Efficient base editing and development in human embryos without chromosomal alterations
Jerabek S; Kim J; Sung J; Jung C; Kulmann MIR; Isado M; Jang H; Li M · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
ABSTRACT Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9 result in frequent aneuploidy and…
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Metadata source: Europe PMC · DOI 10.64898/2026.05.30.728989