Negative / Null Result ReportOpen accessNeuroscience
Sasan Partovi, Bjoern Jacobi, Nora Rapps et al. · 2012 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Brain tumors affecting language-relevant areas may influence language lateralization. The purpose of this study was to systematically investigate language lateralization in brain tumor patients using clinical language fMRI, comparing the results with a group of healthy volunteers. MATERIALS AND METHODS: Fifty-seven strictly right-handed patients with left-hemispheric-space intracranial masses (mainly neoplastic) affecting either the Broca area (n = 19) or Wernicke area (n = 38) were prospectively enrolled in this study. Fourteen healthy volunteers served as a control gr
View details →DOI: 10.3174/ajnr.a3137Cited by 74 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
João Gustavo Claudino, Bruno Mezêncio, Sérgio Tibiriçá Amaral et al. · 2014 · Journal of the International Society of Sports Nutrition
BACKGROUND: Studies involving chronic creatine supplementation in elite soccer players are scarce. Therefore, the aim of this study was to examine the effects of creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players (n = 14 males) during pre-season training. FINDINGS: This was a randomized, double-blind, placebo-controlled parallel-group study. Brazilian professional elite soccer players participated in this study. During the pre-season (7 weeks), all the subjects underwent a standardized physical and specific soccer training. Prior to and after eith
View details →DOI: 10.1186/1550-2783-11-32Cited by 74 Negative / Null Result ReportOpen accessMedicine
Renata Aguiar, Cristina Araújo, G. Martins‐Coelho et al. · 2016 · Arthritis Care & Research
OBJECTIVE: To describe the clinical outcome and safety of rituximab (RTX) treatment in systemic lupus erythematosus (SLE) patients with severe manifestations or whose disease is refractory to standard immunosuppressive therapy, treated at…
View details →DOI: 10.1002/acr.22921Cited by 74 Negative / Null Result ReportMedicine
Piia Seppälä, Saija Mauno, Marja-Liisa Kinnunen et al. · 2011 · The Journal of Positive Psychology
The present study investigated whether work engagement is related to and can explain healthy cardiac autonomic activity as indicated by decreased heart rate (HR; i.e., sympathetic and parasympathetic activity) and increased high-frequency…
View details →DOI: 10.1080/17439760.2011.637342Cited by 74 Negative / Null Result ReportOpen accessPsychology
Matthew J. Hirshberg, Corrina Frye, Cortland J. Dahl et al. · 2022 · Journal of Educational Psychology
s<.031 corrected except mindful action at follow-up). We found no evidence for elevated adverse events and the HMP was equally effective among participants with elevated baseline anxiety and depressive symptoms. These data suggest that the…
View details →DOI: 10.1037/edu0000739Cited by 74 Negative / Null Result ReportOpen accessImmunology and Microbiology
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen et al. · 2024 · Genome Medicine
BACKGROUND: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes and performed a phase 1 clinical trial in triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy, a patient population at high risk of disease recurrence. METHODS: Expressed somatic mutations were identified by tumor/normal exome sequencing and tumor RNA sequencing. The pVACtools sof
View details →DOI: 10.1186/s13073-024-01388-3Cited by 74 Negative / Null Result ReportOpen accessMedicine
Philippa Garety, Clementine Edwards, Hassan Jafari et al. · 2024 · Nature Medicine
Distressing voices are a core symptom of psychosis, for which existing treatments are currently suboptimal; as such, new effective treatments for distressing voices are needed. AVATAR therapy involves voice-hearers engaging in a series of facilitated dialogues with a digital embodiment of the distressing voice. This randomized phase 2/3 trial assesses the efficacy of two forms of AVATAR therapy, AVATAR-Brief (AV-BRF) and AVATAR-Extended (AV-EXT), both combined with treatment as usual (TAU) compared to TAU alone, and conducted an intention-to-treat analysis. We recruited 345 participants with p
View details →DOI: 10.1038/s41591-024-03252-8Cited by 73 Negative / Null Result ReportOpen accessMedicine
Imane Boutitah-Benyaich, Herena Eixarch, Javier Villacieros‐Álvarez et al. · 2025 · Signal Transduction and Targeted Therapy
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in understanding its immunopathogenesis, current immunotherapies remain limited in their ability to halt disease progression, making multiple sclerosis incurable and highlighting the critical need for novel therapeutic strategies. Antigen-specific immunotherapy represents a groundbreaking approach that aims to restore immune tolerance to myelin-derived antigens
View details →DOI: 10.1038/s41392-025-02415-4Cited by 73 Negative / Null Result ReportPsychology
Michael Minkov, Anneli Kaasa · 2020 · Cross Cultural & Strategic Management
Purpose Recent studies exposed serious issues with Hofstede's popular model of culture, especially his uncertainty avoidance (UA) and masculinity-femininity (MAS–FEM) dimensions. However those studies did not focus on work-related issues…
