Negative / Null Result ReportMedicine
Kawata S, Hiramatsu Y, Honke J et al. · 2026 · Annals of surgical oncology
Background Esophagectomy confers high postoperative morbidity and mortality. To improve postoperative outcomes, this study investigated the effectiveness of a 2-week prehabilitation program on the preoperative cardiopulmonary function of…
View details →DOI: 10.1245/s10434-025-18804-6 Negative / Null Result ReportMedicine
Arnalich-Montiel F, Aguado-Casanova V, Vicente-Antolin M et al. · 2026 · European journal of ophthalmology
PurposeThis study aimed to evaluate anatomical changes in the posterior corneal surface in a cohort of patients who underwent Descemet membrane endothelial keratoplasty (DMEK) with manual descemetorhexis in one eye and femtosecond-assisted…
View details →DOI: 10.1177/11206721251379938 Negative / Null Result ReportMedicine
Payne V, Hall M, Johnson MJ · 2025 · Archives of disease in childhood. Fetal and neonatal edition
Objective To investigate the effect of alcohol-impregnated port protectors (AIPPs) on neonatal central line-associated bloodstream infection (CLABSI) rates. Design A quality improvement study. Setting A tertiary neonatal unit in the UK.…
View details →DOI: 10.1136/archdischild-2024-327651 Negative / Null Result Report
Wang Y, Joseph LC, Östlund C et al. · 2025 · Preprint
ABSTRACT BACKGROUND Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated aging disorder characterized by numerous symptoms, including early-onset atherosclerosis, with most patients suffering fatal myocardial infarctions or…
View details →DOI: 10.1101/2025.09.15.676432 Negative / Null Result ReportMedicine
Roemhild K, Li Y, Barmin RA et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Macrophages are key regulators of the tumor microenvironment (TME) and attractive targets for nanomedicine therapies. Because intracellular iron can promote pro-inflammatory macrophage polarization, superparamagnetic iron oxide…
View details →DOI: 10.1016/j.jconrel.2026.114726 Negative / Null Result ReportMedicine
Hartwig N, Wombwell E · 2025 · Infectious diseases now
Purpose This study evaluates 30-day community-acquired pneumonia (CAP) readmission rates dependent on discharge antibiotic selection. Patients and methods This is a retrospective, single-center, observational study of patients discharged…
View details →DOI: 10.1016/j.idnow.2025.105159 Negative / Null Result ReportMedicine
Hellner K, Simon P, De Sutter P et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background The clearance of high-risk oncogenic HPV (hrHPV) and related cervical lesions is associated with the development of a robust T cell response. Therapeutic vaccination that induces HPV antigen-specific T cells is a promising…
View details →DOI: 10.1093/cid/ciaf658 Negative / Null Result ReportMedicine
Kahraman Z, Özden S · 2026 · The Journal of prosthetic dentistry
Statement of problem Because of the multivariable nature of the 3-dimensional (3D) printing process, each stage must be performed under optimal conditions to ensure the trueness and reliability of dental restorations. However, information…
View details →DOI: 10.1016/j.prosdent.2025.09.027 Negative / Null Result ReportMedicine
Lin AT, Niu F, Hui RL et al. · 2025 · Expert opinion on biological therapy
Background Limited real-world studies have evaluated outcomes after switching treatment from a reference product (RP) to a biosimilar product. The objective of this real-world study was to assess the outcomes of switching from RP…
View details →DOI: 10.1080/14712598.2025.2574011 Negative / Null Result Report
Elefson S, Vonderohe C, Stoll B et al. · 2025 · Preprint
Background Biliary atresia (BA) is the leading cause of pediatric liver transplants, however; the cause of biliary atresia (BA) is unknown. Furthermore, the most common treatment for this disease is with a surgical procedure, which has a…
View details →DOI: 10.1101/2025.09.12.675643 Negative / Null Result ReportMedicine
Bürker BS, Brautaset Englund KV, Myrdal Østby C et al. · 2025 · Clinical transplantation
Background Cognitive dysfunction after successful heart transplantation (HTx) is not uncommon. Lower hemoglobin levels have previously been associated with cognitive dysfunction in heart transplant recipients (HTx recipients). In a…
View details →DOI: 10.1111/ctr.70370 Negative / Null Result ReportMedicine
Eloot S, Erlenkötter A, Zawada AM et al. · 2026 · Artificial organs
To date, it remains unclear to what extent dialyzer performance is affected by clotting, and which hemocompatibility parameters can reliably predict this phenomenon. This study investigated the relationship between dialyzer clotting,…
View details →DOI: 10.1111/aor.70039 Negative / Null Result Report
Reinmann N, Vorburger C, Hafer-Hahmann N · 2025 · Preprint
Many parasites change the behavior of their host. Parasitoid wasps, for example, frequently engage in body guard manipulation to induce behaviors in their hosts that enhance parasite survival after pupation. Parasitoids of aphids have…
View details →DOI: 10.22541/au.175320040.09919592/v1 Negative / Null Result ReportMedicine
Wang Z, Mach J, Chen X et al. · 2025 · Current biology : CB
Honeybee foragers explore the environment before they start foraging, following dances, or performing dances. Foragers are therefore familiar with the landscape surrounding the hive during their foraging career. Here, we ask whether…
View details →DOI: 10.1016/j.cub.2025.08.055 Negative / Null Result ReportMedicine
Ardiyanti R, Azrague K, Østerhus SW et al. · 2025 · Chemosphere
The growing demand for phosphorus recovery from wastewater has increased interest in Enhanced Biological Phosphorus Removal (EBPR) processes. However, the fate of per- and polyfluoroalkyl substances (PFAS) in EBPR-derived biosolids remains…
