A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 601 of 664
Thumsová B, Martínez-Silvestre A, Pérez-Vallejo M et al. · 2025 · Current biology : CB
The thermal mismatch hypothesis (TMH), the notion that cool- and warm-adapted hosts have higher infection risk during unusually warm and cool spells, respectively, was recently proposed to explain how temperature shifts driven by climate…
Fridberg G, Amit O, Sherf Y et al. · 2026 · Haematologica
CAR-T has transformed relapsed/refractory LBCL treatment, with CD28-based products yielding rapid responses but higher ICANS rates. With Axicabtagene-ciloleucel and Brexucabtagene-autoleucel, overall and severe ICANS reach 78% and 35%,…
Fuster-Calvo A, Oiler I, MacDonald A et al. · 2025 · Preprint
How macroevolution interacts with ecological networks remains a major question in eco-evolutionary science. We investigate this interplay in the Naesiotus snail radiation of the Galápagos Islands, which encapsulates parasitic nematodes…
Pedraza A, Castaño S, Pereira A et al. · 2026 · British journal of haematology
Despite red blood cell (RBC) immunization being a frequent complication of chronic transfusion in myelodysplastic syndromes (MDS), its prognostic significance remains unclear. We analysed 486 transfused patients diagnosed with MDS.…
Sevik HO, Aytepe O, Kilic MK et al. · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A
Introduction Red cell distribution width (RDW) has recently emerged as a potential biomarker reflecting nutritional and inflammatory status in surgical oncology. While anastomotic leakage (AL) remains a devastating complication after right…
Bouwman V, Pittig A, Engelhard I et al. · 2025 · Preprint
Although exposure-based Cognitive Behavioral Therapy is generally effective for anxiety disorders, many people do not benefit. A better understanding of treatment predictors is required. This study investigated whether the dynamics of…
Henriques DY, Gastrock RQ, Hart BM' · 2025 · Preprint
Abstract How do precision of movement and proprioception influence motor control and adaptation? Several theories—such as the exploration-exploitation hypothesis—propose that variability plays a key role in motor performance and learning.…
Scheirlinckx J, Dupré S, De Fruyt F · 2025 · Preprint
Teachers' social-emotional and instructional (SEI) characteristics shape classroom functioning and student outcomes, yet most research relies exclusively on teacher self-reports, potentially overlooking discrepancies between teachers'…
Reyna NC, Hamilton DA · 2026 · Hippocampus
Alzheimer's disease (AD) is characterized by irreversible neurobiological deterioration and cognitive impairment. AD patients exhibit stress system abnormalities including upregulation of the corticotropin releasing factor type 1 receptor…
Moreira FC, Ribeiro MS, Costa CAS et al. · 2026 · Photochemistry and photobiology
Photobiomodulation (PBM) using red LED light (630 nm) has been investigated for its ability to modulate cellular functions relevant to tissue regeneration. This in vitro study evaluated the effects of PBM on the viability, metabolism, and…
Chua YL, Gowri V, Chan IZ et al. · 2026 · Preprint
How insects transmit food odour preferences acquired during the larval stage to their offspring is unknown. Bicyclus anynana butterfly larvae can learn to prefer a banana-smelling odour, isoamyl acetate (IAA), via feeding on coated leaves,…
Jordan G, Stockinger K, Schiltz C et al. · 2025 · Preprint
Parenting is an emotion-eliciting experience that requires parents to navigate the dual demands of regulating their own and their children’s emotions, drawing on regulatory strategies such as reappraisal and rumination. However, patterns…
Fatt SJ, Hay P, George E et al. · 2025 · Sports medicine - open
Background Disordered eating is common in elite athletes and may be motivated by perceived performance advantages associated with becoming leaner. However, few studies have examined the performance outcomes associated with disordered…
Nielsen FE, Abdullah OB, Chafranska L et al. · 2026 · The American journal of emergency medicine
Background Temperature abnormalities are established prognostic markers in sepsis, but their predictive value in older adults with infection without sepsis remains unclear. Objective To examine the association between arrival temperature…
Wolfer P, Tselekidou F, Baumeister F et al. · 2026 · Journal of communication disorders
This study adopts a twofold approach to examine how bilingual exposure and (socio-)cognitive factors influence narrative macrostructure in children. First, it investigated the impact of Exposure to Additional Languages (EtAL) on the…