View details →DOI: 10.1108/ccsm-05-2020-0120Cited by 73 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Céline Carillier, Hélène Larroque, Christèle Robert-Granié · 2014 · Genetics Selection Evolution
BACKGROUND: All progeny-tested bucks from the two main French dairy goat breeds (Alpine and Saanen) were genotyped with the Illumina goat SNP50 BeadChip. The reference population consisted of 677 bucks and 148 selection candidates. With the two-step approach based on genomic best linear unbiased prediction (GBLUP), prediction accuracy of candidates did not outperform that of the parental average. We investigated a GBLUP method based on a single-step approach, with or without blending of the two breeds in the reference population. METHODS: Three models were used: (1) a multi-breed model, in whi
View details →DOI: 10.1186/s12711-014-0067-3Cited by 73 Negative / Null Result ReportDentistry
Frank Schwarz, Didem Hazar, Kathrin Becker et al. · 2018 · Journal Of Clinical Periodontology
OBJECTIVES: To assess and compare the efficacy and safety of autogenous tooth roots (TR) and autogenous bone blocks (AB) for lateral alveolar ridge augmentation and two-stage implant placement. MATERIAL AND METHODS: A total of 30 patients…
View details →DOI: 10.1111/jcpe.12977Cited by 73 Negative / Null Result ReportOpen accessMedicine
Robert S. Schwartz, Stacia Merkel Kraus, Jonathan Schwartz et al. · 2014 · PubMed
BACKGROUND: Long-term marathon running improves many cardiovascular risk factors, and is presumed to protect against coronary artery plaque formation. This hypothesis, that long-term marathon running is protective against coronary…
Negative / Null Result ReportOpen accessMedicine
Haitao Xiao, Yong Sik Yoon, Seung‐Mo Hong et al. · 2013 · American Journal of Clinical Pathology
OBJECTIVES: To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD). METHODS: Study patients were divided into…
View details →DOI: 10.1309/ajcp8p2dynkgrbviCited by 73 Negative / Null Result ReportHealth Professions
Valarie Blue Bird Jernigan, Marianna S. Wetherill, Jordan Hearod et al. · 2017 · American Journal of Public Health
OBJECTIVES: To examine food insecurity and cardiovascular disease-related health outcomes among American Indians (AIs) in rural Oklahoma. METHODS: We surveyed a cross-sectional sample of 513 AI adults to assess food insecurity domains…
View details →DOI: 10.2105/ajph.2016.303605Cited by 73 Negative / Null Result Report
Marje Prank, Shawn C Kenaley, Gary C Bergstrom et al. · 2019 · Environmental Research Letters
Abstract Long range atmospheric transport is an important pathway for the spread of plant pathogens, such as rust fungi which can devastate cereal crop health and food security worldwide. In recent years, serious concern has been caused by…
View details →DOI: 10.1088/1748-9326/ab57deCited by 73 Negative / Null Result Report
Steffen Klamt, Radhakrishnan Mahadevan, Oliver Hädicke · 2017 · Biotechnology Journal
Apart from product yield and titer, volumetric productivity is a key performance indicator for many biotechnological processes. Due to the inherent trade‐off between the production of biomass as catalyst and of the actual target product,…
View details →DOI: 10.1002/biot.201700539Cited by 73 Negative / Null Result ReportOpen accessNeuroscience
Tom Smeets, Peter van Ruitenbeek, Bart Hartogsveld et al. · 2018 · Brain and Cognition
Instrumental learning, i.e., learning that specific behaviors lead to desired outcomes, occurs through goal-directed and habit memory systems. Exposure to acute stress has been shown to result in less goal-directed control, thus rendering…
View details →DOI: 10.1016/j.bandc.2018.05.005Cited by 73 Negative / Null Result ReportHealth Professions
Stavroula Stavrakaki, Kalliopi Megari, Mary H. Kosmidis et al. · 2012 · Journal of Clinical and Experimental Neuropsychology
We investigated working memory and verbal fluency in simultaneous interpreters, expecting to find enhanced working memory and semantic processing in interpreters relative to others fluent in a second language. The interpreters (n = 15)…
View details →DOI: 10.1080/13803395.2012.667068Cited by 73 Negative / Null Result ReportOpen accessMedicine
Fernando A. Monteiro, Т. Е. Перетолчина, Cristiano Lazoski et al. · 2013 · PLoS ONE
BACKGROUND: Triatoma dimidiata is among the main vectors of Chagas disease in Latin America. However, and despite important advances, there is no consensus about the taxonomic status of phenotypically divergent T. dimidiata populations, which in most recent papers are regarded as subspecies. METHODOLOGY AND FINDINGS: A total of 126 cyt b sequences (621 bp long) were produced for specimens from across the species range. Forty-seven selected specimens representing the main cyt b clades observed (after a preliminary phylogenetic analysis) were also sequenced for an ND4 fragment (554 bp long) and
View details →DOI: 10.1371/journal.pone.0070974Cited by 73 Negative / Null Result ReportImmunology and Microbiology
Richard Stebbings, David Eastwood, Stephen Poole et al. · 2012 · Journal of Immunotoxicology
The failure of regulatory science to keep pace with and support the development of new biological medicines was very publically highlighted in March 2006 when the first-in-man Phase I clinical trial of the immunomodulatory CD28-specific…
