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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19895 results in Negative / Null Result Report · page 583 of 664

Negative / Null Result ReportMedicine

Joint-specific measures improve risk adjustment in total knee arthroplasty: A machine learning approach.

Müller D, Gillani A, Hirschmann MT et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Accurate risk adjustment in total knee arthroplasty (TKA) is essential for outcome prediction and quality assessment. Most existing prediction models rely solely on patient demographics and comorbidities and do not account for…

View details →DOI: 10.1002/ksa.70480
Negative / Null Result ReportMedicine

Bovine colostrum as a human milk fortifier for very preterm infants with slow feeding advancement: a randomized controlled trial.

Jiang PP, Huang HY, Zhao L et al. · 2026 · Pediatric research

Background Fortification of human milk for very preterm infants (VPIs) with alternatives to conventional bovine milk-based fortifiers remains minimally studied. This trial tested whether fortification with protein-rich bovine colostrum…

View details →DOI: 10.1038/s41390-026-04768-0
Negative / Null Result ReportMedicine

Safety and outcome of transscleral fine-needle aspiration biopsy in uveal melanoma: 10-year experience in 347 cases.

Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…

View details →DOI: 10.1097/iae.0000000000004906
Negative / Null Result ReportMedicine

Acute effects of an individually timed lower-limb post-activation performance enhancement protocol on 50 m front crawl performance and race kinematics in national-level swimmers.

Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports

Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…

View details →DOI: 10.1038/s41598-026-51746-x
Negative / Null Result Report

Belgian endive-derived biostimulant activity in Arabidopsis, lettuce and sweet pepper at different developmental stages, environmental conditions, and application methods

Ogunsanya HY, Petit C, Audenaert K et al. · 2026 · Preprint

Belgian endive-derived biostimulant (BEE) was previously shown to enhance root and shoot growth of Arabidopsis thaliana and Plectranthus esculentus in in vitro culturing conditions. In this study, we evaluated the effect of BEE on A.…

View details →DOI: 10.64898/2026.04.15.717650
Negative / Null Result ReportMedicine

<i>Enterobacter</i>-based dietary supplements in both larvae and adult diet affect thermal response of sterile males.

Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research

Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…

View details →DOI: 10.1017/s0007485326101035
Negative / Null Result ReportOpen accessMedicine

Multiple Arterial Grafting in Hemodialysis Patients.

Hachiro K, Takashima N, Kamiya K et al. · 2026 · Circulation reports

Background The effectiveness of multiple arterial grafting (MAG) for hemodialysis (HD) patients is unclear. Methods and results We retrospectively analyzed 149 HD patients who underwent either MAG (n=97) or single arterial grafting (SAG)…

View details →DOI: 10.1253/circrep.cr-25-0302
Negative / Null Result ReportMedicine

Evaluation of postoperative analgesia with perioperative electroacupuncture in clinical dog patients undergoing surgery for cranial cruciate ligament rupture (Tibial Tuberosity Advancement).

Lienert M, Stadler L, Kipfer N et al. · 2026 · Veterinary journal (London, England : 1997)

Objectives To investigate the effect of electroacupuncture on postoperative analgesia in dogs undergoing Tibial Tuberosity Advancement surgery. We hypothesise that acupuncture will reduce pain scores and the need for rescue analgesia…

View details →DOI: 10.1016/j.tvjl.2026.106712
Negative / Null Result ReportMedicine

Correcting photoreceptor diseases at their source: CRISPR strategies for cone-rod dystrophy and achromatopsia.

Zaki HF, Bishri J, Abdul Muqtadir M et al. · 2026 · Experimental eye research

Background Cone-rod dystrophy (CORD) and achromatopsia (ACHM) are inherited retinal dystrophies for which conventional adeno-associated virus (AAV) gene augmentation has important limitations, particularly in autosomal-dominant…

View details →DOI: 10.1016/j.exer.2026.111119
Negative / Null Result ReportMedicine

Responsiveness and Minimal Important Change of the Haemophilia Activities List in Patients With Inherited Bleeding Disorders.

Blokzijl J, Kuijlaars IAR, Pisters MF et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Introduction The Haemophilia Activities List (HAL) is a disease-specific patient-reported outcome measure (PROM) that is widely used in both healthcare and research in people with inherited bleeding disorders (PWBD), but information on…

View details →DOI: 10.1111/hae.70327
Negative / Null Result ReportMedicine

Mortality Risk Prediction from Dense PICU Data from Patients with Suspected Infection: Data-Derived Physiological Trajectories Outperform Expert Assessments When Temporal Resolution Is High.

