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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21360 results · page 599 of 712

Negative / Null Result ReportOpen accessMedicine

Effect of total knee arthroplasty on the spinopelvic parameters: A systemic review and metanalysis.

Jain M, Pal DK, Narayan Sahu R et al. · 2025 · World journal of orthopedics

Background Sagittal spinopelvic alignment (SSA) is essential for preserving a stable and effective upright posture and locomotion. Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis, hips, and…

View details →DOI: 10.5312/wjo.v16.i7.107869
Negative / Null Result ReportOpen accessMedicine

External quality assessments for SARS-CoV-2 genome detection in Austria : A comparison of the first postpandemic round with results from the pandemic era.

Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift

Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…

View details →DOI: 10.1007/s00508-024-02353-1
Negative / Null Result ReportOpen accessMedicine

Developmental Outcomes in Children With Clubfoot: A Twin Study Comparing Affected and Unaffected Siblings.

Katz A, Kreiner M, Korain Blank P et al. · 2025 · Journal of pediatric orthopedics

Background Clubfoot is a congenital condition affecting 1 to 2 per 1000 live births, with treatment primarily involving the Ponseti method and/or surgical intervention. It is important to ascertain whether children affected by clubfoot are…

View details →DOI: 10.1097/bpo.0000000000003049
Negative / Null Result ReportMedicine

Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial.

Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…

View details →DOI: 10.1016/j.jocn.2025.111156
Negative / Null Result ReportOpen accessMedicine

Different interpretations of inconclusive results of SARS-CoV-2 real-time RT PCR.

La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease

We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…

View details →DOI: 10.1016/j.diagmicrobio.2022.115888
Negative / Null Result ReportOpen accessMedicine

Original article: novelty of Canadian manufacture nasopharyngeal swabs for collection of samples being tested for SARS-CoV-2 in a pandemic setting.

Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health

Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…

View details →DOI: 10.3389/fpubh.2024.1344295
Negative / Null Result ReportMedicine

The association between changes in muscle mass and function and mortality in individuals receiving peritoneal dialysis.

Wang L, Xue C, Zhu B et al. · 2025 · Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Background/objective Data in terms of how dynamic changes of muscle mass and function affect mortality in end-stage kidney disease (ESKD) patients undergoing dialysis have led to inconclusive results. The main goal of this research was to…

View details →DOI: 10.1177/08968608241288958
Negative / Null Result ReportOpen accessMedicine

Ultrasound-Guided Versus Freehand Fine Needle Aspiration: A Comparative Study in Diagnosing Non-Salivary, Non-Thyroidal Head, and Neck Masses.

Rajamanickam SK, Prades Morera E, Agarwal A et al. · 2025 · Cureus

Background Fine needle aspiration cytology (FNAC) is widely used to evaluate head and neck masses, with both ultrasound (US)-guided and freehand techniques being employed. While US-guided FNAC is thought to enhance accuracy, freehand FNAC…

View details →DOI: 10.7759/cureus.82830
Negative / Null Result ReportMedicine

Effects of Recreational Cannabis Legalization on Mental Health: Scoping Review.

Fortier A, Zouaoui I, Dumais A et al. · 2024 · Psychiatric services (Washington, D.C.)

Objective Recreational cannabis legalization (RCL) is expanding rapidly. RCL's effects on mental health issues are of particular concern because cannabis use is more frequent among people receiving psychiatric care and is associated with…

View details →DOI: 10.1176/appi.ps.20230434
Negative / Null Result ReportMedicine

Lack of controlled studies on snakebite prevention: a rapid review.

Rodrigo C, Gnanathasan A · 2024 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Globally, snakebites cause an estimated 80 000-140 000 deaths annually. While there are evidence-based recommendations for managing snakebite victims, recommendations on the prevention of snakebites are limited to expert opinions. We…

View details →DOI: 10.1093/trstmh/trad088
Negative / Null Result ReportOpen accessMedicine

High rates of benzimidazole-resistance-associated alleles in Haemonchus contortus and detection of resistance against macrocyclic lactones in strongylids from German alpaca herds.

Hinney B, Wiedermann S, Vaneev X et al. · 2024 · Parasites & vectors

The population of South American camelids (SAC) has been steadily growing in Europe, where they are confronted with the regional endoparasite population of ruminants. As there are no anthelmintic drugs registered for use against nematode…

View details →DOI: 10.1186/s13071-024-06377-4
Negative / Null Result ReportMedicine

Soluble PD-L1 shows no association to relapse and overall survival in early stage non-small cell lung cancer (NSCLC).

Mildner FO, Sykora MM, Hackl H et al. · 2024 · Lung cancer (Amsterdam, Netherlands)

Background Cancer immune evasion is critical in non-small cell lung cancer (NSCLC) and has been targeted by immunotherapy. High soluble (s)PD-L1 is associated with reduced survival and treatment failure in advanced stages. Here we…

View details →DOI: 10.1016/j.lungcan.2024.107955
Negative / Null Result ReportOpen accessMedicine

A prospective cohort study produces inconclusive results in linking dietary calcium intake to overall and specific causes of mortality.

Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports

Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…

View details →DOI: 10.1038/s41598-025-10484-2
Negative / Null Result ReportOpen accessMedicine

Concomitant Autoimmune Liver Disease and Hepatic Actinomycosis: A Diagnostic Challenge-Brief Report and Review of the Literature.

