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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 590 of 664

Negative / Null Result ReportOpen accessMedicine

Enoxaparin, Tinzaparin, and Apixaban Modulate Cancer Cell Procoagulant Activity and Viability: Comparison with Quercetin.

Baghdadi MA, do Carmo Las Casas PHF, Mbemba E et al. · 2026 · Cancers

Background/Objectives : Tissue factor (TF)-expressing cancer cells and their extracellular vesicles (CaCe-dEVs) are key drivers of cancer-associated hypercoagulability and vascular dysfunction. While low-molecular-weight heparins (LMWHs)…

View details →DOI: 10.3390/cancers18111783
Negative / Null Result ReportOpen accessMedicine

Computer-Assisted Intramedullary Nailing of Intertrochanteric Fractures Did Not Prevent Tip-Apex Distance Outliers.

Hansen RH, Rölfing JD, Nielsen CL et al. · 2023 · Journal of clinical medicine

Intertrochanteric femoral fractures are commonly treated with intramedullary nails (IMNs). A tip-apex distance (TAD) of more than 20-25 mm is associated with an increased risk of cut-out. The Stryker Adaptive Positioning System (ADAPT) is…

View details →DOI: 10.3390/jcm12237448
Negative / Null Result ReportOpen accessMedicine

Acidification-dependent suppression of <i>C. difficile</i> by pathogenic and commensal enterococci.

Neubauer HR, Ogunyemi IM, Wood AK et al. · 2026 · Infection and immunity

Clostridioides difficile and vancomycin-resistant Enterococcus faecium (VRE) are commonly co-isolated from hospitalized patients. We sought to develop a co-culture biofilm model to characterize interactions between these two opportunistic…

View details →DOI: 10.1128/iai.00159-26
Negative / Null Result ReportOpen accessMedicine

Safe Administration of Fruquintinib in a Hemodialysis Patient with Metastatic Colorectal Cancer: A Case Report.

Takemura K, Murakawa Y, Kono H et al. · 2026 · Case reports in oncology

Introduction Fruquintinib is a selective vascular endothelial growth factor receptor inhibitor approved for metastatic colorectal cancer (mCRC) that is refractory to standard therapies. While its efficacy and safety have been demonstrated…

View details →DOI: 10.1159/000549871
Negative / Null Result Report

Colloid Mill Modified Zein Suspension Technology for Plant Protein Rich Bird Food: First Clutch Performance Compared with Egg Based Food in Fiorino Canaries

Mevliyaoğulları E · 2026 · Preprint

Abstract Background The present study evaluated a technology-driven approach for producing a plant-protein-rich bird food based on colloid-mill-modified zein suspension and compared its first-clutch reproductive performance with an…

View details →DOI: 10.21203/rs.3.rs-9904294/v1
Negative / Null Result ReportMedicine

Changing the narrative: stories reduce biases against anomalous faces.

Bilici N, Paruzel-Czachura M, Workman CI et al. · 2026 · BMC psychology

Facial anomalies, such as scars, are often linked to an "anomalous-is-bad" stereotype, in which people with visible differences are seen as less warm or less moral. We developed the "Normalizing Anomalies with Mobile Exposure" (NAME)…

View details →DOI: 10.1186/s40359-026-04964-x
Negative / Null Result ReportMedicine

Assessing veterinary students' attitudes towards pain in cattle before and after final-year clinical training.

Tschoner T, Mueller KR, Zablotski Y et al. · 2026 · The Veterinary record

Background Cattle only show subtle signs of pain, making pain assessment difficult. The approach to pain and the use of analgesics depend on the treating person's experience and opinions. Methods Bavarian veterinary students were asked to…

View details →DOI: 10.1002/vetr.70731
Negative / Null Result ReportMedicine

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…

View details →DOI: 10.1017/s1355617726102070
Negative / Null Result ReportMedicine

Changes in corneal astigmatism, axial length and anterior chamber depth after vitrectomy and phacovitrectomy in rhegmatogenous retinal detachment.

Liu N, Zhao J, Wu B et al. · 2026 · International ophthalmology

Purpose To evaluate the changes in corneal astigmatism, axial length and anterior chamber depth following vitrectomy versus phacovitrectomy in patients with rhegmatogenous retinal detachment (RRD) under more detail group.To discuss how to…

View details →DOI: 10.1007/s10792-026-04139-y
Negative / Null Result ReportMedicine

A Virtual Tai Chi Intervention for Older Adults with Mobility Disabilities: Results from a Single-Arm Clinical Trial with the TechSAge Tele Tai Chi Program.

Mitzner TL, Remillard ET, Mumma KT et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Telewellness programs can expand access to exercise and social opportunities for older adults, especially those with mobility disabilities. The TechSAge Tele Tai Chi clinical trial assessed whether the Tai Chi for…

View details →DOI: 10.3390/healthcare14121756
Negative / Null Result ReportMedicine

Polarimetric entropy mapping of retinal pigment epithelium in full-thickness macular hole by polarization-sensitive OCT.

