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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 584 of 725

Negative / Null Result ReportOpen accessMedicine

Treatment outcomes of daptomycin- and vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection.

Lin WT, Yang JL, Lin CY et al. · 2026 · JAC-antimicrobial resistance

Objectives Among patients with daptomycin-resistant and vancomycin-resistant Enterococcus faecium bloodstream infection (BSI), the optimal definitive therapy is uncertain. We estimated the dose effect of daptomycin (≥11 mg/kg versus 8 to…

View details →DOI: 10.1093/jacamr/dlag108
Negative / Null Result ReportOpen accessMedicine

Could high serum C-reactive protein levels serve as a biomarker for children and adolescents diagnosed with generalized anxiety disorder?

Ünal K, Taş Torun Y, Erol ME et al. · 2026 · World journal of clinical pediatrics

Background Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in children and adolescents, frequently linked to difficulties in daily functioning and academic performance. Increasing evidence suggests that immune…

View details →DOI: 10.5409/wjcp.v15.i1.115246
Negative / Null Result ReportOpen accessMedicine

No clear evidence for a domain-general violation of expectation effect in the pupillary responses of 9- to 10-month-olds.

Michel C, Langeloh M, Tünte MR et al. · 2025 · PloS one

Violation of expectation (VOE) paradigms are key to understanding infants' early knowledge. In VOE paradigms, infants are presented sequences of events either according with or violating regularities of their physical or social…

View details →DOI: 10.1371/journal.pone.0332718
Negative / Null Result ReportOpen accessMedicine

Theta Transcranial Alternating Current Stimulation Over the Dorsomedial Prefrontal Cortex Does Not Enhance Long-Term Memory.

Chitic D, Zdravkov KS, Dounavi V et al. · 2026 · The European journal of neuroscience

Long-term memory (LTM) has been associated with neural oscillation in the theta (3-8 Hz) range. Although previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) is a core region for LTM retrieval, causal evidence is…

View details →DOI: 10.1111/ejn.70431
Negative / Null Result ReportOpen accessMedicine

Retrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease - A pilot study.

Wolff A, Feneberg E, Shakhtour J et al. · 2026 · PloS one

Background Chronic inflammatory bowel diseases, encompassing Crohn's disease and ulcerative colitis, are characterized by persistent inflammation of the gastrointestinal tract. While traditionally regarded as confined to the gut, the…

View details →DOI: 10.1371/journal.pone.0340182
Negative / Null Result ReportOpen accessMedicine

Patient-reported outcome measures comparing povidone iodine rinse and chlorhexidine rinse for dental implant therapy: a randomized controlled trial.

Chen J, Chen Z, Yan Q et al. · 2025 · BMC oral health

Objectives To evaluate patient-reported outcome measures (PROMs) of povidone-iodine rinse and chlorhexidine rinse for patients undergoing dental implant treatments, as well as their bacteriostatic efficacy. Materials and methods Patients…

View details →DOI: 10.1186/s12903-025-06560-8
Negative / Null Result ReportOpen accessMedicine

Prospective associations between parental warmth and knowledge in late adolescence and depression and anxiety symptoms in young adulthood: a Swedish cohort study.

Saminathen MG, Lundin A, Raninen J et al. · 2026 · BMC public health

Background Parenting practices, such as emotional support and warmth, are key determinants of adolescent mental health, whereas the role of parental knowledge is less well understood. Parental warmth is thought to foster openness and…

View details →DOI: 10.1186/s12889-026-27712-7
Failed Experiment ReportMedicine

A study of the effects of age on the dynamics of RSV in animal models.

Khan S, Dobrovolny HM · 2021 · Virus research

Respiratory syncytial virus can cause severe illness and even death, particularly in infants. The increased severity of disease in young children is thought to be due to a lack of previous exposure to the virus as well as the limited…

View details →DOI: 10.1016/j.virusres.2021.198524
Negative / Null Result Report

Analysis of expression Quantitative Trait Loci for NLGN4X in relation to language and neurodevelopmental function: an exploratory analysis using FUSION and GTEx workflows

Simpson NH, Bishop DV, Newbury DF · 2021 · Preprint

Language disorders in children are highly heritable, but progress in identifying genetic variants that contribute to language phenotypes has been slow. Here we applied a novel approach by identifying SNPs that are associated with gene…

View details →DOI: 10.1101/2021.06.29.450314
Negative / Null Result ReportOpen accessMedicine

Neoadjuvant Therapy for Localized Pancreatic Cancer.

McKean J, Underwood P, Yasinzai AQK et al. · 2026 · Cancers

Background/objectives Pancreatic ductal adenocarcinoma is an aggressive malignancy with poor long-term survival. While surgical resection followed by adjuvant chemotherapy remains the standard of care for resectable disease, a substantial…

View details →DOI: 10.3390/cancers18061011
Negative / Null Result ReportMedicine

The push-pull of serial dependence effects: Attraction to the prior response and repulsion from the prior stimulus.

