A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21742 results · page 599 of 725
Chai L, Wang H, Yu H et al. · 2025 · Plant, cell & environment
Trehalose 6-phosphate phosphatases (TPPs) play essential roles in carbohydrate distribution between source and sink organs in plants. Here, we show that TPPs also participate in regulating diurnal carbohydrate partitioning. In tomato,…
Marr N, Zamboulis DE, Beaumont RE et al. · 2026 · Scientific reports
Tendon injuries are common, affecting both athletes and the general population. Healing is often poor, with deposition of fibrotic, disorganised scar-like tissue leading to continued pain, dysfunction and reinjury. The pathogeneses of many…
Timm S, Florian A, Fernie AR et al. · 2026 · Planta
Main conclusion Genetic engineering of Arabidopsis thaliana reveals that mitochondrial serine hydroxymethyltransferase 1 (SHMT1) protein abundance does not limit the capacity of photorespiration, photosynthesis, or stomatal conductance.…
Hibner AM, Tong K, Liu L et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association
Objective To investigate single versus combination hemodynamic parameters on intraventricular hemorrhage (IVH) or mortality in preterm infants. Study design Data from 482 infants under 32 weeks gestational age were analyzed, including…
Normand-Gravier T, Solsona R, Arnould F et al. · 2025 · Journal of thermal biology
The use of kaumatherapy (i.e. heat exposure like sauna-bathing) as passive intervention has become of growing interest to promote skeletal muscle adaptations such as strength gains and preservation of muscle mass. Importantly, the effects…
Doğan MB, Gündüz N, Kazan HÖ et al. · 2025 · European journal of radiology
Objective Muscle invasion in bladder cancer is a crucial factor influencing treatment decisions and prognosis. We hypothesize that the integration of tumor shape characteristics with the VI-RADS scoring system improves the predictive…
Wilkening J, Jungeblut HM, Adamovic I et al. · 2025 · Preprint
Intermittent theta burst stimulation (iTBS) is a promising non-invasive treatment for major depressive disorder (MDD), though significant variability exists in patient responses. This quadruple-blind, sham-controlled crossover randomized…
Redwan B, Biancosino C, Fischer S et al. · 2026 · International journal of molecular sciences
Efferocytosis-the tightly regulated clearance of apoptotic cells by phagocytes-maintains tissue homeostasis and is impaired in chronic obstructive pulmonary disease (COPD), where it contributes to persistent inflammation and increases the…
Song S, Wang B, Kong X et al. · 2025 · Journal of cannabis research
Granulocyte colony-stimulating factor (G-CSF) has the capacity to enhance brain repair following various injuries to brain. G-CSF treatment after TBI in rodents has been reported to promote brain repair, hippocampal neurogenesis, and…
El-Salam SA, Aboalnaga AA, Tawfik WA et al. · 2026 · BMC oral health
OBJECTIVE: To evaluate the effect of gradually increasing orthodontic force magnitude compared with a constant force magnitude on the rate of tooth movement during maxillary canine retraction. METHODS: This split-mouth randomized…
Esjaita EI, Fuensalida SE, Giansanti NH et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS
Recent research in both humans and animals has explored alternative routes for drug administration, such as pharmacopuncture, a technique involving the subcutaneous administration of low drug doses at acupuncture points. Among these…
Litman M, Azarpeykan S, Hood RJ et al. · 2025 · Preprint
In patients with ischaemic stroke, retrograde perfusion of the penumbra by the leptomeningeal collateral vessels (LMCs) is a strong predictor of clinical outcome, thus raising the possibility that enhancing LMC flow could offer a novel…
Russo T, Quarta L, Pellegrino F et al. · 2025 · La Radiologia medica
Purpose Artificial intelligence (AI) has been proposed to assist radiologists in reporting multiparametric magnetic resonance imaging (mpMRI) of the prostate. We evaluate the diagnostic performance of radiologists with different levels of…
Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate Polymers.
Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…
Papadakis Z, Panoutsakopoulos V, Schwarz A et al. · 2025 · Journal of the International Society of Sports Nutrition
Background Caffeine's ergogenic potential in vertical jumping remains contested, particularly at dosages compliant with collegiate athletic regulations. The NCAA enforces a caffeine urinary threshold equivalent to ~5 mg/kg body mass, yet…
Tian T, Patel K, Kim D et al. · 2025 · Neurorehabilitation and neural repair
Background Peripheral nerve injuries are common, and there is a critical need for the development of novel treatments to complement surgical repair. Conditioning electrical stimulation (ES; CES) is a novel variation of the well-studied…
Casagrande L, Bernardo CCO, Sestak SS et al. · 2026 · Neurogastroenterology and motility
Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths, significantly disrupting enteric neurotransmission within the colon. While the effects of CRC on the enteric nervous system (ENS) of the colon are well…
Santoro E, Broockman DE, Kalla JL et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, and improving perceptions of the…
Maggu AR, Overath T · 2026 · PloS one
Purpose This study examined whether phonological complexity enhances auditory word learning within a statistical learning framework. Specifically, we tested if exposure to phonologically complex speech patterns (i.e., marked consonant…
Scherkl M, Stranger N, Ciornei-Hoffman A et al. · 2026 · La Radiologia medica
Background Artificial Intelligence (AI) in radiology has shown promise in detecting fractures on initial X-rays. However, the role of follow-up examinations in enhancing AI performance remains unexplored. This study evaluates the impact of…
Borgognoni AB, Freund SS, Baas J et al. · 2026 · Frontiers in surgery
Introduction Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is compromised. Strontium (Sr) has demonstrated osteogenic…
Guichardaz M, Bottini S, Balmas E et al. · 2024 · Preprint
Background Human induced pluripotent stem cells (hiPSCs) are pivotal for studying human development, modeling diseases, and advancing regenerative medicine. Effective control of transgene expression is crucial to achieve temporal and…
Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes
Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…
Sencenbaugh L, Mangold JM, Ulrich DEM et al. · 2025 · Weed Research.
Non‐native annual grasses are degrading rangelands in the western United States and of vital management importance. Novel management strategies are needed to extend current approaches. The aim of this study was to determine if…
Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy
Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…
Naderi A, Gharaat MA, Berjisian E et al. · 2025 · Research in sports medicine (Print)
This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind,…
Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology
The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…
Risinger WB, Matheson PJ, Franklin ME et al. · 2025 · Shock (Augusta, Ga.)
Abstract Background and Hypothesis: Resuscitation strategies incorporating fresh frozen plasma have become the standard of care in the management of traumatic hemorrhagic shock. While plasma resuscitation has been shown to augment the…
Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases
Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…
Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…