A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21350 results · page 584 of 712
Wang J, Soley BDS, Xiao Y et al. · 2026 · Cancer research communications
Cancer-associated fibroblasts (CAFs) display remarkable plasticity, enabling them to adapt to therapeutic and mechanical stress within the tumor microenvironment (TME). Here, we identify a shared mechanotransduction pathway by which BRAF…
Mehedinti R, Earar K, Stefanescu A et al. · 2026 · Preprint
Background: and Objectives: Long-standing contact between oral mucosa and restorative materials may be associated with adaptive epithelial and stromal remodeling. This study evaluated non-dysplastic epithelial plasticity and cumulative…
Lee J, DeGroot W · 2026 · Journal of the American Veterinary Medical Association
Objective To assess whether thoracic radiographs in dogs with gastric dilatation-volvulus (GDV) are associated with the decision to proceed with surgery and survival to discharge. Methods A retrospective cohort study of dogs with GDV…
Lewis J, Liu AM, Johnson C et al. · 2026 · Injury
Background Trauma volume can vary significantly throughout the year. Identifying factors associated with trauma volume variation can be helpful in allocating resources and staff during busy trauma periods. The present study aimed to…
Gunderson AK, Kwon T, Kumarasinghe Y et al. · 2026 · Transactions of the Royal Society of Tropical Medicine and Hygiene
Background Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting. Methods We conducted a cross-sectional…
Gaertner LHC, Reininger KM, Briken P · 2026 · Journal of sex research
Mentalizing ability - the capacity to understand behavior as motivated by intentional mental states - develops within attachment relationships and has recently been suggested to influence sexual health. This study examined whether…
Xu Z, Guo Y, Shao Y et al. · 2026 · Journal of affective disorders
Background Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this…
Piran CMG, Cargnin AVE, Mori MM et al. · 2026 · Revista brasileira de enfermagem
Objectives to analyze factors associated with poor adherence and loss to follow-up among adolescents and young people living with HIV. Methods ambidirectional cohort study of 512 adolescents and young people with HIV receiving treatment at…
Gul F, Ullah A, Li Y et al. · 2026 · BMC endocrine disorders
Obesity, especially visceral obesity, is a major health issue globally, leading to metabolic disorders. Visceral fat accumulation is closely linked to insulin resistance and metabolic abnormalities. The role of branched-chain amino acids…
Sriram N, Muller R, Jain R et al. · 2026 · Clinical neurology and neurosurgery
Objective Surgical decompression is often needed to relieve symptoms and prevent long-term disability from compressive peripheral nerve pathologies. This study applied the Social Vulnerability Index (SVI) to characterize utilization…
Nishioka J, Sasaki A, Ozaki K · 2026 · Preprint
Abstract Herbivorous insects must identify suitable hosts for oviposition and reliably reject unsuitable ones. Whether non-host plants are detected through active deterrent cues or through the mere absence of host-recognition signals…
Kowra S, Singh H, Singh V et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Introduction Estrogens are crucial in the development and growth of skeletal systems. Estrogen receptor alpha (ESRα) and beta (ESRβ) are crucial regulators of estrogen response. Estrogen receptor genes (ESR1 and ESR2) have been extensively…
Deliağa H, Rüzgar M, Altundal B et al. · 2026 · Preprint
Abstract Background Urethral catheterization (UC) is a commonly performed procedure in neonatal care; however, catheter-related urethral trauma remains an underrecognized complication. Evidence regarding clinical characteristics,…
Bartholo BBGR, Bartholo TP, Magalhães ALC et al. · 2026 · Preprint
Abstract Background Asthma during pregnancy remains associated with adverse maternal and perinatal outcomes when poorly controlled, yet the inflammatory mechanisms involved in this context are not fully understood. Thymic stromal…
Borgehammar J, McClenahan B, Miller E et al. · 2026 · The Journal of manual & manipulative therapy
Objective Developing psychomotor competence in orthopedic manual physical therapy (OMPT) techniques is fundamental to post-professional physical therapy education. Concerns persist about whether online instructional models and the rise of…
Vu NTH, Quach DT, Miyauchi S et al. · 2026 · Digestion
Introduction A family history of chronic constipation (CC) is considered an important predisposing factor for developing CC. This study aimed to compare the associations of maternal and paternal histories of CC with constipation in…
Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…
Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…
Kalinowska V, Hughes L, Lancki N et al. · 2026 · Preprint
Abstract Purpose To evaluate whether peri-trigger serum hormone dynamics are associated with mature oocyte yield in planned oocyte cryopreservation cycles across ovulation trigger protocols. Methods We conducted a retrospective study of…
Tall S, Pettersson J, Härkönen T et al. · 2026 · Diabetes care
Objective We assessed whether 1) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is associated with the risk of type 1 diabetes and 2) SARS-CoV-2 vaccination or infection is associated with disease severity at type…
Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…
Nakamura K, Sakai N, Hirai H et al. · 2026 · British journal of clinical pharmacology
Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long-term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their…
Giblett MJ, Lind P, Medland S · 2026 · Preprint
Purpose: Individuals with Autism and/or ADHD often experience stigma related to their diagnosis. Social camouflaging is a coping strategy they can use to hide neurodivergent traits and difficulties, possibly as a response to stigma.…
de Ruyter H, Aitokari L, Iqbal A et al. · 2026 · The Journal of pediatrics
Objective To investigate associations of perinatal and lifestyle factors with alanine aminotransferase (ALT) levels as an early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD). Study design Data from the…
Castillo F, Tafur M, Lin C et al. · 2026 · Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
Introduction Nondiagnostic results after thyroid fine-needle aspiration (FNA) are common and may delay diagnosis. Purpose To identify demographic and sonographic predictors of nondiagnostic cytology at repeat thyroid FNA and to report…
Rotevatn AØ, Eagan TM, McCann A et al. · 2026 · BMC pulmonary medicine
Background and aim Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This…
Başcı ÖK, Sarı ÜS, Uysal S et al. · 2026 · Preprint
Abstract Aim Neuropathic symptoms are among the earliest neurological manifestations of type 2 diabetes mellitus (T2DM) and may precede electrophysiologically confirmed diabetic sensorimotor polyneuropathy (DSPN). The underlying mechanisms…
Kim BI, Cheng R, Grabov E et al. · 2026 · The Journal of arthroplasty
Background Larger femoral heads have been proposed to reduce dislocation risk following total hip arthroplasty (THA). While the benefit of increasing head size from 28 or 32 mm to ≥ 36 mm is well established, it remains unclear whether…
Toptas GR, Firatligil FB, Ozdal BB et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To investigate the association between systemic inflammatory indices, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and…
Soler-Blasco R, Lozano M, González-Safont L et al. · 2026 · Environmental research
Prenatal cadmium (Cd) exposure may impair placental function and disrupt biological processes relevant to foetal neurodevelopment, including oxidative stress and metal homeostasis, but epidemiological evidence linking Cd to childhood…