Sadil P, Cowell RA, Huber DE · 2024 · Psychonomic bulletin & review

In the "serial dependence" effect, responses to visual stimuli appear biased toward the last trial's stimulus. However, several kinds of serial dependence exist, with some reflecting prior stimuli and others reflecting prior responses.…

View details →DOI: 10.3758/s13423-023-02320-3
Negative / Null Result ReportOpen accessMedicine

Examining the relationship between problematic social media use and caffeine use disorder in the context of physical activity: a cross-sectional moderation study among university students.

Orhan BE, Karadağ B, Alkasasbeh WJ et al. · 2026 · Frontiers in nutrition

Introduction Problematic social media use (PSMU) and caffeine use disorder (CUD), a behavioral pattern without formal diagnostic status and a DSM-5 condition listed for further study, respectively, share phenomenological features…

View details →DOI: 10.3389/fnut.2026.1854577
Negative / Null Result ReportOpen accessMedicine

The Somatic Rubber Hand Illusion does not modulate perceived hand position in children with severe visual impairments.

Tammurello C, Coelho LA, Amadeo M et al. · 2026 · Scientific reports

In the Somatic Rubber Hand Illusion (SRHI), synchronous brushing of a participant’s hidden hand and a dummy hand induces proprioceptive drift, a shift in perceived position of the hand towards the dummy hand, along with the sensation of…

View details →DOI: 10.1038/s41598-026-48413-6
Negative / Null Result ReportOpen accessMedicine

A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis.

Sasidharan S, Philips CA, Philips CA et al. · 2026 · Hepatology communications

Background Fatigue affects 60%-80% of patients with cirrhosis, yet no universally effective pharmacologic therapy exists. Taurine, an amino sulfonic acid with antioxidant and membrane-stabilizing properties, may address metabolic…

View details →DOI: 10.1097/hc9.0000000000000938
Negative / Null Result ReportMedicine

Telomere length in individuals with and without major depression and adverse childhood experiences.

Kuehl LK, de Punder K, Deuter CE et al. · 2022 · Psychoneuroendocrinology

Major depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and…

View details →DOI: 10.1016/j.psyneuen.2022.105762
Negative / Null Result ReportOpen accessMedicine

The Variability and Determinants of Serotiny in <i>Pinus Yunnanensis</i>.

Liu Y, Lin H, Yu D et al. · 2026 · Ecology and evolution

Serotiny, a key fire-adaptive trait, enables certain plants to retain seeds in closed cones until triggered by fire, thus facilitating post-fire regeneration. Although serotiny has been observed in many species, the physiological and…

View details →DOI: 10.1002/ece3.72838
Negative / Null Result ReportOpen accessMedicine

Does Pain Self-efficacy influence Initial Forward Bending in Adults with Chronic Low Back Pain following Exercise? A Cohort Study.

McManus F, Pranata A, Simpson JA et al. · 2025 · International journal of sports physical therapy

Background/purpose Chronic low back pain affects how individuals bend. Whether pain self-efficacy, a term describing one's confidence in their ability to perform activities despite experiencing pain, affects how much people with chronic…

View details →DOI: 10.26603/001c.146051
Negative / Null Result ReportOpen accessMedicine

Woody seeds and seedlings are unresponsive to herbivore kairomones.

Headrick KC, Pellegrini BA, Santiago EM et al. · 2026 · AoB PLANTS

Herbivory is particularly threatening to young plants that lack the resources needed to survive an attack. Seeds and seedlings should thus benefit greatly from using pre-attack cues to induce defence before damage. Locomotion mucus from…

View details →DOI: 10.1093/aobpla/plag013
Negative / Null Result ReportOpen accessMedicine

Does civilian oversight impact police legitimacy?

Schiff KJ, Schiff DS, Moy BJ et al. · 2025 · PNAS nexus

Does the implementation of external oversight in policing improve public perceptions of police legitimacy? Civilian review boards (CRBs) are frequently promoted as mechanisms to enhance the legitimacy of police agencies by providing…

View details →DOI: 10.1093/pnasnexus/pgaf267
Negative / Null Result ReportOpen accessMedicine

Magnetic Seizure Therapy vs Electroconvulsive Therapy in Schizophrenia: Prefrontal-Amygdala Plasticity and Cognitive Safety.

Li J, Jin T, Chi Y et al. · 2025 · Neuropsychiatric disease and treatment

Purpose Reducing electroconvulsive therapy (ECT)'s cognitive burden without compromising efficacy is critical. Although magnetic seizure therapy (MST) shows comparable symptom remission in schizophrenia, its neuroanatomical…

View details →DOI: 10.2147/ndt.s531892
Negative / Null Result ReportOpen accessMedicine

Further evidence that averageness and femininity, rather than symmetry and masculinity, predict facial attractiveness judgments.

Lee P, Li J, Rafiee Y et al. · 2025 · Scientific reports

Facial attractiveness influences important social outcomes and most studies investigating possible predictors of facial attractiveness have tested for effects of shape symmetry, averageness (i.e., the converse of distinctiveness), and…

View details →DOI: 10.1038/s41598-025-86974-0