Duong LHK, Lam NV, Tran VT · 2025 · Preprint
Background: Atrial high-rate episodes (AHRE), a form of subclinical atrial fibrillation detected by pacemakers, are linked to increased stroke risk. While NT-proBNP is a known predictor of atrial fibrillation, the predictive value of…
Murray-Watson RE, Guaracha X, Bilinski A et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
IntroductionDuring the COVID-19 pandemic, many communities across the United States experienced surges in hospitalizations, which strained the local hospital capacity. Some risk metrics, such as the Center for Disease Control and…
Kaneva AM, Bojko ER · 2026 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is a novel and promising marker for metabolic abnormalities. Recent studies have demonstrated that UHR is related to a number of diseases that are caused by insulin resistance.…
van Alebeek H, D'Errico L, Delgadillo J et al. · 2026 · Journal of consulting and clinical psychology
Objective The mechanisms underlying psychotherapy's effects remain debated, with some emphasizing theory-specific therapeutic techniques and others highlighting common factors like therapeutic alliance. Evidence is inconclusive partially…
Aschenbrenner AJ, Jackson JJ, Stout SH et al. · 2025 · Preprint
It is becoming common to repeatedly measure cognition over short intervals in order to capture dynamic fluctuations over time, which can be substantial. It is currently unknown whether daily deviations in cognitive performance have…
Gao Y, Yang J · 2026 · Psychology, health & medicine
Numerous studies have examined the association between fear of COVID-19 (FoC-19) and depressive symptoms using cross-sectional designs. However, the directional nature of this relationship remains unclear. The present study addressed this…
Videman K, Leppänen JM, Hallamaa L et al. · 2026 · Acta paediatrica (Oslo, Norway : 1992)
Aim Growth faltering and loss of development potential are common in low- and middle-income countries. We aimed to study whether linear growth before and after 2 years, height-for-age Z-score (HAZ) from 1 month until 13 years and morbidity…
Mudarris MA, Schaefer RS · 2025 · Preprint
Research on sensorimotor synchronization typically examines finger tapping to auditory rhythms. These studies generally investigate timing accuracy, largely neglecting the force of tapping, which provides information on exertion and thus…
Lineweaver TT, Terwillegar S, Aardsma NJ et al. · 2026 · Experimental aging research
This study examined the role of memory-specific self-regulatory focus in guiding young and older adults' usage of everyday memory strategies Participants included 164 young (ages 18-23) and 204 older (ages 68-75) adults. Structural…
Jeay-Bizot L, Basbug M, Maoz U et al. · 2025 · Preprint
Decades of research have shown that early ramping activity is a very reliable antecedent of self-initiated movement. However, the dominant paradigm has been to only analyze data epochs culminating in movement, which discounts how often…
Klim L, Michalik M, Wąsowicz P et al. · 2025 · Preprint
Background: Oral food challenges (OFCs) are still the reference standard for confirming food allergy, yet the influence of previous anaphylaxis on challenge outcomes remains uncertain. Patients with a history of anaphylaxis are often…
Hathaway DB, Sato T, Szpak V et al. · 2026 · Journal of the Academy of Consultation-Liaison Psychiatry
Background Buprenorphine is an effective treatment for opioid use disorder but may be difficult to initiate among hospitalized patients due to concerns about acute pain and withdrawal risks. Objective We sought to evaluate the safety and…
Pexa BS, Giuliani-Dewig HK, Myers JB et al. · 2025 · Journal of athletic training
Context Baseball pitching load is linked to injury in adolescent baseball athletes; however, it is unclear if pitch counts are a good indicator of total upper extremity load during baseball pitching. Objectives The purpose of this study is…
Tanji T, Takahashi K, Matsushita H et al. · 2025 · Preprint
Abstract We examined the relationship between home literacy environment and early literacy acquisition in Japanese syllabic Hiragana and whether this relationship changes during the preschool years. One hundred five Japanese-speaking young…
Pérez Pisón E, Llàcer P, Croset F et al. · 2026 · Medicina clinica
Introduction Pleural effusion (PE) is a frequent complication in acute heart failure (AHF), driven by hydrostatic pressure, impaired lymphatic drainage, and systemic inflammation. This study aimed to evaluate the association between…