Velez T, Badaki-Makun O, Hirsch D et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objective Early identification of mortality risk in critically ill children with suspected infection remains challenging. Whether severity scores (SIRS, pSOFA, Phoenix) add incremental value beyond data-derived physiologic features in…

View details →DOI: 10.1016/j.ijid.2026.108899
Negative / Null Result ReportMedicine

Is There an Added Value of Dual-Time-Point [<sup>68</sup>Ga]Ga-Fibroblast Activation Protein Inhibitor (FAPI) PET/CT in Differentiating Malignant and Benign Uptake Findings?

Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers

Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…

View details →DOI: 10.3390/cancers18121963
Negative / Null Result ReportMedicine

Beyond microprocessor knees: exploring the potential of fully powered prosthetic legs.

Embry KR, Jayaraman C, Yang C et al. · 2026 · Journal of neuroengineering and rehabilitation

Background Powered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological…

View details →DOI: 10.1186/s12984-026-02042-2
Negative / Null Result ReportMedicine

High-dose metoclopramide versus placebo for gastroduodenal visualization during endoscopy in patients with acute upper gastrointestinal bleeding. A triple-blind, randomized clinical trial.

Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…

View details →DOI: 10.1016/j.rgmxen.2026.05.005
Negative / Null Result ReportMedicine

Striatal DAT-SPECT texture beyond mean binding in major depressive disorder.

Tamura T, Abe S, Matsui H et al. · 2026 · Journal of affective disorders

Background Dopaminergic dysfunction has been implicated in major depressive disorder (MDD), but dopamine transporter (DAT) imaging studies using conventional mean binding have yielded inconsistent findings. One possible contributor is that…

View details →DOI: 10.1016/j.jad.2026.122099
Negative / Null Result ReportMedicine

Platelet-rich plasma versus plasma gel for fat graft survival under cigarette smoke exposure: An experimental study.

Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…

View details →DOI: 10.1016/j.bjps.2026.05.060
Negative / Null Result ReportMedicine

To Drain or Not to Drain? The Manchester Buckle Study.

Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…

View details →DOI: 10.1097/iae.0000000000004856
Negative / Null Result ReportMedicine

Exploring hemodynamic measurements from the Tromsø Study for prediction of cardiovascular disease using traditional statistical models and machine learning approaches.

Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports

In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…

View details →DOI: 10.1038/s41598-026-57003-5
Negative / Null Result ReportMedicine

Impact of Novel Tools for Blended and Competency-Based Learning in Veterinary Compounding and Prescribing.

Bröer S, Filor V, Bäumer W · 2026 · Journal of veterinary pharmacology and therapeutics

According to the European Association of Establishments for Veterinary Education (EAEVE), a graduate of veterinary medicine should be able to prescribe and dispense "medicines correctly and responsibly in accordance with legislation and…

View details →DOI: 10.1111/jvp.70062
Negative / Null Result ReportMedicine

Discrepancy Between Biological Activity and Functional Fracture Healing Following Vitamin K2 Supplementation in an Ovariectomized Rat Model of Osteoporosis.

Jecan A, Melinte RM, Tomoaia G et al. · 2026 · Journal of clinical medicine

Background : Vitamin K2 (menaquinone) has been studied as a molecule with important effects on bone metabolism and has been proposed as a potential adjuvant in fracture healing, particularly under osteoporotic conditions. However, its…

View details →DOI: 10.3390/jcm15124510
Negative / Null Result ReportMedicine

Deep Polymerization Performance of a Third-Generation Polywave LED: Comparison of Standard and High-Power Modes in Conventional Resin Composites.

Kılıç HS · 2026 · European journal of dentistry

Objective This article aims to compare the polymerization effectiveness of two curing modes of a polywave LED unit in four conventional resin composites at a 2-mm increment thickness, using bottom/top microhardness ratios as the evaluation…

View details →DOI: 10.1055/s-0046-1820081
Negative / Null Result ReportMedicine

Multi-center pressure reactivity index temporal trajectories for predicting outcome in comatose subarachnoid hemorrhage patients.

Chang JJ, Foreman B, Kepplinger D et al. · 2026 · Neurosurgical review

Pressure reactivity index (PRx) is a surrogate for cerebral autoregulation and has been used for prognostication in aneurysmal subarachnoid hemorrhage (SAH). We examined patient-specific temporal courses of PRx and identified time…

View details →DOI: 10.1007/s10143-026-04323-9
Negative / Null Result ReportMedicine

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19-09, CONPELAN Study.

Chun SH, Seo S, Cho JH et al. · 2026 · Head & neck

Background The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II-IVB NPC were…

View details →DOI: 10.1002/hed.70329
Negative / Null Result ReportMedicine

Health-Related Quality of Life in People Living with HIV andHypertension: Effects of a Short Message Service-Based Mobile HealthIntervention (MOPHADHIV Trial).

Hongoro DJ, Kengne AP, Peer N et al. · 2026 · AIDS and behavior

Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We…

View details →DOI: 10.1007/s10461-026-05128-z