Manni G, Pambianco M, Sicuro C et al. · 2025 · International journal of molecular sciences

Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified…

View details →DOI: 10.3390/ijms26199420
Negative / Null Result ReportMedicine

No detectable impact of ALPS-treated water discharge on tritium levels in terrestrial waters of the upper Ota River catchment, Fukushima, Japan.

Sakuma K, Yoshimura K · 2026 · Journal of environmental radioactivity

Tritium ( 3 H) is the principal radionuclide remaining in ALPS-treated water discharged from the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), and its potential environmental impact has drawn considerable attention. To evaluate possible…

View details →DOI: 10.1016/j.jenvrad.2026.108055
Negative / Null Result ReportOpen accessMedicine

Elevated high sensitivity cardiac troponin T among men with HIV who use stimulants: A cross-sectional study of subclinical cardiovascular injury.

Larson ME, Pan Y, Reidy L et al. · 2026 · PloS one

People with HIV (PWH) experience elevated cardiovascular disease risk compared to people without HIV. Stimulant use may further increase subclinical myocardial injury among PWH, but data on cardiovascular biomarkers, including serum…

View details →DOI: 10.1371/journal.pone.0350086
Negative / Null Result ReportMedicine

Quadrant-Specific Retinal Nerve Fiber Layer Thinning in Hydroxychloroquine Retinal Toxicity: A Controlled OCT-Based Structural and Exposure Analysis in Systemic Lupus Erythematosus.

Geamănu A, Pîrvulescu RA, Tricorache D et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: Hydroxychloroquine (HCQ) is widely used in systemic lupus erythematosus (SLE), yet cumulative exposure may result in progressive retinal toxicity. Structural biomarkers capable of identifying subclinical damage remain…

View details →DOI: 10.3390/diagnostics16121867
Negative / Null Result ReportMedicine

Satellite-Derived NDVI Trend Indicators for Adaptive Management of Trail-Penetrated Special Protection Areas: A Spatiotemporal Assessment with Markov-Chain Risk Projections.

Sung K · 2026 · Environmental management

Trail penetration within strictly designated protected areas is often treated as a conservation concern, yet its consequences for vegetation trends at national scales remain empirically unresolved. This study evaluated whether trail…

View details →DOI: 10.1007/s00267-026-02544-8
Negative / Null Result ReportMedicine

Reliability of Hepatic Steatosis Quantification by Controlled Attenuation Parameter in Steatotic Liver Disease.

Simonis L, Marcour Y, Embacher J et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Assessment of hepatic steatosis is key for diagnosis and monitoring of steatotic liver disease. Controlled attenuation parameter is widely used, but concerns regarding its measurement variability exist. We evaluated the…

View details →DOI: 10.1016/j.cgh.2026.05.006
Negative / Null Result ReportMedicine

Persistence of antenatal anti-D immunoglobulin G at delivery in twin versus singleton pregnancies: a retrospective cohort study.

Ünlü C, Aksoy H · 2026 · BMC pregnancy and childbirth

Background Anti-D immunoglobulin administered in the early third trimester to Rhesus D negative women with Rhesus D incompatibility is widely assumed to provide protection against silent fetomaternal haemorrhage until delivery. However,…

View details →DOI: 10.1186/s12884-026-09530-2
Negative / Null Result ReportOpen accessMedicine

The challenges of implementing less invasive surgical management for cervical cancer in a limited-resource setting in Botswana: A case series.

Corn E, Becht K, Adefres B et al. · 2026 · Gynecologic oncology reports

Purpose Cervical cancer is the number one cause of cancer-related mortality for women in Botswana, where care is complicated by the country's severe shortage of gynecologic oncologists. Recent data suggests that "low-risk" stage I cervical…

View details →DOI: 10.1016/j.gore.2026.102089
Negative / Null Result ReportOpen accessMedicine

Systemic Cytokine Patterns and Histologic Disease Spectrum in Inflammatory Bowel Disease.

Martinos N, Kroupis C, Gypari M et al. · 2026 · Current issues in molecular biology

Background/objectives Histologic mucosal healing is an increasingly recognized therapeutic target in inflammatory bowel disease (IBD), yet reliable non-invasive correlates remain limited. This study aimed to evaluate circulating cytokine…

View details →DOI: 10.3390/cimb48050516
Methods Dead-End

Far-Infrared Therapy and Vascular Access Flow in Hemodialysis Patients With Arteriovenous Fistula or Graft: A Prospective Minimal Detectable Change Analysis

Kim EJ, Kim SY, Kee YK et al. · 2026 · Preprint

Abstract Far-infrared (FIR) therapy has been proposed to improve vascular access flow (Qa) in patients receiving maintenance hemodialysis through an arteriovenous fistula (AVF) or arteriovenous graft (AVG). However, vascular access blood…

View details →DOI: 10.21203/rs.3.rs-9732400/v1
Negative / Null Result ReportOpen accessMedicine

Neutralising antibody responses to emerging SARS-CoV-2 omicron sub-variants are enhanced in persons with hybrid immunity.

Walmsley SL, Nabipoor M, Qi F et al. · 2026 · Clinical & translational immunology

Objectives To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods We explored SARS-CoV-2 neutralizing antibodies in140 adults participating in a longitudinal study of antibody responses to COVID vaccines.…

View details →DOI: 10.1002/cti2.70095