Terao R, Yashiro K, Kuriyama T et al. · 2026 · BMC ophthalmology

Background This study is aimed to evaluate retinal pigment epithelium (RPE) entropy in eyes with full-thickness macular hole (FTMH) using polarization-sensitive optical coherence tomography (PS-OCT). Methods Patients diagnosed with…

View details →DOI: 10.1186/s12886-026-05008-z
Negative / Null Result ReportMedicine

Arterial remodeling and plaque changes after balloon angioplasty for de novo coronary lesions using DCB.

Kerr S, Minatoguchi S, Dumitriu Carcoana AO et al. · 2026 · Cardiovascular intervention and therapeutics

This study evaluated the serial anatomical and morphological changes in de novo coronary lesions treated with a drug-coated balloon (DCB) using integrated-backscatter intravascular ultrasound (IB-IVUS). The aim of this study was to…

View details →DOI: 10.1007/s12928-026-01298-8
Negative / Null Result ReportMedicine

Potential usefulness of [123I]I-MIBG SPECT/CT with AC Quant protocols in diagnostics and treatment monitoring of children with neuroblastoma.

Śliwińska A, Świtaj K, Durma AD · 2026 · Nuclear medicine review. Central & Eastern Europe

Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. Metaiodobenzylguanidine (MIBG) selectively accumulates in adrenergic tissue, enabling its use for diagnostic imaging of NB. The implementation of new…

View details →DOI: 10.5603/nmr.110976
Negative / Null Result ReportMedicine

Real-World Observations on the Diagnosis of Syphilis After Roll-Out of Doxycycline Postexposure Prophylaxis.

Lehman A, Layton P, Mishkulin S et al. · 2026 · Sexually transmitted diseases

Doxycycline postexposure prophylaxis (doxyPEP) may affect RPR titers. We describe syphilis diagnosis following doxyPEP roll-out. Syphilis diagnoses decreased (3.4%-1.5%) among persons prescribed doxyPEP. Diagnosis without laboratory…

View details →DOI: 10.1097/olq.0000000000002298
Negative / Null Result ReportMedicine

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia.

Costa D, Guerra A, Birreci D et al. · 2026 · Movement disorders : official journal of the Movement Disorder Society

Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining…

View details →DOI: 10.1002/mds.70394
Negative / Null Result ReportMedicine

Maxillary Advancement and Impaction Increase the Size of the Nasal Airway Anterior to the Piriform Aperture, but Not Posterior to it.

Giotakis AI, Steinbichler TB, Heppt H et al. · 2026 · The Journal of craniofacial surgery

The exact nasal changes caused by several types of maxillofacial surgery are not yet thoroughly understood. The aim of the present study was to determine the exact nasal airway changes caused by maxillary advancement and impaction. In a…

View details →DOI: 10.1097/scs.0000000000012853
Negative / Null Result ReportOpen accessMedicine

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High-Dose Salbutamol During Resistance Training: A Randomized Controlled Trial.

Hostrup M, Jessen S, Tischer SG et al. · 2026 · Scandinavian journal of medicine & science in sports

Misuse of beta 2 -agonists to promote leanness is increasingly reported among young men undertaking resistance training. However, preclinical models demonstrate adverse cardiac remodeling with high-dose beta 2 -agonist. We investigated…

View details →DOI: 10.1111/sms.70302
Negative / Null Result ReportMedicine

Change in modified star excursion balance test performance between 6 and 12 months after anterior cruciate ligament reconstruction.

Rostron ZPJ, Feller JA, McClelland JA et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To determine the change in modified star excursion balance test scores in patients between 6 and 12 months following anterior cruciate ligament (ACL) reconstruction and the change in the proportion of patients who met…

View details →DOI: 10.1016/j.ptsp.2026.101941
Negative / Null Result ReportMedicine

Proximal Calf Muscle Cross-Sectional Area After Anterior Cruciate Ligament Reconstruction: A Longitudinal MRI Evaluation.

Hart HF, Patterson BE, Atkinson HF et al. · 2026 · Journal of sport rehabilitation

Context Weakness of the quadriceps and hamstrings often persists following rehabilitation after anterior cruciate ligament reconstruction (ACLR). Yet, recovery of the gastrocnemius muscle following ACLR remains unclear. Thus, we aimed to…

View details →DOI: 10.1123/jsr.2026-0023
Negative / Null Result ReportMedicine

Sono-anatomy of the supraclavicular region for ultrasound-guided subclavian vein catheterization: revaluation of a former method.

Berk AZ, Balaban O, Eman A et al. · 2026 · BMC anesthesiology

BACKGROUND/OBJECTIVE: Ultrasound-guided subclavian vein (SCV) catheterization offers an alternative approach to the classical jugular vein catheterization for central venous catheter placement. The objective of this study was to evaluate…

View details →DOI: 10.1186/s12871-026-03857-1
Negative / Null Result ReportOpen accessMedicine

Changes in macular structure after removal of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium.

Lee CH, Kim KH, Choi YJ et al. · 2026 · Scientific reports

This study investigates the effect of epiretinal membrane (ERM) removal in the combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) patients. In this retrospective, comparative case series, 15 CHRRPE patients were…

View details →DOI: 10.1038/s41598-026-39124-z
Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

View details →DOI: 10.1080/13625187.2025.2596612