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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 585 of 725

Replication FailureMedicine

First Constraints on Nuclear Coupling of Axionlike Particles from the Binary Neutron Star Gravitational Wave Event GW170817.

Zhang J, Lyu Z, Huang J et al. · 2021 · Physical review letters

Light axion fields, if they exist, can be sourced by neutron stars due to their coupling to nuclear matter, and play a role in binary neutron star mergers. We report on a search for such axions by analyzing the gravitational waves from the…

View details →DOI: 10.1103/physrevlett.127.161101
Negative / Null Result ReportMedicine

Isokinetic shoulder strength adaptations to weighted jump rope training in CrossFit athletes: A pre-post study.

Torres-Banduc MA, Thapa RK, Pérez MA et al. · 2025 · Shoulder & elbow

Background The isokinetic shoulder profile is commonly used to assess injury risk in overhead sports. CrossFit athletes are vulnerable to shoulder injuries due to high-load, high-repetition demands. This exploratory study aimed to evaluate…

View details →DOI: 10.1177/17585732251409407
Negative / Null Result ReportOpen accessMedicine

Infants Do Not Reliably Track When Bilingual Speakers Switch Languages.

Potter CE, Lew-Williams C · 2025 · Behavioral sciences (Basel, Switzerland)

It is a widely held belief that bilingual infants benefit from hearing each of their languages spoken by different people, as speakers could serve as a cue for separating the two languages. However, it is not yet known whether infants…

View details →DOI: 10.3390/bs15101427
Negative / Null Result ReportOpen accessMedicine

Non-image-forming vision as measured through ipRGC-mediated pupil constriction is not modulated by covert visual attention.

Vilotijević A, Mathôt S · 2024 · Cerebral cortex (New York, N.Y. : 1991)

In brightness, the pupil constricts, while in darkness, the pupil dilates; this is known as the pupillary light response (PLR). The PLR is driven by all photoreceptors: rods and cones, which contribute to image-forming vision, and…

View details →DOI: 10.1093/cercor/bhae107
Replication FailureOpen accessMedicine

Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.

Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions

Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…

View details →DOI: 10.1016/j.invent.2026.100951
Negative / Null Result ReportOpen accessMedicine

Fascia-Focused Versus Conventional Physiotherapy for Chronic Low Back Pain and Comorbid Depression in Psychosomatic Inpatients.

Overmann L, Steinmeier K, Brandl A et al. · 2026 · Journal of clinical medicine

Background: Chronic low back pain (CLBP) and depression often co-occur. This study compared a fascia-focused physiotherapeutic program with a conventional physiotherapeutic and relaxation-based program in psychosomatic inpatients with CLBP…

View details →DOI: 10.3390/jcm15103698
Negative / Null Result ReportOpen accessMedicine

Cerebral "Dirty-Appearing" White Matter in Relation to Cognitive Decline and Dementia Risk in Community-Dwelling Older Adults.

Eiling I, Sigurdsson S, Kuhn-Keller JA et al. · 2026 · Neurology

Background and objectives Cerebral "dirty-appearing" or "diffusely abnormal" white matter (DAWM) represents subtle white matter abnormalities that are associated with progression of cerebral small vessel disease (cSVD), but the association…

View details →DOI: 10.1212/wnl.0000000000218036
Negative / Null Result ReportOpen accessMedicine

Impact of Stroke History on the Risk of Recurrent Hip Fracture or Major Osteoporotic Fractures among Patients with Incident Hip Fracture: A Nationwide Cohort Study.

Hjelholt TJ, Johnsen SP, Brynningsen PK et al. · 2023 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Considerable uncertainty prevails regarding risk factors for recurrent fracture among older patients with hip fracture. We aimed to investigate the relationship between prefracture stroke history, baseline mobility, and the risk of…

View details →DOI: 10.1002/jbmr.4760
Negative / Null Result ReportOpen accessMedicine

Oral bisphosphonates and risk of incident osteoarthritis in individuals with osteoporosis: a target trial emulation.

Hatano M, Kimura Y, Okada A et al. · 2026 · RMD open

Objectives Owing to the underrepresentation of early-stage disease in randomised trials and inconsistent clinical evidence, using oral bisphosphonates to prevent incident osteoarthritis in adults with osteoporosis lacks consensus. We aimed…

View details →DOI: 10.1136/rmdopen-2026-006832
Negative / Null Result ReportOpen accessMedicine

Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence.

Nielsen MB, Çolak Y, Benn M et al. · 2024 · Cardiovascular research

Aims Adiponectin may play an important protective role in heart failure and associated cardiovascular diseases. We hypothesized that plasma adiponectin is associated observationally and causally, genetically with risk of heart failure,…

View details →DOI: 10.1093/cvr/cvad162
Negative / Null Result ReportOpen accessMedicine

Can trade and security alliance help reduce interstate war?

Choi SW · 2024 · PloS one

This study explains how the gap between theory and empirical research hinders scientific progress in the area of international political economy. To demonstrate this point, I use Chen's Extended Dependence Theory, which challenges liberal…

View details →DOI: 10.1371/journal.pone.0304482
Negative / Null Result ReportMedicine

Analysis of retinal blood vessel diameters in patients with COPD undergoing a pulmonary rehabilitation program.

