Negative / Null Result ReportMedicine
Selim AAMA · 2026 · Natural product research
Three hydrazone chromones 3a-c ( 3a, b in trans isomer while 3c was a mixture) and three hydrazone furanochromones 7a-c ( 7a in trans while 7b, c in cis ) carrying carboxylic acid or its bioisostere sulphonamide group were synthesised.…
View details →DOI: 10.1080/14786419.2026.2674712 Negative / Null Result ReportMedicine
Chen L, Liang W, Guo Y et al. · 2026 · Biomedical chromatography : BMC
Paeoniae Radix Alba (PRA, roots of Paeonia lactiflora Pall.) yields stir-baked (sbPRA), charred (cPRA), and carbonized (caPRA) specifications through increasing degrees of stir-baking. In this study, an ultrahigh-performance liquid…
View details →DOI: 10.1002/bmc.70518 Negative / Null Result ReportOpen accessMedicine
Omran SA, Elnaggar MS, Youssef FS et al. · 2026 · Natural products and bioprospecting
Marine-derived Penicillium fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities. The primary origins…
View details →DOI: 10.1007/s13659-026-00633-z Negative / Null Result Report
Burke ND, Anderson AL, Schjenken JE et al. · 2026 · Preprint
ABSTRACT Capacitation, the process whereby sperm gain the functional competence to fertilize an egg in the absence of de novo transcription and translation, is orchestrated by a hierarchy of kinases driving the phosphorylation of sperm…
View details →DOI: 10.64898/2026.06.22.733301 Negative / Null Result ReportMedicine
Kang AJ, Tseng CH, Wei MY · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences
Background Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of ICD-based case…
View details →DOI: 10.1093/gerona/glag157 Negative / Null Result ReportMedicine
Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young
Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…
View details →DOI: 10.1017/s1047951126113493 Negative / Null Result Report
Boscariol R, Tressoldi P · 2026 · Preprint
This preregistered study is a replication and extension of prior exploratory work comparing an Intuition Market (IM) with a traditional Prediction Market (PM) in forecasting binary financial outcomes. A previous exploratory study suggested…
View details →DOI: 10.31234/osf.io/4g5me_v1 Methods Dead-EndOpen accessMedicine
Csonka LL, Tikkakoski A, Karjalainen J et al. · 2026 · Clinical physiology and functional imaging
Background Peak expiratory flow (PEF) obtained from dedicated PEF meters and various types of spirometers is often used interchangeably in research, despite differences in both devices and expiratory maneuver technique. The aim of this…
View details →DOI: 10.1111/cpf.70067 Negative / Null Result Report
Tang L, Sun C, Chen Z et al. · 2026 · Preprint
Abstract Background This study aimed to investigate the effects of curcumin supplementation and aerobic exercise on delaying age-related skeletal muscle atrophy and to further explore their potential synergistic effects. The findings are…
View details →DOI: 10.21203/rs.3.rs-8867508/v1 Negative / Null Result Report
Aghdam EB, Romeralo C, Knapp DG et al. · 2026 · Preprint
Abstract Soilborne oomycetes of the genus Phytophthora are an increasing concern in European beech ( Fagus sylvatica ) forests, where they can damage root systems and contribute to tree decline. Because Phytophthora inoculum may persist in…
View details →DOI: 10.21203/rs.3.rs-9579201/v1 Negative / Null Result Report
Parmar A, Saini N, Chhatre A et al. · 2026 · Preprint
Abstract Smartphone GNSS receivers are increasingly relied upon for location-dependent workflows in surveying, citizen science, agriculture, forestry, and field-based environmental data collection. The release of raw GNSS measurements…
View details →DOI: 10.21203/rs.3.rs-9649996/v1 Negative / Null Result ReportMedicine
Wadington M, Eklund K, Kilgus SP et al. · 2026 · School psychology (Washington, D.C.)