View details →DOI: 10.3109/1547691x.2012.711783Cited by 73 Negative / Null Result ReportOpen accessPsychology
Sabina Eggert, Frauke Ostermeyer, Marcus Hasselhorn et al. · 2013 · Education Research International
The purpose of the present study was to examine the effects of cooperative training strategies to enhance students' socioscientific decision making as well as their metacognitive skills in the science classroom. Socioscientific decision making refers to both “describing socioscientific issues” as well as “developing and evaluating solutions” to socioscientific issues. We investigated two cooperative training strategies which differed with respect to embedded metacognitive instructions that were developed on the basis of the IMPROVE method. Participants were 360 senior high school students who
View details →DOI: 10.1155/2013/309894Cited by 73 Negative / Null Result ReportOpen accessMedicine
Arshad Khan, Lovepreet K. Mann, Ramesha Papanna et al. · 2017 · Scientific Reports
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb. Dil-oxLDL and rMBSA taken up into MSC endosomes colocalized wi
View details →DOI: 10.1038/s41598-017-15290-zCited by 73 Negative / Null Result ReportOpen accessSocial Sciences
Haudi Haudi, Erna Retno Rahadjeng, Ruby Santamoko et al. · 2021 · Uncertain Supply Chain Management
The aim of this research is to analyze the effects of e-Marketing, e-CRM and e-Marketing on e-Loyalty and company performance. The study is quantitative with a questionnaire approach. Data processing tools use the SmartPLS 3.3.3 software.…
View details →DOI: 10.5267/j.uscm.2021.9.006Cited by 73 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
François Renoz, Christine Noël, Abdelmounaim Errachid et al. · 2015 · PLoS ONE
In addition to its obligatory symbiont Buchnera aphidicola, the pea aphid Acyrthosiphon pisum can harbor several facultative bacterial symbionts which can be mutualistic in the context of various ecological interactions. Belonging to a genus where many members have been described as pathogen in invertebrates, Serratia symbiotica is one of the most common facultative partners found in aphids. The recent discovery of strains able to grow outside their host allowed us to simulate environmental acquisition of symbiotic bacteria by aphids. Here, we performed an experiment to characterize the A. pis
View details →DOI: 10.1371/journal.pone.0122099Cited by 73 Negative / Null Result ReportMedicine
Trina Das, Jean‐Jacques Hoarau, Marie Christine Jaffar Bandjee et al. · 2014 · Journal of General Virology
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control…
View details →DOI: 10.1099/vir.0.071175-0Cited by 73 Negative / Null Result ReportOpen accessMedicine
Andrés Cárdenas, Sabrina Faleschini, Andrea P. Cortés Hidalgo et al. · 2019 · Clinical Epigenetics
BACKGROUND: Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA. METHODS: A discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in East
View details →DOI: 10.1186/s13148-019-0653-xCited by 73 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Lydia K. Greene, Kathleen E. Grogan, Kendra Smyth et al. · 2016 · Royal Society Open Science
Animals communicating via scent often deposit composite signals that incorporate odorants from multiple sources; however, the function of mixing chemical signals remains understudied. We tested both a 'multiple-messages' and a 'fixative' hypothesis of composite olfactory signalling, which, respectively, posit that mixing scents functions to increase information content or prolong signal longevity. Our subjects-adult, male ring-tailed lemurs (Lemur catta)-have a complex scent-marking repertoire, involving volatile antebrachial (A) secretions, deposited pure or after being mixed with a squalene-
View details →DOI: 10.1098/rsos.160076Cited by 72 Negative / Null Result ReportOpen accessMedicine
Katherine S. Ruth, Robin N. Beaumont, Jessica Tyrrell et al. · 2016 · Human Reproduction
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: The FSHB promoter polymorphism (rs10835638; c.-211G>T) affects levels of FSHB transcription and, as a result, circulating levels of FSH. FSH is required for normal fertility and genetic variants at the FSHB locus are as
View details →DOI: 10.1093/humrep/dev318Cited by 72 Negative / Null Result ReportOpen accessSocial Sciences
Goele Bossaert, Anke de Boer, Per Frostad et al. · 2015 · Irish Educational Studies
Yearly data are collected describing progress in inclusive education. Frequently used criteria are the percentages of students attending special schooling or percentages of students officially labelled as having special educational needs…
View details →DOI: 10.1080/03323315.2015.1010703Cited by 72 Negative / Null Result ReportMedicine
Ryuji Sakakibara, Kuniko Tsunoyama, H Hosoi et al. · 2010 · LUTS Lower Urinary Tract Symptoms
OBJECTIVES: To compare three positions for defecation by measuring abdominal pressure and the anorectal angle simultaneously. METHODS: We recruited six healthy volunteers. The videomanometric measures included simultaneous fluoroscopic…
View details →DOI: 10.1111/j.1757-5672.2009.00057.xCited by 72 