Vaes AW, Spruit MA, Goswami N et al. · 2022 · Microvascular research

Background Regular exercise positively affects cardiovascular physiology, translating into the adequate capacity of microvascular blood vessels to dilate in response to acute bouts of exercise. However, this remains unstudied in patients…

View details →DOI: 10.1016/j.mvr.2021.104238
Negative / Null Result ReportOpen accessMedicine

The impact of state and trait general and social anxiety on theory of mind.

Foulds C, Khudiakova V, Surtees ADR · 2026 · Scientific reports

Theory of mind is an important skill to function in society. There is evidence that anxiety can impair the ability to use this skill effectively; however, current research is inconclusive, uses heterogeneous measures of theory of mind, and…

View details →DOI: 10.1038/s41598-026-36718-5
Negative / Null Result ReportOpen accessMedicine

Association between serum bilirubin and diabetic retinopathy: results from the NHANES 1999-2018 and Mendelian randomization study.

Niu D, Ye L, Gu X et al. · 2026 · Diabetology & metabolic syndrome

BACKGROUND: Although serum bilirubin levels have been linked to diabetic retinopathy (DR), their causal role remains uncertain. We aimed to assess the relationship between bilirubin levels and diabetic retinopathy (DR) using both…

View details →DOI: 10.1186/s13098-026-02135-x
Negative / Null Result ReportOpen accessMedicine

Comparison of oncological outcomes between wedge resection and segmentectomy for T1a/bN0M0 non-small-cell lung cancer: a population-based retrospective cohort study.

Zhang Z, Lian H, Huang L et al. · 2026 · International journal of surgery (London, England)

Background Sublobar resection, including wedge resection (WR) and segmental resection (SR) has been considered for early-stage non-small-cell lung cancer (NSCLC). However, the optimal sublobar approach continues to be a subject of…

View details →DOI: 10.1097/js9.0000000000003433
Negative / Null Result ReportOpen accessMedicine

No evidence that averaging voices influences attractiveness.

Ostrega J, Shiramizu V, Lee AJ et al. · 2024 · Scientific reports

Vocal attractiveness influences important social outcomes. While most research on the acoustic parameters that influence vocal attractiveness has focused on the possible roles of sexually dimorphic characteristics of voices, such as…

View details →DOI: 10.1038/s41598-024-61064-9
Negative / Null Result ReportOpen accessMedicine

Parietal theta burst TMS does not modulate bistable perception.

Schauer G, Grassi PR, Gharabaghi A et al. · 2024 · Neuroscience of consciousness

The role of the parietal cortex in perceptual awareness and in resolving perceptual ambiguity is unsettled. Early influential transcranial magnetic stimulation studies have revealed differences in conscious perception following parietal…

View details →DOI: 10.1093/nc/niae009
Negative / Null Result ReportOpen accessMedicine

The relationship between aging out of the special supplemental nutrition program for women, infants, and children assistance and weight status in kindergarten.

Lazic A, Thomsen MR, Brown CC et al. · 2025 · Preventive medicine reports

Objective The Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides access to nutritional resources to low-income children starting at birth through enrollment in kindergarten or turning five years old. The…

View details →DOI: 10.1016/j.pmedr.2025.103125
Negative / Null Result ReportMedicine

Name order effects in measuring adolescent social networks using rosters.

Liu S, Nolin DA, Kitts JA · 2024 · Social networks

Recent studies have found order effects in social network data collection, where later names on a roster receive fewer nominations. Some thus argue for randomizing name orders or sampling peer names for survey rosters. We model order…

View details →DOI: 10.1016/j.socnet.2023.07.002
Negative / Null Result ReportOpen accessMedicine

Biomechanical Factors Associated with Intraindividual Differences in Running Economy Across Advanced Footwear Technology Models in Long-Distance Runners.

Fohrmann D, Schaffarczyk M, Menge C et al. · 2026 · Sports medicine - open

Background Advanced footwear technology (AFT) can enhance long-distance running performance by improving running economy (RE). However, the range of the individual improvements is large. Different intra-individual responses in running…

View details →DOI: 10.1186/s40798-026-01005-0
Negative / Null Result ReportOpen accessMedicine

Exploring the Causal Links Between Toxoplasma gondii Infection and Risk of Brain Tumors: A Bidirectional Mendelian Randomization Analysis.

Shi P, Wei G, Li Z et al. · 2026 · Brain and behavior

Background Toxoplasma gondii (T. gondii) is a ubiquitous protozoan parasite capable of establishing lifelong latent infections in the central nervous system. Previous epidemiological studies have suggested a potential association between…

View details →DOI: 10.1002/brb3.71239
Negative / Null Result ReportOpen accessMedicine

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.

Pott J, Mason AM, Salo V et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects lipid metabolism. A recent study identified an association between rs562556 within the PCSK9 gene and breast cancer survival (BCS), suggesting PCSK9 inhibition as an…

View details →DOI: 10.1158/1055-9965.epi-25-1569
Negative / Null Result ReportOpen access

PCSK9 and breast cancer survival: a Mendelian Randomization study

Pott J, Mason A, Salo V et al. · 2025 · Preprint

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is well known for its causal effects on the lipid metabolism. A recent study identified an association between rs562556 within PCSK9 and breast cancer survival (BCS). It was…

View details →DOI: 10.1101/2025.10.03.25337270