Research highlights the importance of the early identification of social, emotional, and behavioral concerns in young children; however, there are limitations regarding the usability and technical adequacy of available measures. The…
View details →DOI: 10.1037/spq0000747 Negative / Null Result Report
Tsuboi R, Murakami S, Miyata M et al. · 2026 · Preprint
Abstract BACKGROUND Dysphagia in Parkinson’s disease (PD) increases aspiration pneumonia risk and is associated with poor prognosis. Although subthalamic nucleus deep brain stimulation (STN-DBS) effectively treats motor symptoms, dysphagia…
View details →DOI: 10.21203/rs.3.rs-9783502/v1 Negative / Null Result ReportMedicine
Liao Y, Zhan L, Li H · 2026 · Basic & clinical pharmacology & toxicology
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression,…
View details →DOI: 10.1111/bcpt.70266 Null DatasetMedicine
Pasotti F, Da Molin S, Bosoni T et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry
Serum free light chains (FLC) κ and λ, and the κ/λ ratio, are key biomarkers for the diagnosis, risk stratification and monitoring of monoclonal gammopathies. However, substantial between-method variability still limits harmonised…
View details →DOI: 10.1016/j.cca.2026.121056 Negative / Null Result ReportMedicine
Neiling SL, Alt M, Kapa LL · 2026 · Language, speech, and hearing services in schools
Background The current project was a prospective feasibility study using a dynamic assessment of statistical learning of a novel morpheme for the identification of developmental language disorder (DLD) in Spanish-English-speaking…
View details →DOI: 10.1044/2026_lshss-25-00141 Negative / Null Result ReportMedicine
Ren X, Dai Q, Jin C · 2026 · Journal of intensive care
Background Existing biomarker studies profile plasma during acute illness, leaving pre-illness proteomic susceptibility to critical care largely uncharacterised. We mapped the baseline proteomic architecture of critical-care outcomes in UK…
View details →DOI: 10.1186/s40560-026-00887-2 Negative / Null Result ReportMedicine
Diamantino GML, Beeler-Marfisi J, Foster RA et al. · 2026 · Veterinary pathology
The objective of this study was to evaluate the effect of different fixatives and demineralizers on immunohistochemical (IHC) detection of antigens in bone marrow (BM). Sternal BM samples were collected within 24 hours of death from dogs…
View details →DOI: 10.1177/03009858261426547 Negative / Null Result ReportMedicine
Xu P, Li Y, Chen Y et al. · 2026 · Children (Basel, Switzerland)
Background Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…
View details →DOI: 10.3390/children13060796 Negative / Null Result ReportMedicine
Pratt AS, Ramos MN, Peña ED et al. · 2026 · Journal of speech, language, and hearing research : JSLHR
Purpose This study attempts to discriminate developmental language disorder (DLD) in bilinguals using only the child's second language (L2), English. We grouped bilinguals by their current weekly language experience (high English…
View details →DOI: 10.1044/2025_jslhr-24-00606 Negative / Null Result ReportMedicine
Wade ML, Litvak MK · 2026 · Zebrafish
Cryopreservation enables the long-term storage of viable biological material at ultra-low temperatures and forms the foundation for germplasm cryobanks that maintain valuable genetic lines of model organisms such as zebrafish ( Danio rerio…
View details →DOI: 10.1177/15458547261441744 Negative / Null Result ReportMedicine
Xu J, Ashebir YA, Shao Y · 2026 · Genes
Background: The dual agonism of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) becomes a groundbreaking treatment for type 2 diabetes (T2D) that achieves robust glycemic control…
View details →DOI: 10.3390/genes17060602 Negative / Null Result Report
Nguyen Van H, Vu Dang L, Nguyen The A et al. · 2026 · Preprint
Objectives: Histologic grade is an important prognostic factor in hepatocellular carcinoma (HCC). Gd-EOB-DTPA-enhanced MRI may provide noninvasive im-aging markers related to tumour differentiation. This study aimed to evaluate the…
View details →DOI: 10.20944/preprints202605.0460.v1 Negative / Null Result ReportMedicine
Shi Y, Li S, He L et al. · 2026 · Annals of clinical microbiology and antimicrobials
Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria.…
View details →DOI: 10.1186/s12941-026-00869-0 Negative / Null Result Report
Keskinel I, Eryilmaz M, Diktas Tahtasakal S · 2026 · Preprint
Objectives: Streptococcus pneumoniae is a major respiratory pathogen. Reports during the COVID-19 era suggest decreased pneumococcal activity. This study aimed to assess the frequency of S. pneumoniae in adult sputum cultures and its…
View details →DOI: 10.20944/preprints202606.0633.v1 Negative / Null Result ReportMedicine
Akmansoy ŞC, Kahramanoğlu E · 2026 · Journal of oral science
Purpose This study compares the marginal and internal gaps for four restorative materials produced by two fabrication methods in both minimally invasive occlusal veneer and conventional onlay cavities. Methods Eighty mandibular molars…
View details →DOI: 10.2334/josnusd.25-0348 Negative / Null Result ReportMedicine
Xie J, Song Z, Fang W et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
This study aimed to elucidate the potential molecular mechanisms by which artificial sweeteners contribute to the initiation and progression of atherosclerosis, with the goal of providing a theoretical basis for the safety evaluation of…
View details →DOI: 10.1007/s00210-026-05241-9 Negative / Null Result ReportMedicine
Robinson E, Chapman C, Orchard F et al. · 2026 · Journal of child and adolescent mental health
Background: Exposure of children and young people to potentially traumatic events is common. There is a need for increased access to early interventions following a potentially traumatic event. Objective: This review aimed to identify…
View details →DOI: 10.2989/17280583.2025.2581754 Failed Experiment Report
Leinbach D, Burcham DC, Kane B · 2026 · Preprint
Trees are routinely pruned to mitigate the risk of wind damage, but there are few studies examining changes in wind loads after pruning, especially for large conifers. In this study, ten Colorado spruces ( Picea pungens ) were monitored…
View details →DOI: 10.64898/2026.06.11.731663 Negative / Null Result ReportMedicine
Fiorenza, Millot, Lecomte et al. · 2026 · The Journal of antimicrobial chemotherapy
Prosthetic joint infections (PJI) of the hip and knee are most often caused by Staphylococcus spp. and require long-term treatment with rifampicin and fluoroquinolone as first-line treatment. However, resistance, contraindications or…
View details →DOI: 10.1093/jac/dkag219 