge in biomedical research. In this study, cationic benzimidazolium surfactants (BI-n) and cationic liposomes…
View details →DOI: 10.1016/j.bbamem.2026.184549 Negative / Null Result ReportMedicine
Nakagawa A, Matsuoka Y, Seo M et al. · 2026 · Circulation journal : official journal of the Japanese Circulation Society
Background Patients with heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV)-pulmonary arterial (PA) uncoupling, as assessed by a decrease ratio of tricuspid annular plane systolic excursion (TAPSE) to PA…
View details →DOI: 10.1253/circj.cj-26-0152 