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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 606 of 664

Negative / Null Result ReportMedicine

Antibody Responses Elicited by Vaccination with Recombinant LaSota Virus Expressing IBV Spike in Chickens with Maternal Antibodies.

Cuadrado C, Breedlove C, Toro H · 2025 · Avian diseases

Vaccination with a recombinant Newcastle disease virus (NDV) LaSota (LS) strain expressing Arkansas (Ark) -type infectious bronchitis virus (IBV) spike ectodomain (Se) protein and granulocyte-macrophage colony-stimulating factor (GMCSF)…

View details →DOI: 10.1637/aviandiseases-d-25-00035
Negative / Null Result ReportMedicine

Stem migration and bone density at ten years : a randomized radiostereometry and dual-energy X-ray absorptiometry study on a short uncemented hip stem with and without a collar.

Daudi S, Zampelis V, Belfrage O et al. · 2025 · The bone & joint journal

Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and…

View details →DOI: 10.1302/0301-620x.107b9.bjj-2024-1720.r1
Negative / Null Result ReportMedicine

The Impact of Intermaxillary Fixation Screws on Long-Term Dental Complications in Pediatric Facial Fractures.

Gündüz N, Duran M, Erdal AI et al. · 2026 · The Journal of craniofacial surgery

Facial fractures are a significant aspect of pediatric trauma cases. The impact of intermaxillary fixation (IMF) using screws on dental development, particularly in pediatric patients undergoing primary and mixed dentition, remains a…

View details →DOI: 10.1097/scs.0000000000011750
Negative / Null Result ReportMedicine

Clinical outcomes according to the location of graft retear after arthroscopy-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears.

Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal

Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…

View details →DOI: 10.1302/0301-620x.107b10.bjj-2024-1573.r2
Negative / Null Result ReportMedicine

Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.

Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine

Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…

View details →DOI: 10.1007/s00134-025-08104-8
Negative / Null Result ReportMedicine

Rabies immunoglobulin overdose in post-exposure prophylaxis.

Łukasik AJ, Podlasin RB · 2025 · Przeglad epidemiologiczny

Rabies is a zoonotic viral infection caused by an RNA virus from the Rhabdoviridae family, a Lyssavirus species with the highest mortality rate among all infectious diseases. Post-exposure propylahis (PEP) should be applied as soon as…

View details →DOI: 10.32394/pe/205745
Negative / Null Result ReportOpen accessMedicine

Simulated brushing effects on surface roughness and color stability of coated additively manufactured dental resin: an in vitro study.

Alsalem Z, Alothemeen M, Alshehri D et al. · 2026 · Journal of medicine and life

This study aimed to evaluate the effect of a glaze coating on the surface roughness and color stability of 3D-printed temporary crown resin materials before and after simulated toothbrushing. Nano-filled ceramic resin specimens were…

View details →DOI: 10.25122/jml-2025-0181
Negative / Null Result ReportMedicine

Prediction of the digestibility and digestible energy content of hay for horses using an enzymatic degradability method.

Andueza D, Martin-Rosset W · 2025 · Animal : an international journal of animal bioscience

The nutritive value of forage for horses is closely dependent on the digestibility of organic matter (OMD), which is typically measured in vivo. Researchers have developed a variety of prediction methods to estimate the digestibility value…

View details →DOI: 10.1016/j.animal.2025.101597
Negative / Null Result ReportOpen accessMedicine

Variations in cow milk and teat skin microbiota across the lactation cycle with intramammary cephalosporin use at dry-off.

Van Beeck W, Lemos MLP, Niesen AM et al. · 2026 · Applied and environmental microbiology

Cephalosporins and other broad-spectrum antibiotics are frequently administered prophylactically into the udder when dairy cows end their lactation cycle, termed dry-off, to reduce mastitis risk. However, the use of antibiotics on cows…

View details →DOI: 10.1128/aem.02312-25
Negative / Null Result ReportOpen accessMedicine

Determining the Minimal Number of Passive Hip and Knee Joint Movement Repetitions Recommended for the Stiff Rectus Femoris Muscle Due to Osgood-Schlatter Disease.

Ikeda N, Yoshikawa A, Yamaguchi S et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Osgood-Schlatter disease (OSD) is a common overuse condition in adolescents characterized by increased stiffness of the rectus femoris muscle, which contributes to pain and functional limitations around the knee. We…

View details →DOI: 10.3390/children13040460
Negative / Null Result ReportMedicine

Permitless Carry Laws and FIREARM-RELATED Injuries at a Level I Trauma Center.

