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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 586 of 725

Negative / Null Result ReportOpen accessMedicine

Safe Administration of Fruquintinib in a Hemodialysis Patient with Metastatic Colorectal Cancer: A Case Report.

Takemura K, Murakawa Y, Kono H et al. · 2026 · Case reports in oncology

Introduction Fruquintinib is a selective vascular endothelial growth factor receptor inhibitor approved for metastatic colorectal cancer (mCRC) that is refractory to standard therapies. While its efficacy and safety have been demonstrated…

View details →DOI: 10.1159/000549871
Negative / Null Result ReportMedicine

Effects of a game-based learning ıntervention on self-reported learning strategies and professional attitudes in kinesiophobia management education: a parallel-group randomized controlled trial.

Yılmaz NA, Caner İ · 2026 · BMC medical education

Innovative educational strategies are increasingly needed in physiotherapy education to support students' learning and professional development. Game-based learning (GBL) is an interactive, student-centered approach that may enhance…

View details →DOI: 10.1186/s12909-026-09782-8
Negative / Null Result Report

Trophic interactions of ants are robust to tree species loss

Spitz J, Langlotz A, Lunow J et al. · 2026 · Preprint

1. How changes in habitat conditions influence insect diversity has been intensively studied. However, whether trophic interactions of insects are also influenced by such changes is largely unknown. Higher habitat heterogeneity is often…

View details →DOI: 10.32942/x2wx00
Negative / Null Result ReportOpen accessMedicine

Sodium in Canadian processed foods between 2010 and 2020: implications for future sodium reduction initiatives.

Ziraldo ER, Yang Y, Arcand J et al. · 2026 · Public health nutrition

Objectives To assess changes in (1) Na content of processed foods in the Canadian food supply and (2) the proportion of products meeting Health Canada's voluntary Na reduction targets (SRT) between 2010 and 2020. Design This repeated,…

View details →DOI: 10.1017/s1368980026102067
Negative / Null Result Report

The overall brain functional connection of morbid obese participants did not change significantly when the rapid decline of body weight after bariatric surgery

bai j, han m, wu x et al. · 2026 · Preprint

Abstract Background It is reported that the micro-functional connections of obese patients are abnormal and vary greatly after bariatric surgery. However the effect and change of the overall brain functional connection remain uncertain.…

View details →DOI: 10.21203/rs.3.rs-8318590/v1
Negative / Null Result ReportMedicine

Engineering a Fungal Non-Reducing Polyketide Synthase with an Apparently Inactive Product-Template Domain Reveals Insights into the Catalytic Reprogramming.

Yin R, Qin Y, Liang X et al. · 2026 · International journal of molecular sciences

Fungal iterative non-reducing polyketide synthases (NR-PKS) contain a unique product template (PT) domain for aromatic cyclization. Among them, some NR-PKSs, such as the sorbicillin NR-PKS (SorB), have an apparently inactive PT. It is…

View details →DOI: 10.3390/ijms27125534
Negative / Null Result ReportMedicine

Complex flow in the proximal internal carotid artery challenges Doppler flow assumptions.

Ling SHT, Zafiris E, Cohen JN et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Conventional duplex ultrasound is commonly used to measure blood velocity in the internal carotid artery (ICA) for disease screening and cerebral or extracranial flow estimation. Pouseillian-based flow calculations assume laminar flow,…

View details →DOI: 10.1152/japplphysiol.00452.2026
Negative / Null Result ReportMedicine

Examining ecological momentary assessment (EMA) alone versus EMA with personalized feedback for hazardous drinking among Korean college students.

Lee S, Lee M, Song H et al. · 2026 · Addictive behaviors

Ecological momentary assessment (EMA) may function not only as an assessment method but possibly also an intervention strategy by increasing self-monitoring and awareness of drinking behavior. Personalized feedback (PF) integrated with EMA…

View details →DOI: 10.1016/j.addbeh.2026.108780
Negative / Null Result ReportMedicine

Rectus Femoris Neuromechanical Responses to Exercise-Induced 3% Body Mass Loss by Baseline Hydration Status: A Randomized Group Comparison.

Skotniczny K, Terbalyan A, Linek P et al. · 2026 · Nutrients

Background Acute dehydration impairs performance, but its effects on resting neuromuscular and tissue mechanics are unclear. We tested whether baseline hydration status and exercise-induced sweat loss alter the resting neuromechanical…

View details →DOI: 10.3390/nu18122015
Negative / Null Result Report

Colloid Mill Modified Zein Suspension Technology for Plant Protein Rich Bird Food: First Clutch Performance Compared with Egg Based Food in Fiorino Canaries

Mevliyaoğulları E · 2026 · Preprint

Abstract Background The present study evaluated a technology-driven approach for producing a plant-protein-rich bird food based on colloid-mill-modified zein suspension and compared its first-clutch reproductive performance with an…

View details →DOI: 10.21203/rs.3.rs-9904294/v1
Negative / Null Result ReportMedicine

Changing the narrative: stories reduce biases against anomalous faces.

Bilici N, Paruzel-Czachura M, Workman CI et al. · 2026 · BMC psychology

Facial anomalies, such as scars, are often linked to an "anomalous-is-bad" stereotype, in which people with visible differences are seen as less warm or less moral. We developed the "Normalizing Anomalies with Mobile Exposure" (NAME)…

View details →DOI: 10.1186/s40359-026-04964-x
Negative / Null Result ReportMedicine

Assessing veterinary students' attitudes towards pain in cattle before and after final-year clinical training.