View details →DOI: 10.1016/j.chemosphere.2025.144730 Negative / Null Result ReportMedicine
Wang Z, Xiao F, Chen M et al. · 2025 · Ecological Indicators
In the past few decades, freshwater lakes in the middle and lower reaches of the Yangtze River have experienced significant ecological degradation, with many lakes transitioning from oligotrophic to eutrophic states. In response to this…
Negative / Null Result ReportMedicine
Pohl V, Haas R, Rosen R et al. · 2025 · Clinical implant dentistry and related research
Objective This randomized controlled trial aimed to evaluate the impact of early versus delayed change of abutment on bone levels, soft tissue, and patient satisfaction with single-tooth immediate implants. Material and methods In 26…
View details →DOI: 10.1111/cid.70088 Negative / Null Result ReportMedicine
Cuttance E, Nortje R, Laven R et al. · 2025 · The Journal of dairy research
This study compared a culture-based protocol in which only cows identified as having intramammary infections due to major pathogens (major IMI) were treated with dry cow antibiotics (DCAT) compared with the current New Zealand somatic cell…
View details →DOI: 10.1017/s0022029925101180 Negative / Null Result ReportMedicine
Gómez DP, Nicolás VR, Marrero GC et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology
Hepatocyte nuclear factor 4 A (HNF4A) is a transcription factor that regulates a diverse range of intestinal epithelial genes involved in tissue renewal, differentiation, and metabolism, among other functions. The HNF4A locus is associated…
View details →DOI: 10.1152/ajpgi.00224.2025 Negative / Null Result ReportOpen accessMedicine
Martin E, Aigrot MS, Frère N et al. · 2025 · Multiple sclerosis journal - experimental, translational and clinical
Background To recover normal functions, remyelination in multiple sclerosis is crucial. Although endogenous remyelination occurs, it is often insufficient, and finding molecules promoting repair of demyelinated lesions is needed.…
View details →DOI: 10.1177/20552173251326913 Negative / Null Result ReportMedicine
Swami U, Jo Y, Narang A et al. · 2025 · European urology oncology
Although obesity has been associated with better overall survival (OS) among patients with metastatic castration-resistant prostate cancer, its association with OS has not been extensively explored in metastatic hormone-sensitive prostate…
View details →DOI: 10.1016/j.euo.2024.10.013 Negative / Null Result ReportOpen accessMedicine
D'Haens G, Danese S, Panaccione R et al. · 2025 · Journal of Crohn's & colitis
Background and aims Tyrosine kinase 2 is a downstream intracellular mediator of interleukin-23 signaling, which has a key role in the pathogenesis of inflammatory bowel disease. Deucravacitinib is a novel, oral, selective, allosteric…
View details →DOI: 10.1093/ecco-jcc/jjaf080 Negative / Null Result ReportMedicine
Clayton AH, Lasser R, Nandy I et al. · 2023 · The Journal of clinical psychiatry
Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive steroid and GABA A receptor positive allosteric modulator, in major depressive disorder (MDD). Methods: The phase 3, double-blind, randomized,…
View details →DOI: 10.4088/jcp.22m14445 Negative / Null Result ReportOpen accessMedicine
Fiorentù G, Bernardinello N, Giulianelli G et al. · 2025 · Advances in therapy
Pulmonary hypertension (PH) is a progressive syndrome characterized by increased pulmonary artery pressure. PH often complicates chronic lung diseases, thus contributing to a substantial disease burden and poor prognosis. The WHO Group 3…
View details →DOI: 10.1007/s12325-025-03129-3 Negative / Null Result ReportMedicine
Bodensohn R, Kaempfel AL, Boulesteix AL et al. · 2023 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Background and purpose There is no randomized evidence comparing whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial…
View details →DOI: 10.1016/j.radonc.2023.109744 Negative / Null Result ReportOpen accessMedicine
Perez PN, Smesseim I, Sterman DH · 2026 · Immunotherapy
Lung cancer is the leading cause of cancer deaths, and despite therapeutic advances, recurrence and resistance persist. Local tumor ablation can function as an in situ vaccine, but thermal techniques may disrupt antigen and extracellular…
View details →DOI: 10.1080/1750743x.2026.2651072 Negative / Null Result ReportMedicine
Gondi V, Pugh SL, Mehta MP et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Hippocampal avoidance (HA) during therapeutic whole-brain radiotherapy reduces the risk of neurocognitive function (NCF) toxicity in patients with brain metastasis. This trial hypothesized that HA during prophylactic cranial…
View details →DOI: 10.1200/jco-25-00221 Negative / Null Result ReportMedicine
Versteegen E, Wang A, Wang X et al. · 2025 · Aquatic toxicology (Amsterdam, Netherlands)
Pharmaceutical contamination in aquatic environments, particularly from neuroactive drugs like antidepressants, potentially affects the behaviour of non-target organisms due to their effects on conserved neuroendocrine systems. Behavioural…
View details →DOI: 10.1016/j.aquatox.2025.107611 Negative / Null Result ReportMedicine
Navarrete Sánchez RA, Tognetti PM, Maddonni GA · 2025 · European Journal of Agronomy.
Maize crops are exposed to heat stress, water restrictions, or combined stress during vegetative stages, which can immediately limit crop growth and extend into the flowering period, affecting grain yield. This study evaluated the effects…
Negative / Null Result ReportOpen accessMedicine
Firlana CR, Emril DR, Syahrizal D et al. · 2026 · Narra J
Sciatic nerve injury results in motor dysfunction and muscle atrophy, with limited effective therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) may promote neuromuscular recovery, but their effects on functional and muscle…
View details →DOI: 10.52225/narra.v6i1.3018 