Herrin J, Givens L, Jordan C et al. · 2025 · The American surgeon

Firearm-related injuries (FRI) are a public health issue in the United States. Permitless carry laws (PCL) eliminate the need for permits to carry firearms. This study evaluates the effects of Alabama's PCL implementation on FRI rates at a…

View details →DOI: 10.1177/00031348251358426
Negative / Null Result ReportOpen accessMedicine

Effect of ultraviolet surface treatment on color stability, surface water contact angle and bond strength of monolithic zirconia.

Yiğit E, Çulhaoğlu AK · 2026 · BMC oral health

BACKGROUND: This laboratory study investigated the impact of ultraviolet light exposure on the color, surface water contact angle, and resin cement–zirconia bond strength. METHODS: Fourty-five zirconia specimens were randomly divided into…

View details →DOI: 10.1186/s12903-026-07963-x
Negative / Null Result ReportMedicine

Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

Giamarellos-Bourboulis EJ, Jemec GBE, Prens EP et al. · 2026 · The British journal of dermatology

Background The results of a previous phase IIa trial suggested efficacy of the anti-C5a compound vilobelimab in a small number of patients with severe hidradenitis suppurativa (HS) refractory to adalimumab treatment. Objectives To study…

View details →DOI: 10.1093/bjd/ljaf398
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of an Antibacterial Envelope in Patients at High Risk of Cardiac Implantable Electronic Device Infection in the Australian Public Healthcare System.

Hill M, Khalaj BH, Shawon MSR et al. · 2026 · Journal of arrhythmia

Background The Worldwide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT) demonstrated a 40% reduction of major cardiac implantable electronic device (CIED) infection with the use of an absorbable antibacterial envelope…

View details →DOI: 10.1002/joa3.70282
Negative / Null Result Report

Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS Randomized Controlled Trial

Chowdhury R, Maiti U, Devi S et al. · 2025 · Preprint

Background Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal…

View details →DOI: 10.1101/2025.08.10.25333400
Negative / Null Result ReportOpen accessMedicine

The impact paradox: mixed-methods evaluation of National Institute of Health and Care Research funding for intellectual disability research in the UK.

Goddard N, Dale M, Bishop R et al. · 2026 · BJPsych open

Background People with intellectual disability experience substantial health inequities, including higher multimorbidity, increased healthcare utilisation and markedly reduced life expectancy. High-quality research is essential to address…

View details →DOI: 10.1192/bjo.2026.11023
Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films - comparison with zeolite- and activated carbon-based carriers.

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International journal of biological macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

View details →DOI: 10.1016/j.ijbiomac.2025.146017
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Balci BB et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v5
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Balci BB et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v3
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Buchanan EM et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v2
Negative / Null Result ReportOpen accessMedicine

A case-control neuroimaging investigation of chronic Zika virus-infected adults.

Jun S, Bido-Medina R, Oviedo J et al. · 2026 · Frontiers in human neuroscience

Background Systemic viral infections with neurotropic potential pose significant global health challenges. The Zika virus (ZIKV) is known for its pronounced neurotropism, with recent infectious clusters raising renewed public health…

View details →DOI: 10.3389/fnhum.2026.1710905
Negative / Null Result ReportMedicine

Does affective processing require awareness? On the use of the Perceptual Awareness Scale in response priming research.

Wentura D, Rohr M, Kiefer M · 2025 · Journal of experimental psychology. General

Masked priming paradigms are frequently used to shine light on the processes of nonconscious cognition. Introducing a new method to this field, Lähteenmäki et al. (2015) claimed that affective priming requires awareness. Specifically, they…

View details →DOI: 10.1037/xge0001648
Negative / Null Result ReportOpen accessMedicine

Biological Therapy Leads to a Reduction in Systemic Inflammation but Leaves Serum Uric Acid Unmodified in Moderate-to-Severe Plaque Psoriasis: A Prospective Longitudinal Cohort Study.

Suiu LI, Vreju FA, Turcu-Stiolica A et al. · 2026 · Journal of clinical medicine

Background/Objective: Psoriasis is a systemic inflammatory disease often associated with metabolic comorbidities, including hyperuricemia. While biological therapies effectively target inflammatory pathways, their specific impact on serum…

View details →DOI: 10.3390/jcm15103817
Negative / Null Result ReportOpen accessMedicine

Are Atrial Fibrillation Risk Loci Universally Applicable? Insights from Whole-Genome Sequencing in a Polish Population.

Wasiak M, Sypniewski M, Dobosz P et al. · 2026 · Medical sciences (Basel, Switzerland)

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide and has a substantial genetic component. Genome-wide association studies (GWASs) have identified more than 100 susceptibility loci; however,…

View details →DOI: 10.3390/medsci14010155