Tschoner T, Mueller KR, Zablotski Y et al. · 2026 · The Veterinary record

Background Cattle only show subtle signs of pain, making pain assessment difficult. The approach to pain and the use of analgesics depend on the treating person's experience and opinions. Methods Bavarian veterinary students were asked to…

View details →DOI: 10.1002/vetr.70731
Negative / Null Result ReportMedicine

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…

View details →DOI: 10.1017/s1355617726102070
Negative / Null Result ReportMedicine

Changes in corneal astigmatism, axial length and anterior chamber depth after vitrectomy and phacovitrectomy in rhegmatogenous retinal detachment.

Liu N, Zhao J, Wu B et al. · 2026 · International ophthalmology

Purpose To evaluate the changes in corneal astigmatism, axial length and anterior chamber depth following vitrectomy versus phacovitrectomy in patients with rhegmatogenous retinal detachment (RRD) under more detail group.To discuss how to…

View details →DOI: 10.1007/s10792-026-04139-y
Negative / Null Result ReportMedicine

A Virtual Tai Chi Intervention for Older Adults with Mobility Disabilities: Results from a Single-Arm Clinical Trial with the TechSAge Tele Tai Chi Program.

Mitzner TL, Remillard ET, Mumma KT et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Telewellness programs can expand access to exercise and social opportunities for older adults, especially those with mobility disabilities. The TechSAge Tele Tai Chi clinical trial assessed whether the Tai Chi for…

View details →DOI: 10.3390/healthcare14121756
Negative / Null Result ReportMedicine

Polarimetric entropy mapping of retinal pigment epithelium in full-thickness macular hole by polarization-sensitive OCT.

Terao R, Yashiro K, Kuriyama T et al. · 2026 · BMC ophthalmology

Background This study is aimed to evaluate retinal pigment epithelium (RPE) entropy in eyes with full-thickness macular hole (FTMH) using polarization-sensitive optical coherence tomography (PS-OCT). Methods Patients diagnosed with…

View details →DOI: 10.1186/s12886-026-05008-z
Negative / Null Result ReportMedicine

Arterial remodeling and plaque changes after balloon angioplasty for de novo coronary lesions using DCB.

Kerr S, Minatoguchi S, Dumitriu Carcoana AO et al. · 2026 · Cardiovascular intervention and therapeutics

This study evaluated the serial anatomical and morphological changes in de novo coronary lesions treated with a drug-coated balloon (DCB) using integrated-backscatter intravascular ultrasound (IB-IVUS). The aim of this study was to…

View details →DOI: 10.1007/s12928-026-01298-8
Negative / Null Result ReportMedicine

Long-Term Therapy with Eculizumab Biosimilar in Patients with Atypical Haemolytic Uraemic Syndrome: Outcomes of a Prospective Observational Study.

Kotenko O, Kozlovskaya N, Emirova K et al. · 2026 · Nephron

Background The objective of a multicentre, prospective, observational study of an eculizumab biosimilar (Elizaria®) was to analyse the efficacy and safety of long-term complement inhibitor therapy in patients with atypical haemolytic…

View details →DOI: 10.1159/000552914
Negative / Null Result ReportMedicine

Quantitative and Comparative Analysis of Dream Content in Parkinson's Disease Patients Undergoing Deep Brain Stimulation: A Pilot Study.

Joswig H, Oreizi-Esfahani S, Medack S et al. · 2026 · World neurosurgery

Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, resulting in motor and nonmotor symptoms including diminished sleep quality and altered dream…

View details →DOI: 10.1016/j.wneu.2026.124816
Negative / Null Result ReportOpen accessMedicine

Physical activity and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) plasma levels in different age cohorts.

Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one

Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…

View details →DOI: 10.1371/journal.pone.0349883
Negative / Null Result ReportMedicine

Psychopathological correlates of early childhood sleep terror: associations with nutritional biomarkers, behavioral dysregulation, and sleep disturbance.

Esen Öksüzoğlu M, Kabukçu HO · 2026 · BMC psychiatry

Background Sleep terror (ST) is a common NREM parasomnia in early childhood and may be associated with broader emotional and behavioral dysregulation. However, its links with psychopathological symptoms and nutritional biomarkers remain…

View details →DOI: 10.1186/s12888-026-08298-1
Negative / Null Result ReportMedicine

Airway Mucus Occlusions in Ex-Smokers with and Without COPD.

Tcherner S, Durom E, Peters J et al. · 2026 · COPD

In patients with moderate-to-severe COPD, airway mucus-occlusions correlate with airflow limitation, exacerbation and mortality-risk. However, the clinical relevance of mucus-plugs in milder COPD is not well-understood. We evaluated…

View details →DOI: 10.1080/15412555.2026.2681969
Negative / Null Result Report

Investigating the Mediating Role of Family Support and Peer Acceptance in the Relationship Between Prosocial Behavior and Well-being of Children: A Causal Mediation Analysis

Sevahil D · 2026 · Preprint

The aim of this study was to examine the causal pathways from prosocial behavior to well-being in different grades of primary school children. We assessed for whether family support andpeer acceptance mediate this relationship, along to…

View details →DOI: 10.31234/osf.io/nyahz_v1